6533b838fe1ef96bd12a473b
RESEARCH PRODUCT
Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19).
Astrid LièvreAnthony TurpinIsabelle Ray-coquardKarine Le MalicotJuliette ThariatGuido AhleCindy NeuzilletXavier PaolettiOlivier BouchéKais AldabbaghPierre MichelDidier DebieuvreAnthony CanellasMarie WislezLucie LaurentMay MabroRaphael ColleAnne-claire Hardy-bessardLaura MansiEmeline ColombaJean BourhisPhilippe GorpheYoann PointreauAhmed IdbaihRenata UrsuAnna Luisa Di StefanoGérard ZalcmanThomas AparicioSolenne MoulinOlivier LeleuSylvie LeparreeHenri GoasdoueChristine PiprotGerald TourneurVincent BayartDelphine LignierEmma LachaierMarwa KhamariAlexandre CoutteNicolas SiembidaAline HouessinonJean Marc RegimbeauBruno ChauffertAurélie MoreiraVincent HautefeuilleChristine HeeMathieu BooneCéline BihanEmilie ChiveStéphane Poulet-potriquierRachida FahemDominique LuetGuillaume RoquinCarole VitelliusNathanaëlle Cornet-trichereauFrançois-xavier Caroli-boscAnne Thirot-bidaultStanislas RopertJulie Gachet - MassonMélanie DehaisGwen-ael L'helgoualc'hIbrahim Ali-mahamadouSafia TalfiLaure BelmontDieudonné KilendoNasro BenrezzakEmeline DubiefGuillaume ConroyLaurence DeliqueMaud BassoIsabelle PonsKarine SalignonAnne-laure VillingEmmanuelle MougenotCassandra PorebskiAsma GuiatniNicolas CloarecLaurent MineurMarie BouchaudCéleste DavidAnnie PeytierThomas GrelettyFranck AudemarEmanuelle VignesFloriane MinneGuillaume GoldzakFabienne HuysmanFayçal HocineZaher LakkisLaura MansiGuillaume MeynardHamadi AlmotlakElodie KlajerXu-shan SunLaura MansiJulie WasselinPascale CatalaClaire MazuyHélène VandammeJean-briac PrevostAurélie FadinLaurent BassonJean-baptiste HuguetEmmanuelle Dos SantosBérangère JanyAlain SaadFrédéric GoutorbeEric OziolMohamed RamdaniOuafae KadiriDelphine GarbayClotilde HuetEtienne Giroux LeprieurWen TengJustine MonvoisinPatrick Arnaud CoffinSylvie RouxHubert OrfeuvreMélanie ChagrosDidier PillonAgathe RassoulPierre Guillaume PoureauCécile NovelloFrançois DucrayCécile TroubaVianney BastitEmmanuel BabinJuliette ThariatVincent LeonAnne-catherine CourtecuisseJulie VambreVincent TackChristophe DesauwFatima MeniaiChristina PeresAurélie EsparcieuxHervé PerrierNathalie DouxRégis KaphanBertrand RoquesChristine RebischungDominique MilleGaëlle FernandesNaceur AbdelliNatacha JoussetPierre CombeEric JonveauxPatrick DumontMarc KanaanCorinne Berthelot GrasValérie PanisLaure KaluzinskiMarjolène Venant-valeryYou-heng LamLaura ValleeFrédéric RiviereMuriel DurandDihya BenghadidEmilie VilleneuveOlivia Hentic DhomeLucie LaurentZedjiga BounouarLouis De MestierJacqueline DuboisMagali EyrieyLionel MoreauGuido AhleLaure BelmontDib BaihasKaïs AldabbaghDominique DegriffoletVirginie SebbaghJean-christophe SeghezziMarion Lozach-brugirardJulie MandrouLoubna MavierFlorence HennetierJean-philippe WagnerElisabeth CarolaKarthiga ChandirakumaranSandrine LoutskiIsabelle Cojean-zelekAmina BourasSandrine LacourFahem FrouraHadjer Ben NadjiSophie CattelainFranck DarloyGeneviève Jolimoy BoilleauCyrielle MaissiatAriane Darut-jouveVéronique LorgisIkram Charifi-alaouiFrançois GhiringhelliAntoine DrouillardMarie ChaixSylvain ManfrediCôme LepageAlice GagnaireMarianne LatournerieSofia JourdanNora PerrotMireille FoliaAnne MinelloJean-louis JouveLaura MansiMarielle FeryAlain LandauSafia TalfiLaure BelmontDiane EvrardBruno ValenzaJean-françois PaitelLaetitia ChablaisThomas KreitmannLaurence Lancry-lecomteAdrien MonardEve FaugerasPaul BoucheretCécile GlommeauChristine TchikladzeClaire Garnier TixidreJérôme LongManel ZaidiPaul BoucheretVéronique DelabarreJuliette MeyzencVéronique DelabarreAdrien MonardLoïc FerrandDenis Moro-sibilotPaul BouheretCécile LeyronnasAdrien MonardCamille HerveVéronique DelabarreAudrey ThoorEmanuelle JacquetGaël RothVidesheka Madapathage-senanyakePeggy ChupeauElsa BieberMaud RossoIsabelle LepageFrank PriouMargot LalySylvie AprelonNatacha SobolakHelen HomokosYoann PointreauClaire MazuyFabienne WatelleAlice Pham-beckerGéraldine LauridantMarielle