showing 36 of ~574560 from 574555 documents
Effects of Flavonoids on Cancer, Cardiovascular and Neurodegenerative Diseases: Role of NF-κB Signaling Pathway
2023
Flavonoids are polyphenolic phytochemical compounds found in many plants, fruits, vegetables, and leaves. They have a multitude of medicinal applications due to their anti-inflammatory, antioxidative, antiviral, and anticarcinogenic properties. Furthermore, they also have neuroprotective and cardioprotective effects. Their biological properties depend on the chemical structure of flavonoids, their mechanism of action, and their bioavailability. The beneficial effects of flavonoids have been proven for a variety of diseases. In the last few years, it is demonstrated that the effects of flavonoids are mediated by inhibiting the NF-κB (Nuclear Factor-κB) pathway. In this review, we have summar…
Training in Diagnostic Hysteroscopy: The "Arbor Vitae" Method
2023
Background and Objectives: Diagnostic hysteroscopy is the gold standard in the diagnosis of intrauterine pathology and is becoming an essential tool in the daily practice of gynecology. Training programs for physicians are necessary to ensure adequate preparation and learning curve before approaching patients. The aim of this study was to describe the “Arbor Vitae” method for training in diagnostic hysteroscopy and to test its impact on the knowledge and skills of trainees using a customized questionnaire. Materials and Methods: A three-day hysteroscopy workshop combining theory and practical “hands on “sessions with dry and wet labs has been described. The aim of the course is to teach ind…
A Critical Perspective on the Supplementation of Akkermansia muciniphila: Benefits and Harms
2023
Akkermansia muciniphila is a mucin-degrading bacterium of the intestinal niche, exerting beneficial effects on the host metabolic profile. Accumulating evidence indicated Akkermansia as a promising therapeutic probiotic against metabolic disorders such as obesity, type 2 diabetes and cardiovascular diseases. However, in specific intestinal microenvironments, its excessive enrichment may be not beneficial. Conditions like inflammatory bowel disease (IBD), Salmonella typhimurium infection or post-antibiotic reconstitution may not benefit from Akkermansia supplementation. Furthermore, using Akkermansia in patients with endocrine and gynecological disorders—such as polycystic ovary syndrome (PC…
Intramuscular migration of calcium deposits into the deltoid muscle: two cases of a rare complication of rotator cuff calcific tendinopathy
2023
Rotator cuff calcific tendinopathy is a common non-traumatic shoulder pain condition that occurs predominantly in the supraspinatus tendon. Ultrasound-guided percutaneous irrigation of calcific tendinopathy (US-PICT) is a valid treatment in the resorptive phase. A complication of calcific tendinopathy is migration of calcium deposits outside the tendon. The most common site of migration is the subacromialsubdeltoid bursa (SASD). Another, but not frequent, type of migration is the intramuscular migration which mostly affects the supraspinatus, the infraspinatus and the biceps brachii muscles. This paper reports two cases of migration of calcification from the supraspinatus tendon to the delt…
A genome‐wide comparison between selected and unselected Valle del Belice sheep reveals differences in population structure and footprints of recent …
2023
About three decades of breeding and selection in the Valle del Belìce sheep are expected to have left several genomic footprints related to milk production traits. In this study, we have assembled a dataset with 451 individuals of the Valle del Belìce sheep breed: 184 animals that underwent directional selection for milk production and 267 unselected animals, genotyped for 40,660 single-nucleotide polymorphisms (SNPs). Three different statistical approaches, both within (iHS and ROH) and between (Rsb) groups, were used to identify genomic regions potentially under selection. Population structure analyses separated all individuals according to their belonging to the two groups. A total of fo…
ΓΝΩΘΙ ΜΑΘΗΜΑ (GNŌTHI MATHĒMA) Or What are the foundations of our thinking?
2023
The words ΓΝΩΘΙ ΣΕΑΥΤΟΝ (Gnothi Seauton) are inscribed at the entrance to the Temple of Apollo at Delphi. The paraphrase ΓΝΩΘΙ ΜΑΘΗΜΑ we use to ask some questions in addressing the main question – what is the basis of our thinking?
