showing 36 of ~574560 from 574555 documents
Exploring Gameful Motivation of Autonomous Learners
2022
In this explorative study, we investigated motives of autonomous learners to participate in an online course, and how these motives are related to gameplay motivations, engagement in the course experience, and learning outcomes. The guiding premise for the study has been the idea that learning and game playing carry phenomenal similarities that could be revealed by scrutinizing motives for participating in a massive open online course that does not involve any intentionally game-like features. The research was conducted by analyzing survey data (N = 705) collected from individuals who had voluntarily participated in an open online course about artificial intelligence and its societal impact…
RF Acquisition System Based on μTCA for Testing of High-Gradient Acceleration Cavities
2022
The radio frequency (RF) laboratory hosted in the Corpuscular Physics Institute (IFIC) of the University of Valencia is designed to house a high-power and high-repetition-rate facility to test normal conduction RF accelerator cavities in the S-Band (2.9985 GHz) in order to perform R&D activities related to particle accelerator cavities. The system, which manages the entire process of RF signal generation, data acquisition and closed-loop control of the laboratory, is currently based on a modular and compact PXI platform system. This contribution details the development of a platform with similar features, but which is based on open architecture standards at both the hardware and softwar…
Neurological Screening in Elderly Liver Transplantation Candidates: A Single Center Experience.
2022
Background: Cerebral small vessels disease (cSVD) is an age-related disorder and risk factor for stroke and cognitive/motor impairments. Neurological complications (NCs) are among the causes of adverse outcomes in older liver transplant recipients. This study sought to determine whether cSVD predicts acute NCs in over 65-year-old liver transplant patients. Methods: Data were collected, from a retrospective medical chart review, of 22 deceased donor liver transplant recipients aged 65 years or older with a pre-operative brain magnetic resonance imaging (MRI). We used the Fazekas score (0–3) as a quantitative measurement of the vascular lesion load seen in the MRI. We analyzed all post-operat…
Vitamin D Deficiency in Cushing’s Disease: Before and After Its Supplementation
2022
Background: The primary objective of the study was to assess serum 25-hydroxyvitamin D [25(OH)D] values in patients with Cushing’s disease (CD), compared to controls. The secondary objective was to assess the response to a load of 150,000 U of cholecalciferol. Methods: In 50 patients with active CD and 48 controls, we evaluated the anthropometric and biochemical parameters, including insulin sensitivity estimation by the homeostatic model of insulin resistance, Matsuda Index and oral disposition index at baseline and in patients with CD also after 6 weeks of cholecalciferol supplementation. Results: At baseline, patients with CD showed a higher frequency of hypovitaminosis deficiency (p = 0…
Modulating the reaction pathway of phenyl diazonium ions using host–guest complexation with cucurbit[7]uril
2022
Aryl diazonium ions are known to be an important intermediate in the divergent synthesis of azo compounds and substituted aromatics. The presence of more than one electrophilic center in a diazonium ion could lead to undesirable side reactions during a synthesis. Herein, we report that the electrophilic α-carbon on a phenyl diazonium [PhN2]+ ion can be selectively deactivated upon host–guest complexation with cucurbit[7]uril (CB7) in aqueous media, achieving a ∼60-fold increase in the half-life of [PhN2]+. Notably, however, the electrophilic nitrogen of the encapsulated diazonium ion remains active towards diazo coupling with strong nucleophiles, allowing the formation of azo compounds usin…
Finance journal rankings : A paper affiliation methodology
2022
PurposeIn this paper, the authors use a new methodology, called paper affiliation index, to create finance journal ranking using expert judgment and research impact, both of which are based on secondary, objective measures, thus making it possible to produce lists every year without human manipulation at virtually no cost.Design/methodology/approachBibliometrics. Python implementation.FindingsA new ranking with 65 finance journals.Research limitations/implicationsThis procedure helps to reduce bias and to deal with known problems associated with current methodologies. The data used in the methodology comes from public sources; the procedure is therefore easily replicable. This methodology i…
Fundamental Analysis of Grid-Forming Converters Enhanced with Feedforward Controls
2022
