6533b85cfe1ef96bd12bc08c
RESEARCH PRODUCT
A case of guillain-barre syndrome in a patient with non small cell lung cancer treated with chemotherapy
C. IntriviciGiuseppe CiceroNicola GebbiaA. CaraceniCarmelo Carlo ArcaraGiuseppe BadalamentiFabio Fulfarosubject
medicine.medical_specialtyLung Neoplasmsmedicine.medical_treatmentBone NeoplasmsGuillain-Barre SyndromeDeoxycytidineGastroenterologyPathogenesisCerebrospinal fluidCarcinoma Non-Small-Cell LungInternal medicineAntineoplastic Combined Chemotherapy ProtocolsElectroneuronographyParalysismedicineHumansPharmacology (medical)Lung cancerPharmacologyChemotherapyGuillain-Barre syndromebusiness.industryGuillain-Barré Syndrome neuropathy chemotherapy toxicity lung cancerImmunoglobulins IntravenousMiddle Agedmedicine.diseaseGemcitabineFacial nerveSurgeryInfectious DiseasesOncologyFemaleCisplatinmedicine.symptombusinessdescription
Guillain-Barré Syndrome (GBS) is a demyelinating polyneuropathy of probable autoimmune pathogenesis characterized by rapidly progressive symmetric paralysis. In the literature some cases of GBS associated with anticancer chemotherapy are reported. We present a case of a 55-year old woman who complained of progressive motor deficit in four limbs, areflexia in lower limbs and facial nerve paralysis one week after beginning cisplatin-gemcitabine chemotherapy for metastatic lung cancer. The cerebrospinal fluid analysis showed a strong positive Pandy reaction with 435 mg/dl total protein. The electromyography and the electroneuronography established the diagnosis of inflammatory demyelinating polyneuropathy. Specific therapy with intravenous immunoglobulin 25 g/day in 5 administrations for 5 days was started with complete benefit.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-06-01 |