The Correlation between Adolescent Daily Breakfast Consumption and Socio-Demographic:Trends in 23 European Countries Participating in the Health Beha…
2023
Breakfast is often considered the most important meal of the day and can benefit adolescent health in several ways. The aims of the present study were (1) to identify adolescents’ socio-demographic (sex, family affluence and family structure) determinants of daily breakfast consumption (DBC) and (2) to describe trends in DBC among adolescents across 23 countries. Cross-sectional surveys of nationally representative samples of adolescents (aged 11, 13, and 15 years) (n = 589,737) participating in the Health Behaviour in School-aged Children (HBSC) survey from 2002 to 2018 were used. Multilevel logistic regression analyses modeled DBC over time, adjusted for family affluence, family structure…
The influence of architecture, design and physical environment in residential buildings on cardiovascular disease – rationale and protocol for an ove…
2023
Introduction and Objective. Architecture and design solutions profile the environment and living conditions in residential housing and may have an impact on health. The aim of the study was to summarise all published systematic reviews (SRs) with or without meta-analysis (MAs), which assess the effect on cardiovascular disease (CVD) of the architecture, design and physical environment in residential buildings. Materials and method. This study presents the rationale and protocol of an overview of SRs. It was prepared according to Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). Four bibliographical databases will be searched. Eligible SRs can include RC…
MOBILE MAPPING FOR CULTURAL HERITAGE: THE SURVEY OF THE COMPLEX OF ST. JOHN OF THE HERMITS IN PALERMO (ITALY)
2023
Abstract. During the 11th and 12th century, the Arab-Norman architectural style characterized the most beautiful and important Cultural Heritage buildings in Sicily, and especially in Palermo (Italy). The relevance of these monuments is highlighted by their inclusion in the UNESCO World Heritage Sites List in 2015. For many years, the University of Palermo has been studying and documenting several Arab-Norman cultural assets, and in particular, the complex of St. John of the Hermits in Palermo (Italy). A first detailed 3D survey of the main structures of this complex was carried out using a terrestrial laser scanner while the 3D survey of the entire complex was made using a Mobile Mapping S…
A Marble Bust Newly Discovered by the Trapani Lombardo Family of Reggio Calabria (Southern Italy)
2023
This research concerns a stylistic and archaeometric study of an ancient marble female bust recently discovered by the Trapani Lombardo family of Reggio Calabria (Southern Italy) and delivered to the Superintendency of Archaeology, Fine Arts, and Landscape for the metropolitan city of Reggio Calabria and Vibo Valentia (SABAP). Based on the first technical, stylistic, and iconographic observations made by the competent bodies, it is a half-length portrait bust from the Roman era, which precisely had the function of faithfully reproducing the physiognomy of the depicted subject. The research aimed to establish the authenticity of the artwork and the origin of the raw material, providing indic…
How to Ensure the Development of SMEs in Post-Pandemic Economy? A Start-ups Case Study
2023
Abstract After the humanitarian crisis, caused by COVID-19, enterprises have to face a post-pandemic economic crisis. As small and medium-sized enterprises (SMEs) constitute 99% of EU enterprises and create every third workplace (European Parliament, 2021), it is important to monitor their situation not only to survive but also to develop and build strong economies in the future. The aim of this research is to investigate development trends and opportunities in (SMEs’) development, with a special focus on start-ups (STPS) as representative of these. Also, special attention is paid to the concept of sustainable development (SD), which fulfils the UN 2030 Agenda for Sustainable Development Go…
Tirsos
2023
