6533b853fe1ef96bd12ad516

RESEARCH PRODUCT

Angioma-Like Pseudometamorphosis in Wilms' Tumors Subjected to Preoperative Radio- and Chemotherapy

E.w. BechtH. J. RumpeltD. FrohnebergW. ThoenesP. Gutjahr

subject

MalePathologymedicine.medical_specialtymedicine.medical_treatmentNephrectomyWilms TumorPreoperative carePathology and Forensic MedicineHemangiomaAngiomaMetaplasiaPreoperative CareHumansMedicineStage (cooking)ChildMetaplasiaChemotherapybusiness.industryInfantWilms' tumorCell Biologymedicine.diseaseKidney NeoplasmsNephrectomyHemangioma CavernousChild PreschoolFemalemedicine.symptombusiness

description

Six Wilms' tumors (stage III-V), which had undergone preoperative irradiation and chemotherapy, were examined histologically. While mesenchymal and differentiated epithelial tumor elements were preserved to a large extent, blastemic tumor structures were almost completely lacking. Instead, pseudoangioma-like structures similar to cavernous hemangioma prevailed. As demonstrated by transitional pictures, the pseudoangioma-like pattern is a result of the fact that blastemic tumor elements are replaced by blood after therapy-induced necrosis and lysis. The clinical advantages of preoperative treatment are briefly discussed, especially for patients with advanced tumors.

yearjournalcountryeditionlanguage
1983-06-01Pathology - Research and Practice
https://doi.org/10.1016/s0344-0338(83)80040-5