Les sépultures de Truchtersheim "Holderacker" (Bas-Rhin) et les pratiques funéraires du Bronze A1 dans le sud de la plaine du Rhin supérieur

2023

Die Freilegung 2019 eines kleinen frühbronzezeitlichen (2030-1900 v. Chr.) Bestattungsensemblesin Truchtersheim „Holderacker“, etwa 12 km nordwestlich von Straßburg, hat uns bewegt uns mit der gesamten für das Elsassverfügbaren Dokumentation der frühbronzezeitlichen Bestattungssitten zu befassen. Dieser bisher kaum dokumentiertechronologische Horizont wurde kürzlich durch eine Reihe von Funden bereichert, die vorwiegend zwischen 2017 und 2019bei präventivarchäologischen Operationen im Vorfeld der Bauarbeiten der Westumgehung von Straßburg entdeckt wurden.Das bescheidene regionale Corpus mit 20 Gräbern erlaubt nur begrenzte Beobachtungen, es weist jedoch doch mehrere für dieFrühbronzezeit ch…

Aging and chronic inflammation: highlights from a multidisciplinary workshop

2023

Abstract: Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic antigenic stress notably caused by chronic infections such as cytomegalovirus (CMV), and immune cell senescence with acquisition of an inflammatory senescence-associated secretory phenotype (SASP). For this reason, and due to the SASP originating from other tissues, aging is commonly accompanied by low-grade chronic inflammation, termed “inflammaging”. After decades of accumulating evide…

Mothers’ self-representations and representations of childhood on social media

2023

Funding Information: This work was supported by Kone Foundation, Academy of Finland (#320370), Strategic Research Council (#327237), Strategic Research Council (#327395), Intimacy in Data-driven Culture (IDA). The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Publisher Copyright: © 2023, Minna Kallioharju, Terhi-Anna Wilska and Annamari Vänskä. Purpose: The purpose of this paper is to examine mothers’ social media accounts that focus on children’s fashion. The authors probed children’s fashion photo practices as representations of the mothers’ extended self and the kind of childhood representations produce…

Ainedidaktiikan monimuotoisuus näkyy terminologian kirjossa

2023

Alternative Systems: The Interplay between Criminal Groups’ Influence and Political Trust on Civic Honesty in the Global Context

2023

Individuals’ endorsement of standards of civic honesty is necessary for democracies to flourish. A critical driver of civic honesty is the relationship of trust between individuals and institutions. Research has yet to systematically assess the contextual factors that may moderate this relationship. In the present study, we examined the societal influence of organized criminal groups. Criminal groups operate as alternative systems of authority that erode the reliability of institutions' moral standards. We employed a new indicator that quantifies their societal influence to test the hypothesis that the association between individuals’ political trust and civic honesty would weaken in countr…

Sulle riforme istituzionali: brevi note

2023

It is a contribution to the debate on institutional reforms with reflections on the method and merits of the reforms

Polysaccharide-based supramolecular bicomponent eutectogels as sustainable antioxidant materials

2023

In this work, we obtained supramolecular gels in deep eutectic solvents (DES) from polysaccharides like chitosan and chitosan : cellulose composites. We thoroughly characterized our gels by determining the minimum gelation concentration, as well as their porosity and swelling. We also investigated their mechanical properties by rheology, and morphology by scanning electron measurements. These properties were mainly influenced by the number of hydrogen bond sites on the hydrogen bond donor, (HBD), while FTIR-ATR investigation suggested that, upon gelation, cholinium cations interpose between polysaccharide chains affecting interchain hydrogen bonding. Our gels also exhibited self-healing and…

Lasten ja nuorten oikeudet oppimiseen ja hyvinvointiin vaarantuivat koronapandemian aikana

