showing 36 of ~574560 from 574555 documents
Phytochemical investigation and antitumor activity of coumarins from Sicilian accession of Ferulago nodosa (L.) Boiss. roots
2023
Ferulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area being present in Crete, Greece, Albania, and probably in Macedonia. From the roots of this accession of species, not previously investigated, four coumarins, grandivittin, aegelinol benzoate, felamidin and aegelinol, and two terpenoids, (2E)-3-methyl-4-[(3-methyl-1-oxo-2-buten-1yl)oxy]-2-butenoic acid and pressafonin-A, were isolated and spectroscopically characterized. The last one was never detected in Ferulago species. The evaluation of the anti-tumor effects of F. nodosa coumarins on colon cancer HCT116 cells showed only a modest effect on reduction of tumor cell viability. For aegelinol, the red…
Comparison between SiC and GaN switching devices in fast-recharging systems for electric vehicles
2023
Recently, the improvement of the semiconductor devices to achieve higher efficiency and higher power density has risen to interest. Si carbide and gallium nitride offer faster switching frequency and lower losses; however, the knowledge of the behaviour of these devices is not mature. In this paper, a system for fast charging of batteries for electric vehicles based on an isolated DC-DC converter equipped with both SiC and GaN devices is presented and an interesting experimental comparison among these two technologies will be given in terms of dynamic performances, electromagnetic compatibility, stability, efficiency, and so on.
Synthesis, X-ray Structure of Two Hexa-Coordinated Ni(II) Complexes with s-Triazine Hydrazine Schiff Base Ligand
2023
The hydrazine s-triazine ligand (E)-4,4’-(6-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-1,3,5-triazine-2,4-diyl)dimorpholine (DMPT) was used to synthesize two new Ni(II) complexes via a self-assembly technique. The two complexes were synthesized by a one-pot synthesis strategy and characterized by elemental analysis, FTIR and single-crystal X-ray diffraction analysis to be [Ni(DMPT)(H2O)3](NO3)2.3H2O (1) and [Ni(DMPT)(H2O)3](NO3)2.H2O (2). The structures of both complexes were very similar regarding the coordination sphere and counter anions, but differ only in the number of the crystal water molecules. In the case of complex 1, there are three water molecules instead of one H2O molecu…
Erenumab and Possible CGRP Effect on Chronotype in Chronic Migraine: A Real-Life Study of 12 Months Treatment
2023
The introduction of monoclonal antibodies (mAbs) directed against the calcitonin gene-related peptide (CGRP), or its receptor (CGRPr), revolutionized migraine management due to their high efficacy and few side effects. Data suggest that the CGRP may even be implicated in circadian rhythm, but studies about the effect of anti-CGRP treatments on sleep are still lacking. The aim of the present study was to assess the effect of erenumab (70 and 140 mg per month), a human mAb directed against CGRPr, on chronotype in chronic migraineurs; secondly, we assessed its efficacy, safety, and the effects on anxiety and depression. Sleep was evaluated using self-administrable questionnaires investigating …
The Contribution of Bullying Involvement and Alexithymia to Somatic Complaints in Preadolescents
2023
Somatic complaints during preadolescence are connected to individual and contextual factors, and extant research highlights the relevance of alexithymia and bullying involvement. In this cross-sectional study, we explored the joint and unique influence of bullying involvement—as perpetrators, victims, or outsiders—and alexithymia on somatic complaints in a sample of 179 Italian middle-school students (aged 11–15). Findings revealed an indirect association between bullying perpetration and victimization complaints through alexithymia. We also found a significant direct association between victimization and somatic complaints. No significant association between outsider beha…
Latviešu studenšu korporācijas "Dzintra" regālijas LU Muzeja krājumā
2023
Šī ir pirmā LU Muzeja rubrika par LU studenšu akadēmiskajām mūža organizācijām, kur izvēlētas latviešu studenšu korporācijas "Dzintra" regālijas LU Muzeja krājumā. Raksts analizē šo regāliju pielietojumu un simbolisko nozīmi, uzsverot arī pašas studenšu korporācijas nozīmi un lomu Latvijas valsts un LU vēsturē. Tiek konstatēts fakts, ka studenšu korporācija ne tikai ir interešu pulciņš, bet arī liela saistību uzņemšanās pret Latvijas valsti un tās sabiedrību.
