showing 36 of ~574560 from 574555 documents
Safety and benefit of incretin-based therapies in patients with type 2 diabetes: learnings and reflections
2022
Passions de l’intérêt. Matérialisme et anthropologie chez Helvétius et Diderot
2022
International audience; Qu’en est-il de la « philosophie de l’intérêt » dans l’histoire du matérialisme du XVIIIe siècle ? En prenant l’intérêt depuis son déploiement anthropologique chez Helvétius et Diderot, ce livre apporte les éléments pour une révision de l’histoire moderne de la philosophie.On suivra le fil conducteur qui définit la science de l’homme comme le domaine des lois de l’intérêt, c’est-à-dire ce qui, chez Condillac, présidait à la genèse des opérations mentales : un mouvement propre à l’homme ordonné par la recherche du plaisir et la fuite de la douleur. La science de l’homme comme être intéressé se déploie en une théorie de la connaissance comme intérêt, une analyse des pa…
Safety and efficacy of a probiotic-containing infant formula supplemented with 2'-fucosyllactose: a double-blind randomized controlled trial
2022
Abstract Background Human milk oligosaccharides (HMOs) have important and diverse biological functions in early life. This study tested the safety and efficacy of a starter infant formula containing Limosilactobacillus (L.) reuteri DSM 17938 and supplemented with 2’-fucosyllactose (2’FL). Methods Healthy infants < 14 days old (n = 289) were randomly assigned to a bovine milk-based formula containing L. reuteri DSM 17938 at 1 × 107 CFU/g (control group; CG) or the same formula with added 1.0 g/L 2’FL (experimental group; EG) until 6 months of age. A non-randomized breastfed group served as reference (BF; n = 60). The primary endpoint was weight gain through 4 months of age in the formula-…
Competition, Gender Equality, and Doping in Sports in the Red Queen Effect Perspective
2022
The nature of sports is characterized by a strong competitive component that generates inequalities among athletes at different levels, specifically in relation to gender, technology, and doping. These inequalities can be represented according to the Red Queen effect perspective, which has been previously hypothesized in other competitive environments (evolutionary biology and economics, for instance). The Red Queen effect considers each competitive environment to require a constant effort to maintain a position of competitive advantage in order reach the best result possible. Therefore, the aim of the current paper is to provide an innovative perspective for the understanding of competitio…
European Society of Cardiology
2022
Abstract Aims This report from the European Society of Cardiology (ESC) Atlas Project updates and expands upon the widely cited 2019 report in presenting cardiovascular disease (CVD) statistics for the 57 ESC member countries. Methods and results Statistics pertaining to 2019, or the latest available year, are presented. Data sources include the World Health Organization, the Institute for Health Metrics and Evaluation, the World Bank, and novel ESC sponsored data on human and capital infrastructure and cardiovascular healthcare delivery. New material in this report includes sociodemographic and environmental determinants of CVD, rheumatic heart disease, out-of-hospital cardiac arrest, left…
Development of a predictive model for the shelf-life of Atlantic mackerel (Scomber scombrus)
2022
Despite its commercial value, the shelf-life of the Atlantic mackerel (Scomber scombrus) during refrigerated storage was poorly investigated. In this regard, the Quality Index Method (QIM) was proposed as a suitable scoring system for freshness and quality sensorial estimation of fishery products. This study aims to develop a deterministic mathematical model based on dynamic temperatures conditions and a suc-cessive statistical analysis of the results obtained. This model will be exploited to predict the shelf-life of the Atlantic mackerel based on specific storage temperatures. A total of 60 fresh fishes were subdivided into two groups and respectively stored in ice for 12 days at a consta…
New Insights in Prevention and Treatment of Cardiovascular Disease
2022
Cardiovascular (CV) disease (CVD) is still a major cause of morbidity and mortality in many countries in Europe although considerable efforts have been made in recent decades to address this disease in an even more “comprehensive” approach [...]