La ceca de Tirsos se asocia al grupo numismático del noroeste del valle del Ebro, comúnmente conocido como "monedas vasconas" (Villaronga 1993; Beltrán y Velaza 2009). Se desconoce su localización, aunque podría estar situada en las zonas altas de Aragón o de Navarra (TIR K-30, s.v. Tirsos). El área marcada en el mapa es orientativa. Se conocen dos tipos, que siguen un estándar de 10-11 g, para las unidades. El primero MIB 1a (= ACIP 1699, CNH 262/1) y 1b lleva en el anverso una cabeza masculina barbada, con collar, a derecha. En el reverso lleva un jinete con arma arrojadiza a derecha (García-Bellido 1999: 211-212) y …
Belaiskom
2023
Ceca de ubicación desconocida, aunque por la leyenda belaiskom se ha relacionado con las monedas con leyenda kontebakom bel(Konterbia Belaisca = Botorrita, Zaragoza). La leyenda belai - skom, al igual que otras terminadas en -om, ha sido considerada como un adjetivo denominativo, en este caso aplicado a la materia de la moneda, en nominativo de singular masculino o en nominativo-acusativo singular neutro (Villar 1995: 127; Estarán y Beltrán 2015: 291-292). No obstante también existe la propuesta de identificarla como un genitivo del plural, indicador de origen y alusión a los habitantes de la ciudad responsable de su acuñación (de Hoz 2017: …
Technology-enhanced or Technology-exhausted Learning in Adult Migrant Literacy Education in Finland : Exploring Teachers’ Experiences and Views in Pr…
2023
This exploratory mixed data study investigated the role of technology in adult migrant language and late literacy education in Finland. In addition to an online pre-pandemic survey targeted at Finnish language and literacy teachers, four in-service teachers were interviewed during the COVID-19 pandemic in late 2020. With means of qualitative content analysis an account of teachers’ individual experiences and views of technology-equipped language and literacy learning was generated. Problematic issues were the use of devices for educational purposes, lacking user experience, inadequate provision of suitable devices, IT courses, and insufficient support for learners and teachers, causing ineq…
Nertobis
2023
Fue una ciudad celtibérica, mencionada por Ptolomeo (2.6.57) y por Apiano (Ib. 48,50). Se propone su localización en La Torre (Calatorao, Zaragoza) (Díaz y Medrano 1989: 93-97; Medrano y Díaz 2000: 271; Fatás 1992: 229) o entre esta ciudad, Riclay y La Almunia de Doña Godina (Beltrán 1995: 106; DCPH II: 286). No existen evidencias para decidir si fue una ciudad adcrita a los belos o a los titos (Fatás 1992:229; Burillo 1998: 160-161), aunque existe preferencia por los belos. La acuñación se inició siguiendo un estándar de ca. 12 g, que posteriormente se reducirá a ca. 9 g, aunque la mitad MIB 4, pesa …
Limittäiskielisyys osana kuvataiteen prosesseja
2023
Tässä artikkelissa käsittelen kahdeksan Berliinissä asuneen suomalaislähtöisen kuvataiteilijan käsityksiä kielten merkityksestä identiteettiinsä ja taiteeseensa. Vastaan kolmeen tutkimuskysymykseen; ensinnäkin siihen, miten eri kielten käyttö on vaikuttanut taiteilijoiden identiteettiin, toisekseen siihen, miten he käyttävät kieliä visuaalisessa taiteessaan ja lopuksi siihen, mikä rooli kielellä, monikielisyydellä/limittäiskieleilyllä on heidän taiteessaan. Kesällä 2019 ja talvella 2021 kerätty aineisto koostuu kuvataiteilijoiden haastatteluista, ottamistani valokuvista taiteilijoiden työhuoneilta ja heidän töistään sekä heidän julkaisemistaan kirjoista ja nettisivuista. Tässä artikkelissa …
Burzau = Bursau
2023
Se localiza en Borja (Zaragoza), en los cabezos de 'El Castillo', 'La Corona', 'La Cueva Esquilar' y zonas aledañas del casco urbano de Borja (Serrano et al. 2018). A pesar de no conocerse muchos hallazgos, el área de dispersión es notable (Aguilera 2009: 164). Un ejemplar del tipo MIB 1, bastante gastado apareció en el tesoro de Azaila I, lo que sugiere que algunos tipos se acuñaron en la segunda mitad del siglo II a.C. La ceca ha sido estudiada recientemente por Aguilera (2009), en cuyo trabajo ofrece un recorrido historiográfico y una sistematización de las emisiones. Los seis tipos identificados, hasta el momento, incluyen unidades, mitades y ¿cuartos? de la segunda mitad del siglo II a…
Kontebakom Bel | Konterbia Belaiska
2023