The grid-forming control for power converters can be enhanced by proper feedforward terms included in the active power control loop. Two basic structures are identified, the feedforward angle and the feedforward frequency. The formal analysis of the transfer functions reveals a structural similarity. The two schemes exhibit however a fundamental difference in their transient capabilities. The grid-forming controls are characterized with the introduction of two specific factors, for the direct assessment of the inertia and the damping which can be provided by the grid-forming converter. The sensitivity analysis of the two feedforward schemes indicates that the enhancement of the transient pe…
Behavioral Activation through Virtual Reality for Depression: A Single Case Experimental Design with Multiple Baselines
2022
Behavioral activation (BA) is a structured psychotherapeutic approach for the treatment of major depressive disorder (MDD), which aims at increasing the engagement in activities that might bring enjoyment and meaning to patients’ lives. Although a growing body of evidence supports the effectiveness of BA, enhancing the motivation and activity level of depressed patients is often challenging. In the present study, we explored the effectiveness of a brief BA treatment supported by virtual reality (VR) to facilitate the visualization and anticipation of four pleasurable activities that we tried to re-introduce in the patients’ daily routine. To do so, we conducted a single-case experimental de…
PTEN Deletion in Adult Mice Induces Hypoinsulinemia With Concomitant Low Glucose Levels
2022
The PI3K/AKT pathway, negatively regulated by PTEN, plays a paramount role in glucose metabolism regulation due to its activation by the insulin receptor signaling pathway. We generated a PTEN-KO mouse to evaluate the systemic effect of the overactivation of the PI3K/AKT pathway in insulin signaling and glucose homeostasis. Our results demonstrate that PTEN-KO mice show very low glucose levels in the fasted state, which poorly respond to glucose and pyruvate administration. Insulinemia decreased without alterations in pancreatic islets. Among the possible reasons, we uncover the deregulation of the expression of proximal tubule glucose transporter and consequent glycosuria. Moreover, we evi…
IMAGE ORIENTATION WITH A HYBRID PIPELINE ROBUST TO ROTATIONS AND WIDE-BASELINES
2022
Abstract. The extraction of reliable and repeatable interest points among images is a fundamental step for automatic image orientation (Structure-From-Motion). Despite recent progresses, open issues in challenging conditions - such as wide baselines and strong light variations - are still present. Over the years, traditional hand-crafted methods have been paired by learning-based approaches, progressively updating the state-of-the-art according to recent benchmarks. Notwithstanding these advancements, learning-based methods are often not suitable for real photogrammetric surveys due to their lack of rotation invariance, a fundamental requirement for these specific applications. This paper p…
Reciprocal Relationships Between Perceived Supportive School Climate and Self-reported Truancy : A Longitudinal Study from Grade 6 to Grade 9
2022
This longitudinal study of 1,066 Finnish students examined bidirectional reciprocal relationships between changes in perceived supportive school climate and changes in self-reported truancy from the last year of primary school (Grade 6) to the last year of lower secondary school (Grade 9). The results of the random intercept cross-lagged panel model showed, first, that a decrease in positive perceptions of school climate at the previous time point predicted more self-reported truancy at the following time point. Second, an increase in self-reported truancy predicted less positive perceptions of supportive school climate. The study indicates that students’ perceptions of supportive school cl…
Diversity Assessment and DNA-Based Fingerprinting of Sicilian Hazelnut (Corylus avellana L.) Germplasm
2022
The characterization of plant genetic resources is a precondition for genetic improvement and germplasm management. The increasing use of molecular markers for DNA-based genotype signature is crucial for variety identification and traceability in the food supply chain. We collected 75 Sicilian hazelnut accessions from private and public field collections, including widely grown varieties from the Nebrodi Mountains in north east Sicily (Italy). The germplasm was fingerprinted through nine standardized microsatellites (SSR) for hazelnut identification to evaluate the genetic diversity of the collected accessions, validating SSR discrimination power. We identified cases of homonymy and synonym…
Strengths and Weaknesses of Cancer Pain Management in Italy: Findings from a Nationwide SIAARTI Survey
2022
Objectives: Despite guidelines, a large percentage of cancer patients continue to suffer from ineffectively treated pain. The authors undertook this survey to assess the strengths and weaknesses of cancer pain management in Italy. Design: This was a prospectively administered survey. Participants: The participants were anesthesiologists of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Intervention: A 58-item questionnaire covered the demographics and features of cancer pain management in the Italian context. Results: The authors received responses from 611 pain therapists of 279 centers. Only 22% of physicians are exclusively pain therapists. Seve…
