6533b85dfe1ef96bd12bea2c

RESEARCH PRODUCT

Characteristics and Clinical Outcome of Breast Cancer Patients with Asymptomatic Brain Metastases

Valentina NekljudovaTjoung Won Park-simonTanja FehmT. HesseArkadius PolasikPeter A. FaschingK RieckeJulia ReyKristina LübbeIsabell WitzelVolker MöbusSibylle LoiblCarsten DenkertRudolf WeideChristoph MundhenkeVolkmar MüllerMarcus SchmidtMarc ThillElena LaakmannT Neunhöffer

subject

0301 basic medicineCancer Researchmedicine.medical_specialtyNeoplasm metastasisMetastasePrognoseContext (language use)lcsh:RC254-282AsymptomaticGastroenterologyArticle03 medical and health sciencesbreast cancer0302 clinical medicineBreast cancerbrain metastasesInternal medicineBrustkrebsasymptomaticMedicineClinical significanceddc:610Treatment outcomeHirnmetastasePerformance statusbusiness.industrylcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseMetastatic breast cancer030104 developmental biologyRisk factorsOncologyLead time bias030220 oncology & carcinogenesisCohortBreast neoplasmsmedicine.symptombusinessDDC 610 / Medicine & health

description

Background: Brain metastases (BM) have become a major challenge in patients with metastatic breast cancer. Methods: The aim of this analysis was to characterize patients with asymptomatic BM (n = 580) in the overall cohort of 2589 patients with BM from our Brain Metastases in Breast Cancer Network Germany (BMBC) registry. Results: Compared to symptomatic patients, asymptomatic patients were slightly younger at diagnosis (median age: 55.5 vs. 57.0 years, p = 0.01), had a better performance status at diagnosis (Karnofsky index 80&ndash

yearjournalcountryeditionlanguage
2020-09-28Cancers
https://doi.org/10.3390/cancers12102787