2023

• Lasten ja nuorten oppimiseen ja hyvinvointiin liittyvät oikeudet vaarantuivat korona-aikana. • Osa lapsista ja nuorista ei saanut tarvitsemaansa ja toivomaansa tukea. • Lasten ja nuorten väliset erot hyvinvoinnissa kasvoivat. • Korona-aika lisäsi lasten ja nuorten yksinäisyyden kokemuksia. • Tulevissa etäopetustilanteissa tulisi huolehtia siitä, että lasten ja nuorten hyvinvointia ja yhteenkuuluvuuden tunnetta tuetaan vahvemmin. nonPeerReviewed

Evoluzione del ruolo del Presidente del Consiglio dei Ministri e riforme istituzionali

2023

The parliamentary form of government, lacking adequate stabilizing elements, generates inefficiencies and institutional dysfunctions. The changes that it has undergone have determined new balances between powers, which favor the Executive, and, within this, the monocratic role of the President of the Council of Ministers. These changes highlight even more the need to carry out institutional reforms that rationalize the strengthening of the head of government, providing for suitable counterweights, and restructuring the relationship of trust in order to ensure its stability.

Nähdyksi, kuulluksi ja ymmärretyksi tuleminen rakentaa resilienssiä varhaisnuoruudessa

2023

• Valtaosa varhaisnuorista voi hyvin, mutta eriarvoistumiskehitys ja haavoittuvuustilanteiden kasautuminen muodostavat kasvavan yhteiskunnallisen haasteen. • Väitöstutkimukseni punaisena lankana kulkee ymmärrys haavoittuvuuden ja resilienssin rakentumisesta vuorovaikutuksessa ja ihmissuhteissa. • Vanhemman luottamus kykyynsä selviytyä vanhemmuuden haasteista ja se, ettei hän koe jäävänsä yksin, heijastuu myönteisesti varhaisnuoren valmiuksiin solmia ja ylläpitää merkityksellisiä ihmissuhteita. • Oppilaan tarpeisiin joustavasti sovitettu tunnetuki vahvistaa sinnikkyyttä ja myönteisyyttä oppimisessa. • Haavoittuvuustilanteiden ennaltaehkäisemiseksi ja lievittämiseksi tarvitaan ymmärrystä ja r…

Use-wear analysis applied in a dissected palimpsest at the Middle Palaeolithic site of El Salt (eastern Iberia): working with lithic tools in a narro…

2023

Los análisis de uso-desgaste son muy útiles para aumentar el conocimiento sobre las dinámicas económicas y de subsistencia llevadas a cabo por los neandertales. En términos generales, los resultados funcionales provienen tradicionalmente del análisis de herramientas pertenecientes a unidades estratigráficas cuya escala temporal se refiere al tiempo geológico. Esto se debe a que muchos yacimientos neandertales son palimpsestos de ocupaciones reiteradas a lo largo del tiempo, que deben ser diseccionadas para acercarnos a la escala temporal humana. En la unidad estratigráfica Xa de El Salt (Alcoi, este de Iberia) se han llevado a cabo estudios arqueoestratigráficos de alta resolución temporal.…

Metabolic memory in diabetic foot syndrome (dfs): epigenetic changes of the expression of micro-rnas and single nucleotide polymorphisms (snps) frequ…

2023

Background: Diabetic foot is a significant cause of morbidity in diabetic patients, with a rate that is approximatelytwice that of patients without foot ulcers. “Metabolic memory” represents the epigenetic changes induced by chronic hyperglycaemia, despite the correction of the glucose levels themselves. These epigenetic modifications appear to perpetuate the damage caused by persistently elevated glucose levels even in their absence, acting at various levels, mostly affecting the molecular processes of diabetic ulcer healing. Methods: The aim of our cross-sectional study was to analyse a cohort of patients with diabetes with and without lower limb ulcers. We examined the effects of epigene…

A numerical recipe for the computation of stationary stochastic processes' autocorrelation function

