6533b86efe1ef96bd12cbdec
RESEARCH PRODUCT
Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX.
Jean-françois EmileCatherine JuliéKarine Le MalicotCome LepageJosep TaberneroEnrico MiniGunnar FolprechtJean-luc Van LaethemStéphanie DimetCamille Boulagnon-rombiMarc-antoine AllardFrédérique Penault-llorcaJaafar BennounaPierre Laurent-puigJulien TaiebJosef ThalerRichard GreilJohannes GaenzerWolfgang EistererJoerg TschmelitschFelix KeilHellmut SamoniggAugust ZaberniggFranz SchmidGünther StegerRobert SteinacherJohannes AndelBjörn JagdtAlois LangMichael FridrikReinhold FüggerFriedrich HofbauerEwald WoellDietmar GeisslerAlfred LenauerManfred PragerGeert D'haensGauthier DemolinJoseph KergerGuido DeboeverGilbert GhillebertMarc PolusEric Van CutsemHassan Rezaie KalantariThierry DelaunoitJean Charles GoeminneMarc PeetersPhilippe VergauweGhislain HoubiersYves HumbletJos JanssensDirk SchrijversErik VanderstraetenJean-luc Van LaethemJan VermorkenDaniel Van DaeleMichel FerranteFrederic ForgetAlain HendliszMette YilmazSvend Erik NielsenLene VestermarkJim LarsenMohamed-ayman ZawadiOlivier BoucheLaurent MineurJaafar Bennouna-louridiLouis Marie DourtheMarc YchouEveline BoucherJulien TaiebDenis PezetFrancoise DesseigneMichel DucreuxPatrick TexereauLaurent MiglianicoPhilippe RougierSerge FratteCharles-briac LevacheYacine MerroucheStephen EllisChristophe LocherJean-francois RameeClaire GarnierFrederic ViretBruno ChauffertIsabelle Cojean-zelekPierre MichelCedric LecailleChristian BorelJean-francois SeitzDenis SmithCatherine Lombard-bohasThierry AndreJean-marc GornetFrancine FeinMarie-aude Coulon-sfairiMarie-christine KaminskyJean-paul LagasseDominique LuetPierre-luc EtienneMohamed GasmiAndre VanoliSuzanne NguyenThomas AparicioHervé PerrierNoel StremsdoerferPhilippe LaplaigeDominique ArseneDominique AubyLaurent BedenneRomain CoriatBernard DenisPatrick GeoffroyGilles PiotYves BecouarnGilbert BordesGael DeplanqueOlivier DupuisFrederic FrugeRosine GuimbaudThierry LecomteGérard LledoIradej SobhaniAmani AsnaciosAhmed AzzedineChristophe DesauwMarie-pierre GalaisDany GargotYou-heng LamAbakar Abakar-mahamatJean-francois BerdahSylviane CatteauMarie-christine Clavero-fabriJean-francois CodoulJean-louis LegouxDenis GoldfainPierre GuichardDenis Pere VergeJocelyne ProvencalBruno VedrenneCatherine Brezault-bonnetDenis CleauJean-paul DesirDavid FallikBruno GarciaMarie-hélène GaspardDominique GenetJohannes HartwigYves KrummelTamara Matysiak BudnikVanessa Palascak-juifHarizo RandrianariveloYves RinaldiAlbert AlebaAriane Darut-jouveAimery De GramontHerve HamonFrederic WendehenneAxel MatzdorffMichael Konrad StahlWolfgang ScheppMartin BurkLothar MuellerGunnar FolprechtMichael GeisslerLuisa Mantovani-loefflerThomas HoehlerWalter AspergerHendrik KroeningLudwig Fischer Von WeikersthalStefan FuxiusMatthias GroschekJohannes MeilerTanja TrarbachJacqueline RauhNicolas ZiegenhagenAlbrecht KretzschmarUllrich GraevenArnd NuschGoetz Von WichertRalf-dieter HofheinzGerhard KleberKarl-heinz SchmidtUrsula Vehling-kaiserClaudia BaumJochen SchuetteGeorg Martin HaagWilhelm HoltkampJochen PotenbergTobias ReiberGeorg SchliesserHans-joachim SchmollWolfgang Schneider-kappusWolfgang AbenhardtClaudio DenzlingerJan HenningBartscht MarxsenHans Guenter DerigsHelmut LambertzIngulf Becker-boostKarel CacaChristian ConstantinThomas DeckerHenning EschenburgSigrun GabiusHolger HebartAlbrecht HoffmeisterHeinz-august HorstStephan KremersMalte LeithaeuserSebastian MuellerSiegfried WagnerSeverin DaumFrank SchlegelMartina StauchVolker HeinemannEvaristo MaielloLuciano LatiniAlberto ZaniboniDino AmadoriGiuseppe AprileSandro BarniRodolfo MattioliAndrea MartoniRodolfo PassalacquaMario NicoliniEnzo PasquiniCarla RabbiEnrico AitiniAlberto RavaioliCarlo BaroneGuido BiascoStefano TamberiAngelo GambiClaudio VerusioMarina MarzolaGiorgio LelliCorrado BoniStefano CascinuPaolo BidoliMassimo VaghiGiorgio CrucianiFrancesco Di CostanzoAlberto SobreroEnrico MiniRoberto PetrioliMassimo AgliettaOscar AlabisoFederico CapuzzoAlfredo FalconeDomenico Cristi CorsiRoberto LabiancaStefania SalvagniSilvana ChiaraLibero CiuffredaFrancesco FerraùFrancesco GiulianiSara LonardiNicola GebbiaGiovanni MantovaniEvaristo SanchesJuan Carlos MellidezPedro SantosJoao FreireCristina SarmentoLuis CostaAntonio Moreira PintoSergio BarrosoJorge Espirito SantoFátima GuedesAmélia