6533b838fe1ef96bd12a5121

RESEARCH PRODUCT

GLP-1 Analog Liraglutide Improves Vascular Function in Polymicrobial Sepsis by Reduction of Oxidative Stress and Inflammation

Konstantina FilippouSwenja Kröller-schönSanela KalinovicAndreas DaiberMarkus BosmannMarkus BosmannFranziska AustSimeon TsohataridisJohanna HelmstädterKatie FrenisKsenija Vujacic-mirskiThomas MünzelMatthias OelzeLeonie KüsterSebastian StevenKarin Keppeler

subject

0301 basic medicineLipopolysaccharidePhysiologyglucagon-like peptide-1 (GLP-1)Clinical Biochemistryperitoneal and polymicrobial sepsisInflammationRM1-950030204 cardiovascular system & hematologyPharmacologymedicine.disease_causeBiochemistryArticleendothelial dysfunctionSepsis03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicineoxidative stressvascular inflammationEndothelial dysfunctionInterleukin 6Molecular Biologyliraglutidebiologybusiness.industrySeptic shockCell Biologybacterial infections and mycosesmedicine.diseasececal ligation and puncture (CLP)Nitric oxide synthase030104 developmental biologychemistrybiology.proteinTherapeutics. Pharmacologymedicine.symptombusinessOxidative stressincretins

description

Sepsis causes high mortality in the setting of septic shock. LEADER and other trials revealed cardioprotective and anti-inflammatory properties of glucagon-like peptide-1 (GLP-1) analogs like liraglutide (Lira). We previously demonstrated improved survival in lipopolysaccharide (LPS)-induced endotoxemia by inhibition of GLP-1 degradation. Here we investigate the effects of Lira in the polymicrobial sepsis model of cecal ligation and puncture (CLP). C57BL/6J mice were intraperitoneally injected with Lira (200 µg/kg/d

yearjournalcountryeditionlanguage
2021-07-23Antioxidants
10.3390/antiox10081175https://www.mdpi.com/2076-3921/10/8/1175