Unit Interval Time and Magnitude Monitoring Using Beta and Unit Gamma Distributions
2022
Quick detection of an assignable cause is necessary for process accuracy with respect to the specifications. The aim of this study is to monitor the time and magnitude processes based on unit-interval data. To this end, maximum exponentially weighted moving average (Max-EWMA) control chart for simultaneous monitoring time and magnitude of an event is proposed. To be precise, beta and unit gamma distributions are considered to develop the Max-EWMA chart. The chart’s performance is accessed using average run length (ARL), the standard deviation of run length (SDRL), and different quantiles of the run length distribution through extensive Monte Carlo simulations. Besides a comprehensive simula…
Older Women's Loneliness and Depression Decreased by a Reminiscence Program in Times of COVID-19.
2022
The confinement caused by the current COVID-19 pandemic protects physical health, but in turn, has a long-lasting and far-reaching negative psychosocial impact; anxiety, stress, fear and depressive symptoms. All of these have a particular impact on vulnerable older people, putting them at serious risk of loneliness. Women report feeling lonelier than men, affecting women to a greater extent. The present study aims to analyze the efficacy of an integrative reminiscence intervention in older women living in nursing homes to reduce the effects of loneliness and depression after COVID-19. 34 older women living in nursing homes are included into study and were divided into intervention group (N …
Effects of Tray-Drying on the Physicochemical, Microbiological, Proximate, and Sensory Properties of White- and Red-Fleshed Loquat (Eriobotrya Japoni…
2022
Loquat fruits, highly valued by consumers for their characteristic aroma and pleasant taste, have a short post-harvest life and are susceptible to mechanical damage, loss of firmness, and initial organoleptic characteristics. The aim of this work was to develop a drying method suitable for storing loquat fruits in polyamide/polyethylene (PA/PE) bags containing two gaseous mixtures (treatments): MAPN2 (100% N2) and MAPP (21% O2 and 0.04% CO2), at room temperature (20 ± 1 °C) for at least 2 months. The effects of these conditions on the physico-chemical, microbiological, proximate, and sensory properties of fruit stored over a 50-day time interval were studied. The results showed that convect…
Intercultural Aspects of Specialized Translation The Language of Traditional Chinese Medicine in a Globalized Context
2022
Traditional Chinese Medicine (TCM) has a very ancient history and its importance for human health has long been acknowledged worldwide. The significant role that TCM plays in the global healthcare system has been officially recognized by the World Health Organization (WHO), which devoted a chapter to TCM in the 2019 latest version of the International Classification of Diseases and Related Health Problems (ICD-11). TCM, alone or in combination with Western Medicine (WM), has been recommended for various health conditions (Aung et al., 2013; Cai et al., 2015; Zhang et al., 2015) – including mild COVID-19-related symptoms (Zhao et al. 2021). As a result of globalization, which has fostered th…
Surgical Antimicrobial Prophylaxis in Abdominal Surgery for Neonates and Paediatrics: A RAND/UCLA Appropriateness Method Consensus Study.
2022
Surgical site infections (SSIs), i.e., surgery-related infections that occur within 30 days after surgery without an implant and within one year if an implant is placed, complicate surgical procedures in up to 10% of cases, but an underestimation of the data is possible since about 50% of SSIs occur after the hospital discharge. Gastrointestinal surgical procedures are among the surgical procedures with the highest risk of SSIs, especially when colon surgery is considered. Data that were collected from children seem to indicate that the risk of SSIs can be higher than in adults. This consensus document describes the use of preoperative antibiotic prophylaxis in neonates and children that ar…
Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain.
