showing 36 of ~574560 from 574555 documents
Uterine cervical stenosis: from classification to advances in management. Overcoming the obstacles to access the uterine cavity
2023
Background: To date hysteroscopy is the gold standard technique for the evaluation and management of intrauterine pathologies. The cervical canal represents the access route to the uterine cavity. The presence of cervical stenosis often makes entry into the uterine cavity difficult and occasionally impossible. Cervical stenosis has a multifactorial etiology. It is the result of adhesion processes that can lead to the narrowing or total obliteration of the cervical canal. Purpose: In this review, we summarize the scientific evidence about cervical stenosis, aiming to identify the best strategy to overcome this challenging condition. Methods: The literature review followed the scale for the q…
La tecnica del bilanciamento nella giurisprudenza dei tribunali internazionali
2023
La presente ricerca esamina il ruolo della tecnica del bilanciamento tra interessi, principi o valori nel ragionamento del giudice internazionale. Da un punto di vista tecnico, essa tenta di chiarire le funzioni che il bilanciamento può svolgere nell’ambito dell’esercizio della funzione giudiziaria internazionale, e quale sia la struttura dell’argomentazione giudiziaria che su essa si fondi, sempre che un approccio comune tra i diversi tribunali internazionali sia riscontrabile. Da un punto di vista di politica giudiziaria, intende fornire alcune possibili spiegazioni della diversa propensione dei diversi tribunali internazionali a fare ricorso a tale tecnica o, nella giurisprudenza di uno …
Implementare il patrimonio archivistico: ricostruzione virtuale di una villa non realizzata di Giuseppe Samonà in Sicilia
2023
Questo saggio vuole essere una testimonianza dell’importanza culturale e cognitiva degli archivi (del progetto) intesi come patrimonio pubblico. L’azione di re-immaginarli può costituire un veicolo per la loro conoscenza? Con l’analisi di un caso-studio di un’abitazione non realizzata di un architetto del Novecento come Giuseppe Samonà si prova a verificare l’efficacia degli strumenti digitali per l’interpretazione dell’architettura come mezzi per l’implementazione comunicativa di un archivio.
Involvement of SYCP2L and TDRD3 gene variants on ovarian reserve and reproductive outcomes: a cross-sectional study
2023
Objective: Single nucleotide variants have been implicated in the response to fertility treatment and a pharmacogenomic approach may help to customize therapy based on patient genome. We aimed to evaluate the effect, individual and combined, of SYCP2L (rs2153157:G>A) and TDRD3 (rs4886238:G>A) variants on ovarian reserve, response to controlled ovarian stimulation (COS) and reproductive outcomes of women undergoing in vitro fertilization (IVF) treatment. Methods: This cross-sectional study included 149 normoovulatory women undergoing IVF. Genotyping was performed using the TaqMan real-time polymerase chain reaction method. Clinical parameters and reproductive outcomes were compared acc…
Repetitiveness Measures based on String Attractors and Burrows-Wheeler Transform: Properties and Applications
2023
L’histoire de La Balutie, un gisement oublié, voisin de Lascaux et de Regourdou
2023
Cette contribution a pour objet de retranscrire l’histoire du site paléolithique de La Balutie (Montignac-Lascaux, Dordogne, France). L’histoire de ce site très tôt oublié, n’est ni sensationnelle, ni exceptionnelle, mais s’avère retranscrire l’atmosphère caractérisant les débuts des explorations des gisements préhistoriques de Dordogne. On y retrouve de grands noms de la Préhistoire de Dordogne qui n’ont légué que peu d’écrits sur le site, du mobilier trié (surtout lithique) du Paléolithique moyen et supérieur qui a alimenté de nombreuses collections privées avant d’être dispersé au sein de diverses institutions, et un contexte local compliqué et agrémenté de conflits. Notre connaissance d…
A critical review on latest innovations and future challenges of electrochemical technology for the abatement of organics in water
2023
Updated water directives and ambitious targets like the United Nations’ Sustainable Development Goals (SDGs) have emerged in the last decade to tackle water scarcity and contamination. Although numerous strategies have been developed to remove water pollutants, it is still necessary to enhance their effectiveness against toxic and biorefractory organic molecules. Comprehensive reviews have highlighted the appealing features of the electrochemical technologies, but much progress has been made in recent years. In this timely review, a critical discussion on latest innovations and perspectives of the most promising electrochemical tools for wastewater treatment is presented. The work describes…
Intensity interferometry for ultralight bosonic dark matter detection
2023
