showing 36 of ~574560 from 574555 documents
Diabetes is not associated with COVID-19-related mortality in older institutionalized people
2021
Diabetes & Metabolism - Sous presse. Manuscrit accepte. Disponible en ligne depuis le mercredi 27 janvier 2021
Living in the “Bubble”: Athletes' Psychological Profile During the Sambo World Championship
2021
Background: The COVID-19 pandemic has changed the way we conduct daily life, as well as sports training and sports competitions. Given the stress produced by COVID-19, and the “bubble” safety measures for the World Sambo Championship, held in Novi Sad, from the 6th to the 8th of November, 2020, athletes might have experienced more stress than athletes normally would in non-pandemic conditions. Therefore, the current study aimed to create a psychological profile of sambo athletes participating in the Sambo World Championship and living in this condition.Methods: One-hundred-fifteen participants took part in the study, completing the Profile of Mood Scale (POMS), the Pittsburg Sleep Quality I…
Predicting sediment deposition rate in check-dams using machine learning techniques and high-resolution DEMs
2021
Sediments accumulated in check dams are a valuable measure to estimate soil erosion rates. Here, geographic information systems (GIS) and three machine learning techniques (MARS-multivariate adaptive regression splines, RF-random forest and SVM-support vector machine) were used, for the first time, to predict sediment deposition rate (SR) in check-dams located in six watersheds in SW Spain. There, 160 dry-stone check dams (~ 77.8 check-dams km−2), accumulated sediments during a period that varied from 11 to 23 years. The SR was estimated in former research using a topographical method and a high-resolution Digital Elevation Model (DEM) (average of 0.14 m3 ha−1 year−1). Nine environmental-to…
Corrigendum to: “Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort”☆ (J Hepatol…
2021
A multinational study exploring adolescent perception of school climate and mental health.
2021
School climate is a topic of increasing importance internationally. The current study investigated the established measurement invariance of an eight-factor school climate scale using a multinational sample of secondary students. School climate factor means across 14 international groups were compared and findings on the association between school climate factors and mental health were also investigated. Findings, from this study, illustrate several cross-national similarities regarding the ways in which secondary students perceive school climate and the influence of school climate on student mental health. These findings can support school psychologists' efforts to identify strategies and …
Alkaline fuel cell technology - A review
2021
Abstract The realm of alkaline-based fuel cells has with the arrival of anionic exchange membrane fuel cells (AEMFCs) taken a great step to replace traditional liquid electrolyte alkaline fuel cells (AFCs). The following review summarises progress, bottleneck issues and highlights the most recent research trends within the field. The activity of alkaline catalyst materials has greatly advanced, however achieving long-term stability remains a challenge. Great AEMFC performances are reported, though these are generally obtained through the employment of platinum group metals (PGMs), thus emphasising the importance of R&D related to non-PGM materials. Thorough design strategies must be utilise…
Teachers’ Knowledge Regarding Autism Spectrum Disorder (ASD): A Systematic Review
2021
The increasing number of students with autism spectrum disorder (ASD) in mainstream education environments require teachers to know how to identify their needs, being capable to adapt their education processes and make their inclusion easier. The purpose of this study is to conduct a systematic review about teachers’ knowledge of ASD, including teachers from any stage and specialization. The research has been conducted from four databases (Web of Science, Scopus, PsycInfo and Google Scholar) during the period of 2015–2020. In total, 25 articles were analyzed. The results show that, in general, teachers’ knowledge of ASD is poor. It depends on the education stage (being higher in early child…
Modified 2016 American College of Rheumatology Fibromyalgia Criteria, the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovation…
2021