Developing response-ability in human-wasp encounters
2023
Learning to live with unloved others is crucial in the ecological crisis. Unloved wasps are feared and disliked for their sting. Understanding of their ecological importance is increasing, however. Human-wasp encounters are changing with environmental changes, and strategies for multispecies cohabitation are needed. This multispecies study highlights features of wasp biology affecting human-wasp encounters and analyzes how conflicted human-wasp relations could be mitigated. The geographical focus is Finland, in the Northern boreal region. Biological analysis specified spatiotemporal aspects affecting human-wasp encounters: human and wasp habitats and preferences overlap ubiquitously. From a…
Moving mass over a viscoelastic system: asymptotic behaviours and insights into nonlinear dynamics
2023
AbstractMoving masses are of interest in many applications of structural dynamics, soliciting in the last decades a vast debate in the scientific literature. However, despite the attention devoted to the subject, to the best of the authors’ knowledge, there is a lack of analysis about the fate of a movable mass when it rolls or slips with friction on a structure. With the aim of elucidating the dynamics of the simplest paradigm of this system and to investigate its asymptotic response, we make reference to a two-degree-of-freedom model made of an elastically vibrating carriage surmounted by a spherical mass, facing the problem both theoretically and experimentally. In case of linear systems…
Diritti fondamentali, terrorismo e privazione della cittadinanza
2023
This article intends to contribute to the debate on the legal legitimacy of the revocation of citizenship as a measure to counter terrorism, examining in a comparative perspective the recent legislative developments and the related case law in Belgium, France, the United Kingdom and Italy.
Inference of the Life Cycle of Environmental Phages from Genomic Signature Distances to Their Hosts
2023
The environmental impact of uncultured phages is shaped by their preferred life cycle (lytic or lysogenic). However, our ability to predict it is very limited. We aimed to discriminate between lytic and lysogenic phages by comparing the similarity of their genomic signatures to those of their hosts, reflecting their co-evolution. We tested two approaches: (1) similarities of tetramer relative frequencies, (2) alignment-free comparisons based on exact k = 14 oligonucleotide matches. First, we explored 5126 reference bacterial host strains and 284 associated phages and found an approximate threshold for distinguishing lysogenic and lytic phages using both oligonucleotide-based methods. The an…
The Riverine Organism Drift Imager: A new technology to study organism drift in rivers and streams
2023
1. Drift or downstream dispersal is a fundamental process in the life cycle of many riverine organisms. In the face of rapidly declining freshwater biodiversity, there is a need to enhance our capacity to study the drift of riverine organisms, by overcoming the limitations of traditional labour-intensive sampling methods that result in data of low temporal and spatial resolution. 2. To address this need, we developed a new technology, the Riverine Organism Drift Imager (RODI), which combines in situ imaging with machine-learning classification. This technique expands on the traditional methodology by replacing the collection cup of a drift net with a camera system that continuously images r…
Winnicott and the (un)integrated self
2023
The capacity to relax and letting one's mind wander is one of the cornerstones of psychoanalysis. In cases where this capacity seems hindered, the reasons are characteristically sought from particular and specific inhibitions: what is thereby taken to be interfered is not the capacity of relaxation but only the activation of this capacity in a particular regard. In contrast to this mainstream way of thinking, Winnicott argues that the capacity for mental relaxation is a developmental achievement and presupposes a safe sense of integration. The present article investigates this dynamism. It clarifies how an integral sense of self arises out of primary unintegration, explains how a well-estab…
“Golden” Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on the Redox Balance in the High-Fat-Diet-Fed Rat
2023
Tomato fruits defined as “golden” refer to a food product harvested at an incomplete ripening stage with respect to red tomatoes at full maturation. The aim of this study is to explore the putative influence of “golden tomato” (GT) on Metabolic Syndrome (MetS), especially focusing on the effects on redox homeostasis. Firstly, the differential chemical properties of the GT food matrix were characterized in terms of phytonutrient composition and antioxidant capacities with respect to red tomato (RT). Later, we assessed the biochemical, nutraceutical and eventually disease-modifying potential of GT in vivo in the high-fat-diet rat model of MetS. Our data revealed that G…