2023

Many natural phenomena exhibit a stochastic nature that one attempts at modeling by using stochastic processes of different types. In this context, often one is interested in investigating the memory properties of the natural phenomenon at hand. This is usually accomplished by computing the autocorrelation function of the numerical series describing the considered phenomenon. Often, especially when considering real world data, the autocorrelation function must be computed starting from a single numerical series: i.e. with a time-average approach. Hereafter, we will propose a novel way of evaluating the time-average autocorrelation function, based on the preliminary evaluation of the quantit…

Franchisor practices for optimal omnichannel deployment in franchising networks

2023

International audience; This research contributes to theory by extending the knowledge on power in franchise relationships to the case of omnichannel marketing. As the relative autonomy of franchisees can be an obstacle to optimal omnichannel integration, the research uncovers three broad forms of franchisor practices to align franchisees to the omnichannel strategy, rooted in an enforcing, a collaborative, and an empowering stance.

The Cyclicality of Bank Credit Losses and Capital Ratios under Expected Loss Model

2023

We model the evolution of stylised bank loan portfolios to assess the impact of IFRS 9 and US GAAP expected loss model (ECL) on the cyclicality of loan loss provisions (LLPs), realised losses and capital ratios of banks, relative to the incurred loss model of IAS 39. We focus on the interaction between the changes in LLPs charges (the flow channel) and stocks (the stock channel) under ECL. Our results show that, when GDP growth doesn’t demonstrate high volatility, ECL model smooths the impact of credit losses on profits and capital resources, reducing the pro-cyclicality of capital and leverage ratios, especially under US GAAP. However, when GDP growth is highly volatile, the large differen…

Azulene as a biphenyl mimetic in orexin/hypocretin receptor agonists

2023

Azulene is a rare ring structure in drugs, and we investigated whether it could be used as a biphenyl mimetic in known orexin receptor agonist Nag 26, which is binding to both orexin receptors OX1 and OX2 with preference towards OX2. The most potent azulene-based compound was identified as an OX1 orexin receptor agonist (pEC50 = 5.79 +/- 0.07, maximum response = 81 +/- 8% (s.e.m. of five independent experiments) of the maximum response to orexin-A in Ca2+ elevation assay). However, the azulene ring and the biphenyl scaffold are not identical in their spatial shape and electron distribution, and their derivatives may adopt different binding modes in the binding site. Peer reviewed

New Insight on Medieval Painting in Sicily: The Virgin Hodegetria Panel in Monreale Cathedral (Palermo, Italy)

2023

: The Virgin Hodegetria, located in the Cathedral of Santa Maria Nuova in Monreale, near Palermo (Italy), probably dating the first half of the 13th century, is one of the earliest examples of medieval panel painting in Sicily. A diagnostic campaign was carried out on the panel aiming to identify the constituting materials and the executive technique, as well as to assess the state of conservation for supporting the methodological choice of the restoration intervention. Both non invasive (X-ray radiography, digital microscope, multispectral imaging, ED-X-ray fluorescence) and micro-invasive (polarised light microscopy, ESEM-EDX, ATR-FTIR spectroscopy and micro-Raman spectroscopy) analyses w…

Hybrid Identities of Development Studies in Tanzania

2023

This article addresses identities, hierarchies of knowledge and power relations in academia in postcolonial settings, in the context of development studies in Tanzania. Based on literatures on organizational identity and postcolonial hybridity, it establishes a conceptual lens of hybrid identity, scrutinizing how the identity of the discipline of development studies is constructed. Based on analysis of interviews with staff in development studies, we identify four relationships where differences and asymmetries were articulated: with other disciplines, with past development studies, with global theorizing on development, and with partners in the global North. We conclude in discussing how a…