Objective To study the prevalence of fibromyalgia (FM) in the general population according to a 2016 modification of the American College of Rheumatology criteria (FM 2016) and the Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society pain taxonomy criteria (AAPT), and to compare diagnostic and clinical variables between the criteria sets. Methods We studied 2,531 randomly selected subjects from the German general population in 2019. Pain regions from the Michigan Body Map were fitted to the FM 2016 and the AAPT criteria, and criteria symptom items were derived from validated questionnaires assessing somatic and psychol…
UV laser induced photolysis of glycolic acid isolated in argon matrices
2021
The photochemistry of matrix-isolated glycolic acid, induced by UV light, was studied by FTIR spectroscopy and B3LYPD3/6-311++G(3df,3pd) calculations. Several decomposition pathways were found to take place upon 212 nm and 226 nm wavelengths irradiation. A number of complexes formed between photoproducts were identified, among them those of formaldehyde with water, carbon monoxide and carbon dioxide as well as the H2O-CO complexes. The structure and spectroscopic assignment of the photoproducts were made comparing the experimental results with the theoretical predictions and available literature data. The observed formation of different complexes indicates various pathways for their formati…
Strength and Power Characteristics in National Amateur Rugby Players
2021
Rugby players need muscular strength and power to meet the demands of the sport
INfluenza Vaccine Indication during therapy with Immune checkpoint inhibitors: A multicenter prospective observational study (INVIDIa-2)
2021
BackgroundUntil now, no robust data supported the efficacy, safety and recommendation for influenza vaccination in patients with cancer receiving immune checkpoint inhibitors (ICIs).MethodsThe prospective multicenter observational INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors (INVIDIa-2) study investigated the clinical effectiveness of influenza vaccination in patients with advanced cancer receiving ICIs, enrolled in 82 Italian centers from October 2019 to January 2020. The primary endpoint was the time-adjusted incidence of influenza-like illness (ILI) until April 30, 2020. Secondary endpoints regarded ILI severity and vaccine safety.ResultsThe study enrolle…
Convex and expansive liftings close to two-isometries and power bounded operators
2021
Abstract In the context of Hilbert space operators, there is a strong relationship between convex and expansive operators and 2-isometries. In this paper, we investigate the bounded linear operators T on a Hilbert space H which have a 2-isometric lifting S on a Hilbert space K containing H as a closed subspace invariant for S ⁎ S . This last property holds in particular when S | K ⊖ H is an isometry. We relate such 2-isometric liftings S by some convex, concave or expansive liftings of the same type as S. We also examine some power bounded operators with such liftings, as well as an intermediate expansive lifting associated with T on the space H ⊕ l + 2 ( H ) . The latter notion is used to …
Social isolation causes downregulation of immune and stress response genes and behavioural changes in a social insect
2021
Humans and other social mammals experience isolation from their group as stressful, triggering behavioural and physiological anomalies that reduce fitness. While social isolation has been intensely studied in social mammals, it is less clear how social insects, which evolved sociality independently, respond to isolation. Here we examined whether the typical mammalian responses to social isolation, e.g., an impaired ability to interact socially and immune suppression are also found in social insects. We studied the consequences of social isolation on behaviour and brain gene expression in the ant Temnothorax nylanderi. Following isolation, workers interacted moderately less with adult nestma…
Pretreatment metastatic growth rate determines clinical outcome of advanced melanoma patients treated with anti-PD-1 antibodies: a multicenter cohort…
2021
BackgroundCheckpoint inhibitors revolutionized the treatment of metastatic melanoma patients. Although tumor burden and lactate dehydrogenase (LDH) are associated with overall survival (OS), the impact of tumor growth kinetics remains elusive and in part contradictory. The aims of this study were to develop a novel simple and rapid method that estimates pretreatment metastatic growth rate (MGR) and to investigate its prognostic impact in melanoma patients treated with antiprogrammed death receptor-1 (PD-1) antibodies.MethodsMGR was assessed in three independent cohorts of a total of 337 unselected consecutive metastasized stage IIIB–IV melanoma patients (discovery cohort: n=53, confirmation…