Novel insights into cancer stem cells targeting: CAR-T therapy and epigenetic drugs as new pillars in cancer treatment
2023
Cancer stem cells (CSCs) represent the most aggressive subpopulation present in the tumor bulk retaining invasive capabilities, metastatic potential and high expression levels of drug efflux pumps responsible for therapy resistance. Cancer is still an incurable disease due to the inefficacy of standard regimens that spare this subpopulation. Selective targeting of CSCs is still an unmet need in cancer research field. Aberrant epigenetic reprogramming promotes the initiation and maintenance of CSCs, which are able to escape the immune system defense. Promising therapeutic approaches able to induce the selective inhibition of this stem-like small subset include immunotherapy alone or in combi…
Prognostic Factors in Staged Bilateral Total Knee Arthroplasty—A Retrospective Case Series Analysis
2023
Background: Bilateral osteoarthritis of the knee is an indication for a bilateral total knee replacement (TKR) procedure. The goal of our study was to assess the sizes of the implants used during the first and second stages of TKR procedures in order to compare their size and identify the prognostic factors for the second procedure. Methods: We evaluated 44 patients who underwent staged bilateral TKR procedures. We assess the following prognostic factors from the first and second surgery: duration of anesthesia, femoral component size, tibial component size, duration of hospital stay, tibial polyethylene insert size, and the number of complications. Results: All assessed prognostic factors …
Forhandlinger Med Omkostninger. Muslimske Foregangskvinner i Den Norske Offentligheten.
2023
The last few years an increasing number of Muslim women have found a clear voice in the public sphere in Norway. Research into Islam confirms that Muslims, especially Muslim women, are presented in media in a way that is unrecognizable to themselves. The debates in the media surrounding Islam, especially the hijab controversy in both 2004 and 2009, have centered around gender equality, collective peer pressure vs individual freedom, and the urge to be made visible vs invisibility. This article explores how Muslim women in the public sphere in Norway negotiate identity in a partially contradictory dichotomy. Applying the perspective of theory on cultural studies, I will demonstrate how women…
Nuclear analytical techniques used to study the trace element content of Centaurium erythraea Rafn, a medicinal plant species from sites with differe…
2023
Centaurium erythraea (Gentianaceae) is a medicinal plant species with therapeutic potential officially listed in the pharmacopoeias of many European, Asian and American countries. It has had many uses in natural medicine since ancient times and it is collected mostly from wild populations. The aim of this study is to investigate the trace element composition of C. erythraea using instrumental neutron activation analysis (INAA). The results of the performed investigations show that INAA has proved to be an efficient analytical technique for the determination of trace elements in medicinal plants. The studied plant contains elements important to the human diet and metabolism that are needed f…
Artificial intelligence to counteract “KPI overload” in business process monitoring: the case of anti-corruption in public organizations
2023
PurposeThe nature and amount of data that public organizations have to monitor to counteract corruption lead to a phenomenon called “KPI overload”, consisting of the business analyst feeling overwhelmed by the amount of information and resulting in the absence of appropriate control. The purpose of this study is to develop a solution based on Artificial Intelligence technology to avoid data overloading and, at the same time, under-controlling in business process monitoring.Design/methodology/approachThe authors adopted a design science research approach. The authors started by observing a specific problem in a real context (a healthcare organization); then conceptualized, designed and imple…
Du monde et de ses versions: quand traduire c'est faire
2023
Les imaginaires du traduire traversent les langues, les discours, les espaces, le temps historique, la valeur des textes et des idées, jusqu’à souligner la dimension constitutive des pratiques traduisantes dans le processus de signification symbolique du monde. Ainsi, la traduction et ses imaginaires fonctionnent toujours comme un mode possible de rapport au réel qui intègre les mécanismes sociaux, épistémiques, cognitifs et culturels de la réception.