2022
The aim of this study was to develop and refine a heterologous mouse model of endometriosis-associated pain in which non-evoked responses, more relevant to the patient experience, were evaluated. Immunodeficient female mice (N = 24) were each implanted with four endometriotic human lesions (N = 12) or control tissue fat (N = 12) on the abdominal wall using tissue glue. Evoked pain responses were measured biweekly using von Frey filaments. Non-evoked responses were recorded weekly for 8 weeks using a home cage analysis (HCA). Endpoints were distance traveled, social proximity, time spent in the center vs. outer areas of the cage, drinking, and climbing. Significant differences between groups…
Recipient Design by Gestures : How Depictive Gestures Embody Actions in Cooking Instructions
2022
This paper investigates how depictive gestures, i.e., hand movements that depict actions, scenes or objects, are configured and used for accomplishing instructions. By drawing on video recordings of second language interactions in cooking classes for newcomers in Finland, we focus on instructions that project a certain type of complying bodily action as the relevant next action. We demonstrate that the instructions are designed to be sensitive not only to the contingencies of the material ecology of the kitchen but also to the epistemic and linguistic asymmetries between the participants. The analysis shows how depictive gestures contribute to the forward-feeding function of cooking instruc…
Editorial: The Incredible Challenge of Digitizing the Human Brain
2022
The world we live in is drastically different from previous decades in terms of digitalization expansion. Logically, one might expect that these changes modify the way we behave, our habits, the way we do tasks, communicate and access information (Moret-Tatay et al., 2018; Wang et al., 2021). And, therefore, the functioning of the brain and even its anatomy. If so, it seems imperative to examine how it affects our cognition. Furthermore, based on the assumption that the brain is plastic and adaptable, some alterations and changes are expected to optimize resources or even compensations by improving other skills (Oliveira et al., 2018; Bubbico et al., 2020; Della Gatta et al., 2021).
Maradona and China: Perceptions and representations of a sports myth
2022
This article highlights specific aspects of the relationship between Maradona and the People���s Republic of China (PRC) to trace the development of the ���one-athlete brand��� in global sport and the construction of the ���foreign��� sports myth in China. These aspects include the aligned development of football in China and Maradona as an icon, manifested in the gap in the domestic space for Western athletic icons in China and Maradona���s rise during the 1986 World Cup; the political identity and interpretation of Maradona as a supporter of communist and socialist regimes amidst China���s opening and international integration; and the modern development of the Chinese sports machine and …
Non-homogeneous Dirichlet problems with concave-convex reaction
2022
The variational methods are adopted for establishing the existence of at least two nontrivial solutions for a Dirichlet problem driven by a non-homogeneous differential operator of p-Laplacian type. A large class of nonlinear terms is considered, covering the concave-convex case. In particular, two positive solutions to the problem are obtained under a (p -1)-superlinear growth at infinity, provided that a behaviour less than (p -1)-linear of the nonlinear term in a suitable set is requested.
Chitosan Functionalized with Carboxyl Groups as a Recyclable Biomaterial for the Adsorption of Cu (II) and Zn (II) Ions in Aqueous Media
2022
The modification of chitosan represents a challenging task in obtaining biopolymeric materials with enhanced removal capacity for heavy metals. In the present work, the adsorption characteristics of chitosan modified with carboxyl groups (CTS-CAA) towards copper (II) and zinc (II) ions have been tested. The efficacy of the synthesis of CTS-CAA has been evaluated by studying various properties of the modified chitosan. Specifically, the functionalized chitosan has been characterized by using several techniques, including thermal analyses (differential scanning calorimetry and thermogravimetry), spectroscopies (FT-IR, XRD), elemental analysis, and scanning electron microscopy. The kinetics an…
