TRPM8 Channel Activation Reduces the Spontaneous Contractions in Human Distal Colon

6533b861fe1ef96bd12c4f9f

RESEARCH PRODUCT

TRPM8 Channel Activation Reduces the Spontaneous Contractions in Human Distal Colon

Antonella Amato Laura Lentini Flavia Mulè Simona Terzo Pierenrico Marchesa

subject

0301 basic medicine Male Gene Expression Pharmacology Settore BIO/09 - Fisiologia lcsh:Chemistry Tissue Culture Techniques chemistry.chemical_compound 0302 clinical medicine Intestinal Mucosa Receptor lcsh:QH301-705.5 Spectroscopy human colon contractility Aged 80 and over Tetraethylammonium Depolarization General Medicine Iberiotoxin Middle Aged Computer Science Applications 030220 oncology & carcinogenesis Tetrodotoxin Female Muscle Contraction Agonist Serotonin medicine.drug_class Colon TRPM Cation Channels Tetrodotoxin Apamin Catalysis Article Inorganic Chemistry 03 medical and health sciences IBS medicine TRPM8 Humans Physical and Theoretical Chemistry Molecular Biology Aged Organic Chemistry Muscle Smooth Tetraethylammonium chloride Phosphinic Acids 1-[Diisopropyl-phosphinoyl]-alkane (DIPA)030104 developmental biology chemistry lcsh:Biology (General)lcsh:QD1-999 Apamin TRPM-8 Peptides

description

The transient receptor potential-melastatin 8 (TRPM8) is a non-selective Ca2+-permeable channel, activated by cold, membrane depolarization, and different cooling compounds. TRPM8 expression has been found in gut mucosal, submucosal, and muscular nerve endings. Although TRPM8 plays a role in pathological conditions, being involved in visceral pain and inflammation, the physiological functions in the digestive system remain unclear as yet. The aims of the present study were: (i) to verify the TRPM8 expression in human distal colon

year	journal	country	edition	language
2020-07-29	International Journal of Molecular Sciences

10.3390/ijms21155403 http://dx.doi.org/10.3390/ijms21155403

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