La testimonianza scritta nel processo tributario
2023
L’abolizione del divieto di prova testimoniale nel processo tributario e la contestuale introduzione della prova per testimoni in forma scritta mutuata dal codice processuale civile hanno consentito di superare le antinomie di un assetto ormai da tempo ritenuto inconciliabile con i principi desumibili dalla nuova formulazione dell’art.111 Cost.. L’inserimento del nuovo mezzo istruttorio ha determinato una radicale trasformazione della disciplina dell’istruzione probatoria nel processo tributario, perché affianca una prova tipicamente costituenda alle prove precostituite tradizionalmente rimesse alle parti, rendendo ormai evidente la necessità di specifiche norme che regolino nel processo tr…
Hyvinvointi-, hius- ja kauneusalan ammatteihin opiskelevat kriittisinä nettilukijoina
2023
Tutkimuksessa selvitettiin ammatillisen koulutuksen opiskelijoiden (hyvinvointi-, hius- ja kauneusala) kriittistä nettilukutaitoa. Lisäksi tarkasteltiin aikaisemman tiedon, tekstien lukemisjärjestyksen ja perustelutaitojen yhteyttä siihen, kuinka hyvin opiskelijat osasivat arvioida luotettavia (varmentaminen) ja epäluotettavia (kyseenalaistaminen) nettitekstejä sekä erottaa luotettavat tekstit epäluotettavista. Tutkimukseen osallistui 82 opiskelijaa, joista valtaosa oli 15–18-vuotiaita. Opiskelijat lukivat ja arvioivat kaksi luotettavaa ja kaksi epäluotettavaa tekstiä sokerin vaikutuksista. Opiskelijat arvioivat kirjoittajan asiantuntijuutta, tarkoitusperiä, julkaisupaikkaa ja evidenssin la…
Chromosome Painting in Cercopithecus petaurista (Schreber, 1774) Compared to Other Monkeys of the Cercopithecini Tribe (Catarrhini, Primates)
2023
The Cercopithecini tribe includes terrestrial and arboreal clades whose relationships are controversial, with a high level of chromosome rearrangements. In order to provide new insights on the tribe’s phylogeny, chromosome painting, using the complete set of human syntenic probes, was performed in Cercopithecus petaurista, a representative species of the Cercopithecini tribe. The results show C. petaurista with a highly rearranged karyotype characterized by the fission of human chromosomes 1, 2, 3, 5, 6, 8, 11, and 12. These results compared with the literature data permit us to confirm the monophyly of the Cercopithecini tribe (fissions of chromosomes 5 and 6), as previously proposed by ch…
L'Imaginaire du traduire. Langues, textes et pratiques des savoir
2023
Comment la traduction a-t-elle changé et continue-t-elle de transformer l’histoire de la réalité ? De quelle manière les pratiques de traduction sont-elles en mesure d’alimenter des valeurs et des savoirs dans le champ épistémique de réception ? À partir de plusieurs orientations théoriques et de l’analyse de documents textuels variés – esthétiques et scientifiques – les contributions réunies ici envisagent la traduction comme une opération cognitive essentielle dans le processus de signification symbolique du monde. Dans cette perspective, l’imaginaire du traduire fonctionne comme un dispositif herméneutique nous aidant à réfléchir sur les principes d’articulation anthropologique entre tra…
The Impact of Omnichannel Strategies on Franchisee-Franchisor Relationship Quality
2023
International audience; While omnichannel strategies have become increasingly ubiquitous in franchising, there is a dearth of academic research on how franchisees perceive omnichannel retailing and how the latter impacts the franchise relationship. Yet, the rise of omnichannel strategies could modify the relationship between the franchisor and the franchisees in different ways. For instance, the diversity of channels could reduce the ability of franchisors to monitor their franchisees and could empower the latter (Lee et al., 2019). Some channels, mainly the brand’s website, could introduce new forms of intra-brand competition between the franchisor and franchisees’ units (Bridges, 2017; Cl…
What the hell are you doing? A PRISMA systematic review of psychosocial precursors of slut-shaming in adolescents and young adults
2023
Slut-shaming is a form of discrimination against those who violate gender stereotypes, independent of that person's gender identity or sexual orientation or sexual behaviour and appearance. Slut-shaming is a sexual stigmatisation perpetrated both by women and men through rumours, criticism and ostracism and it has severe negative effects both on self-identity and interpersonal relations. This review focuses on psychosocial factors associated with vulnerability to slut-shaming exposure and was carried out using the new Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. Articles were retrieved from Scopus and Web of Science databases. After having initially …