Effective targeting of breast cancer stem cells by combined inhibition of Sam68 and Rad51
2022
AbstractBreast cancer (BC) is the second cause of cancer-related deceases in the worldwide female population. Despite the successful treatment advances, 25% of BC develops resistance to current therapeutic regimens, thereby remaining a major hurdle for patient management. Current therapies, targeting the molecular events underpinning the adaptive resistance, still require effort to improve BC treatment. Using BC sphere cells (BCSphCs) as a model, here we showed that BC stem-like cells express high levels of Myc, which requires the presence of the multifunctional DNA/RNA binding protein Sam68 for the DNA-damage repair. Analysis of a cohort of BC patients displayed that Sam68 is an independen…
Readers’ Theater Projects for Special Education : A Randomized Controlled Study
2022
A randomized controlled trial was conducted to study the effectiveness of two readers’ theater (RT) programs in promoting reading skills and motivation of dysfluent readers in Grades 3–4. One program (RT Goal) included a goal of preparing a performance for an audience (n = 50), while another program (RT Practice) did not include such a goal (n = 49). A group of dysfluent readers receiving traditional oral reading intervention (Control group; n = 59) and a group of classroom peers (Mainstream group; n = 159) served as controls. The results indicate that both RT groups and the Control group developed at a higher rate in oral reading speed during the intervention period than the Mainstream gro…
In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum a…
2022
Oily skin from overactive sebaceous glands affects self-confidence and personality. There is report of an association between steroid 5-alpha reductase gene (SRD5A) expression and facial sebum production. There is no study of the effect of Asparagus racemosus Willd. root extract on the regulation of SRD5A mRNA expression and anti-sebum efficacy. This study extracted A. racemosus using the supercritical carbon dioxide fluid technique with ethanol and investigated its biological compounds and activities. The A. racemosus root extract had a high content of polyphenolic compounds, including quercetin, naringenin, and p-coumaric acid, and DPPH scavenging activity comparable to that of the standa…
Keep Them Engaged! Investigating the Effects of Self-centered Social Media Communication Style on User Engagement in 12 European Countries
2022
On Facebook, patterns of user engagement largely shape what types of political contents citizens can see on the platform. Higher engagement leads to higher visibility. Therefore, one of the major goals of political actors' Facebook communication is to produce content with the potential to provoke user engagement, and thereby increase their own visibility. This study introduces the concept of self-centered social media communication style which focuses on 'salient' and 'owned' issues with populist and negative appeals and investigates how user engagement is related to its main elements. We also explore how users' receptivity to these content-related factors is shaped by country context. More…
Atomic physics, optical technologies and medical physics, 10-11.02.2022.,Riga
2022
80th International Scientific Conference of the University of Latvia Section ‘Atomic physics, optical technologies and medical physics’ will be held by Institute of Atomic Physics and Spectroscopy (IAPS) on 10-11.02.2022. The section will present the recent results, achieved by IAPS researchers and the IAPS partners in the following research fields: optical phenomena in gas, liquid, solid state and biological samples, optical methods for diagnostics, chemical analysis and optical sensor technologies, quantum optics and telecommunication, modelling, novel nanomaterials and their biomedical applications. Total 27 abstracts.
Anodal Transcranial Direct Current Stimulation Over Prefrontal Cortex Slows Sequence Learning in Older Adults
2022
Aging is associated with declines in sensorimotor function. Several studies have demonstrated that transcranial direct current stimulation (tDCS), a form of non-invasive brain stimulation, can be combined with training to mitigate age-related cognitive and motor declines. However, in some cases, the application of tDCS disrupts performance and learning. Here, we applied anodal tDCS either over the left prefrontal cortex (PFC), right PFC, supplementary motor complex (SMC), the left M1, or in a sham condition while older adults (n = 63) practiced a Discrete Sequence Production (DSP), an explicit motor sequence, task across 3 days. We hypothesized that stimulation to either the right or left P…
La co-construction de l’action contre la précarité étudiante : quelle place des organisations étudiantes pendant la crise sanitaire à Paris ?
