6533b86ffe1ef96bd12cd4c0

RESEARCH PRODUCT

Steroidal saponins from Raphia vinifera and their cytotoxic activity

Godloves Fru ChiGodloves Fru ChiJapheth O. OmbitoArmelle T. MbavengRodrigue V. Tchangna SopBonaventure T. NgadjuiGaëlle S. NguenangGhislain W. FotsoThomas A. EfferthVictor Kuete

subject

Models MolecularClinical BiochemistryMolecular ConformationAntineoplastic Agents030209 endocrinology & metabolismArecaceaeBiochemistryLeukemia cell line03 medical and health sciences0302 clinical medicineEndocrinologyCell Line TumorIc50 valuesHumansCytotoxic T cellCytotoxicityMolecular BiologyPharmacologybiologyChemistryOrganic ChemistrySaponinsbiology.organism_classificationMass spectrometricRaphia viniferaPhytochemicalBiochemistry030220 oncology & carcinogenesisSteroids

description

Abstract Phytochemical analysis of the fruits of Raphia vinifera led to the isolation of four new steroidal saponins (1–4), along with six known secondary metabolites (6–10). The structures of the isolated compounds were determined based on the analyses of NMR and mass spectrometric data, and chemical degradation reactions. Among the compounds tested, 1 and 4 showed the most promising cytotoxic activity against the drug-sensitive CCRF-CEM leukemia cell lines, with IC50 values of 3.55 µM and 7.14 µM, respectively.

yearjournalcountryeditionlanguage
2020-07-16Steroids
https://doi.org/10.1016/j.steroids.2020.108724