Healthcare Professional Communication on Sexual Health: A Report from the Italian Working Group on Adolescents and Young Adults with Cancer

2023

Background: Sexual function is an important concern for adolescent and young adult (AYA) with cancer. The aim of this study was to explore the attitude of Italian health care professionals who deal with AYA patients with cancer toward sexual health communication. Materials and methods: A 11-question survey was developed by the AIOM (Associazione Italiana di Oncologia Medica) and AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) AYA workgroup and sent to AIOM and AIEOP members. Results: The sample comprised 360 respondents, 54.2% AIEOP and 45.8% AIOM members. Eighty percent were physicians, 14.5% nurses, 4.7% psychologists, and 0.8% other professionals. Medical oncologists are mo…

Tre note allo ps.-Scilace

2023

Si discutono problemi testuali relativi a tre passi dello ps.-Scilace.

Notes introductives

2023

La thèse de Jean Charles sur la CGTU que nous présentons aujourd’hui relève sans exagération du mythe historiographique. Depuis un demi-siècle, tout historien du mouvement ouvrier a, à un moment ou un autre, entendu parler de ce travail, soit de manière critique, soit de manière élogieuse, mais dans les deux cas de manière fantasmée. En effet la thèse de Jean Charles débutée au deuxième mitan des années 1960, sous la direction de Jacques Droz, puis d’Antoine Prost et intitulée « La CGTU et l’...

Relaxation result for differential inclusions with Stieltjes derivative

2023

The aim of this paper is to provide a Filippov-Wa\.{z}ewski Relaxation Theorem for the very general setting of Stieltjes differential inclusions. New relaxation results can be deduced for generalized differential problems, for impulsive differential inclusions with multivalued impulsive maps and possibly countable impulsive moments and also for dynamic inclusions on time scales.

Muutosvoimavarojen yhteydet henkilöstön työhyvinvointiin sekä työpaikan ja alanvaihtoaikeisiin terveysalan organisaation muutosprosessissa

2023

Tutkimme kahden vuoden seurantatutkimuksessa, miten muutosvoimavarat (viestintä, osallistuminen päätöksentekoon, muutostuki) ovat yhteydessä terveydenhuoltoalan henkilöstön työhyvinvointiin (työuupumus, työn imu) sekä työpaikan ja alanvaihtoaikeisiin organisaatiomuutoksen aikana. Tutkimukseen osallistui 303 sairaanhoitopiirin työntekijää, joista 87 prosenttia oli naisia ja potilastyössä toimivia 74 prosenttia. K-keskiarvoklusteroinnilla tunnistimme tutkimuksen lähtötilanteessa kolme muutosvoimavaraprofiilia: vähäiset muutosvoimavarat (41 % tutkittavista), korkeat muutosvoimavarat (23 %) ja keskimääräiset muutosvoimavarat (36 %). Vähäisten muutosvoima-varojen profiilissa yliedustettuina oliv…

Liquid Structure Scenario of the Archetypal Supramolecular Deep Eutectic Solvent: Heptakis(2,6-di-O-methyl)-β-cyclodextrin/levulinic Acid

2023

The concept of supramolecular solvents has been recently introduced, and the extended liquid-state window accessible for mixtures of functionalized cyclodextrins (CDs) with hydrogen bond (HB) donor species, e.g., levulinic acid, led to the debut of supramolecular deep eutectic solvents (SUPRA-DES). These solvents retain CD’s inclusion ability and complement it with enhanced solvation effectiveness due to an extended HB network. However, so far, these promising features were not rationalized in terms of a microscopic description, thus hindering a more complete capitalization. This is the first joint experimental and computational study on the archetypal SUPRA-DES: heptakis- (2,6-di-O-methyl)…

Hybris e rivoluzione. Il caso della rivolta cilena

2023

This paper discusses the binomial hybris and revolution. In particular, the question of whether the excessive dominants’ arrogance, who have too much both in material and symbolic terms, is sufficient to explain the deflagration of an insurgency and the interruption of a legal order. The question will be addressed by interweaving the reflections of authors who have discussed this topic with a material collected by the author through a legal-political ethnography conducted in Chile during the revolt that broke out in October 2019 and led to a new constituent phase. Categories and definitions used in this text are partly borrowed from the course devoted to political change and revolution taug…

International survey of antibiotic dosing and monitoring in adult intensive care units

