6533b832fe1ef96bd129ad37

RESEARCH PRODUCT

Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira

Juan CarmonaPeter D. CaryTrevor A. CrabbAsmita V. PatelGerald BlundenPablo MeléndezManuel CostaIrama RamírezSimon L. CroftManuel JimenezAlfredo Carabot

subject

ChalconeMagnetic Resonance Spectroscopymedicine.drug_classStereochemistryDimerAntiprotozoal AgentsPlant ScienceHorticultureBiologyPharmacognosyBiochemistryFlavonesKB Cellschemistry.chemical_compoundChalconemedicineAnimalsHumansMenispermaceaeTrypanosoma cruziMolecular BiologyFlavonoidschemistry.chemical_classificationEukaryotaGeneral MedicineCissampelosPlant Components Aerialbiology.organism_classificationAntineoplastic Agents PhytogenicchemistryCissampelos pareiraAntiprotozoalDimerization

description

From the aerial parts of Cissampelos pareira L. (Menispermaceae), a chalcone-flavone dimer has been isolated which, mainly from NMR spectroscopic and MS data, was proved to be 2-(4-hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy-4,6-dimethoxybenzoyl)-furano[3,2-g]benzopyran-4-one. This has been assigned the trivial name cissampeloflavone. The compound has good activity against Trypanosoma cruzi and T. brucei rhodesiense and has a low toxicity to the human KB cell line.

yearjournalcountryeditionlanguage
2003-09-01Phytochemistry
https://doi.org/10.1016/s0031-9422(03)00241-3