Cardinal inequalities involving the Hausdorff pseudocharacter

2023

We establish several bounds on the cardinality of a topological space involving the Hausdorff pseudocharacter $H\psi(X)$. This invariant has the property $\psi_c(X)\leq H\psi(X)\leq\chi(X)$ for a Hausdorff space $X$. We show the cardinality of a Hausdorff space $X$ is bounded by $2^{pwL_c(X)H\psi(X)}$, where $pwL_c(X)\leq L(X)$ and $pwL_c(X)\leq c(X)$. This generalizes results of Bella and Spadaro, as well as Hodel. We show additionally that if $X$ is a Hausdorff linearly Lindel\"of space such that $H\psi(X)=\omega$, then $|X|\le 2^\omega$, under the assumption that either $2^{<\mathfrak{c}}=\mathfrak{c}$ or $\mathfrak{c}<\aleph_\omega$. The following game-theoretic result is shown: i…

Zoological Checklists: From Natural History Museums to Ecosystems

2023

Backwards and forwards at once, the zoological checklists bring the past into the present and draw a direction towards the future. They cover historical and current information providing open data for environmental issues. The present-day research framework aims to produce papers reporting lists of animal species, after a couple of decades of absolute refusal of such inventories, years where the prevalence of studies has been focused on ecological or molecular statistics. Now, the contemporary era is moving towards the gathering of organized data, shared on web platforms, and cross-linked in a sort of global metadata outcome. It means that a single record of the occurrence of a species can …

Smart Data Blending Framework to Enhance Precipitation Estimation through Interconnected Atmospheric, Satellite, and Surface Variables

2023

Accurate precipitation estimation remains a challenge, though it is fundamental for most hydrological analyses. In this regard, this study aims to achieve two objectives. Firstly, we evaluate the performance of two precipitation products from the Integrated Multi-satellitE Retrievals for Global Precipitation Measurement (GPM-IMERG) for Sicily, Italy, from 2016 to 2020 by a set of categorical indicators and statistical indices. Analyses indicate the favorable performance of daily estimates, while half-hourly estimates exhibited poorer performance, revealing larger discrepancies between satellite and ground-based measurements at sub-hourly timescales. Secondly, we propose four multi-source me…

LAVORATORI MIGRANTI POETI DELLA CINA CONTEMPORANEA POESIE

2023

In questo volume sono presentati 24 poeti lavoratori cinesi contemporanei e le loro opere in traduzione dal cinese all'italiano con una selezione dei temi trattati. This volume presents 24 contemporary Chinese workers who are also poets and their works in translation from Chinese into Italian with a selection of the topics covered.

The Role of Micronutrients in Human Papillomavirus Infection, Cervical Dysplasia, and Neoplasm

2023

There is evidence that diet and nutrition are modifiable risk factors for several cancers. In recent years, attention paid to micronutrients in gynecology has increased, especially regarding Human papillomavirus (HPV) infection. We performed a review of the literature up until December 2022, aiming to clarify the effects of micronutrients, minerals, and vitamins on the history of HPV infection and the development of cervical cancer. We included studies having as their primary objective the evaluation of dietary supplements, in particular calcium; zinc; iron; selenium; carotenoids; and vitamins A, B12, C, D, E, and K. Different oligo-elements and micronutrients demonstrated a potential prote…

New opportunities for kaonic atoms measurements from CdZnTe detectors

2023

We present the tests performed by the SIDDHARTA-2 collaboration at the DA{\Phi}NE collider with a quasi-hemispherical CdZnTe detector. The very good room-temperature energy resolution and efficiency in a wide energy range show that this detector technology is ideal for studying radiative transitions in intermediate and heavy-mass kaonic atoms. The CdZnTe detector was installed for the first time in an accelerator environment to perform tests on the background rejection capabilities, which were achieved by exploiting the SIDDHARTA-2 Luminosity Monitor. A spectrum with an $^{241}Am$ source has been acquired, with beams circulating in the main rings, and peak resolutions of 6% at 60 keV and of…

Upgrading Treatment and Molecular Diagnosis in Endometrial Cancer-Driving New Tools for Endometrial Preservation?