2023

Background: In recent years, numerous dosing studies have been conducted to optimize therapeutic antibiotic exposures in patients with serious infections. These studies have led to the inclusion of dose optimization recommendations in international clinical practice guidelines. The last international survey describing dosing, administration and monitoring of commonly prescribed antibiotics for critically ill patients was published in 2015 (ADMIN-ICU 2015). This study aimed to describe the evolution of practice since this time. Methods: A cross-sectional international survey distributed through professional societies and networks was used to obtain information on practices used in the dosing…

Interventionist research in management accounting: promoting engagement through face-to-face dialogues

2023

PurposeThis paper explores face-to-face dialogues between practitioners and interventionist researchers in the management accounting (MA) field during real-time interactions for the development of accounting devices. It aims to shed light on whether and how these dialogues can affect the construction of meanings around the devices, thereby influencing the course of interventionist research (IVR) projects.Design/methodology/approachThis study presents a reflective analysis (both in itinere and ex-post) of an IVR project conducted by one of the authors within a healthcare organisation. It draws on a dialogical perspective to delve into the conversations between the author and the organisation…

Intrahepatic cholestasis of pregnancy after ovarian hyperstimulation syndrome with wild-type ABCB4 gene: a peculiar case and literature review

2023

Background: Intrahepatic cholestasis of pregnancy (ICP) in the first trimester occurring after ovarian hyperstimulation syndrome (OHSS) is a rare condition and few cases are reported in the literature. Hyperestrogenism may explain this problem in genetically predisposed women. The objective of this article is to report one of these rare cases and offer an overview of the other published cases. Case presentation: We report a case of severe OHSS followed by ICP in the first trimester. The patient was admitted to the intensive care unit and was treated according to the guidelines for the management of OHSS. Moreover, the patient also received ursodeoxycholic acid for ICP, which brought to an i…

Spheroids of adipose derived stem cells show their potential in differentiating towards the angiogenic lineage

2023

Introduction: Adipose derived stem cells (ASCs) are a mesenchymal stem cell population of great scientific interest due to their abundance and easiness in obtaining them from adipose tissue. Recently, several techniques for three dimensional (3D) ASCs cultivation have been developed to obtain spheroids of adipose stem cells (SASCs). It was already proved that ASCs are able to differentiate towards the endothelial lineage thus, for the first time, we investigated the ability of our 3D SASCs to differentiate endothelially and the effects of not differentiated SASC secreted factors on specific cultured cells. Materials and methods: SASCs were differentiated with a specific medium towards endot…

Uterine sarcomas: A critical review of the literature

2023

This review aims to provide a comprehensive description of surgical approaches for the management of uterine sarcomas. Uterine sarcomas are rare uterine neoplasms. Frequently, diagnosis is made after hysterectomy or myomectomy scheduled for presumed benign leiomyomas. The gold standard for surgical treatment of uterine sarcomas is hysterectomy with bilateral salpingo-oophorectomy. It is possible to adopt a fertility-sparing approach for those patients who wish to maintain their fertility. The role of pelvic lymphadenectomy is controversial; in fact, removal of lymph nodes is only recommended in the case of radiological suspicion of nodal involvement. Use of a morcellator is associated with …

A Deadly Liaison between Oxidative Injury and p53 Drives Methyl-Gallate-Induced Autophagy and Apoptosis in HCT116 Colon Cancer Cells

2023

Methyl gallate (MG), which is a gallotannin widely found in plants, is a polyphenol used in traditional Chinese phytotherapy to alleviate several cancer symptoms. Our studies provided evidence that MG is capable of reducing the viability of HCT116 colon cancer cells, while it was found to be ineffective on differentiated Caco-2 cells, which is a model of polarized colon cells. In the first phase of treatment, MG promoted both early ROS generation and endoplasmic reticulum (ER) stress, sustained by elevated PERK, Grp78 and CHOP expression levels, as well as an upregulation in intracellular calcium content. Such events were accompanied by an autophagic process (16–24 h), where prolonging the …

The Gliadin Hydrolysis Capacity of B. longum, L. acidophilus, and L. plantarum and Their Protective Effects on Caco-2 Cells against Gliadin-Induced I…

2023

Background: Non-celiac wheat sensitivity (NCWS) is a poorly understood gluten-related disorder (GRD) and its prominent symptoms can be ameliorated by gluten avoidance. This study aimed to determine the effectiveness of a probiotic mixture in hydrolyzing gliadin peptides (toxic components of gluten) and suppressing gliadin-induced inflammatory responses in Caco-2 cells. Methods: Wheat dough was fermented with a probiotic mix for 0, 2, 4, and 6 h. The effect of the probiotic mix on gliadin degradation was monitored by SDS-PAGE. The expression levels of IL-6, IL-17A, INF-G, IL-10, and TGF-B were evaluated using ELISA and qRT-PCR methods. Results: According to our findings, fermenting wheat dou…