Ultralight bosonic dark matter (UBDM) can be described by a classical wave-like field oscillating near the Compton frequency of the bosons. If a measurement scheme for the direct detection of UBDM interactions is sensitive to a signature quadratic in the field, then there is a near-zero-frequency (dc) component of the signal. Thus, a detector with a given finite bandwidth can be used to search for bosons with Compton frequencies many orders of magnitude larger than its bandwidth. This opens the possibility of a detection scheme analogous to Hanbury Brown and Twiss intensity interferometry. Assuming that the UBDM is virialized in the galactic gravitational potential, the random velocities pr…
Exploring Heterogeneity with Category and Cluster Analyses for Mixed Data
2023
Precision medicine aims to overcome the traditional one-model-fits-the-whole-population approach that is unable to detect heterogeneous disease patterns and make accurate personalized predictions. Heterogeneity is particularly relevant for patients with complications of type 2 diabetes, including diabetic kidney disease (DKD). We focus on a DKD longitudinal dataset, aiming to find specific subgroups of patients with characteristics that have a close response to the therapeutic treatment. We develop an approach based on some particular concepts of category theory and cluster analysis to explore individualized modelings and achieving insights onto disease evolution. This paper exploits the vi…
Agnostic application of a Multigene Panel Testing including tumor susceptibility genes in Breast, Ovarian, Pancreatic and Prostate cancer patients
2023
Effect of maternal age and body mass index on induction of labor with oral misoprostol for premature rupture of membrane at term: A retrospective cro…
2023
The aim of this study was to evaluate the effect of maternal age and body mass index (BMI) on induction of labor with oral misoprostol for premature rupture of membrane (PROM) at term. We have conducted retrospective cross-sectional study, including only term (37 weeks or more of gestation) PROM in healthy nulliparous women with a negative vaginal-rectal swab for group B streptococcus, a single cephalic fetus with normal birthweight, and uneventful pregnancy that were induced after 24 h from PROM. Ninety-one patients were included. According to the multivariate logistic regression, age and BMI odds ratio (OR) for induction success were 0.795 and 0.857, respectively. The study population was…
THERMOFLUID-DYNAMICS OF DEMO DIVERTOR CASSETTE
2023
The divertor is a critical in-vessel component of nuclear fusion reactors, being responsible for the fulfilment of certain fundamental functions for the machine: it must be able to handle the power deposited by charged particle and neutron irradiation, ensure the presence of channels through which the fusion ashes can be removed from the Vacuum Vessel (VV), provide plasma-compatible surfaces, and shield the VV and magnets from nuclear loads. The heat load that can be tolerated by the divertor under normal and off-normal operating conditions is a pivotal parameter when dimensioning a fusion power plant since exceptionally high heat fluxes can be observed in some regions of the divertor, in t…
Ruolo dei linfociti citotossici T CD8+ HLA-E ristretti in risposta ad epitopi di Mycobacterium tuberculosis veicolati tramite un tossoide ricombinant…
2023
POTENTIAL APPLICATIONS OF LIQUID BIOPSY IN IMMUNOTHERAPY: ROLE OF EXOSOMES, MICRORNAS AND PLASMA EXPRESSION LEVELS OF IMMUNE CHECKPOINTS IN PATIENTS …
2023
IL RICONOSCIMENTO DELLE EMOZIONI FACCIALI NEI DISTURBI PSICOTICI: UNO STUDIO SUI MECCANISMI GENETICI ED EPIGENETICI
2023
La schizofrenia e altri disturbi psicotici sono disturbi complessi con eziologia multifattoriale che comprende fattori genetici e ambientali. L’architettura genetica di questi disturbi coinvolge numerosi loci implicati nel conferire il rischio di sviluppare la malattia. Inoltre, gli studi che indagano l’eziologia molecolare di questi disturbi hanno mostrato un interesse crescente per le variazioni epigenetiche, specialmente la metilazione del DNA. I disturbi della social cognition, come le difficoltà nel riconoscimento delle emozioni facciali (FER), sono associati con i disturbi psicotici; tuttavia, il loro legame con la genetica e l’epigenetica di questi disturbi sono questioni ancora aper…
Ideals generated by the inner 2-minors of collections of cells
2023
In 2012 Ayesha Asloob Qureshi connected collections of cells to Commutative Algebra assigning to every collection $\mathcal{P}$ of cells the ideal of inner 2-minors, denoted by $I_{\mathcal{P}}$, in the polynomial ring $S_{\mathcal{P}}=K[x_v:v\text{ is a vertex of }\mathcal{P}]$. Investigating the main algebraic properties of $K[\mathcal{P}]=S_{\mathcal{P}}/I_{\mathcal{P}}$ depending on the shape of $\mathcal{P}$ is the purpose of this research. Many problems are still open and they seem to be fascinating and exciting challenges.\\ In this thesis we prove several results about the primality of $I_{\mathcal{P}}$ and the algebraic properties of $K[\mathcal{P}]$ like Cohen-Macaulyness, normali…