2023

One emerging problem for onco-gynecologists is the incidence of premenopausal patients under 40 years of age diagnosed with stage I Endometrial Cancer (EC) who want to preserve their fertility. Our review aims to define a primary risk assessment that can help fertility experts and onco-gynecologists tailor personalized treatment and fertility-preserving strategies for fertile patients wishing to have children. We confirm that risk factors such as myometrial invasion and The International Federation of Gynecology and Obstetrics (FIGO) staging should be integrated into the novel molecular classification provided by The Cancer Genome Atlas (TCGA). We also corroborate the influence of classical…

Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas

2023

Unsatisfactory outcomes for relapsed/refractory lymphoma patients prompt continuing efforts to develop new therapeutic strategies. Our previous studies on pyrrole-based anti-lymphoma agents led us to synthesize a new series of twenty-six pyrrolo[3′,4':3,4]cyclohepta[1,2-d] [1,2]oxazole derivatives and study their antiproliferative effects against a panel of four non-Hodgkin lymphoma cell lines. Several candidates showed significant anti-proliferative effects, with IC50's reaching the sub-micromolar range in at least one cell line, with compound 3z demonstrating sub-micromolar growth inhibitory effects towards the entire panel. The VL51 cell line was the most sensitive, with an IC50 value of…

Signs of local adaptation by genetic selection and isolation promoted by extreme temperature and salinity in the Mediterranean seagrass Posidonia oce…

2023

Adaptation to local conditions is known to occur in seagrasses; however, knowledge of the genetic basis underlying this phenomenon remains scarce. Here, we analysed Posidonia oceanica from six sites within and around the Stagnone di Marsala, a semi-enclosed coastal lagoon where salinity and temperature exceed the generally described tolerance thresholds of the species. Sea surface temperatures (SSTs) were measured and plant samples were collected for the assessment of morphology, flowering rate and for screening genome-wide polymorphisms using double digest restriction-site-associated DNA sequencing. Results demonstrated more extreme SSTs and salinity levels inside the lagoon than the outer…

Le territoire de la Belgique actuelle, lieu d’échanges artistiques (XVe – XVIIIe siècles)

2023

National audience; À partir de leurs champs de recherche respectifs, trois historiens de l’art interrogeront le rôle joué par les anciens Pays-Bas et la principauté de Liège sur la scène artistique européenne durant les Temps modernes. Le thème des voyages et des échanges, de leurs circonstances, leurs motivations et leurs modalités sera au centre des débats, de même que la question des transferts culturels et des mutations qui en résultèrent. Ces réflexions conduiront à reconsidérer la place occupée par les pays correspondant à la Belgique actuelle dans notre perception de l’histoire de l’art aujourd’hui.

Breeding of Orchids Using Conventional and Biotechnological Methods: Advances and Future Prospects

2023

The domestication of plants, including ornamental plants, is an ancient tradition based on human curiosity and is the first form of plant breeding based on modern agriculture. However, recent advances in biotechnology, molecular biology, and genetic engineering, associated with better knowledge of the genome, have enabled numerous achievements to advance agriculture towards a new green revolution. In orchids, it has not been different, and recent advances in genome sequencing and the development of more sophisticated breeding techniques based on biotechnology have demonstrated their applicability for the constitution of more sophisticated cultivars. However, conventional breeding by directe…

Anemia as a risk factor for disease progression in patients admitted for COVID-19: data from a large, multicenter cohort study

2023

: In respiratory infections, anemia is both a consequence of acute inflammation and a predictor of poor clinical outcomes. There are few studies investigating the role of anemia in COVID-19, suggesting a potential role in predicting disease severity. In this study, we aimed to assess the association between the presence of anemia at admission and incidence of severe disease and death in patients hospitalized for COVID-19. Data from all adult patients admitted for COVID-19 in University Hospital "P. Giaccone" Palermo, and University Hospital of Bari, Italy, were retrospectively collected from 1st of September 2020 to 31 August 2022. The association between anemia (defined as Hb < 13 g/dl …

