showing 36 of ~574560 from 574555 documents
Riflessioni e traiettorie di ricerca interdisciplinari sulla transizione ecologica
2023
Il volume 13 di AGATHÓN segue il precedente sulla Innovability©® | Transizione Digitale e raccoglie saggi e ricerche su Innovability©® | Transizione Ecologica, consapevole della sua incalzante attualità, ma anche del portato che la proposta di una doppia chiave di interpretazione suggerisce. I contributi del volume ci consegnano riflessioni e traiettorie di ricerca basate sulla necessità di una natura multiscalare degli interventi, che garantisca effetti indotti a un contesto ambientale più ampio di quello di riferimento, e di team che affrontino le criticità con un approccio collaborativo inter e transdisciplinare olistico e sistemico, in una sorta di speciazione delle discipline che ne mo…
Sicurezza e populismo. I migranti alla frontiera del diritto penale
2023
Il presente lavoro di ricerca ha ad oggetto la criminalizzazione delle migrazioni nell'èra del cosiddetto populismo, e in particolare del populismo penale. Invero, negli ultimi anni si è assistito ad una espansione incontrollata del potere punitivo che, sotto la pressione di un bisogno collettivo di sicurezza, ha condotto ad una vera e propria disumanizzazione del diritto penale (e punitivo-amministrativo), nel duplice significato che quest’ultima espressione rivestiva secondo la giurispoeta Mireille Delmas-Marty: "quello di un diritto penale che si sta deumanizzando, e quindi deumanizzato, in quanto sempre più distante dai principi dell'umanesimo giuridico; e quello di un diritto penale de…
Indeksi liikuntaympäristöjen monipuolisuudesta asukkaiden lähialueella
2023
Liikunta on välttämätöntä terveyden ylläpitämiselle, ja sillä on lukemattomia positiivisia vaikutuksia sekä fyysiseen että psyykkiseen hyvinvointiin. Liikuntaympäristöjen monipuolisuus lähellä kotia voi edistää liikunnan harrastamista ja fyysisesti aktiivista elämäntapaa. Liikunnallisen elämäntavan mahdollistaminen kaikille, etenkin huono-osaisilla alueilla, voi tasoittaa alueiden välisiä hyvinvointieroja ja näin vähentää segregaation vaikutuksia. Suomessa yhdenvertaisten liikuntapalvelujen järjestäminen asukkaille on pääosin kuntien vastuulla. Tässä artikkelissa esittelemme uuden indeksin, jolla voidaan kuvata ja analysoida asukkaiden lähialueella olevien erityyppisten liikuntaympäristöjen…
A comprensive spectral-timing study of Ultraluminous X-ray sources
2023
Connexive Logic, Probabilistic Default Reasoning, and Compound Conditionals
2023
We present two approaches to investigate the validity of connexive principles and related formulas and properties within coherence-based probability logic. Connexive logic emerged from the intuition that conditionals of the form if not-A, then A, should not hold, since the conditional’s antecedent not-A contradicts its consequent A. Our approaches cover this intuition by observing that the only coherent probability assessment on the conditional event A | not-A is p(A | not-A) = 0. In the first approach we investigate connexive principles within coherence-based probabilistic default reasoning, by interpreting defaults and negated defaults in terms of suitable probabilistic constraints on con…
Ympäristönsuojelulaki vuotaa: turvekiista tunnustuskamppailuna
2023
Tutkimme Keski-Suomessa pitkään jatkunutta turvekiistaa selvittämällä kyselyllä ja haastatteluilla kansalaisten käsityksiä turvetuotannosta ja sen vesistövaikutuksista. Tutkimuksemme osoittaa, että poliittis-hallinnollinen järjestelmä ei ole kyennyt täyttämään ympäristönsuojelulain tavoitetta turvata kansalaisille terveellinen ja viihtyisä ympäristö ja parantaa kansalaisten mahdollisuuksia vaikuttaa ympäristöä koskevaan päätöksentekoon. Lailla ei ole edellytyksiä säännellä kaikkia niitä luontoa hyödyntäviä toimintoja, joiden kansalaiset kokevat saastuttavan vesiympäristöään. Tämä puute näkyy esimerkiksi turpeennoston kaltaisissa toiminnoissa, jotka aiheuttavat vesistöjen hajakuormitusta eri…
A survey on algebraic dilatations
2023
In this text, we wish to provide the reader with a short guide to recent works on the theory of dilatations in Commutative Algebra and Algebraic Geometry. These works fall naturally into two categories: one emphasises foundational and theoretical aspects and the other applications to existing theories.
Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differ…
2023
: Among all cancers, colorectal cancer (CRC) is the 3rd most common and the 2nd leading cause of death worldwide. New therapeutic strategies are required to target cancer stem cells (CSCs), a subset of tumor cells highly resistant to present-day therapy and responsible for tumor relapse. CSCs display dynamic genetic and epigenetic alterations that allow quick adaptations to perturbations. Lysine-specific histone demethylase 1A (KDM1A also known as LSD1), a FAD-dependent H3K4me1/2 and H3K9me1/2 demethylase, was found to be upregulated in several tumors and associated with a poor prognosis due to its ability to maintain CSCs staminal features. Here, we explored the potential role of KDM1A tar…
The analysis of SUDEP forensic autopsies leading to preventable events
2023
Introduction: The diagnosis of unexpected death by excluding non-natural causes, particularly in subjects with epilepsy, is a topic of interest and it is difficult to identify in the forensic field. Health professionals sometimes are faced with cases of sudden death, generally in young adults with a long history of epilepsy that require, for judicial purposes, an explanation in terms of cause and means to determine the death. SUDEP is an entity diagnosed by the exclusion of other causes that may have led to death, and then for forensic purposes, it requires particular attention and knowledge, and there is difficulty in identifying it. Our contribution aims to illustrate the scientific commu…
Ricerca-formazione nel Service e-Learning: significare l’esperienza attraverso la scrittura riflessiva e immaginativa in rete
2023
This paper analyses a Service e-Learning course carried out at the University of Palermo, in the academic year 2022/23, with 260 students enrolled in the first year of the Bachelor of Science in Primary Education (LM-85bis), in order to describe and understand how this pedagogical research-training approach can determine professional development by supporting critical reflection and self-assessment processes. Specifically, the investigation aims to explore on the one hand, the perspective of reflective and imaginative writing as a useful critical-reflexive device aimed at supporting emancipative learning processes, and, on the other, the idea that the learner is perpetually under constructi…
Caries Severity, Decayed First Permanent Molars and Associated Factors in 6-7 Years Old Schoolchildren Living in Palermo (Southern Italy).
2023
To date, there are very few epidemiologic studies on caries disease in 6–7 year old children living in Sicily (Southern Italy). The first permanent molar (FPM) is the most commonly affected tooth in this target population, and a one-unit increase in the number of decayed FPMs is predictive of caries in other teeth and in adulthood. The primary aim of this research is to estimate the prevalence of caries in 6–7 year old schoolchildren living in Palermo and, as a secondary aim, to estimate the prevalence of affected FPMs. It was designed as a cluster cross-sectional survey on 995 children from 16 schools, selected based on their geographical location, in one of the eight city districts. Carie…
Calculus of Variation and Path-Integrals with Non-Linear Generalized Functions
2023
The calculus of variation and the construction of path integrals is revisited within the framework of non-linear generalized functions. This allows us to make a rigorous analysis of the variation of an action that takes into account the boundary effects, even when the approach with distributions has pathological defects. A specific analysis is provided for optimal control actions, and we show how such kinds of actions can be used to model physical systems. Several examples are studied: the harmonic oscillator, the scalar field, and the gravitational field. For the first two cases, we demonstrate how the boundary cost function can be used to assimilate the optimal control adjoint state to th…
Metric Learning in Histopathological Image Classification: Opening the Black Box
2023
The application of machine learning techniques to histopathology images enables advances in the field, providing valuable tools that can speed up and facilitate the diagnosis process. The classification of these images is a relevant aid for physicians who have to process a large number of images in long and repetitive tasks. This work proposes the adoption of metric learning that, beyond the task of classifying images, can provide additional information able to support the decision of the classification system. In particular, triplet networks have been employed to create a representation in the embedding space that gathers together images of the same class while tending to separate images w…
pH-Responsive Cyclodextrin-Surfactant Inclusion Complexes: Thermodynamics and Structural Aspects
2023
This thesis presents the investigation of the multilevel assembly of the alkyl oligoethylenoxide carboxylic acids and cyclodextrins. The aim of the work is to combine the short-range host-guest and long-range electrostatic interactions to form highly-ordered supramolecular complexes. The interactions between the components affect their individual response and their properties; therefore, the knowledge of the nature and the influence of their chemical structure is essential to understand the system’s behaviour. Polyoxyethylene alkyl carboxylic acids are an attractive class of surfactants to integrate both inclusion complexes and polyelectrolyte systems due to their pH and thermoresponsivenes…
Persona e fondamenti dello Stato in Giorgio La Pira
2023
The contribution reconstructs the philosophical contribution offered by Giorgio La Pira to the realization of the Republican constitution
Dépenses d’enseignement dans les collèges privés et publics et indice de positionnement social : une analyse spatiale et longitudinale
2023
Introduction En France, depuis 1963, date d’instauration de la carte scolaire, l’affectation des élèves dans un collège est fonction de son lieu de résidence. Ainsi, chaque élève est affecté à un collège public à proximité de son domicile. Par essence, cette méthode d’affectation reproduit au sein des collèges la ségrégation résidentielle. La possibilité d’obtenir des dérogations à cette affectation administrative, l’assouplissement de la carte scolaire de 2007, et la liberté de scolariser so...
