6533b862fe1ef96bd12c74c0
RESEARCH PRODUCT
19F-MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation
Manfred ThelenClaus P. HeusselMichael QuintelWolfgang SchreiberHans-ulrich KauczorBalthasar EberleMarc D. SchmittnerSimone Laukemper-ostendorfKlaus MarkstallerNorbert WeilerKatja BurgerAlexander Scholzsubject
medicine.diagnostic_testChemistryPerflubronbusiness.industryMagnetic resonance imagingPartial pressureBackground noisechemistry.chemical_compoundIn vivomedicineRadiology Nuclear Medicine and imagingPartial liquid ventilationRespiratory systemNuclear medicinebusinessLongitudinal Relaxation TimeBiomedical engineeringdescription
A method for in vivo measurement of oxygen partial pressure (pO2) in porcine lungs during partial liquid ventilation (PLV) with perflubron (PFOB) was developed. A pulse sequence for high-resolution MRI of the distribution of PFOB in the lung after intratracheal administration was developed as well. Moreover, quantitative measurements of longitudinal relaxation time T(1) of (19)F resonances for assessment of regional pO2 are described. Due to the need to acquire data during a single expiratory breathhold, only low SNRs were achieved in vivo. Therefore, simulations were performed to investigate the influence of background noise on T(1) values calculated from data with low SNR. Based on these simulations, a postprocessing strategy was developed to correct for systematic errors by background noise prior to quantitative analysis. Results of a pilot study in pigs under conditions of PLV are presented.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-12-20 | Magnetic Resonance in Medicine |