6533b7dbfe1ef96bd1270a6e
RESEARCH PRODUCT
3He-MRI-based measurements of intrapulmonarypO2 and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations
Wolfgang SchreiberGorden HanischBalthasar EberleNorbert WeilerWerner HeilKlaus MarkstallerT. GrossmannHans-ulrich KauczorErnst W. OttenAnselm DeningerMichael EbertReinhard Surkausubject
Reproducibilitymedicine.diagnostic_testChemistryApneaMagnetic resonance imagingNuclear magnetic resonanceTime courseHealthy volunteersmedicineMolecular MedicineRadiology Nuclear Medicine and imagingmedicine.symptomSpectroscopyRegional differencesLung functionAcquisition techniquedescription
We applied a recently developed method of following the time course of the intrapulmonary oxygen partial pressure p(O2)(t) during apnea by (3)He MRI to healthy volunteers. Using two imaging series with different interscan times during two breathholds (double acquisition technique), relaxation of (3)He due to paramagnetic oxygen and depolarization by RF pulses were discriminated. In all four subjects, the temporal evolution of p(O2) was found to be linear, and was described by an initial partial pressure p(0) and a decrease rate R. Also, regional differences of both p(0) and R were observed. A correlation between p(0) and R was apparent. Finally, we discuss limitations of the double acquisition approach.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-01-01 | NMR in Biomedicine |