Mihi cane et populo: Cicerone e l’autorappresentazione del successo oratorio. La questione del consenso popolare (Cic. Brut. 183–200)
2022
Come si rappresenta il proprio successo? La tradizione poetica greca e latina conosce straordinarie immagini di consacrazioni delle virtù di poeta, elaborate con ricche e ornate costruzioni, la cui persistenza nella memoria letteraria ne assicura la vitalità. A fronte di tali esibizioni virtuosistiche, che dichiarano l’orgoglio del successo, ve ne sono altre, costruite altrettanto finemente ma dall’architettura più complessa, perché fondata su una più mediata strategia. Su una di queste, proveniente da un testo in prosa, ma da un autore quale Cicerone che ambiva non a caso anche al riconoscimento come poeta, vorrei provare a riflettere. Il passo in questione è un’ampia sequenza del Brutus (…
Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties
2022
Due to its chemical properties and multiple molecular effects on different tumor cell types, the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with significant potential in cancer therapy. PN has been shown to induce either classic apoptosis or alternative caspase-independent forms of cell death in many tumor models. The therapeutical potential of PN has been increased by chemical design and synthesis of more soluble analogues including dimethylaminoparthenolide (DMAPT). This review focuses on the molecular mechanisms of both PN and analogues action in tumor models, highlighting their effects on gene expression, signal transduction and execution of different ty…
Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells E…
2022
Idebenone is a ubiquinone short-chain synthetic analog with antioxidant properties, which is believed to restore mitochondrial ATP synthesis. As such, idebenone is investigated in numerous clinical trials for diseases of mitochondrial aetiology and it is authorized as a drug for the treatment of Leber’s hereditary optic neuropathy. Mitochondria of retinal pigment epithelium (RPE) are particularly vulnerable to oxidative damage associated with cellular senescence. Therefore, the aim of this study was to explore idebenone’s cytoprotective effect and its underlying mechanism. We used a human-RPE cell line (ARPE-19) exposed to idebenone pre-treatment for 24 h followed by conditions …
Allee effect in a manipulative parasite within poikilothermic host under temperature change
2022
AbstractTemperature and intraspecific competition are important factors influencing the growth of all organisms, including parasites. The temperature increase is suggested to stimulate the development of parasites within poikilothermic hosts. However, at high parasite densities, this effect could be diminished, due to stronger intraspecific competition. Our study, for the first time, addressed the joint effects of warming and parasite abundances on parasite growth in poikilothermic hosts. The growth of the common fish parasite larvae (trematode Diplostomum pseudospathaceum) within the rainbow trout at different infection intensities and temperatures (15°C and 18°C) was experimentally invest…
Does Drug Holiday Affect Jaw Trabeculation in Medication Related Osteonecrosis of the Jaw? – A Pilot Study
2022
The role of drug holiday in long term antiresorptive drug users to prevent MRONJ is debated for quite some time. We aimed to compare jawbone trabeculation between patients on drug holiday with those not on drug holiday among Medication Related Osteonecrosis of the Jaw (MRONJ) cases using fractal analysis and to estimate the frequency of MRONJ despite being on drug holiday.The sample of 18 MRONJ cases were divided into drug holiday, and non-drug holiday groups. Non-drug holiday group was further divided into pre- and post- drug holiday groups. Jawbone trabeculation was assessed utilizing fractal analysis method (ImageJ software) by two observers. ANOVA was used to compare the fractal dimensi…
Haplotype analyses reveal novel insights into tomato history and domestication driven by long-distance migrations and latitudinal adaptations.