MonteiroAnabela SaIrene FurtadoRamon SalazarEnrique Aranda AguilarFernando Rivera HerreroJosep TaberneroJavier Sastre ValeraManuel Valladares AyerbesJaime Feliu BatlleSilvia GilAlbert Abad EsteveCarlos Garcia-gironGuillermo Lopez VivancoAntonia Salud SalviaVicente Alonso OrduñaRuth Vera GarciaJavier GallegoBartomeu Massuti SuredaJordi RemonMaria Jose Safont AguileraLuis Cirera NoguerasBernado Queralt MerinoCristina Gravalos CastroPurificacion Martinez De PradoCarlos Pijaume PericayManuel Constenla FigueirasInmaculada Guasch JordanMaria Jose Gome ReinaAmelia Lopez-ladron GarciaAntonio Arrivi Garcia-ramosAndres CervantesCarlos Fernandez MartosEugenio Marcuello GasparInes Cabezas MonteroPilar Escudero EmperadorAna Leon CarboneroManuel Gallen CastilloTeresa Garcia GarciaJose Garcia LopezEncarnacion Gonzalez FloresMonica Guillot MoralesMarta Llanos MuñozAna López MartínJoan MaurelJuan Carlos CamaraRosario Dueñas GarciaMercedes SalgadoIsabel Hernandez BusquierTeresa Checa RuizAdelaida Lacasta MuñoaMiquel Nogue AliguerAmalia Velasco Ortiz De TarancoMiguel Mendez UreñaFerran Losa GaspaJose Juan PonceCarlos Bosch RoigPedro Valero JimenezAntonio Galan BrotonsSantiago Albiol RodriguezJose Ales MartinezLiliana Canosa RuizMargarita Centelles RuizJohn BridgewaterRob Glynne-jonesSaad TahirTamas HickishJim CassidyLeslie Samuelsubject
0301 basic medicineOncologyMaleCancer ResearchOrganoplatinum CompoundsColorectal cancermedicine.medical_treatmentMedizinLeucovorinProspective cohort study[ SDV.CAN ] Life Sciences [q-bio]/Cancer0302 clinical medicineFOLFOXOrganoplatinum Compounds/therapeutic useAntineoplastic Combined Chemotherapy ProtocolstudyLymphocytesProspective StudiesProspective cohort studyLeucovorin/therapeutic useMiddle AgedPrognosis3. Good healthColorectal carcinomaOncologyFluorouracil030220 oncology & carcinogenesisPredictive value of testsColonic NeoplasmsBiomarker (medicine)Lymphocytes/pathologyFemaleFluorouracilAdjuvantmedicine.drugAdultmedicine.medical_specialty[SDV.CAN]Life Sciences [q-bio]/CancerFluorouracil/therapeutic useBiomarkers Tumor/analysis03 medical and health sciencesLymphocytes Tumor-InfiltratingPredictive Value of TestsBiomarker; Colorectal carcinoma; Immune response; Prospective cohort study; Oncology; Cancer ResearchInternal medicinemedicineBiomarkers TumorHumansImmune responseSurvival analysisAgedbusiness.industryBiomarkermedicine.diseaseSurvival AnalysisSurgery030104 developmental biologyProspective cohort Multivariate AnalysisColonic Neoplasms/diagnosisAntineoplastic Combined Chemotherapy Protocols/therapeutic usebusinessdescription
IF 6.029; International audience; BackgroundThe prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. However, no validated test is currently available for clinical practice. We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use.Patients and methodsAccording to National Institutes of Health criteria, we designed a prospective validation of this biomarker in patients included in the PETACC8 phase III study. Primary objective was to compare percentage of patients alive and without recurrence at 2 years in patients with high versus low LI (#NCT02364024). Associations of LI with patient recurrence and survival were analysed, and multivariable models were adjusted for treatment and relevant factors. Automated testing of LI was performed on virtual slides without access to clinical data.ResultsAmong the 1220 CC patients enrolled, LI was high, low and not evaluable in 241 (19.8%), 790 (64.8%) and 189 (15.5%), respectively. Primary objective was met with a 2-year recurrence rate of 14.4% versus 21.1% in patients with high and low LI, respectively (p = 0.02). Patients with high LI also had better disease free survival (DFS) and overall survival (OS). Tumour stage, grade, RAS status and BRAF status were with LI the only prognostic markers in multivariable analysis for OS. Subgroup analyses revealed that high LI had better DFS and OS in mismatch repair (MMR) proficient patients, and in patients without RAS mutation, but not in MMR deficient and RAS mutated patients.ConclusionAlthough this is the first validation with high level of evidence (IIB) of the prognostic value of a LI test in colon cancers, it still needs to be confirmed in independent series of colon cancer patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-09-01 |