6533b85cfe1ef96bd12bd42b

RESEARCH PRODUCT

Potentially Detrimental Effects of Hyperosmolality in Patients Treated for Traumatic Brain Injury

Chiara RobbaManu MalbrainAndrzej JaroszyńskiMagdalena BielaczRafael BadenesDorota Siwicka-gierobaWojciech DabrowskiJoanna Sołek-pastuszkaKatarzyna KotfisBohatyrewicz Romuald.

subject

medicine.medical_specialtyKidneyOsmotic concentrationTraumatic brain injurybusiness.industryosmolar gapmannitolRGeneral MedicineReviewmedicine.diseaseHypertonic salinePlasma osmolalitymedicine.anatomical_structureEndocrinologyImmune systemInternal medicineRenal physiologymedicineMedicineAdverse effectbusinessosmolalitytraumatic brain injury (TBI)hypertonic saline

description

Hyperosmotic therapy is commonly used to treat intracranial hypertension in traumatic brain injury patients. Unfortunately, hyperosmolality also affects other organs. An increase in plasma osmolality may impair kidney, cardiac, and immune function, and increase blood–brain barrier permeability. These effects are related not only to the type of hyperosmotic agents, but also to the level of hyperosmolality. The commonly recommended osmolality of 320 mOsm/kg H2O seems to be the maximum level, although an increase in plasma osmolality above 310 mOsm/kg H2O may already induce cardiac and immune system disorders. The present review focuses on the adverse effects of hyperosmolality on the function of various organs.

yearjournalcountryeditionlanguage
2021-09-01Journal of Clinical Medicine
10.3390/jcm10184141https://www.mdpi.com/2077-0383/10/18/4141