Enseñanza mutua en línea: una investigación piloto realizada con los estudiantes universitarios

2023

In academic year 2020-2021, a pilot research was carried out on distance peer teaching, which was hypothesized as effective tool to reduce some of the negative effects that distance teaching, imposed by the Coronavirus pandemic, caused among students enrolled in the first year of the three-year degree course in Educational Sciences at the University of Palermo during the academic year 2019-2020. Nineteen students attending the second year of this course, after having participated in a specific training activity (15 h), from March to June 2021 helped 35 fellow students to advance their careers by catching up as many first-year exams as possible through distance support. In July 2021, the gro…

Characterization of trace elements in thermal and mineral waters of Greece

2023

: Natural thermal and mineral waters are widely distributed along the Hellenic region and are related to the geodynamic regime of the country. The diverse lithological and tectonic settings they are found in reflect the great variability in their chemical and isotopic composition. The current study presents 276 (published and unpublished) trace element water data and discusses the sources and processes affecting the water by taking into consideration the framework of their geographic distribution. The dataset is divided in groups using temperature- and pH-related criteria. Results yield a wide range of concentrations, often related to the solubility properties of the individual elements and…

Second order nonlinear optics in AlGaAs metasurfaces

2023

Recently, nonlinear optics at the nanoscale level has emerged as a promising branch of nanophotonics. In this work, we focus our attention on Aluminum Gallium Arsenide (AlGaAs) nanoantennas and metasurfaces for efficient and controlled second harmonic photon emission. After a brief introduction concerning the main studies in this field, we present the latest results achieved in AlGaAs platforms both in the lossless and absorption regimes.

"Lights and Shades" of Fertility Preservation in Transgender Men Patients: A Clinical and Pathological Review

2023

Fertility preservation (FP) is becoming a critical issue in transgender men who desire biological offspring in the future. The prevalence of transgender individuals in the United States is increasing, and as a result, the demand for gender-affirming surgeries (GAS) and associated FP techniques is rising. Despite the growing demand, there is currently no personalized approach to FP for transgender men, and the available techniques have limitations that require further investigation. In the present review we carefully examine the existing literature on this topic to highlight the shortcomings of current methods and areas where additional research is needed to advance the field. Hormonal thera…

Iron-mediated oxidative stress induces PD-L1 expression via activation of c-Myc in lung adenocarcinoma

2023

Introduction: The PD-1/PD-L1 axis is hijacked by lung adenocarcinoma (LUAD) cells to escape immune surveillance. PD-L1 expression in LUAD is affected, among others, by the metabolic trafficking between tumor cells and the tumor microenvironment (TME). Methods: Correlation between PD-L1 expression and iron content within the TME was established on FFPE LUAD tissue samples. The effects of an iron rich microenvironment on PD-L1 mRNA and protein levels were assessed in vitro in H460 and A549 LUAD by using qPCR, western blot and flow citometry. c-Myc knockdown was performed to validate the role of this transcription factor on PD-L1 expression. The effects of iron-induced PD-L1 on T cell immune f…

Offline commissioning of a new gas cell for the MARA Low-Energy Branch

2023

Results of offline commissioning tests for a new dedicated gas cell for the Mass Analysing Recoil Apparatus (MARA) Low-Energy Branch are reported. Evacuation time, ion survival and transport efficiency in helium buffer gas were characterized with a radioactive 223Ra 𝛼-recoil source. Suppression of the ion signal, originating from non-neutralized species in the gas cell, was explored with 219Rn ions, the daughter recoil of 223Ra, as a function of voltage applied to one of the ion-collector electrodes. Two-step laser resonance ionization of stable tin isotopes produced inside the gas cell from a heated bronze filament was demonstrated, and broadening of the atomic resonances in argon buffer …