2022
Abstract A novel haplotype-based approach that uses Procrustes analysis and automatic classification was used to provide further insights into tomato history and domestication. Agrarian societies domesticated species of interest by introducing complex genetic modifications. For tomatoes, two species, one of which had two botanical varieties, are thought to be involved in its domestication: the fully wild Solanum pimpinellifolium (SP), the wild and semi-domesticated Solanum lycopersicum var. cerasiforme (SLC) and the cultivated S. l. var. lycopersicum (SLL). The Procrustes approach showed that SP evolved into SLC during a gradual migration from the Peruvian deserts to the Mexican rainforests…
Color and Timbre Gestures: An Approach with Bicategories and Bigroupoids
2022
White light can be decomposed into different colors, and a complex sound wave can be decomposed into its partials. While the physics behind transverse and longitudinal waves is quite different and several theories have been developed to investigate the complexity of colors and timbres, we can try to model their structural similarities through the language of categories. Then, we consider color mixing and color transition in painting, comparing them with timbre superposition and timbre morphing in orchestration and computer music in light of bicategories and bigroupoids. Colors and timbres can be a probe to investigate some relevant aspects of visual and auditory perception jointly with thei…
Is periodontitis associated with obstructive sleep apnea? A systematic review and meta-analysis
2022
There are conflicting results on the association between periodontitis and obstructive sleep apnea (OSA). In the present study, we performed a contemporaneous systematic review and meta-analysis to clarify this issue. We also tried to find out whether periodontitis is associated with OSA severity.We searched the literature published from the inception to 31 December 2021 from the databases of Embase, PubMed, Scopus, and Web of Science, using a combination of suitable keywords, without language restriction. We included observational studies recruiting adults (≥18 years old) that evaluated the association between periodontitis and OSA. Two investigators screened independently the titles and a…
The Advances and Challenges of Liposome-Assisted Drug Release in the Presence of Serum Albumin Molecules: The Influence of Surrounding pH
2022
The aim of this study is to prepare a liposomal delivery system for 5-methyl-12 (H)-quino[3,4-b]-1,4-benzothiazine chloride (5-MBT) and study the in vitro release characteristics. The release of 5-MBT from a liposomal complex with human serum albumin (HSA) [LDPPC/5-MBT]:HSA was examined using the spectrophotometric method and differential scanning calorimetry (DSC). Electronic paramagnetic resonance was used to assess the influence of the pH of the environment on the conformation of phospholipids, the latter determining the degree of release of the encapsulated compound. The applied mathematical models made it possible to determine the necessary analytical parameters to facilitate the proce…
Survival, morphological variability, and performance of Opuntia ficus-indica in a semi-arid region of India
2022
Cactus pear (Opuntia ficus-indica (L.) Mill.) can survive extreme environmental condition and is known for its fodder potential in many parts of the world. The morphological diversity of 15 introduced accessions was evaluated at Jhansi, Uttar Pradesh, India. The plants were established in 2013. Survival and nutrient status were evaluated after two years. Above-ground plant height, biomass, primary and secondary cladode numbers, primary and secondary cladode lengths and below-ground root length, weight, and surface area measurements were done six years after cladode planting. Yellow San Cono, White Roccapalumba, and Seedless Roccapalumba survived 100%. The discriminant traits according to pr…
Nivolumab VERSUS Cabozantinib as Second-Line Therapy in Patients With Advanced Renal Cell Carcinoma: A Real-World Comparison
2022
Background: Tyrosine-kinase inhibitors (TKIs) still represent a first-line option for selected patients with metastatic Renal Cell Carcinoma (mRCC). We aimed to compare the real-world efficacy of nivolumab or cabozantinib as second-line therapy in specific mRCC subpopulations. Patients and Methods: We retrospectively collected data from 11 centers from Italy, Spain and US. Overall Survival (OS) and Progression-Free Survival (PFS) were analyzed using Kaplan-Meier curves. Cox proportional models were used at univariate and multivariate analyses. Results: We collected data from 343 patients with mRCC, 123 (36%) treated with cabozantinib and 220 (64%) with nivolumab. The median OS resulted long…
Worldwide experience of homozygous familial hypercholesterolaemia:retrospective cohort study
2022
[Background]: Homozygous familial hypercholesterolaemia (HoFH) is a rare inherited disorder resulting in extremely elevated low-density lipoprotein cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Current guidance about its management and prognosis stems from small studies, mostly from high-income countries. The objective of this study was to assess the clinical and genetic characteristics, as well as the impact, of current practice on health outcomes of HoFH patients globally.