Petrology and geochemistry of peri-Mediterranean carbonatite magmatism: case studies from Fuerteventura (Canary Islands) and Mt. Vulture volcano (sou…
2023
Carbonatites are rare magmatic rocks of great scientific and economic importance, and carbonatite magmatism is mainly associated with intraplate continental tectonic settings, with some rare occurrences in oceanic contexts. Despite their importance, many aspects of carbonatite petrogenesis and evolution processes remain still poorly constrained. In order to further constrain the mantle source and the storage system of carbonatite magmas, Fuerteventura (Canary Islands) was taken as a representative case study of oceanic carbonatites, while Mt. Vulture (southern Italy) was taken as a representative case study of intra-continental carbonatites, with a two-fold aim: to understand (i) the role o…
Does taking additional Maths classes in high school affect academic outcomes?
2023
Several studies in the mathematical education literature show the effect of students’ high school skills in maths on their success at higher levels of education and work. In particular, the importance of maths course taking in US high schools is highlighted to be important for college enrolment and completion. The choice of taking additional maths courses or, as in Italy, of choosing a high-school curriculum with more maths, is not random: it depends on several substantial factors such as gender and socio-economic status. This selection bias implies that the differences in the academic outcomes might be traceable not only to mathematics ability and knowledge. In this paper, the aim is to es…
Evaluation of Borderline Ovarian Tumor Recurrence Rate after Surgery with or without Fertility-Sparing Approach: Results of a Retrospective Analysis
2023
Borderline ovarian tumors (BOTs) comprise 15-20% of primary ovarian neoplasms and represent an independent disease entity among epithelial ovarian cancers. The present study (Clinical Trial ID: NCT05791838) aimed to report a retrospective analysis of the management and outcomes of 86 consecutive BOTs patients, 54 of which were at a reproductive age. All patients with BOTs undergoing surgical treatment from January 2010 to December 2017 were included. Data were retrospectively reviewed. High levels of Ca-125 were observed in 25.6% of the FIGO stage I patients and 58.3% of the advanced disease patients. Fertility-sparing surgery and comprehensive surgical staging were performed in 36.7% and 4…
Geogenic carbon dioxide degassing from active tectonic areas of the Balkan Peninsula
2023
Sin dagli anni ’70, la ricerca scientifica ha evidenziato una forte relazione tra il degassamento di carbonio profondo e le aree tettonicamente attive, sottolineando l’elevata importanza del contributo di queste emissioni nella quantificazione del carbonio globale. La Penisola Balcanica presenta grandi aree caratterizzate da degassamento di carbonio di origine mantellica, da attività vulcaniche Quaternarie, da un’elevata sismicità e da strutture tettoniche a scala regionale. Purtroppo, la stima del degassamento di anidride carbonica profonda in quest’area è ancora poco studiata. La ricerca di questa tesi di dottorato si è focalizzata sulla (i) stima dell’output di carbonio profondo dalle gr…
Multi-disciplinary analysis to construct a crustal model of the Sicily Channel using geological and geophysical techniques (data): impacts on geologi…
2023
To understand the dynamics of crustal deformation and earthquakes in active orogenic systems, it is essential to have a detailed view of the lithospheric structures in three dimensions (3D). Several studies in the literature explain how 3D visualization can enable the recognition of tectonic structures or to be able to establish connections between intraplate volcanoes (Wu et al., 2016; Lei & Zhao, 2016; Tan et al., 2019). This work aims to define and discretize a 1D-velocity model of the Sicily Channel; create a detailed 3D lithospheric model of the Sicily Channel using a multidisciplinary approach to evaluate the geological hazard elements that affect the Iblean foreland integrating bathy…
Integration of CSR into CEOs’ compensation: effects on social and financial performance of French listed firms
2023
Based on the stakeholder model of corporate governance, this research analyzes the relationship between the integration of corporate social responsibility (CSR) into CEO compensation and corporate social and financial performance, in firms listed on France’s SBF 120 stock market between 2015 and 2019. The results of panel data regressions show that indexing CEO compensation on CSR criteria only influence corporate social performance Moreover, social performance has a positive impact on financial performance and a mediating effect between the integration of CSR criteria into CEO compensation and financial performance.