FeryAnthony TurpinCharlotte DujardinAnthony TurpinEtienne LenglinAimée Nienguet TsotaSophie DominguezAlexandra ForestierFranck NouvelJustine LerooyCéline RatajczakCéline RatajczakAnthony TurpinOlivier RomanoDorothéee BrzyskiAurélien BarriereDominique GenetJulien TisseXavier ZasadnyAdeline GreletAmélie Hennion-imbaultEglantine HaustraeteSamy LouafiIbrahim Ali-mahamadouManal AwadYounes ZekriCaroline CheneauNolwen LeissenJoëlle EgreteauAlexandra BreantMatthieu SarabiStéphanie LabonneJulien ForestierCéline LeclercqFlorence Prunier-bossionIsabelle Ray CoquardMarielle GuilletAurélie TheillaumasEmilie PromeThomas WalterPierre PhilouzeMarielle GuilletMelody LawoSolène De TalhouetJohanne BeuvelotYann MolinMarie Bellecoste MartinMaud SaussereauHervé PerrierLauren AgnelliNicolas FakhryChristophe LaplaceEmmanuelle Norguet MonnereauCéline BoucardKahina DjenadCatherine FontaineJean-françois SeitzLaétitia DahanJulie SigrandMuriel DulucChristophe LocherMarjory FleuryVidesheka Madapathage-senanyakeAnge Brou MarieRamdane BerkaneSéverine PoupblancDominique AubyDaniela PetranPatrick TexereauElodie GuerineauMorgan AndreLinda MahjoubiLaura MansiFanny SarrazinSonia JeansonAnthony GschwendVirginie BirrDidier DebieuvreMathieu ForeMonique NoirclercSihem DahouDominique SpaethMélanie LambotinThomas LeluBenjamin LinotNathalie HugonDominique RousseauHélène CastanieCarole LenneAlain LortholaryAnatole CessotMessaouda MerzougCécile NaudinJean-michel VannetzelGhina AzizYacine Hadj ArabStéphanie PernesIsabelle Roche-lachaiseFrédéric FiteniHadjer YahiaouiGwendoline Marel LopezJeanne OddozFabienne PeiraOlivier MichelJérôme MeunierBrahim OuahraniAntoine RogerSonia BrancoVan NguyenMathilde GisselbrechtGhania HammadPierre MordantMagda StroksztejnMarc PocardLuc Nlo MeyengueThomas AparicioEmmanuelle SaccoSophie Simon AnneElizabeth Fabre-guillevinMarie WislezMarine SlimAziz ZaananJacques CadranelDiane EvrardJohan PluvyRénata UrsuAmyrath GeraldoRime LihiMaryline VoZohra BroukRaphaël ColleMostefa BennamounFabrice LacanChristophe LouvetSoraya MebarkiMarianne VeyriElena PaillaudChristelle LucasOlivier DubreuilJamila LyamaniAhmed IdbaihHanane AgguiniEmilie SoularueAnthony CanellasGérard ZalcmanClément JourdaineBenjamin VerillaudHakima HerzineEric RaymondNathalie MathiotLola Jade PalmieriChristian EpanyaJulien TaiebEliane BertrandGaël GoujonCéline NamourBenoit GazeauBiljana ZafirovaHaitham MirghaniCatherine BelinKahina BelkhirMyriam GharibAurore VozyKarim AmraneJean-philippe SpanoJohanna WassermannLoic FeuvretJean-baptiste BachetSara PhilonenkoLaetitia GuillotMarion ZabbeStéphanie GibiatCamille BaylotAude JouinotNicolas LeducSabine VieillotLaurie JamesCamille DucerfJean-frédéric BlancMarielle GuilletClaire Falandry LegerVirginie WautotMarion ChauvenetAude VincentDavid TougeronSandrine GoulventLoubna MavierEtienne SucAnne-pascale LaurentyEric MarquisMargaux BonnaireMaxime DewolfEsteban BrenetDelphine BillardClaude-fabien LitreAntoine DumazetDamien BotsenEsteban BrenetMarion VazelClaire CarlierEric MarquisDavid BonneraveCharles Marchand-cretyOlivier BouchePatricia FosseDavid SefriouiPierre MichelSarah WatsonCindy NeuzilletFatah TorcheThierry MuronStéphane NaturRomain DesgrippesVéronique BihelFrançois-régis FerrandCaroline LeitererJulie LavoleClaire MoquetNathalie PressoirCatherine DziukalaCatherine Ligeza PoissonAbdelhalim NajiNicolas WillietJean-marc PhelipFabrice Di PalmaAmina Kherrour MehdiJulien Langrand-escurePierre FournelGrégoire PigneLéa Saban-rocheNicolas MagneCécile VassalJean-philippe JacquinCarole RamirezAlexis VallardOlivier CollardThierry MuronRomain RivoirardIvan GraberStéphanie Trager MauryElodie DuboissetJorge Ayllon UgarteDalilia RamiChristine SalerManon ReinboltClara Le FevreMeher Ben AbdelghaniLouis-marie DourtheJoffrey Perruisseau-carrierMarlène Nguimpi-tambouFlavie BarretLuisa Di Stefano AnnaAnnie BalthazardMay MabroCamille Vassord-dangMathilde Le MarchandJulien VergniolIulia PriponAxelle DaemaegdtVanessa LatryMuna LarrieuGaëlle LandryLaetitia Touihri MaximinFrancesco Del PianoAgnès BarletMylène VernisseSophie LafondCharline GeninCamille Sibertin-blancEmilien ChabrillacCaroline GregoireSébastien VergezQuentin PanouilleRosine GuimbaudFloriane RichaLoïc LebellecSophie GouninGuillaume BuiretMarine BaudinHervé HamonAnne-claire DeshorgueMarielle FeryEduardo BarrascoutStéphanie LegrandGéraldine LauridantMorgane HoulzeLinda CambulaAnthony LopezGuillaume FouquetKahina TouabiAdeline GermainBenoit GodbertFlorence VoivretJulie PerrinLaura MansiRosa Da SilvaEmilie Bernichonsubject