The Role of Early Revascularization and Biomarkers in the Management of Diabetic Foot Ulcers: A Single Center Experience
2022
Diabetic neuropathy and Peripheral Arterial Disease (PAD) are the main etiological factors in foot ulceration. Herein, we report our experience of diabetic foot ulceration (DFU) management, with an analysis of the relationship between the rate of lower extremity amputation, in persons with infected DFU, after revascularization procedures performed to prevent major amputation. This study highlights the role of different biomarkers, showing their usefulness and potentiality in diabetic foot ulcer management, especially for the early diagnosis and therapy effectiveness monitoring. A retrospective analysis, from September 2016 to January 2021, of diabetic patients presenting diabetic foot with …
Risk Factors for Intra-Abdominal Candidiasis in Intensive Care Units: Results from EUCANDICU Study
2022
INTRODUCTION: Intra-abdominal infections represent the second most frequently acquired infection in the intensive care unit (ICU), with mortality rates ranging from 20% to 50%. Candida spp. may be responsible for up to 10-30% of cases. This study assesses risk factors for development of intra-abdominal candidiasis (IAC) among patients admitted to ICU. METHODS: We performed a case-control study in 26 European ICUs during the period January 2015-December 2016. Patients at least 18 years old who developed an episode of microbiologically documented IAC during their stay in the ICU (at least 48 h after admission) served as the case cohort. The control group consisted of adult patients who did no…
Development of a novel rapamycin loaded nano- into micro-formulation for treatment of lung inflammation
2022
AbstractIt has recently emerged that drugs such as the mTOR inhibitor rapamycin (Rapa) may play a key role in the treatment of airway inflammation associated with lung diseases, such as chronic obstructive pulmonary disease, asthma, and cystic fibrosis. Nevertheless, Rapa clinical application is still prevented by its unfavorable chemical-physical properties, limited oral bioavailability, and adverse effects related to non-specific biodistribution. In this paper, the design and production of a novel formulation of Rapa based on nano into micro (NiM) particles are detailed. To achieve it, Rapa-loaded nanoparticles were produced by nanoprecipitation of an amphiphilic pegylated poly-ɛ-caprolac…
Conceptions of healthcare professionals about rehabilitees’ participation in goal setting in an acute hospital : a phenomenographic study
2022
Purpose: In acute care, effective goal-setting is an essential phase of a successful rehabilitation process. However, professionals’ knowledge and skills in rehabilitee-centered practice may not always match the ways of implementing goal-setting. This study aimed to describe the variation in how acute hospital professionals perceive and comprehend rehabilitee participation in rehabilitation goal-setting. Methods: Data were collected by interviewing 27 multidisciplinary rehabilitation team members in small groups shortly after rehabilitation goal-setting sessions. A qualitative research design based on phenomenography was implemented. Results: We identified four conceptions of rehabilitee pa…
The correlated expression of COX-2 and keratin 15 in radicular cysts
2022
The expression of cyclooxygenase-2 (COX-2) and Keratin-15 (K15) in radicular cysts (RCs) is poorly understood. Identifying the expression of these two markers may modify the current treatment of RC. The objective of this study was to evaluate the expression of COX-2 and its relationship to K15 expression in the odontogenic epithelial cells of the RC.A total of 18 RCs were immunohistochemically analyzed for COX-2 and K15 expression. The cellular inflammatory reaction in the cyst wall was also assessed by measuring the percentage of inflammatory cells to the total number of cells.COX-2 expression in the odontogenic epithelium of RC was absent in 11.1 % (n=2), mild in 27.8 % (n=5), moderate in…
Public and Private Economic Feasibility of Green Areas as a Passive Energy Measure: A Case Study in the Mediterranean City of Trapani in Southern Ita…
2022
Green infrastructure in urban environments provides a wide range of ecological, social, aesthetic, and health co-benefits. Urban plant covers in particular contribute to improved outdoor environmental conditions that, in turn, influence the energy behavior of buildings and their indoor thermo-hygrometric comfort performance. Within this context, this study illustrates a methodology aimed at verifying the economic feasibility of alternative types of green areas for public and private stakeholders, which are analyzed as passive energy measures. Therefore, our methodology integrates approaches from different disciplines and consists of a microclimatic analysis of different vegetation scenarios…