La ciudad se localiza en Cabezo de las Minas (Botorrita, Zaragoza), como lo atestiguan sus menciones en documentos epigráficos hallados en la propia ciudad y la abundancia de monedas con la leyenda bel / kontebakom (de Hoz y Michelena 1974: 114; Fatás 1980; Díaz y Medrano 1990: 181-182; DCPH II: 255; M. Beltrán 1976: 71-84; Estarán y Beltrán 2015: 204-205). La ausencia de monedas con leyenda belaiskom en el yacimiento Cabezo de la Minas, sugiere que no existe relación entre ambas ciudades. La producción monetaria se puede agrupar en dos fases. La primera está ausente del tesoro de Azaila, por lo que podría datarse entre e…
Terkakom
2023
Localizada, con probabilidad, en Tierga (Zaragoza) (Untermann 1974: 288; ACIP p. 283; TIR K-30, s.v. Terkakom). Étnicamente podría pertenecer a los Belos (Burillo 1995: 173; Gozalbes 2009: 151), pero se ha descartado cualquier relación con Turiazu a pesar de la coincidencia de los tres delfines que puede deberse a estar siguiendo influencias semejantes (Gozalbes 2009: 151). Se han identificado, hasta el momento, dos tipos de unidades, según tengan tres o dos delfines rodeando el retrato en el anverso, que se datan ambos entre el 120 y el 80 a.C. El primer tipo (ACIP 1519 | CNH 229/1 | Vives 48/1), presenta en el anverso una cabeza masculina y tres delfines; en el…
Tamaniu
2023
Se desconoce el lugar en el que estuvo localizada esta ceca, aunque se identifica con la ciudad mencionada por Ptolomeo (geog. 2,6.62, Damania, erróneamente atribuida a la Edetania) y por Plinio (N.H. 3.24, Damanitanos, estipendiarios del convento Caesaragustanus). De entre las opciones propuestas, la de La Muela de Hinojosa de Jarque (Teruel) es la que parece que más se impone (Burillo y Herrero 1983: 41-58; CNH p. 246; Beltrán 1995: 105, n. 247; ACIP p. 303). Se conocen dos fases de producción monetaria, en las que siempre se acuñaron unidades con un peso medio que se encuentra en la franja de 8-9 g, y excepcionalmente de 10 g en el último tipo ac…
Allium sphaeronixum (Amaryllidaceae), A New Species from Turkey
2023
In this paper, Allium sphaeronixum, a new species of the sect. Codonoprasum from Turkey, is described and illustrated. The new species is endemic to Central Anatolia, limited to the area of Nevşehir, where it grows on sandy or rocky soil at an elevation of 1000–1300 m a.s.l. Its morphology, phenology, karyology, leaf anatomy, seed testa micromorphology, chorology, and conservation status are examined in detail. The taxonomic relationships with the closest allied species, A. staticiforme and A. myrianthum, are also highlighted and discussed.
Tarmeskom = Bormeskom = Borneskon
2023
La leyenda tarmeskom alude a una ciudad que no se cita en las fuentes clásicas. Su localización es incierta, aunque siempre se ha situado en el valle medio del río Ebro. Recientemente se ha propuesto ubicarla en Tiermes, sobre la base de los hallazgos monetarios y la nueva lectura tarmeskom, frente a la tradicional bormeskom (Jordán 2005 y 2008: 122; de Hoz 2017: 90). La producción monetaria de esta ceca ha sido estudiada en un artículo reciente por Illarregui (2016), en el que se discuten todos los aspectos más relevantes. La producción monetaria de Tarmeskom fue modesta y seguramente debió realizarse en dos fases; quizá…
Olkairun
2023
Ceca de ubicación desconocida, aunque por estilo y tipología podría englobarse dentro del grupo que empleó cabezas de tipo “vascón”, sin que ello implique una vinculación étnica (Villaronga 1993 y 2009; Beltrán y Velaza 2009: 108, n. 1 y 126). Ha sido estudiada por Villaronga (2009) y Martínez Chico y Amela (2018), quienes dan a conocer un hallazgo en Cigales (Valladolid), y proponen una localización en la cabecera meridional del valle alto del Ebro (Martínez Chico y Amela 2018). El área marcada en el mapa es orientativa. Solo se conoce una emisión de bronces de la segunda mitad del siglo …
Samala
2023
Samala es un topónimo celtibérico en nominativo singular (Untermann 1975: 314; Jordán 2007: 824; de Hoz 2017: 134), cuya localización se desconoce. La leyenda, el estilo y la metrología de las monedas, de ca. 9 g de promedio, la vinculan con el grupo de las cecas celtibéricas. Los hallazgos son muy raros, ya que sólo conocemos un moneda hallada en Numancia (Saavedra 1861: 112, nº 19 = Ripollès y Abascal 2000: nº 1587). La producción monetaria fue muy reducida, ya que apenas si se conocen unas pocas decenas de monedas. Sólo acuñó unidades que hemos dividido en dos variantes. Aparentemente son iguales, pero un atento examen de las piezas muestra que existen dos grupos, no muy alejados en el t…
Oncogenic BRAF and p53 Interplay in Melanoma Cells and the Effects of the HDAC Inhibitor ITF2357 (Givinostat)