Sicilian semi- and supercentenarians: identification of age-related T cell immunophenotype to define longevity trait
2023
: The immunophenotype of oldest centenarians, i.e., semi- and supercentenarians, could provide important information about their ability to adapt to factors associated with immune changes, including ageing per se and chronic Cytomegalovirus infection. We investigated, by flow cytometry, variations in percentages and absolute numbers of immune cell subsets, focusing on T cells, and pro-inflammatory parameters in a cohort of 28 women and 26 men (age range 19-110 years). We observed variability in hallmarks of immunosenescence related to age and Cytomegalovirus serological status. The eight oldest centenarians showed the lowest percentages of naïve T cells, due to their age, and the highest pe…
L'unità produttiva digitale
2023
Lo scritto tratta in primo luogo del diritto di stabilire una RSA sul posto di lavoro: la tesi è che ogni sindacato rappresentativo ha il diritto di stabilire la propria rappresentanza sul posto di lavoro. In secondo luogo, l'autore esamina le condizioni alle quali i diritti sanciti dal titolo III dello Statuto dei lavoratori possono operare nel contesto digitale, abbracciando una nozione fluida di unità di produzione.
Anti-Inflammatory Effects of Nutritionally Relevant Concentrations of Oleuropein and Hydroxytyrosol on Peripheral Blood Mononuclear Cells: An Age-Rel…
2023
: Immunosenescence and inflammaging facilitate the insurgence of chronic diseases. The Mediterranean diet is a non-invasive intervention to improve the chronic low-grade inflammatory status associated with aging. Olive oil oleuropein (OLE) and hydroxytyrosol (HT) demonstrated a controversial modulatory action on inflammation in vitro when tested at concentrations exceeding those detectable in human plasma. We studied the potential anti-inflammatory effects of OLE and HT at nutritionally relevant concentrations on peripheral blood mononuclear cells (PBMCs) as regards cell viability, frequency of leukocyte subsets, and cytokine release, performing an age-focused analysis on two groups of subj…
Parathyroid Hormone Related Protein (PTHrP)-Associated Molecular Signatures in Tissue Differentiation and Non-Tumoral Diseases
2023
On Overcoming the Alleged Alienation between Christianity and Physics
2023
The difference of mindsets is considered the main cause of alienation between Christianity and Physics: trust in high cognitive value of ordinary experience and language (Christianity) versus estimated low cognitive value (Physics). The Catholic tradition encourages to trust into a high cognitive value of ordinary experience and language. As samples are presented a certain ambivalence intrinsic to the method of Physics and a logical mistake that has led to the concept of particle-wave dualism.
