6533b856fe1ef96bd12b3083

RESEARCH PRODUCT

Multirotations-CT während kontinuierlicher Beatmung: Vergleich unterschiedlicher Dichtebereiche bei gesunden Lungen und im Lavage-ARDS Modell

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description

PURPOSE In this animal study, density ranges for CT-based quantification of ventilated lung area were determined. Healthy lungs and ARDS lungs were compared during artificial respiration. MATERIAL AND METHODS CT-scans were performed in 5 anesthetized pigs using a dynamic multiscan CT option on a predefined transverse slice (slice thickness 1 mm; effective temporal resolution, 250 ms). During continuous CT acquisition, airway pressure was increased or decreased in a stepwise manner. In all images, areas of defined HU ranges were determined planimetrically. The lower threshold was set to -910 HE in all images. The upper threshold was varied from -800 HE to -200 HE in steps of 100 HE. RESULTS During inspiration in healthy lungs the HU-range of -910 to -700 HU showed the largest increase in area. During inspiration in ARDS lungs the HU range from -910 to -300 HU allowed the most sensitive assessment of area changes. These findings can be explained by recruitment of atelectases (HU-range > -300 HU) and their transition to a HU range from -700 to -300 HU. CONCLUSION Dynamic multiscan CT acquisitions are a useful method to determine changes of ventilated lung area during a respiratory cycle. Different HU-ranges are required to access volume changes in healthy lungs and in ARDS lungs.