6533b833fe1ef96bd129b7b1
RESEARCH PRODUCT
Decline in the incidence of colorectal cancer and the associated mortality in young Italian adults
Zorzi M.Cavestro G. M.Guzzinati S.Dal Maso L.Rugge M.Mazzoleni G.Morrone G.Caputo E.Galasso R.Citarella A.Sampietro G.Magoni M.Cavalieri D'oro L.Ardizzone A.D'argenzio A.Sciacca S.Pisani S.Ricci P.Giorno A.Ferretti S.Palma F.Serraino D.Iacovacci S.Quarta F.Filiberti R. A.Vitarelli S.Russo A. G.Carrozzi G.D'orsi G.Fusco M.Sini G. M.Vitale F.Michiara M.Boschetti L.Chiaranda G.Rosso S.Tumino R.Mangone L.Valenti Clemente S.Falcini F.Caiazzo A. L.Cesaraccio R.Madeddu A.Fanetti A. C.Minerba S.Caldarella A.Candela G.Piffer S.Stracci F.Tagliabue G.Tolin M.Brustolin A.Castelli M.subject
0301 basic medicine2312ColonPopulationSocio-culturalecolorectal cancercolorectal cancer screening03 medical and health sciencesYoung Adult0302 clinical medicineEpidemiology of cancerMedicineHumans1506Risk factoreducationeducation.field_of_studycancer epidemiology Colorectal cancer colorectal cancer screeningbusiness.industryIncidence (epidemiology)Mortality ratescreeningIncidenceGastroenterologyCancermedicine.diseaseObesityAnnual Percent ChangeEurope030104 developmental biologyItaly030211 gastroenterology & hepatologyepidemiologybusinessColorectal NeoplasmsDemographycancer epidemiologySEER Programdescription
Objective The incidence of colorectal cancer (CRC) declines among subjects aged 50 years and above. An opposite trend appears among younger adults. In Europe, data on CRC incidence among younger adults are lacking. We therefore aimed to analyse European trends in CRC incidence and mortality in subjects younger than 50 years. Design Data on age-related CRC incidence and mortality between 1990 and 2016 were retrieved from national and regional cancer registries. Trends were analysed by Joinpoint regression and expressed as annual percent change. Results We retrieved data on 143.7 million people aged 20–49 years from 20 European countries. Of them, 187 918 (0.13%) were diagnosed with CRC. On average, CRC incidence increased with 7.9% per year among subjects aged 20–29 years from 2004 to 2016. The increase in the age group of 30–39 years was 4.9% per year from 2005 to 2016, the increase in the age group of 40–49 years was 1.6% per year from 2004 to 2016. This increase started earliest in subjects aged 20–29 years, and 10–20 years later in those aged 30–39 and 40–49 years. This is consistent with an age-cohort phenomenon. Although in most European countries the CRC incidence had risen, some heterogeneity was found between countries. CRC mortality did not significantly change among the youngest adults, but decreased with 1.1%per year between 1990 and 2016 and 2.4% per year between 1990 and 2009 among those aged 30–39 years and 40–49 years, respectively. Conclusion CRC incidence rises among young adults in Europe. The cause for this trend needs to be elucidated. Clinicians should be aware of this trend. If the trend continues, screening guidelines may need to be reconsidered.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |