6533b861fe1ef96bd12c581c

RESEARCH PRODUCT

Auditory and Cognitive Deficits Associated with Acquired Amusia after Stroke: A Magnetoencephalography and Neuropsychological Follow-Up Study

Heli SilvennoinenMatti LaineMarja HietanenSeppo SoinilaElina PihkoElina PihkoTeppo SärkämöTaina AuttiMari TervaniemiMari Tervaniemi

subject

PITCHMalemagnetoencephalographyMiddle Cerebral ArteryAnatomy and Physiologylcsh:MedicineMismatch negativity312 Clinical medicineNeuropsychological TestsAudiologymagnetic fieldsCardiovascularSocial and Behavioral SciencesBehavioral NeuroscienceLearning and MemoryCognition0302 clinical medicinePsychologyMedicinelcsh:Sciencemagnetoencephalography and neuropsychologicalClinical NeurophysiologyMultidisciplinarymedicine.diagnostic_testBRAIN RESPONSES05 social sciencesStroke RehabilitationCognitive flexibilityNeuropsychologyMagnetoencephalographyElectroencephalographyExperimental Psychologyfollow-up studyMiddle Aged3. Good healthElectrophysiologyStrokeHemorrhagic StrokeClinical PsychologyMemory Short-TermNeurologyMedicineSensory PerceptionFemaleMUSIC PERCEPTION DEFICITSResearch ArticleAdultCORTEXmedicine.medical_specialtyMISMATCH NEGATIVITY MMN515 PsychologyCognitive NeuroscienceCerebrovascular DiseasesNeuroimagingAmusiaAuditory cortex050105 experimental psychologyLateralization of brain functionPerceptual Disorders03 medical and health sciencesNeuropsychologyDiagnostic MedicineSPEECH INTONATIONHumans0501 psychology and cognitive sciencesBiologyMusic TherapyIschemic StrokeAuditory CortexCONGENITAL AMUSIAbusiness.industryMEMORYlcsh:R3112 NeurosciencesMagnetoencephalographymedicine.diseaseAuditory and cognitive deficits6131 Theatre dance music other performing artsNeuroanatomyDISCRIMINATIONBrain Injurieslcsh:QNEURAL-NETWORKSbusinessNeurocognitive030217 neurology & neurosurgeryNeuroscienceFollow-Up Studies

description

Acquired amusia is a common disorder after damage to the middle cerebral artery (MCA) territory. However, its neurocognitive mechanisms, especially the relative contribution of perceptual and cognitive factors, are still unclear. We studied cognitive and auditory processing in the amusic brain by performing neuropsychological testing as well as magnetoencephalography (MEG) measurements of frequency and duration discrimination using magnetic mismatch negativity (MMNm) recordings. Fifty-three patients with a left (n = 24) or right (n = 29) hemisphere MCA stroke (MRI verified) were investigated 1 week, 3 months, and 6 months after the stroke. Amusia was evaluated using the Montreal Battery of Evaluation of Amusia (MBEA). We found that amusia caused by right hemisphere damage (RHD), especially to temporal and frontal areas, was more severe than amusia caused by left hemisphere damage (LHD). Furthermore, the severity of amusia was found to correlate with weaker frequency MMNm responses only in amusic RHD patients. Additionally, within the RHD subgroup, the amusic patients who had damage to the auditory cortex (AC) showed worse recovery on the MBEA as well as weaker MMNm responses throughout the 6-month follow-up than the non-amusic patients or the amusic patients without AC damage. Furthermore, the amusic patients both with and without AC damage performed worse than the non-amusic patients on tests of working memory, attention, and cognitive flexibility. These findings suggest domain-general cognitive deficits to be the primary mechanism underlying amusia without AC damage whereas amusia with AC damage is associated with both auditory and cognitive deficits. Peer reviewed

yearjournalcountryeditionlanguage
2010-12-01
10.1371/journal.pone.0015157https://aaltodoc.aalto.fi/handle/123456789/25682