Gender-neutral Language in EU Secondary Legislation: The Case of the English Language
2023
English does not have a grammatical gender, thus having an “intrinsic predisposition towards gender-neutral forms” (Poddighe 2020, 3). Most personal nouns do not indicate a specific gender, as in the case of person or engineer. However, there are also personal nouns with lexical gender, such as king or queen (Hellinger 2001). As a result, in English there is a risk of creating sentences that are not gender-neutral. Within the EU, the promotion of the use of a more inclusive language represents an important objective. For this reason, in recent years, various documents containing guidelines on gender-neutral language have been elaborated to encourage members of the EU institutions to adopt a…
Ordine pubblico, gestazione per altri e diritti dei minori: riflessioni a partire dalla sentenza SS.UU. 30 dicembre 2022, n. 38162
2023
Il contributo esamina la questione della trascrivibilità del certificato di nascita formato all'estero di un bambino nato tramite gestazione per altri da una coppia di uomini e si confronta criticamente con la soluzione della sua contrarietà all'ordine pubblico internazionale formulata dalle sezioni unite civili della Suprema Corte di Cassazione. Anche alla luce della giurisprudenza della Corte europea dei diritti dell'uomo, vengono evidenziati gli elementi che, nell'adozione in casi particolari ex art. 44, lett. d), l. n. 184/1983, si frappongono ad una piena realizzazione del superiore interesse del minore riguardo alla formalizzazione del legame con il genitore intenzionale. Viene quindi…
Editorial: CAR T-cells: novel therapeutic approaches in the new era of cancer immunotherapy
2023
Immunotherapy has emerged as one of the most effective treatments capable of overcoming tumor resistance mechanisms due to its ability to modulate the patient’s immune response against cancer. Personalized anti-tumor therapy based on T cells engineered to express a cancer-specific chimeric antigen receptor (CAR) acts directly on the immune system of patients. Specifically, this therapy enhances the recognition of cancer cells by T lymphocytes, thus promoting their elimination. In this Research Topic several aspects of CAR T-cell therapy, with particular emphasis on novel findings aimed at ameliorating the effectiveness of CAR T-cell-based immunotherapy and reducing side effects, are describ…
Global Real-World Outcomes of Patients Receiving Immuno-Oncology Combinations for Advanced Renal Cell Carcinoma: The ARON-1 Study
2023
Background: Immuno-oncology combinations have achieved survival benefits in patients with metastatic renal cell carcinoma (mRCC). Objective: The ARON-1 study (NCT05287464) was designed to globally collect real-world data on the use of immuno-combinations as first-line therapy for mRCC patients. Patients and methods: Patients aged ≥ 18 years with a cytologically and/or histologically confirmed diagnosis of mRCC treated with first-line immuno-combination therapies were retrospectively included from 47 International Institutions from 16 countries. Patients were assessed for overall survival (OS), progression-free survival (PFS), and overall clinical benefit (OCB). Results: A total of 729 patie…
A framework for Population Protocols in VANETs
2023
Migrants and Practitioners united in a Flipped Classroom. An Interethnic Communication Path for Individual and Community Well-Being
2023
Background. A pilot-training experience focused on the integration of migrants from African coasts in Sicily (South Italy). Specifically, the challenge was to increase awareness of the need to obtain a variety of flexible skills among people who work in the context of the delicate and complex area of migration and multi-cultural community needs. Methods. The methodological choice of the Flipped classroom allows an enhancement of practitioner awareness (pedagogists and psychologists) about migration, enrolled on the course above mentioned which took place in Palermo (Sicily) in 2021. Results. The authors focused on migrants, who, together with teachers, ran all the sessions of the project an…
THE HDAC INHIBITOR ITF2357 (GIVINOSTAT) AS A KEY PLAYER IN EPIGENETIC TARGETING OF MELANOMA AND COLON CANCER CELLS
2023
Histone deacetylase inhibitors (HDACIs) are epigenetic compounds that have been recently considered for their promising anti-tumor activity. The aim of this PhD thesis was to elucidate and characterize the anti-tumor effect of the HDAC inhibitor ITF2357 (Givinostat) in melanoma and colon cancer cells that are characterized by oncogenic BRAF mutations. Interestingly, data reported in this thesis demonstrate that ITF2357 exerts a remarkable anti-tumor effect in melanoma cells by inducing a switch from a pro-survival autophagy to caspase-dependent apoptosis. The thesis provides the first evidences that ITF2357 is able to target oncogenic BRAF and oncogenic p53. The ITF2357 decreasing effect on…