Present Uncertainty and Looking to the Past: The Ambiguous Literary Nationalism of Putnam’s Monthly

2023

Putnam’s Monthly (1853-1857) was one of the best literary and general interest magazines in antebellum America. Besides its high quality, what made the New York-based magazine stand out was its commitment to publishing American writers and focusing on American themes at a time when, with no reliable international copyright protection in place, many periodicals in the United States were in the habit of reprinting the works of foreign (primarily British) authors, sometimes without payment. However, despite its optimistic literary nationalism, Putnam’s Monthly expressed uncertainty about the quality of contemporary American literature and, indeed, about the capacity of American society to enco…

Investigating the Reliability of Stationary Design Rainfall in a Mediterranean Region under a Changing Climate

2023

Extreme rainfall events have been more frequent in recent decades, potentially as a climate change effect. This has been leading to a higher risk of the failure of existing hydraulic infrastructures, and to a higher awareness regarding the unreliability of design rainfall calculated with reference to historical data recorded in the last century. With this in mind, the present study questions the stationary assumption of the rainfall Depth–Duration–Frequency curves commonly used in Sicily, the biggest island of the Mediterranean Sea. Quantiles derived from the most up-to-date regional method, regarding Sicily, based on observations in the period 1928–2010, have been compared with those extra…

Current distribution along electrodialysis stacks and its influence on the current-voltage curve: behaviour from near-zero current to limiting plateau

2023

The current maldistribution along the flow path of electrodialysis (ED) units is a well-known phenomenon. However, it has been poorly quantified via experimental tests so far. This work aimed at measuring the current distribution in an ED stack with 40 cm path length, provided with four-segment electrodes. The current-voltage curve (CVC) of each segment was recorded under several operating conditions of inlet concentrations and feed velocity. In the CVC of the first segment, the current increased approaching a saturation, while in that of the remaining segments it passed through a maximum and then settled at near-zero values when high voltage values were applied. The current fraction on the…

Individualized Thresholds of Hypoxemia and Hyperoxemia and their Effect on Outcome in Acute Brain Injured Patients: A Secondary Analysis of the ENIO …

2023

Background: In acute brain injury (ABI), the effects of hypoxemia as a potential cause of secondary brain damage and poor outcome are well documented, whereas the impact of hyperoxemia is unclear. The primary aim of this study was to assess the episodes of hypoxemia and hyperoxemia in patients with ABI during the intensive care unit (ICU) stay and to determine their association with in-hospital mortality. The secondary aim was to identify the optimal thresholds of arterial partial pressure of oxygen (PaO2) predicting in-hospital mortality. Methods: We conducted a secondary analysis of a prospective multicenter observational cohort study. Adult patients with ABI (traumatic brain injury, suba…

The avidin-theophylline complex: A structural and computational study

2023

: The interaction between avidin and its counterpart biotin is one of central importance in biology and has been reproposed and studied at length. However, the binding pocket of avidin is prone to promiscuous binding, able to accommodate even non-biotinylated ligands. Comprehending the factors that distinguish the extremely strong interaction with biotin to other ligands is an important step to fully picture the thermodynamics of these low-affinity complexes. Here, we present the complex between chicken white egg avidin and theophylline (TEP), the xanthine derivative used in the therapy of asthma. In the crystal structure, TEP lies in the biotin-binding pocket with the same orientation and …

Kotoutumiskoulutuksen opetussuunnitelman perusteet kuvaa tavoitettaan osallisuutta epämääräisesti ja kapeasti

2023

Kotoutumiskoulutuksen uudessa perusteasiakirjassa korostuu osallisuuden käsite. Se jää kuitenkin määrittelemättä: osallisuuteen viitataan sekä kapearajaisesti työmarkkinaosallisuutena että epäsuorasti niin, että käsitteen varsinainen merkitys jää avoimeksi. Tutkimuskirjallisuudessa osallisuus edellyttää laaja-alaista sosiaalis-yhteiskunnallista kuulumista ja yhdenvertaisuutta. nonPeerReviewed

Multimodal Strategies to Fight Obesity: Research on Tailored Therapies Based on Natural and Synthetic Compounds for Prevention, Management and Treatm…

