showing 36 of ~574560 from 574555 documents
Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
2022
6 p.-2 fig.-2 tab.
Polypoidal choroidal vasculopathy in pachychoroid: combined treatment with photodynamic therapy and aflibercept
2022
Abstract Introduction To evaluate the effects of combined therapy using intravitreal Aflibercept (IVA) and photodynamic therapy (PDT) on polypoidal choroidal vasculopathy related to pachychoroid disease (PPCV).Methods Patients with PPCV were treated with PDT combined with 3 IVA injections on a monthly basis, followed by pro re nata criteria. The 12-month follow-up consisted of multiple revaluations of visual acuity and SSOCT parameters of clinical activity.Results Nineteen eyes were included in the study; mean age was 65.5 years. Visual acuity improved after 12 months (0.35 ± 0.25 to 0.2 ± 0.20 logMAR, p = 0.005). Percentage of eyes with intraretinal and subretinal fluid reduced from baseli…
Multidimensional Prayer Inventory: Psychometric Properties and Clinical Applications
2022
Prayer is one of the most important aspects of religious/spiritual life. The psychological literature has identified various types of prayer and a few methods for measuring it. The Multidimensional Prayer Inventory (MPI) has received much attention from researchers since it allows for the capture of the most universal forms of prayer, characteristic of the Judeo-Christian tradition: Adoration, Confession, Thanksgiving, Supplication, and Reception. The aim of this article was to examine psychometric properties and clinical applications of the Polish MPI. In four studies, we established the internal structure of the MPI using Principal Component Analysis (PCA, study 1) and Confirmatory Factor…
The influence of advanced age and obesity on pregnancy course and outcome in patients with diabetes mellitus
2022
Introduction: Older women are at greater risk of suffering from a series of comorbidities such as obesity, diabetes, and hypertension that could negatively affect pregnancy course and outcomes. This study aims to investigate the impact of maternal age and pre-pregnancy body mass index (BMI) on pregnancy outcomes of women with diabetes mellitus (DM). Material and methods: The study included 323 diabetic pregnant women. All complications throughout pregnancy and the early neonatal period were noted. The women were divided into groups according to age decade and BMI. Results: 84.8% of women reported pregnancy complications, with a higher prevalence in obese women (p = 0.003). However, most chi…
Association of Dietary Patterns with MRI Markers of Hepatic Inflammation and Fibrosis in the MAST4HEALTH Study
2022
Whereas the etiology of non-alcoholic fatty liver disease (NAFLD) is complex, the role of nutrition as a causing and preventive factor is not fully explored. The aim of this study is to associate dietary patterns with magnetic resonance imaging (MRI) parameters in a European population (Greece, Italy, and Serbia) affected by NAFLD. For the first time, iron-corrected T1 (cT1), proton density fat fraction (PDFF), and the liver inflammation fibrosis score (LIF) were examined in relation to diet. A total of 97 obese patients with NAFLD from the MAST4HEALTH study were included in the analysis. A validated semi-quantitative food frequency questionnaire (FFQ) was used to assess the quality of diet…
Design and evaluation of the psychosocial intervention programme to promote intercultural integration in the Cuban university context
2022
En 2013, El present estudi va tenir com a objectiu dissenyar un programa d'intervenció psicosocial, per a la promoció de la integració intercultural en la Universidad Central “Marta Abreu” de Las Villas, des d'un enfocament historicocultural de les mediacions per la subjectivitat. La recerca és d’intervenció i continua un enfocament qualitatiu i interpretatiu. En aquest marc, es va realitzar una sistematització d'experiències i es va proposar un programa d'intervenció psicosocial. El programa integra els següents components: fonaments teoricometodològics psicosocials, estructura organitzativa i avaluació del programa. L'avaluació del programa, abans de la seva implementació, va correspondre…
Comparative evaluation of bond strength of resin cements with and without 10-methacryloyloxydecyl dihydrogen phosphate (mdp) to zirconia and effect o…
2022
To compare bond strength of resin cements with and without 10-Methacryloyloxydecyl Dihydrogen Phosphate (MDP) to zirconia and evaluate effect of thermocycling on bond strength.Standardised test specimens were fabricated as per ADA specification 131. Each Zirconia specimen was mounted in autopolymerzing acrylic resin material. The specimens were divided into 2 groups: Group 1 - specimens bonded with resin cement containing 10-MDP and Group II - specimens bonded with resin cement without 10-MDP. Forty samples of resin cement cylinders were prepared with dimensions of 6mm height and 4mm diameter in line with ADA specification 27 were cured onto the zirconia surface of 10mm x10mm x5mm using cus…
Molecular Mechanisms Leading from Periodontal Disease to Cancer
2022
Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axi…
Convergence of prices on the pig market in selected European Union countries. Case study
2022