13P Comparison study of different programmed death-ligand 1 (PD-L1) assays, readers and scoring methods in triple-negative breast cancer (TNBC)
2021
The role of heat shock proteins in neoplastic processes and the research on their importance in the diagnosis and treatment of cancer
2021
Heat shock proteins (HSPs) are chaperones with highly conservative primary structure, necessary in the processes of protein folding to the most energetically advantageous conformation and maintaining their stability. HSPs perform a number of important functions in various cellular processes and are capable of modulating pathophysiological conditions at the cellular and systemic levels. An example is the high level of HSP expression in neoplastic tissues, which disrupts the apoptosis of transformed cells and promotes the processes of proliferation, invasion, and metastasis. In addition, an increasing amount of information is appearing about the participation of HSPs in the formation of multi…
Prevention of overweight and obesity in a Norwegian public health care context: a mixed-methods study
2021
Abstract Background Greater understanding about the prevention and treatment of overweight and obesity in preschool children within public health care is needed. This study assessed the impact of The First Steps module in routine primary health care including mapping of height/weight and diet followed by parental counselling of healthy habits on overweight and obesity in children aged 2 to 7 years. Further, we explored the experiences of public health nurses (PHNs) with the module. Methods Body weight and height obtained in 2014 and 2016 were extracted retrospectively for 676 children from the health records of children at 2, 4, or 6 years of age in five child health centers in Southern Nor…
Operazioni del capitale. Capitalismo contemporaneo tra sfruttamento ed estrazione Sandro Mezzadra e Breitt Neilson. Recensione di Federico Di Blasio
2021
Recensione di Operazioni del capitale. Capitalismo contemporaneo tra sfruttamento ed estrazione di Sandro Mezzadra e Breitt Neilson Capital Operations Review. Contemporary Capitalism between Exploitation and Extraction by Sandro Mezzadra and Breitt Neilson
Fundamentals and implementation of Microbiological Diagnostic Stewardship Programs.
2021
Microbiological diagnostic stewardship programs promote coordinated measures aimed at optimizing the use of diagnostic techniques, thus favouring the adoption of adequate and cost-effective therapeutic, clinical and preventive decisions. The implementation of microbiological diagnostic stewardship relies upon the creation of multidisciplinary committees led by clinical microbiologists for the design of diagnostic algorithms, the adequacy of the laboratory computer system to monitor the relevance of the requested diagnostic tests, the implementation of a quality control system, the design and performance of studies of cost-effectiveness, the training of the petitioner and the technical and n…
May Measurement Month 2019 : an analysis of blood pressure screening results from Poland
2021
Abstract May Measurement Month 2019 is the third edition of a global initiative organized by the International Society of Hypertension aimed at raising awareness of hypertension and the need for blood pressure (BP) screening. We present data analysis from Poland. To evaluate the potential of opportunistic BP measurements as a tool for cardiovascular disease prevention programmes. To collect new country data for further annual comparisons. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in 201 sites in May 2019. BP was measured in 7072 subjects (mean age: 54 ± 15 years; 62.3% females). After multiple imputation, the age- and sex-standardized systolic BP (SBP) a…
Testing the Stage-Discharge Relationship in Sloping SMBF Flumes
2021
The Samani, Magallanez, Baiamonte, Ferro (SMBF) flume is a simple and inexpensive instrument for indirect discharge measurement that was originally proposed for use in a horizontal channel and then also applied in sloping channels. The contraction of the flow cross section, aimed at establishing a critical flow condition, is simply obtained by applying two half cylinders to the walls of a rectangular cross section. In this paper a theoretical approach previously proposed for a horizontal SMBF flume is first extended to a sloping SMBF flume and a new stage-discharge relationship is deduced. Then, this equation is experimentally tested using laboratory measurements from literature for differe…
Exploring a new incubation model for FinTechs: Regulatory sandboxes
2021