Deep learning techniques for visual object tracking
2023
Visual object tracking plays a crucial role in various vision systems, including biometric analysis, medical imaging, smart traffic systems, and video surveillance. Despite notable advancements in visual object tracking over the past few decades, many tracking algorithms still face challenges due to factors like illumination changes, deformation, and scale variations. This thesis is divided into three parts. The first part introduces the visual object tracking problem and discusses the traditional approaches that have been used to study it. We then propose a novel method called Tracking by Iterative Multi-Refinements, which addresses the issue of locating the target by redefining the search…
The evolution and ecology of multiple antipredator defences
2023
Prey seldom rely on a single type of antipredator defence, often using multiple defences to avoid predation. In many cases, selection in different contexts may favour the evolution of multiple defences in a prey. However, a prey may use multiple defences to protect itself during a single predator encounter. Such “defence portfolios” that defend prey against a single instance of predation are distributed across and within successive stages of the predation sequence (encounter, detection, identification, approach (attack), subjugation and consumption). We contend that at present, our understanding of defence portfolio evolution is incomplete, and seen from the fragmentary perspective of speci…
Development of a Tumor-Derived Extracellular Vesicle Engineering Protocol for Targeted Chemotherapeutic: A Novel Experimental Model using Malignant P…
2023
Colorectal cancer-derived small extracellular vesicles induce TGFβ1-mediated epithelial to mesenchymal transition of normal hepatocytes: new insights…
2023
More than 50% of patients affected by colorectal cancer (CRC) present liver metastasis, which is the most frequent cause of CRC-associated death. Numerous studies have shown that metastatic cascade is the result of complex mechanisms based on two-way interactions between invasive CRC cells and liver resident cells. In recent years, several findings have demonstrated that small extracellular vesicles (SEVs) released by cancer cells play a crucial role in the formation of pre-metastatic niche in the liver, specifically affecting the activities of non-parenchymal cells as Kupffer cells and hepatic stellate cells. However, although hepatocytes (heps) are the most conspicuous in the liver, their…
RHEUMATOID ARTHRITIS INDUCED BY INTRA-ARTICULAR INJECTION OF COMPLETE FREUND’S ADJUVANT ALTERS THE EXPRESSION OF VARIOUS HSPS IN THE DIFFERENT REGION…
2023
Photoreforming of organics in aqueous suspension of Nb2O5/C3N4 composites to obtain H2
2023
Photocatalysis based on the use of semiconductors has gained, during the recent years, increased attention as promising sustainable process for H2 and fine chemicals production, given the possibility of activating such photocatalysts by visible light radiation. The photo-reforming activity in this work has been measured under both UV-LED irradiation and natural sunlight illumination. Moreover, the presence of metallic Pt as co-catalysts has been studied. Carbon nitride (C3N4) based materials are good candidates for solar energy conversions. The choice of C3N4 and Nb2O5 arises from the fact that their heterojunction can lead to lower recombination between the photo-generated electrons and ho…
Catalytic valorisation of Chlorella sp. algae to obtain 5-Hydroxymethylfurfural in the presence of Nb2O5 or NbOPO4
2023
Microalgae are interesting biomass able to growth in not-arable lands, in wastewaters or seawaters. There are plenty of species of microalgae and several of them find application in various industrial sectors because they are source of several products in an integrated biorefinery view. In this work two acidic heterogeneous catalysts, namely Nb2O5 and NbOPO4 have been used. Both are commercial products provided by CBMM and they have been physico-chemically characterised. The isomerisation/dehydration reactions proceed through a tandem pathway involving the Lewis and Brønsted acid sites provided by the surface of the acidic solids giving rise to the isomerization of glucose to fructose, foll…
Energy Communities in urban areas: Comparison of energy strategy and economic feasibility in Italy and Spain
2023