2023
Oncogenic BRAF mutations have been widely described in melanomas and promote tumour progression and chemoresistance. We previously provided evidence that the HDAC inhibitor ITF2357 (Givinostat) targets oncogenic BRAF in SK-MEL-28 and A375 melanoma cells. Here, we show that oncogenic BRAF localises to the nucleus of these cells, and the compound decreases BRAF levels in both the nuclear and cytosolic compartments. Although mutations in the tumour suppressor p53 gene are not equally frequent in melanomas compared to BRAF, the functional impairment of the p53 pathway may also contribute to melanoma development and aggressiveness. To understand whether oncogenic BRAF and p53 may cooperate, a po…
An Analysis of the Immunomodulatory Properties of Human Spheroids from Adipose-Derived Stem Cells
2023
Aims Current methods to induce tolerance following allotransplantation or in autoimmunity carry significant morbidity, and research is very active in investigating alternative methods which could minimize toxicity. Spheroids from adipose stem cells (SASCs) are increasingly gaining interest, they hold a great proliferative and differentiating potential. An immunomodulatory effect has not been investigated on SASCs yet. In this study, we analysed the immunomodulatory properties of SASCs and compared them to ADSCs. Main methods Adipose stem cells (SASCs and ADSCs) and peripheral blood mononuclear cells (PBMCs) were collected from healthy individuals. We analysed the cytokine production and pro…
Normalized Solutions to the Fractional Schrödinger Equation with Potential
2023
AbstractThis paper is concerned with the existence of normalized solutions to a class of Schrödinger equations driven by a fractional operator with a parametric potential term. We obtain minimization of energy functional associated with that equations assuming basic conditions for the potential. Our work offers a partial extension of previous results to the non-local case.
The Value of Organic plus. Analysing Consumers’ Preference for Additional Ethical Attributes of Organic food Products
2023
AbstractOrganic Plus attributes strengthen the sustainability of the organic products and differentiate them from the ‘conventionalized’ organic ones. Products with Organic Plus attributes seem appreciated by organic consumers. However, research on consumers’ preference for Organic Plus is still scarce, leaving gaps in the understanding of the consumers’ characteristics of organic products with Plus attributes. In order to enrich the knowledge of consumers’ preference for organic products with Plus attributes, the present study aims to achieve three Objectives: (1) identifying which Plus attributes, among fair prices to local farmers, integration of people with disabilities and eco-friendli…
Soziale Medien als fünfte Gewalt: Strategische Organisation deutscher und finnischer Gegenredekampagnen auf Facebook
2023
Social media, as the fifth estate, increasingly influence public discourses and play a major role in shaping public opinion. Undoubtedly, they have the potential to promote participation and democracy. On the other side, they also constitute a risk for democratic societies, as the spread of hate speech and fake news has shown. As a response, forms of counterspeech organised by civil society have emerged in social media to counter the normalisation of hate speech and democracy-threatening discourses. In order to influence discourse in social media in terms of the fifth estate, counterspeech campaigns must be visible also quantitatively. In this ethnographic contrastive study, I analysed…
Sport e soggetti fragili: tra ordinamento sportivo, tutele civilistiche e libertà costituzionali
2023
The paper analyzes the evolution of sporting activity for disabled people, focusing in particular on the problems concerning the performance of risky sporting activities by people with mental disabilities; these problems per- tain to the relationship between the protection of health understood as the interest of the community and the protection of health understood as the right to the pursuit of happiness, which also involve the question of the limits to the acts of disposing of one's body, and which are resolved through a continuous dialogue between the sports system and the state system.