2022
International audience
Magnetotransport Studies of Encapsulated Topological Insulator Bi2Se3 Nanoribbons
2022
This research was funded by the Latvian Council of Science, project “Highly tunable surface state transport in topological insulator nanoribbons”, No. lzp-2020/2-0343, and by the European Union’s Horizon 2020 research and innovation program, Grant Agreement No. 766714/ HiTIMe. Institute of Solid-State Physics, University of Latvia as the Center of Excellence has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2.
Task-oriented reading efficiency : interplay of general cognitive ability, task demands, strategies and reading fluency
2022
AbstractThe associations among readers’ cognitive skills (general cognitive ability, reading skills, and attentional functioning), task demands (easy versus difficult questions), and process measures (total fixation time on relevant and irrelevant paragraphs) was investigated to explain task-oriented reading accuracy and efficiency (number of scores in a given time unit). Structural equation modeling was applied to a large dataset collected with sixth-grade students, which included samples of dysfluent readers and those with attention difficulties. The results are in line with previous findings regarding the dominant role of general cognitive ability in the accuracy of task-oriented reading…
Roles of the Core Components of the Mammalian miRISC in Chromatin Biology
2022
The Argonaute (AGO) and the Trinucleotide Repeat Containing 6 (TNRC6) family proteins are the core components of the mammalian microRNA-induced silencing complex (miRISC), the machinery that mediates microRNA function in the cytoplasm. The cytoplasmic miRISC-mediated post-transcriptional gene repression has been established as the canonical mechanism through which AGO and TNRC6 proteins operate. However, growing evidence points towards an additional mechanism through which AGO and TNRC6 regulate gene expression in the nucleus. While several mechanisms through which miRISC components function in the nucleus have been described, in this review we aim to summarize the major findings that have …
A Central Nervous System Focused Treatment Program for People with Frozen Shoulder: A Feasibility Study
2022
Background: Frozen shoulder (FS) is a highly disabling pathology of poorly understood etiology, which is characterized by the presence of intense pain and progressive loss of range of motion (ROM). The aim of this study is to evaluate the feasibility and clinical impact of a CNS-focused treatment program for people with FS. Methods: 10 subjects with primary FS received a 10-week CNS-focused intervention including sensory discrimination training and graded motor imagery techniques delivered as clinic sessions (60 min) and home therapy (30 min five times per week). Measurements were taken at baseline, after a 2-week “washout” period, after treatment, and at three months follow-up.…
Infrasonic, Acoustic and Seismic Waves Produced by the Axion Quark Nuggets
2022
We advocate an idea that the Axion Quark Nuggets (AQN) hitting the Earth can be detected by analysing the infrasound, acoustic and seismic waves which always accompany the AQN's passage in the atmosphere and underground. Our estimates for the infrasonic frequency $\nu\simeq 5$ ~Hz and overpressure $\delta p\sim 0.3 ~$Pa for relatively large size dark matter (DM) nuggets suggest that sensitivity of presently available instruments is already sufficient to detect very intense (but very rare) events today with existing technology. A study of much more frequent but less intense events requires a new type of instruments. We propose a detection strategy for a systematic study to search for such re…
Halloysite based geopolymers filled with wax microparticles as sustainable building materials with enhanced thermo-mechanical performances
2022
This work proposes a novel protocol for the fabrication of halloysite based geopolymers filled with beeswax microparticles obtained from Pickering emulsions. The actual filling of the microwax into the geopolymers has been demonstrated by using several techniques, including thermal analyses, spectroscopies, microscopies and contact angle experiments. According to the morphological and structural investigations, microwax spherical particles (diameter ranging between ca. 3 and 5 μm) have been homogeneously dispersed within the geopolymeric network conferring excellent properties to the hybrid geopolymers in terms of mechanical performances and heat storage capacity although their low content …
Unique Problems Require Unique Solutions—Models and Problems of Linking School Effectiveness and School Improvement
2022
The article aims to outline the proposals for linking school effectiveness research and school improvement that are currently relevant in international discussion and to ask how they deal with the ‘technology deficit’ at the level of model improvement. We will first show the difference between school improvement and school effectiveness. Then, we outline areas showing basic problems associated with linking school effectiveness and school improvement. After that, we present a summary of two relevant models for linking school effectiveness research and school improvement—Comprehensive Framework of Effective School Improvement and Dynamic Model of Educational Effectiveness&md…
Modern Finnish Economic History
2022
The Finnish economy has experienced a relative late growth and catch-up process in relation to many other advanced Western economies. During this growth period, Finland also experienced a rapid structural change from an agrarian society to a developed service society. In a small open economy, the export industries have played a vital role in this development. Over several centuries, the forest industries have had a dominating impact in exports, along with the metal industries; however, the latter, as well as the electronics industry, with Nokia as the flagship company, gained more importance in the late 20th century in aggregate exports. The egalitarian educational system has to a large ext…
Cavity-induced bifurcation in classical rate theory
2022
We show how coupling an ensemble of bistable systems to a common cavity field affects the collective stochastic behavior of this ensemble. In particular, the cavity provides an effective interaction between the systems, and parametrically modifies the transition rates between the metastable states. We predict that the cavity induces a collective phase transition at a critical temperature which depends linearly on the number of systems. It shows up as a spontaneous symmetry breaking where the stationary states of the bistable system bifurcate. We observe that the transition rates slow down independently of the phase transition, but the rate modification vanishes for alternating signs of the …
"Dangerous liaisons: NAFLD and liver fibrosis increase cardiovascular risk in HIV".
