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RESEARCH PRODUCT

966 The Nonthyroidal Illness Syndrome in Septic Children

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Backgroud The interpretation of thyroid function tests in the PICU patients can be difficult because thyroid hormone concentrations are affected by nonthyroidial stresses. Most patients fall into sick euthyroid syndrome or nonthyroidal illness syndrome (NTIS). The TH therapy during critical illness remains controversial. Aim To evaluate the NTIS in septic children. Method The prospective study conducted on 65 patients admitted in PICU during 12 months period. Inclusion criteria: age > 1 month, admission for critical illness, treatment with corticosteroids, no (documented) history of thyroid pathology. The patients were divided into 2 groups: sepsis and non-sepsis group (dehydration, poisoning, cardiac failure). All patients received corticosteroids. Some of them received in addition dopamine or presented malnutrition. The thyroid hormone assessment was made after the critical diagnosis was established. Results Sepsis group: 30 patients. Non-sepsis group: 35 patients. NTIS was strongly correlated with sepsis (p Conclusion The study confirmed significant correlation between NTIS and sepsis in children (40%). Reassessment of thyroid function should be done away from critical episode.