Haemodynamic predictors of a penetrating atherosclerotic ulcer rupture using fluid-structure interaction analysis

6533b836fe1ef96bd12a0190

RESEARCH PRODUCT

Haemodynamic predictors of a penetrating atherosclerotic ulcer rupture using fluid-structure interaction analysis

Roberto Baglini Antonino Rinaudo Andrea Amaducci Michele Pilato Giuseppe D'ancona Fabrizio Follis Salvatore Pasta

subject

Male medicine.medical_treatment Hemodynamics Aorta Thoracic Medicine Thoracic aorta Hematoma medicine.diagnostic_test Endovascular Procedures Models Cardiovascular Settore ING-IND/34 - Bioingegneria Industriale Anatomy Treatment Outcome Atherosclerosi Cardiology Wall shear stre Cardiology and Cardiovascular Medicine Brief Communications Blood Flow Velocity Human Pulmonary and Respiratory Medicine medicine.medical_specialty Aortography Aortic Rupture Aortic Diseases Aortography Blood Vessel Prosthesis Implantation Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di Macchine Penetrating atherosclerotic ulcer Penetrating atherosclerotic ulcer Internal medicine medicine.artery Fluid-structure interaction Shear stress Humans Arterial Pressure Computer Simulation Hemodynamic Aortic rupture Ulcer Aged Endovascular Procedure business.industry Hemodynamics Stent medicine.disease Atherosclerosis Aortic Disease Blood pressure Regional Blood Flow Surgery Stress Mechanical business Tomography X-Ray Computed

description

We present preliminary data on the flow-induced haemodynamic and structural loads exerted on a penetrating atherosclerotic aortic ulcer (PAU). Specifically, one-way fluid-structure interaction analysis was performed on the aortic model reconstructed from a 66-year-old male patient with a PAU that evolved into an intramural haematoma and rupture of the thoracic aorta. The results show that elevated blood pressure (117 mmHg) and low flow velocity at the aortic wall (0.15 m/s(2)) occurred in the region of the PAU. We also found a low value of time-averaged wall shear stress (1.24 N/m(2)) and a high value of the temporal oscillation in the wall shear stress (oscillatory shear index = 0.13) in the region of the PAU. After endovascular treatment, these haemodynamic parameters were distributed uniformly on the luminal surface of the stent graft. These findings suggest that wall shear stress could be considered one of the major haemodynamic factors indicating the structural fragility of the PAU wall, which ultimately lead to PAU growth and rupture.

year	journal	country	edition	language
2013-06-04

10.1093/icvts/ivt245 http://hdl.handle.net/10447/376276