Energy communities using renewable energy sources directly contributes to reduction of climate-change gas emissions and energy consumption in the European Union. In addition, energy communities enable citizens to transform from (passive) consumers to prosumers (active consumers and producers) and to play a proactive role in the deployment of energy transition in urban areas. As the transposition of European rules about energy communities into the national laws of EU Member States is very articulated and differentiated, this study proposes a framework to analyze and compare regulatory and financial instruments. This framework is applied to the analysis of the case of Italy and Spain, as repr…
Mediterranean Diet, Sustainability, and Tourism—A Study of the Market’s Demand and Knowledge
2023
Globalization intensified competitiveness among agribusinesses worldwide in recent years. The European Commission focused on enhancing sustainable agriculture and food products’ territorial uniqueness for competing in the international market. The Mediterranean diet (MD) is a model of feeding and lifestyle belonging to the ancient Mediterranean culture, which also embodies a sustainable food system. Therefore, in 2010, UNESCO recognized the MD as Intangible Cultural Heritage of Humanity, and Sicily (southern Italy) is its official physical site. Despite its worldwide fame, the notion of the MD runs the risk of being mystified because it is described most often as something that does not cor…
Pääkirjoitus: Tutkimustiedon julkaiseminen suomen kielellä on tärkeää
2023
Suomen kielen käyttö tieteellisessä julkaisemisessa on ajankohtainen aihe. Julkaisukulttuurissa on kuluneen kymmenen vuoden aikana tapahtunut selvä muutos. Julkaisutahti on nopeutunut ja julkaiseminen pirstaloitunut. Tutkijoille julkaisukanavaan ja raportointikieleen liittyvien vaihtoehtojen pohtimisesta on tullut tärkeä osa arkea, ja samalla julkaiseminen on voimakkaasti, melko nopeasti ja vähin äänin englanninkielistynyt. Muutosten taustalla eivät kuitenkaan ole yksittäisten tutkijoiden itsenäiset valinnat vaan laajempi tiede- ja korkeakoulupolitiikkaan sekä kansainvälisiin virtauksiin kytkeytyvä ilmiö, jonka kaikkia vaikuttimia ja varsinkaan kaikkia seurauksia ei vielä tunneta. nonPeerRe…
Healthcare Professional Communication on Sexual Health: A Report from the Italian Working Group on Adolescents and Young Adults with Cancer
2023
Background: Sexual function is an important concern for adolescent and young adult (AYA) with cancer. The aim of this study was to explore the attitude of Italian health care professionals who deal with AYA patients with cancer toward sexual health communication. Materials and methods: A 11-question survey was developed by the AIOM (Associazione Italiana di Oncologia Medica) and AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) AYA workgroup and sent to AIOM and AIEOP members. Results: The sample comprised 360 respondents, 54.2% AIEOP and 45.8% AIOM members. Eighty percent were physicians, 14.5% nurses, 4.7% psychologists, and 0.8% other professionals. Medical oncologists are mo…
Il progetto di Archeologia Virtuale ad Alesa Arconidea
2023
The Virtual Archaeology project at Alesa Arconidea · Virtual Archeology is the field of application that finalizes the use of information technologies for the knowledge, enhancement and communication of the archaeological heritage. It deals with the reconstruction of artifacts, buildings, landscapes of the past through three-dimensional models, hypertexts and multimedia solutions. The goal of Virtual Archeology is to promote the development of formalized investigation procedures and methodologies to acquire, represent, process and communicate data while producing new information and research tools that go beyond traditional forms and bring a contribution to the progress of the studies and p…
Racialized immigrants becoming part of the city : connecting migration, space and race : commentary to van Liempt
2023
Building on Ilse van Liempt’s (2023) lecture, this commentary addresses the connection and shift between forced displacement and local emplacement by addressing what becoming part of the city means for racialized immigrants. By bringing forward the notion of racialization I hope to contribute to a growing body of literature discussing how malleable and productive the concept of race – albeit erased and relegated to the past – keeps on shaping conversations about and across Europe. Connecting migration, space and race offers a particularly rich context in which to have this discussion because, as all three elements are mutually constructive, addressing them together exposes some of the compl…