6533b834fe1ef96bd129e278

RESEARCH PRODUCT

European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): part I.

Robert HuddartJohannes ClassenRoberto SalvioniRainer SouchonWalter AlbrechtXavier Garcia Del MuroMalcolm David MasonMichael BambergJohnathan JoffeJutta ScheiderbauerAnnette DieingOscar Leiva GalvisNiels E. SkakkebækRonald De WitWilliam G. JonesSophie D. FossåKai Uwe KoehrmannH. G. DerigsSilke GillessenMartin FennerSergei TjulandinC ClemmWolfgang HoeltlPadraig WardeAude FlechonLuis Paz AresPieter H.m. De MulderS. KlieschNicola NicolaiThomas PowlesLászló KisbenedekLothar WeissbachCraig R. NicholsHans Von Der MaaseMichael JewettJörg PontMarkus A. KuczykVolker LoyChristian WittekindPeter AlbersJose Ramon Germa-lluchFelix SedlmayerGiovanni RostiD. OndrušPilar LagunaHeinz SchmidbergerIstván BodrogiGabriella Cohn-cedermarkEva Cavallin-ståhlJörg BeyerTim OliverArthur GerlGedske DaugaardStefan WeinknechtTobias PottekHans-joachim SchmollMaike De WitRolf MuellerMaria De SantisMichael HartmannGraham M. MeadOliver RickJean Pierre DrozChristian K. KollmannsbergerHans U. SchmelzKarim FizaziGosse O N OosterhofLori WoodThomas GaulerAslam SohaibSusanne KregeFerran AlgabaAlan HorwichEva WinterStéphane CulineGiorgio PizzocaroOlbjørn KleppAxel HeidenreichKlaus Peter DieckmannJörg T. HartmannMark SchraderLajos GécziCarsten Bokemeyer

subject

MaleMESH: Combined Modality TherapyBiopsyConsensus Development Conferences as Topic030232 urology & nephrologyMembrane transport and intracellular motility [NCMLS 5]MESH: Biopsy0302 clinical medicineStage I SeminomaMESH: Practice Guidelines as TopicMedicineSocieties MedicalMESH: Testicular NeoplasmsConsensus conferenceMESH: Neoplasm StagingNeoplasms Germ Cell and EmbryonalPrognosisPrimary tumorCombined Modality Therapy3. Good healthEurope030220 oncology & carcinogenesisPractice Guidelines as TopicMESH: Neoplasms Germ Cell and Embryonalmedicine.medical_specialty[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]ConsensusUrologyMESH: Societies MedicalMEDLINEMESH: Prognosis03 medical and health sciencesSDG 3 - Good Health and Well-beingTesticular NeoplasmsInterventional oncology [UMCN 1.5]HumansMESH: ConsensusTesticular cancerNeoplasm StagingGynecologyMESH: Humansbusiness.industryMESH: Consensus Development Conferences as Topicmedicine.diseaseMESH: MaleClinical trialGerm cell cancerFamily medicineGerm cell tumorsMESH: Europebusiness

description

Objectives: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. Methods: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.

10.1016/j.eururo.2007.12.024https://hdl.handle.net/2066/70330