Research on incubation models indicates that incubators and accelerators are crucial catalysts for the development of start-ups. To facilitate start-ups in financial markets, several regulatory authorities have adopted a new incubation model called a ‘regulatory sandbox’. Regulatory sandboxes enable eligible applicants to test their technology-enabled financial solutions for a certain period of time (subject to conditions the regulator imposes). As such, these instruments allow innovation while preventing severe instability in financial markets caused by systemic risk. Despite their importance, management research has devoted little attention to studying how sandboxes operate as a new incub…
Digital knowledge sharing and creative performance: Work from home during the COVID-19 pandemic
2021
Abstract The outbreak of the COVID-19 pandemic and the resulting social distancing requirements have led to major disruptions in the world of work. The outcomes of the enforced and large-scale work from home (WFH) practices are currently largely unexplored. This study aims to address this gap in the research by investigating the external and internal digital knowledge sharing (DKS) and creative performance (CP) of employees under these extraordinary circumstances. The social capital theory was utilized as the theoretical lens for examining the associations of DKS and CP with demographic, individual, and organizational factors. An online cross-sectional survey was carried out among knowledge…
Accretion onto Neutron Stars: spectral and timing investigation of Low Mass X-ray Binaries
2021
Images of Europe. The Union between Federation and Separation
2021
This book deals with the fundamental semantics of images of Europe, which consist of valences, mirror beliefs and affectivities. This is why it relaunches the importance of the European discourse in its symbolic dimension. As such, it explores the many images of Europe, or rather the many images through which European discourse is actually constituted in daily life, in search of their enunciative responsibility in today’s world for determining the current “State of the Union”. The identity of the European continent is based on a millenary tension between universalism and particularism: images of Europe have in fact been alternately inspired, over the centuries, by a model of homogeneity – R…
DLG4-related synaptopathy: a new rare brain disorder
2021
Contains fulltext : 245031.pdf (Publisher’s version ) (Closed access) PURPOSE: Postsynaptic density protein-95 (PSD-95), encoded by DLG4, regulates excitatory synaptic function in the brain. Here we present the clinical and genetic features of 53 patients (42 previously unpublished) with DLG4 variants. METHODS: The clinical and genetic information were collected through GeneMatcher collaboration. All the individuals were investigated by local clinicians and the gene variants were identified by clinical exome/genome sequencing. RESULTS: The clinical picture was predominated by early onset global developmental delay, intellectual disability, autism spectrum disorder, and attention deficit-hyp…
Pre-imaginal exposure to Oberon® disrupts fatty acid composition, cuticular hydrocarbon profile and sexual behavior in Drosophila melanogaster adults
2021
International audience; Oberon® is a commercial formulation of spiromesifen, a pesticide inhibitor of lipid biosynthesis via acetyl CoA carboxylase, widely used in agricultural crop protection. However, its mode of action requires further analysis. We currently examined the effect of this product on Drosophila melanogaster as a non-target and model organism. Different concentrations of spiromesifen were administered by ingestion (and contact) during pre-imaginal development, and we evaluated its delayed action on adults. Our results suggest that spiromesifen induced insecticidal activity on D. melanogaster. Moreover, spiromesifen treatment significantly increased the duration of larval and …
Parte III. Cap. IX. I Fattori della produzione agricola.
2021
The process of modernization and innovation in the agricultural sector requires careful analysis regarding financial resources and the need to strengthen economic structures within it. The specific discipline of agricultural credit is different from that provided for other productive activities. The "naturalness" of the agricultural product is reflected in the incidence of credit risk. These economic evaluations, which are at the basis of what is known as agricultural exceptionalism, have repercussions on the legal system of access to credit, requiring, for example, a differentiated system of evaluation of creditworthiness.