The role of polaronic states in the enhancement of CO oxidation by single-atom Pt/CeO2
2023
Single Atom Catalysts (SACs) have shown that the miniaturization of the active site implies new phenomena like dynamic charge transfer between isolated metal atoms and the oxide. To obtain direct proof of this character is challenging, as many experimental techniques provide averaged properties or have limitations with poorly conductive materials, leaving kinetic measurements from catalytic testing as the only reliable reference. Here we present an integrated Density Functional Theory-Microkinetic model including ground and metastable states to address the reactivity of Pt1/CeO2 for CO oxidation. Our results agree with experimentally available kinetic data in the literature and show that CO…
High-density single nucleotide polymorphism markers reveal the population structure of 2 local chicken genetic resources
2023
Italy counts a large number of local chicken populations, some without a recognized genetic structure, such as Val Platani (VPL) and Cornuta (COS), which represent noteworthy local genetic resources. In this study, the genotype data of 34 COS and 42 VPL, obtained with the Affymetrix Axiom600KChicken Genotyping Array, were used with the aim to investigate the genetic diversity, the runs of homozygosity (ROH) pattern, as well as the population structure and relationship within the framework of other local Italian and commercial chickens. The genetic diversity indices, estimated using different approaches, displayed moderate levels of genetic diversity in both populations. The identified ROH h…
Performance-based research funding: Evidence from the largest natural experiment worldwide
2023
A performance-based research funding system (PRFS) is a nationwide incentive scheme that promotes and rewards university research performance through competition for government funding. The UK’s PRFS, currently the Research Excellence Framework (REF), is considered the oldest, largest and most developed payment-by-results system in academia worldwide. Surprisingly, and despite the strong criticisms, little has been done to quantitatively and casually evaluate the intended and unintended effects of the PRFSs. In this paper, we evaluate the incremental impact of the REF 2014 in the fields of Economics and Business. We use a synthetic control method to compare the performance of UK universitie…
Small-time bilinear control of Schrödinger equations with application to rotating linear molecules
2023
In [14] Duca and Nersesyan proved a small-time controllability property of nonlinear Schrödinger equations on a d-dimensional torus $\mathbb{T}^d$. In this paper we study a similar property, in the linear setting, starting from a closed Riemannian manifold. We then focus on the 2-dimensional sphere $S^2$, which models the bilinear control of a rotating linear top: as a corollary, we obtain the approximate controllability in arbitrarily small times among particular eigenfunctions of the Laplacian of $S^2$.
Z-Scan theory for thin film measurements: Validation of a model beyond the standard approach using ITO and HfO2
2023
The Z-Scan technique is an easy and widespread approach to evaluate the nonlinear optical coefficient of materials. However, the evaluation of the same coefficients for thin films requires complex experimental setups that allow to remove the contributions of the substrate. Here, we propose a simple, yet effective, theoretical approach that allows to include the substrate contribution to the focusing effect when scanning along the propagation axis. The proposed method therefore removes the need of complex experimental setups and paves the way for a simpler retrieval of optical properties of complex nanostructures.
The linearized Calderón problem for polyharmonic operators
2023
In this article we consider a linearized Calderón problem for polyharmonic operators of order 2m (m ≥ 2) in the spirit of Calderón’s original work [7]. We give a uniqueness result for determining coefficients of order ≤ 2m − 1 up to gauge, based on inverting momentum ray transforms. peerReviewed
Review of carbon emissions offsetting guidelines using instructional criteria
2023
Abstract Purpose Carbon offsetting is one of the tools that companies can use to achieve their climate targets. The ability of a company to offset its emissions successfully depends on the availability and quality of guidance on the subject. This study explores how well existing offsetting guidelines equip corporations to achieve successful emissions offsetting. Methods Instructional criteria were developed and used to evaluate seven guidelines. The contents of each guideline were assessed based on how they instruct a company to achieve emissions offsetting that fulfills five criteria for appropriate offsetting: target affiliation, Paris compatibility, effectiveness, prioritizing removals, …
Design and model test of a soft-connected lattice-structured floating solar photovoltaic concept for harsh offshore conditions
2023
Various types of floating solar photovoltaic (FPV) devices have been previously proposed, designed and constructed with applications primarily limited to onshore water bodies or nearshore regions with benign environmental conditions. This paper proposes a novel FPV concept which can survive harsh environmental conditions with extreme wave heights above 10 m. This concept uses standardised lightweight semi-submersible floats made of circular materials as individual modules. The floating modules are soft connected with ropes to form an FPV array. We first present the conceptual design of the floats and the connection systems, including hydrostatic, hydrodynamic, and structural assessments of …
Experimental Tests to Validate a Simple Procedure to Design Dual-Diameter Drip Laterals on Flat Fields
2023
Multiple-diameter laterals reduce the total cost in microirrigation systems, however, the length of each sublateral should be determined carefully to assure appro-priate performance of emitter flow rates. The most accurate method is the numerical trial and error, which is time-consuming. A series of research efforts have been made to propose simple analytical design procedures. By using the power-law form of the Darcy-Weisbach formula, and equal emitters spacing for the sublaterals, Sadeghi et al. (Sadeghi et al. in J Irrig Drain E-ASCE 142:04,016,020, 2016) extended a previously introduced design solution for one-diameter laterals to tapered laterals. Recently, a simplified procedure to de…