Male0301 basic medicineCancer Researchmedicine.medical_treatmentDiseaselaw.inventionCohort Studies0302 clinical medicineMechanical ventilationRisk FactorslawNeoplasmsMedicineProspective StudiesProspective cohort studyOriginal ResearchCancerIntensive care unit3. Good healthDeathOncology030220 oncology & carcinogenesisFemaleFranceImmunotherapyCohort studymedicine.medical_specialtychemotherapy. radiotherapyAntineoplastic Agents[SDV.CAN]Life Sciences [q-bio]/Cancer03 medical and health sciencesInternal medicineHumansChemotherapyIntensive care unitMortalityPandemicsAgedRetrospective StudiesChemotherapyRadiotherapySARS-CoV-2business.industryCancerCOVID-19Retrospective cohort studyOdds ratiomedicine.diseaseAged; Antineoplastic Agents/adverse effects; Antineoplastic Agents/therapeutic use; COVID-19/mortality; Cohort Studies; Female; France/epidemiology; Humans; Male; Neoplasms/mortality; Neoplasms/therapy; Neoplasms/virology; Pandemics; Prospective Studies; Retrospective Studies; Risk Factors; SARS-CoV-2/isolation & purification; COVID-19; Cancer; Chemotherapy; Death; Immunotherapy; Intensive care unit; Mechanical ventilation; Mortality; Radiotherapy030104 developmental biologybusinessdescription
Background Cancer patients are thought to have an increased risk of developing severe Coronavirus Disease 2019 (COVID-19) infection and of dying from the disease. In this work, predictive factors for COVID-19 severity and mortality in cancer patients were investigated. Patients and Methods In this large nationwide retro-prospective cohort study, we collected data on patients with solid tumours and COVID-19 diagnosed between March 1 and June 11, 2020. The primary endpoint was all-cause mortality and COVID-19 severity, defined as admission to an intensive care unit (ICU) and/or mechanical ventilation and/or death, was one of the secondary endpoints. Results From April 4 to June 11, 2020, 1289 patients were analysed. The most frequent cancers were digestive and thoracic. Altogether, 424 (33%) patients had a severe form of COVID-19 and 370 (29%) patients died. In multivariate analysis, independent factors associated with death were male sex (odds ratio 1.73, 95%CI: 1.18-2.52), ECOG PS ≥ 2 (OR 3.23, 95%CI: 2.27-4.61), updated Charlson comorbidity index (OR 1.08, 95%CI: 1.01-1.16) and admission to ICU (OR 3.62, 95%CI 2.14-6.11). The same factors, age along with corticosteroids before COVID-19 diagnosis, and thoracic primary tumour site were independently associated with COVID-19 severity. None of the anticancer treatments administered within the previous 3 months had any effect on mortality or COVID-19 severity, except cytotoxic chemotherapy in the subgroup of patients with detectable SARS-CoV-2 by RT-PCR, which was associated with a slight increase of the risk of death (OR 1.53; 95%CI: 1.00-2.34; p = 0.05). A total of 431 (39%) patients had their systemic anticancer treatment interrupted or stopped following diagnosis of COVID-19. Conclusions Mortality and COVID-19 severity in cancer patients are high and are associated with general characteristics of patients. We found no deleterious effects of recent anticancer treatments, except for cytotoxic chemotherapy in the RT-PCR-confirmed subgroup of patients. In almost 40% of patients, the systemic anticancer therapy was interrupted or stopped after COVID-19 diagnosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-10-08 |