6533b86ffe1ef96bd12ce936

RESEARCH PRODUCT

SYMPATHETIC NERVOUS SYSTEM AND BLOOD-PRESSURE CONTROL IN ESSENTIAL HYPERTENSION

U. CordesA. DistlerT Philipp

subject

AdultMaleBlood pressure controlmedicine.medical_specialtySympathetic nervous systemSympathetic Nervous SystemRestPhysical ExertionBlood PressurePhysical exerciseEssential hypertensionNorepinephrineInternal medicineReninHumansMedicineInverse correlationbusiness.industryAngiotensin IIGeneral MedicineMiddle Agedmedicine.diseaseAngiotensin IIHormonesmedicine.anatomical_structureEndocrinologyPressor responsePathophysiology of hypertensionHypertensionRegression AnalysisFemalebusiness

description

Abstract In normotensive subjects an inverse correlation was observed between an index of sympathetic nervous activity (the plasma-noradrenaline concentration during physical exercise) and reactivity to exogenous noradrenaline. This relationship was invariably disturbed in age-matched patients with essential hypertension. Multiple-regression analysis revealed a highly significant correlation between the combination of both factors and the height of mean arterial blood-pressure ( r =0·91). The findings suggest that sympathetic nervous activity and pressor response to noradrenaline together form an important determinant of the arterial blood-pressure level. An inverse relationship could be demonstrated between plasma-renin concentration and pressor response to angiotensin II in normotensives, and this relationship was unchanged in hypertensive patients. Therefore angiotensin II does not appear to contribute directly to high blood-pressure.

yearjournalcountryeditionlanguage
1978-11-04The Lancet
https://doi.org/10.1016/s0140-6736(78)92526-6