2023

Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster

2023

Radiosumins are a structurally diverse family of low molecular weight natural products that are produced by cyanobacteria and exhibit potent serine protease inhibition. Members of this family are dipeptides characterized by the presence of two similar non-proteinogenic amino acids. Here we used a comparative bioinformatic analysis to identify radiosumin biosynthetic gene clusters from the genomes of 13 filamentous cyanobacteria. We used direct pathway cloning to capture and express the entire 16.8 kb radiosumin biosynthetic gene cluster from Dolichospermum planctonicum UHCC 0167 in Escherichia coli. Bioinformatic analysis demonstrates that radiosumins represent a new group of chorismate-der…

Fusioni o confusioni? Due documenti greci con note in arabo nella Sicilia orientale (XII secolo)

2023

The article presents two twelfths-century deeds of sale. produced in the Sicilian Val Demone, where a majority Greek population, tenacious of Byzantine tradition, resided. Both documents are drawn up according to Greek legal norms, but included notes of. confirmation and validation, written in Arabic, which utilize and adapt legal formulae and styles established in the Islamic legal sphere. Each, in its different way, point to a certain synthesis, or fusion, of Greek-Byzantine and Muslim practice, and a juridical multiculturalism that one can find also in other inter-religious contexts.

ISIM - INFRASTRUCTURES & STRUCTURES INFORMATION MODELING: A NEW CONCEPT OF BIM FOR INFRASTRUCTURES

2023

The application of Building Information Modeling (BIM) in infrastructure and structural projects, known as Integrated Structural and Infrastructure Modeling (ISIM), has gained attention in recent years due to its potential to revolutionize the construction industry. By providing a digital representation of the built environment, BIM allows for improved collaboration and communication between project stakeholders, leading to enhanced project outcomes. The ISIM approach is centered on the creation of a digital twin, a three-dimensional model of the infrastructure or structure, which serves as a virtual replica of the physical asset. This digital twin provides a platform for analysis, decision…

Surgical neuropelveology: laparoscopic nerve-sparing excision of a pelvic schwannoma

2023

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Mechanical and environmental performance comparisons of improved asphalt pavement wearing courses with high quality aggregates, steel slags, and poly…

2023

The use of waste materials in the construction of hot mix asphalt (HMA) pavements is an important opportunity for environmental sustainability. When properly designed, the alternative mixtures may also guarantee excellent mechanical performance. In this study, the results of an experimental analysis carried out on dense-graded HMAs are presented. In particular, the performance of a "traditional" surface mixture with limestone aggregate (designed with neat bitumen or a polymer-modified bitumen within the typical acceptance requirements for intended use in wearing courses) was compared with two alternative mixtures. The research investigated a surface mixture including coarse basaltic aggrega…

Can conservation agriculture deeply change the structure of weed communities

2023

International audience

Implementing AI Ethics: Making Sense of the Ethical Requirements

2023

Society’s increasing dependence on Artificial Intelligence (AI) and AI-enabled systems require a more practical approach from software engineering (SE) executives in middle and higher-level management to improve their involvement in implementing AI ethics by making ethical requirements part of their management practices. However, research indicates that most work on implementing ethical requirements in SE management primarily focuses on technical development, with scarce findings for middle and higher-level management. We investigate this by interviewing ten Finnish SE executives in middle and higher-level management to examine how they consider and implement ethical requirements. We use et…

Tranexamic acid for the prevention of blood loss after cesarean section: an updated systematic review and meta-analysis of randomized controlled tria…

2023

Objective: Tranexamic acid (TXA) is a cost-effective intervention for the prevention of postpartum hemorrhage (PPH) in women undergoing cesarean section but the evidence to support its use is conflicting. We conducted this meta-analysis to evaluate the efficacy and safety of TXA in low- and high-risk cesarean deliveries. Data sources: We searched MEDLINE (via PubMed), Embase, the Cochrane Library, ClinicalTrials.gov, and WHO International Clinical Trials Registry Platform (ICTRP) portal from inception to April 2022 (updated October 2022 and February 2023) with no language restrictions. Additionally, grey literature sources were also explored. Study eligibility criteria: All randomized contr…

Environmental Aspect Concerning Phthalates Contamination: Analytical Approaches and Assessment of Biomonitoring in the Aquatic Environment

2023

This review is a survey of recent progress in studies concerning the impact of phthalic acid esters in aquatic organisms. After introducing the classification, properties, sources, fate, and toxic effects related to phthalates, an overview of the techniques of extraction and analysis of these substances is provided. As a result, the general concepts of environmental bioindicators, biomonitoring systems, and other concepts related to phthalate contamination in the aquatic environment are presented. Recent bioaccumulation data of different phthalates are summarised in a table and organised according to the type of organism, tissue, and geographical area of sampling. Bioindicator organisms tha…