2022
Objectives Non-alcoholic fatty liver disease (NAFLD) is strongly associated with cardiovascular disease in the general population. We aimed to assess the impact of NAFLD and liver fibrosis on intermediate-high cardiovascular risk in people living with HIV. Methods We included people living with HIV from three cohorts. NAFLD and significant liver fibrosis were defined using transient elastography: controlled attenuation parameter >= 288 dB/m and liver stiffness measurement >= 7.1 kPa, respectively. Cardiovascular risk was assessed with the atherosclerotic cardiovascular disease (ASCVD) risk estimator in patients aged between 40 and 75 years and categorised as low if <5%, borderline …
Spectral signatures of axionlike dark matter
2022
We derive spectral line shapes of the expected signal for a haloscope experiment searching for axionlike dark matter. The knowledge of these line shapes is needed to optimize an experimental design and data analysis procedure. We extend the previously known results for the axion-photon and axion-gluon couplings to the case of gradient (axion-fermion) coupling. A unique feature of the gradient interaction is its dependence not only on magnitudes but also on directions of velocities of galactic halo particles, which leads to the directional sensitivity of the corresponding haloscope. We also discuss the daily and annual modulations of the gradient signal caused by the Earth's rotational and o…
Tetracyclic silaheterocycle formed through a pericyclic reaction cascade including a two-fold intramolecular C–C bond activation
2022
Reductive debromination of the tribromoamidosilane 2 gave the tetracyclic silaheterocycle 3 through a unique reaction cascade involving unprecedented two-fold intramolecular cycloaddition by transient silylenes. Experimental and computational analyses of the reaction mechanism allowed the identification of the key intermediates that lead to the silaheterocycle 3 or, alternatively, to the cyclotrisilene 19. peerReviewed
Validity and Reliability of questionnaires measuring attitudes to oral health: A review of the literature
2022
The instruments used to assess attitudes to oral health must be validated in order for their results to be reliable and comparable with other variables. The aim of this review was to analyze the ability of self-administered questionnaires to validly and reliably measure attitudes to oral health.A bibliographic review was carried out using the following databases, Medline (PubMed), SCOPUS and Web of Science from the year 2016 to 2021, using the keywords: (questionnaire* OR survey*) AND (attitude* OR behav*) AND ("oral health" OR "dental care") AND (validity OR reliability).A total of 234 original articles were found in the databases, only 22 met the selection criteria, of which 13 were aimed…
Study of light scalar mesons through Ds+→π0π0e+νe and KS0KS0e+νe decays
2022
Practitioners’ Perceptions of Co-Product Allocation Methods in Biorefinery Development—A Case Study of the Austrian Pulp and Paper Indust…
2022
The utilization of coproducts is a strategy that can be applied to increase the economic and environmental performance of industrial processes and thus reach an objective targeted in several environmental policies. In multi-output production processes, allocation needs to be performed to assess the products’ environmental and economic performance. It is crucial to choose an adequate allocation method, because this choice has been shown to strongly influence overall outcomes. Consequently, rash choices can lead to poor decision-making. Various ways to apply and combine allocation methods can be found in the academic literature, but it is often difficult to find sufficient guidance on how to …