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RESEARCH PRODUCT
Objective Assessment of Nuclear and Cortical Cataracts through Scheimpflug Images: Agreement with the LOCS III Scale.
Domínguez-vicent AlbertoBirkeldh UlrikaLaurell Carl-gustafCarl-gustaf LaurellNilson MariaBrautaset Runesubject
0301 basic medicineMaleScheimpflug principlelcsh:MedicineDiagnostic Techniques OphthalmologicalSeverity of Illness IndexMachine Learning0302 clinical medicineMedicine and Health Scienceslcsh:ScienceOptical PropertiesLens (Anatomy)PhysicsAged 80 and overMultidisciplinaryApplied MathematicsSimulation and ModelingOphthalmic ProceduresCataract SurgeryMiddle AgedOptical LensesOptical EquipmentPhysical SciencesEngineering and TechnologyFemaleAnatomyAlgorithmsResearch ArticleOpacityAdultDiagnostic Imagingmedicine.medical_specialtyComputer and Information SciencesScale (ratio)OpacityImaging TechniquesOcular AnatomyMaterials ScienceMaterial PropertiesEquipmentSurgical and Invasive Medical ProceduresImage AnalysisResearch and Analysis MethodsLens nucleusCataract03 medical and health sciencesMachine Learning AlgorithmsYoung AdultCataractsRegion of interestOcular SystemArtificial IntelligenceOphthalmologymedicineHumansAgedPixelCataractslcsh:RBiology and Life SciencesCorrectionLens Nucleus CrystallineLens Cortex Crystallinemedicine.diseaseIntensity (physics)Ophthalmology030104 developmental biologyLens DisordersCase-Control Studies030221 ophthalmology & optometryEyesCognitive Sciencelcsh:QHeadMathematicsNeurosciencedescription
Purpose To assess nuclear and cortical opacities through the objective analysis of Scheimpflug images, and to check the correlation with the Lens Opacity Classification System III (LOCS III). Methods Nuclear and cortical opacities were graded according to the LOCS III rules after pupil dilation. The maximum and average pixel intensity values along an elliptical mask within the lens nucleus were taken to analyse nuclear cataracts. A new metric based on the percentage of opaque pixels within a region of interest was used to analyse cortical cataracts. The percentage of opaque pixels was also calculated for half, third and quarter areas from the region of interest’s periphery. Results The maximum and average intensity values along the nucleus were directly proportional to the LOCS III grade: The larger the LOCS III value, the larger maximum and average intensity ones. These metrics showed a positive and significant correlation with the LOCS grade: The larger the LOCS grade, the higher was percentage of opaque pixels along the cortex within the same mask’s size. This metric showed a significant correlation to the LOCS grade. Conclusion The metrics used to assess nuclear opacities showed good correlation with the LOCS III. The percentage of opaque pixels showed to be a useful metric to measure objectively the severity of the cortical opacity. These metrics could be implemented in an algorithm to detect and grade lens opacities automatically and objectively.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-02-18 | PloS one |