The Concept of Religious Pluralism in a Globalized World: An Analytical and Comparative Study of John Hick and Hossein Nasr's Theories

2023

As a researcher and author in the field of comparative religion, I have dedicated my academic journey to the study of philosophy and religion. It is through this pursuit that I have developed a deep passion for expanding my knowledge and understanding of various religious traditions, beliefs, and practices. My academic pursuits have granted me the opportunity to delve into the intricate complexities of different religious systems, exploring their historical, cultural, and philosophical dimensions. I find great fulfillment in unraveling the mysteries and nuances of religious texts, rituals, and the diverse ways in which individuals and communities express their spiritual beliefs. For me, the…

Vertically Aligned Nanowires and Quantum Dots: Promises and Results in Light Energy Harvesting

2023

The synthesis of crystals with a high surface-to-volume ratio is essential for innovative, high-performance electronic devices and sensors. The easiest way to achieve this in integrated devices with electronic circuits is through the synthesis of high-aspect-ratio nanowires aligned vertically to the substrate surface. Such surface structuring is widely employed for the fabrication of photoanodes for solar cells, either combined with semiconducting quantum dots or metal halide perovskites. In this review, we focus on wet chemistry recipes for the growth of vertically aligned nanowires and technologies for their surface functionalization with quantum dots, highlighting the procedures that yie…

Evaluation of Anal Sphincter with High Resolution Anorectal Manometry and 3D Reconstruction in Patients with Anorectal Malformation

2023

Background: Patients with anorectal malformation (ARM) need long-term follow-up, in order to evaluate fecal continence; the main predictors of longer-term success are the type of ARM, associated anomalies and sacral integrity. Three-Dimensional High Resolution Anorectal Manometry (3D-HRAM) gives detailed information on pressure on the anal complex profile. Our objective was to analyze anal sphincter activity in ARM patients with 3D-HRAM establishing the correlation between manometric and clinical data. Methods: Forty ARM patients were submitted to 3D-HRAM: manometric, anatomical and clinical scores were correlated with each other and with the bowel management response (BM). Results: A posit…

Granger Causality Analysis of Transient Calcium Dynamics in the Honey Bee Antennal Lobe Network

2023

Odorant processing presents multiple parallels across animal species, and insects became relevant models for the study of olfactory coding because of the tractability of the underlying neural circuits. Within the insect brain, odorants are received by olfactory sensory neurons and processed by the antennal lobe network. Such a network comprises multiple nodes, named glomeruli, that receive sensory information and are interconnected by local interneurons participating in shaping the neural representation of an odorant. The study of functional connectivity between the nodes of a sensory network in vivo is a challenging task that requires simultaneous recording from multiple nodes at high temp…

Muistisairautta sairastavan ikääntyvän puolison toimijuus parisuhteessa

2023

Tässä laadullisessa tutkimuksessa selvitimme, miten muistisairautta sairastava ikääntyvä puoliso ja hänen puoliso-omaishoitajansa kuvaavat muistisairaan puolison toimijuutta parisuhteessa. Analysoimme aineiston sisällönanalyysin keinoin. Muodostimme aineistosta neljä pääteemaa. Puoliso-omaishoitajat kuvasivat muistisairaan toimijuutta eri tavalla kuin sairastavat itse.  Puoliso-omaishoitaja kuvasi muistisairaan puolison toimijuutta touhuamisena, mutta sairastavalla käyttäytymisen taustalla oli huoli kotitöistä. Kun muistisairas puoliso havaitsi, ettei kykene tekemään jotakin, mielenkiinto asiaa kohtaan väheni. Puoliso-omaishoitaja näki tilanteessa aloitekyvyttömyyttä. Parisuhteen yhteisissä…

Nitrogen-fixing cushion Astragalus siculus modulates soil fertility, microclimate, plant facilitation, bacterial and fungal microbiota along an eleva…

2023

Question: Cushion-forming vascular plants are adapted to alpine environments and act as ecosystem engineers by moderating microclimate and creating a fertility island under their canopy. Most of the available studies on cushion ecology have been devoted to plant facilitation, but none used a holistic approach that considers the response of co-existing plant species with other key ecosystem players. Here, we quantified the biogenic effect and facilitation capacity of Astragalus siculus, a spiny nitrogen-fixing cushion plant, and test the hypothesis that the facilitation effect would increase with elevation as stress gradient.Location: Mount Etna, the highest active volcano in the Mediterrane…