6533b832fe1ef96bd129ad3b

RESEARCH PRODUCT

Resting state glucose utilization and the CERAD cognitive battery in patients with Alzheimer's disease

Frode WillochMarkus SchwaigerKazunari IshiiKatharina BürgerRolf R. EngelA. DrzezgaHarald HampelPeter BartensteinH.-j. MöllerStefan J. Teipel

subject

MaleAgingmedicine.medical_specialtyNeuropsychological TestsAudiologyFunctional LateralityCognitionAlzheimer DiseaseFluorodeoxyglucose F18Image Processing Computer-AssistedmedicineHumansDementiaVerbal fluency testRegistriesNeuropsychological assessmentEpisodic memoryAgedBrain ChemistrySex Characteristicsmedicine.diagnostic_testResting state fMRIGeneral NeuroscienceNeuropsychologyCognitionMiddle Agedmedicine.diseaseGlucosePositron emission tomographyData Interpretation StatisticalPositron-Emission TomographyFemaleNeurology (clinical)RadiopharmaceuticalsGeriatrics and GerontologyPsychologyNeuroscienceDevelopmental Biology

description

The present study examined the cortical functional representation of neuropsychological domains in Alzheimer's disease (AD) using positron emission tomography (PET) and the neuropsychological assessment battery of the Consortium to Establish a Registry of Alzheimer's Disease (CERAD). Thirty patients with clinical probable AD and 10 elderly healthy controls underwent (18)FDG brain PET imaging during a resting state. Correlations between metabolic values and cognitive measures were determined using a region of interest analysis with NEUROSTAT (University of Michigan, USA) and a voxel-based analysis with SPM96 (Wellcome Department, London, UK). Specific correlations were seen between measures of episodic memory, verbal fluency and naming and left hemispheric temporal and prefrontal metabolism. Drawing was correlated with metabolism in left prefrontal and left inferior parietal regions. The presented data support the use of metabolic-cognitive correlations to demonstrate the neuronal substrates of cognitive impairment in AD. Subtests of the CERAD battery give a good representation of left, but not of right hemisphere function in AD.

yearjournalcountryeditionlanguage
2004-04-10Neurobiology of Aging
https://doi.org/10.1016/j.neurobiolaging.2005.03.015