Opposing health effects of hybridization for conservation
2021
The continuing decline of many natural plant and animal populations emphasizes the importance of conservation strategies. Hybridization as a management tool has proven successful in introducing gene flow to small, inbred populations, but can be also associated with health risks. For example, hybridization can change susceptibility to infection in either direction due to heterosis (hybrid vigor) and outbreeding depression, but such health effects have rarely been considered in the genetic management of populations. Here, we investigated the effects of experimental outcrossing between the critically endangered Saimaa landlocked salmon (Salmo salar m. sebago) and the genetically more diverse A…
Different trophic positions among social vespid species revealed by stable isotopes
2021
The social vespid wasps are common insect predators and several species behave in unison in the same biotopes. It is commonly accepted that social wasps are mainly opportunistic generalist predators without differences in prey selection and hence they compete for the same food resources. Trophic positions of six vespid wasp species and their potential prey from four sites in Finland and one in the UK were evaluated using carbon and nitrogen stable isotopes (δ13C and δ15N). The difference in isotope values indicated different trophic positions among species. In general, Dolichovespula spp. showed higher δ15N values than Vespula spp., which suggests that Dolichovespula forage on higher trophi…
Neural-level associations of non-verbal pragmatic comprehension in young Finnish autistic adults
2021
This video-based study examines the pragmatic non-verbal comprehension skills and corresponding neural-level findings in young Finnish autistic adults, and controls. Items from the Assessment Battery of Communication (ABaCo) were chosen to evaluate the comprehension of non-verbal communication. Inter-subject correlation (ISC) analysis of the functional magnetic resonance imaging data was used to reveal the synchrony of brain activation across participants during the viewing of pragmatically complex scenes of ABaCo videos. The results showed a significant difference between the ISC maps of the autistic and control groups in tasks involving the comprehension of non-verbal communication, there…
Remeex® System Effectiveness in Male Patients with Stress Urinary Incontinence
2021
Background: When conservative management fails, patients with stress urinary incontinence (SUI) are considered for surgical treatment. Simpler, more economical and less invasive surgical techniques, such as the Remeex® system, have been developed. Objectives: To analyze the objective effectiveness of the Remeex® system in the treatment of male stress urinary incontinence. To study survival and complication rates of the Remeex® system in male SUI patients. Materials and methods: Prospective observational study between July 2015 and May 2020. Group A (n = 7
P051 Macrophages as a source of Notch Ligands in Crohn’s disease: implications in fibrosis
2021
Abstract Background Fibrosis constitute the main complications associated to Crohn’s disease (CD). Notch signalling has been implicated in lung, kidney, liver and cardiac fibrosis. Macrophages contribute to fibrosis through the release of different mediators and the pattern of secretion may vary according to their microenvironment. The aim of the present study is to analyze the role of Notch ligands derived from macrophages in the complications of CD. Methods We have analyzed: the mRNA expression of cytokines and Notch ligands in CD patients with fistulizing and stenting pattern, the mRNA and protein expression of macrophage markers and Notch ligands in macrophages treated with the main cyt…
Assessment of the interpretability of data mining for the spatial modelling of water erosion using game theory
2021
Abstract This study undertook a comprehensive application of 15 data mining (DM) models, most of which have, thus far, not been commonly used in environmental sciences, to predict land susceptibility to water erosion hazard in the Kahorestan catchment, southern Iran. The DM models were BGLM, BGAM, Cforest, CITree, GAMS, LRSS, NCPQR, PLS, PLSGLM, QR, RLM, SGB, SVM, BCART and BTR. We identified 18 factors usually considered as key controls for water erosion, comprising 10 factors extracted from a digital elevation model (DEM), three indices extracted from Landsat 8 images, a sediment connectivity index (SCI) and three other intrinsic factors. Three indicators consisting of MAE, MBE, RMSE, and…
Heavy metal uptake by plants from wastewater of different pulp concentrations and contaminated soils
2021
There is a lack of information on the extent of mineral extraction by plants from wastewater in arid and semi-arid environments in developing countries. This research assesses the performance of Alhagi and Mallow plant species for the absorption of heavy metals around the tailings dam of a copper mine in Iran. The industrial wastewater, known as the pulp, from the copper mine site has different concentrations of heavy metals. In a laboratory setting the plants were cultivated and irrigated with different pulp concentrations (0, 20, 40, 60, 80, and 100%) in water. Heavy metals (chromium, manganese, cadmium, and lead) accumulation in the aerial parts and roots of the plants, and the in-situ s…
Obesogenic Diets Cause Alterations on Proteins and Theirs Post-Translational Modifications in Mouse Brains
2021
Obesity constitutes a major global health threat and is associated with a variety of diseases ranging from metabolic and cardiovascular disease, cancer to neurodegeneration. The hallmarks of neurodegeneration include oxidative stress, proteasome impairment, mitochondrial dysfunction and accumulation of abnormal protein aggregates as well as metabolic alterations. As an example, in post-mortem brain of patients with Alzheimer’s disease (AD), several studies have reported reduction of insulin, insulin-like growth factor 1 and insulin receptor and an increase in tau protein and glycogen-synthase kinase-3β compared to healthy controls suggesting an impairment of metabolism in the AD patient’s …