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RESEARCH PRODUCT

Ancient goat genomes reveal mosaic domestication in the Fertile Crescent

Matthew J. CollinsMatthew J. CollinsHossein DavoudiLiora Kolska HorwitzBoris GasparianHossein Azizi KharanaghiVictoria E. MullinVictoria E. MullinDaniel G. BradleyGuy Bar-ozMarjan MashkourMarjan MashkourMarta Pereira VerdugoSepideh MaziarRoghayeh Rahimi SorkhaniAli A. VahdatiDelphine DecruyenaereAzadeh Fatemeh MohasebAzadeh Fatemeh MohasebAndrew J. HareÖZlem ÇEvikDavid OrtonJean-denis VigneNorbert BeneckeCevdet Merih ErekGary O. RollefsonMatthew D. TeasdaleMatthew D. TeasdaleEberhard SauerValeria MattiangeliCanan ÇAkirlarAndrea ManicaJoachim BurgerRon PinhasiHoma FathiTristan CumerSanaz Beizaee DoostRon KehatiKevin G. DalyBenjamin S. ArbuckleLouise MartinPierpaolo Maisano DelserPierpaolo Maisano DelserFrançois PompanonRoya KhazaeliAmelie ScheuAmelie Scheu

subject

0301 basic medicineFollistatinMESH: DomesticationAGRICULTURE1103CATTLEMESH: FollistatinMESH: AfricaGenome[SHS]Humanities and Social SciencesDomestication0601 history and archaeologyMESH: AnimalsMESH: Genetic VariationMESH: PhylogenyPhylogenyZAGROSmedia_common2. Zero hunger[SDV.EE]Life Sciences [q-bio]/Ecology environmentGenome1311MultidisciplinaryMiddle East060102 archaeologyMosaicismMESH: AsiaGoats06 humanities and the artsEuropeAnimals DomesticMESH: MosaicismReproductionTRAITSAsia[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistorymedia_common.quotation_subject1204BiologyDNA MitochondrialMESH: GoatsMosaic03 medical and health sciencesPhylogeneticsGenetic variationAnimalsMESH: GenomeMESH: Animals DomesticDNA AncientDietary change[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM]Domestication[SDV.GEN]Life Sciences [q-bio]/GeneticsNEAR-EASTMESH: DNA MitochondrialGenetic VariationMESH: DNA AncientGENEMODEL030104 developmental biologySHEEPEvolutionary biologyORIGINSAfricaMESH: Europe

description

How humans got their goatsLittle is known regarding the location and mode of the early domestication of animals such as goats for husbandry. To investigate the history of the goat, Dalyet al.sequenced mitochondrial and nuclear sequences from ancient specimens ranging from hundreds to thousands of years in age. Multiple wild populations contributed to the origin of modern goats during the Neolithic. Over time, one mitochondrial type spread and became dominant worldwide. However, at the whole-genome level, modern goat populations are a mix of goats from different sources and provide evidence for a multilocus process of domestication in the Near East. Furthermore, the patterns described support the idea of multiple dispersal routes out of the Fertile Crescent region by domesticated animals and their human counterparts.Science, this issue p.85

10.1126/science.aas9411http://dx.doi.org/10.1126/science.aas9411