Editorial: Effect of neurophysiological conditions and mental workload on physical and cognitive performances: a multidimensional perspective
2023
The Research Topic "Effect of Neurophysiological Conditions and Mental Workload on Physical and Cognitive Performances: a Multidimensional Perspective" compiles recent advances in the multidimensional assessment of the effect of neurophysiological status and mental workload on physical and cognitive performance (Aghajani et al., 2017; Perpetuini et al., 2022). Due to technological and data analytics tool advancements, non-invasive and real-time monitoring of the activity of the human central and autonomic nervous systems is now possible, facilitating the quantification of the relationship between physiology and human performance (Ashkanasy, 2004; Cardone et al., 2022). Moreover, questionnai…
Step-by-Step Regeneration of Tentacles after Injury in Anemonia viridis—Morphological and Structural Cell Analyses
2023
Benthic marine invertebrates, such as corals, are often subjected to injury caused by several sources. Here, the differences and characteristics in injured and health tissues in terms of cellular components are shown through a histological investigation of the soft coral Anemonia viridis at 0 h, 6 h, 24 h, and 7 days after injury caused by tentacle amputation. In addition, a new tool was used for the first time in invertebrates, positron emission tomography, in order to investigate the events that occur during regeneration within a longer time period (0 h, 24 h, and 14 days after the tentacles were cut). Higher integrated density values were measured through a densitometric analysis in sect…
Machine Learning for Early Diagnosis of ATTRv Amyloidosis in Non-Endemic Areas: A Multicenter Study from Italy
2023
Background: Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv) is an adult-onset multisystemic disease, affecting the peripheral nerves, heart, gastrointestinal tract, eyes, and kidneys. Nowadays, several treatment options are available; thus, avoiding misdiagnosis is crucial to starting therapy in early disease stages. However, clinical diagnosis may be difficult, as the disease may present with unspecific symptoms and signs. We hypothesize that the diagnostic process may benefit from the use of machine learning (ML). Methods: 397 patients referring to neuromuscular clinics in 4 centers from the south of Italy with neuropathy and at least 1 more red flag, as well as undergoin…
Sustained attention required for effective dimension-based retro-cue benefit in visual working memory
2023
In visual working memory (VWM) tasks, participants’ performances can be improved through the use of dimension-based retro-cues, which direct internal attention to prioritize a particular dimension (e.g., color or orientation) of VWM representations even after the stimuli disappear. This phenomenon is known as the dimension-based retro-cue benefit (RCB). The present study investigates whether sustained attention is required for the dimension-based RCB by inserting interference or interruption between the retro-cue and the test array to distract attention. We tested the effects of perceptual interference or cognitive interruption on dimension-based RCB when the interference (Experiments 1 and…
Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome
2023
Multiple myeloma (MM) is a hematologic malignancy with a multistep evolutionary pattern, in which the pro-inflammatory and immunosuppressive microenvironment and genomic instability drive tumor evolution. MM microenvironment is rich in iron, released by pro-inflammatory cells from ferritin macromolecules, which contributes to ROS production and cellular damage. In this study, we showed that ferritin increases from indolent to active gammopathies and that patients with low serum ferritin had longer first line PFS (42.6 vs. 20.7 months and, p = 0.047, respectively) and OS (NR vs. 75.1 months and p = 0.029, respectively). Moreover, ferritin levels correlated with systemic inflammation markers …
Dealing with missing participants in the opening phases of a videoconference
2023