Overlapped Bayesian spatio-temporal models to detect crime spots and their possible risk factors based on the Opole Province, Poland, in the years 20…
2023
AbstractGeostatistical methods currently used in modern epidemiology were adopted in crime science using the example of the Opole province, Poland, in the years 2015–2019. In our research, we applied the Bayesian spatio-temporal random effects models to detect ‘cold-spots’ and ‘hot-spots’ of the recorded crime numbers (all categories), and to ascertain possible risk factors based on the available statistical population (demographic), socio-economic and infrastructure area characteristics. Overlapping two popular geostatistical models in the analysis, ‘cold-spot’ and ‘hot-spot’ administrative units were detected which displayed extreme differences in crime and growth rates over time. Additio…
Effects of a Feedback-Demanding Stroke Clock on Acute Stroke Management: A Randomized Study.
2023
Background and Purpose: This randomized study aimed to evaluate whether the use of a stroke clock demanding active feedback from the stroke physician accelerates acute stroke management. Methods: For this randomized controlled study, a large-display alarm clock was installed in the computed tomography room, where admission, diagnostic work-up, and intravenous thrombolysis occurred. Alarms were set at the following target times after admission: (1) 15 minutes (neurological examination completed); (2) 25 minutes (computed tomography scanning and international normalized ratio determination by point-of-care laboratory completed); and (3) 30 minutes (intravenous thrombolysis started). The resp…
Kalakorikos
2023
Kalakorikos Algunos autores la citan como ciudad berona (DCPH II: 221-222); en época sertoriana se la nombra como celtibérica, pero en el siglo Ia.C. Estrabón (3,4,10) la cita en territorio vascón. Poco antes del 27 a.C. obtuvo el estatuto de municipio de cives romani (Plinio, N.H.III, 24), utilizando el latín en sus series monetales (RPC I, 431-451).La producción monetaria se puede agrupar en dos fases. De la primera se conocen tres tipos (MIB 1-3), fechados los tres primeros entreca. 140 y el 120 a.C, y de la segunda sólo un tipo (MIB 4), emitido entre ca. 120 y el 100 a.C. En el anverso, en el cual no llevanleyenda, se representa una cabez…
Older Adults Learning Digital Skills Together: Peer Tutors’ Perspectives on Non-Formal Digital Support
2023
In later life, digital support is predominantly received outside of formal education from warm experts such as children, grandchildren, and friends. However, as not everyone can rely on this kind of informal help, many older adults are at risk of being unwillingly left without digital support and necessary digital skills. In this article, we examine non-formal digital support and peer tutoring as a way to promote digital and social inclusion through the acquisition of necessary digital skills. First, we ask: (a) What is peer tutoring, in the field of digital training, from the peer tutors’ point of view? Then, based on the first research question, we further ask (b) what are the key charact…
Auditing Public Debt Using Risk Management
2023
The Audit Office of the Republic of Cyprus conducted the first-ever audit of the country’s public debt, seeking answers to two key questions. Is government debt sustainable, and is debt financing efficient and effective in securing the lowest cost with acceptable risks? The audit’s findings were discussed by the parliament and can have significant ramifications for public finance. However, public debt management is quite complex, and the International Organization of Supreme Audit Institutions suggests that sufficient technical knowledge is essential in undertaking an audit, including an understanding of the uncertain macroeconomy, financing conditions, and government fiscal stance. We use…
The second life of terrestrial and plastic carbon as nutritionally valuable food for aquatic consumers
2023
Primary production is the basis for energy and biomolecule flow in food webs. Nutritional importance of terrestrial and plastic carbon via mixotrophic algae to upper trophic level is poorly studied. We explored this question by analysing the contribution of osmo- and phagomixotrophic species in boreal lakes and used 13C-labelled materials and compound-specific isotopes to determine biochemical fate of carbon backbone of leaves, lignin–hemicellulose and polystyrene at four-trophic level experiment. Microbes prepared similar amounts of amino acids from leaves and lignin, but four times more membrane lipids from lignin than leaves, and much less from polystyrene. Mixotrophic algae (Cryptomonas…