Abstract The paper explores the social interaction that takes place during the initial phases of videoconferences. The focus is on the problem of absent participants, which is often considered a reason for delaying the official beginning of the meeting. One of the resources that the participants have is to reach the absent participant by cellphone. We observed a recurrent pattern of action whereby one of the participants disengages from the video meeting to reach the missing person by phone. This negotiation process moves through four steps: (1) the detection of the problem, (2) the offer to call the missing person by one participant, (3) the acceptance of this offer by the moderator, and (…
On conditional probabilities and their canonical extensions to Boolean algebras of compound conditionals
2023
In this paper we investigate canonical extensions of conditional probabilities to Boolean algebras of conditionals. Before entering into the probabilistic setting, we first prove that the lattice order relation of every Boolean algebra of conditionals can be characterized in terms of the well-known order relation given by Goodman and Nguyen. Then, as an interesting methodological tool, we show that canonical extensions behave well with respect to conditional subalgebras. As a consequence, we prove that a canonical extension and its original conditional probability agree on basic conditionals. Moreover, we verify that the probability of conjunctions and disjunctions of conditionals in a rece…
La casa-hospital de San Nicolás 'catalanorum' de Roma: características y localización cerca del Arco dei cenci (h. 1350-1519)
2023
Este artículo revisa los estudios precedentes sobre la casa-hospital de San Nicolás, una de las estructuras asistenciales de la Corona de Aragón en Roma durante la Baja Edad Media. Gracias al empleo de pruebas documentales, corrige la localización tradicional de este inmueble, trasladándola de Corte Savella al «area cinciana». Además, describe la configuración del edificio, analiza su antigüedad y estudia las sucesivas restauraciones, hasta su adquisición por Virgilio Cenci en 1518. The purpose of this essay is to re-examine the studies on the hospital of San Nicolás in Rome, one of the health care institutions of the Crown of Aragon during the Late Middle Ages. Through the use of documenta…
Adjuvant capecitabine in triple negative breast cancer patients with residual disease after neoadjuvant treatment: real-world evidence from CaRe, a m…
2023
BackgroundIn triple negative breast cancer patients treated with neoadjuvant chemotherapy, residual disease at surgery is the most relevant unfavorable prognostic factor. Current guidelines consider the use of adjuvant capecitabine, based on the results of the randomized CREATE-X study, carried out in Asian patients and including a small subset of triple negative tumors. Thus far, evidence on Caucasian patients is limited, and no real-world data are available.MethodsWe carried out a multicenter, observational study, involving 44 oncologic centres. Triple negative breast cancer patients with residual disease, treated with adjuvant capecitabine from January 2017 through June 2021, were recrui…
Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia
2023
: Background Evidence suggests that LPA risk genotypes are a possible contributor to the clinical diagnosis of familial hypercholesterolemia (FH). This study aimed at determining the prevalence of LPA risk variants in adult individuals with FH enrolled in the Italian LIPIGEN (Lipid Transport Disorders Italian Genetic Network) study, with (FH/M+) or without (FH/M-) a causative genetic variant. Methods and Results An lp(a) [lipoprotein(a)] genetic score was calculated by summing the number risk-increasing alleles inherited at rs3798220 and rs10455872 variants. Overall, in the 4.6% of 1695 patients with clinically diagnosed FH, the phenotype was not explained by a monogenic or polygenic cause …
Rejoinder: fractures in the edifice of PLS
2023
Purpose This study aims to provide a response to the commentary by Yuan on the paper “Marketing or Methodology” in this issue of EJM. Design/methodology/approach Conceptual argument and statistical discussion. Findings The authors find that some of Yuan’s arguments are incorrect, or unclear. Further, rather than contradicting the authors’ conclusions, the material provided by Yuan in his commentary actually provides additional reasons to avoid partial least squares (PLS) in marketing research. As such, Yuan’s commentary is best understood as additional evidence speaking against the use of PLS in real-world research. Research limitations/implications This rejoinder, coupled with Yuan’s comm…