Due to its specificity, animal production depends to a lesser extent than plant production on agrometeorological conditions. Interdependence between the prices of animal products and climatic conditions manifests itself primarily through the fodder markets, which determine the profitability of animal breeding and keeping. The process of economic integration should contribute to a decline in price differentiation between European Union (EU) countries. In the case of the pig market, however, it is necessary to bear in mind the pig cycle, which particularly affects the supply of livestock and their prices. The Common Agricultural Policy (CAP) currently implemented is not adapted to the turbule…
Revista Fuentes
2022
El actual contexto educativo necesita una intensa alfabetización digital de todo el profesorado, lo que ha requerido una modificación significativa en los perfiles docentes convencionales. En el caso del profesorado especialista en Pedagogía terapéutica que trabaja con alumando con necesidades educativas especiales, la digitalización ha supuesto un desafío. Tales cambios han requerido dotarse de nuevas habilidades para transformar la información en conocimientos, guiar el proceso de enseñanza aprendizaje en un entorno novedoso y generar un espacio de inclusión educativa. El objetivo de esta investigación es identificar cuáles son los perfiles de los profesionales especialistas en Pedagogía …
Electrochemical detection of chloride ions using Ag-based electrodes obtained from compact disc
2022
Abstract In this work electrochemical sensors fabricated from compact disc material (waste or new) are used to quantify chloride ions in different types of samples. All three electrodes, working, counter, and pseudo-reference electrodes, were fabricated from the compact disc and directly used. Different parameters were studied in order to demonstrate the possibility of using this waste material for efficient and low-cost electrochemical sensors. Chloride sensing performance was evaluated using linear scan voltammetry as the detection technique. A sensitivity of 0.174 mA mM−1 cm−2 with a limit of detection of 20 μM and excellent selectivity against many interferents was observed. Selectivity…
Socio-spatial polarisation and policy response: Perspectives for regional development in the Baltic States
2022
Based on a relational understanding of socio-spatial polarisation as a nested, multidimensional and multi-scalar process, the paper applies a comparative perspective on current trends of socio-spatial development in Estonia, Latvia and Lithuania. Comparing current scholarship and data on demographic and economic processes of centralisation and peripheralisation, we also examine political debates around issues of polarisation in different scholarly national perspectives. Despite variations in national discourses, our comparative perspective conveys strong similarities between the three Baltic countries in terms of socio-economic and demographic concentration in the capital regions to the di…
Anodic Alumina Membranes: From Electrochemical Growth to Use as Template for Fabrication of Nanostructured Electrodes
2022
The great success of anodic alumina membranes is due to their morphological features coupled to both thermal and chemical stability. The electrochemical fabrication allows accurate control of the porous structure: in fact, the membrane morphological characteristics (pore length, pore diameter and cell density) can be controlled by adjusting the anodizing parameters (bath, temperature, voltage and time). This article deals with both the fabrication and use of anodic alumina membranes. In particular, we will show the specific role of the addition of aluminum ions to phosphoric acid-based anodizing solution in modifying the morphology of anodic alumina membranes. Anodic alumina membranes were …
Potential for cascading impacts of environmental change and policy on indigenous culture.
2022
AbstractGlobal environmental and societal changes threaten the cultures of indigenous peoples and local communities (IPLC). Despite the importance of IPLC worldviews and knowledge to sustaining human well-being and biodiversity, risks to these cultural resources are commonly neglected in environmental governance, in part because impacts can be indirect and therefore difficult to evaluate. Here, we investigate the connectivity of values associated with the relationship Ngātiwai (a New Zealand Māori tribe) have with their environment. We show that mapping the architecture of values-environment relationships enables assessment of how deep into culture the impacts of environmental change or pol…
La domotica assistiva per la rivitalizzazione di centri urbani minori
2022
Re-Inhabiting Inner Areas Triggering New Regeneration Trajectories: The Case Study of Sicani in Sicily
2022
The Italian debate on the so-called ‘inner areas’ has received a much-needed boost, following the COVID-19 pandemic, which has further highlighted the differences between metropolitan and inner areas. While the progressive depopulation of inner areas is a worrying phenomenon, the limits of incessant urbanisation and the concentration of settlement and infrastructure policies in large conurbations have become evident. Departing from the framework of the B4R-Branding4Resilience research project of national interest and, by continuing in the furrow initiated by the SNAI, but also surpassing it, the aim of the University of Palermo’s research is to define the requirement for a…
Mixed component metal-organic frameworks: Heterogeneity andcomplexity at the service of application performances
2022
The synthesis of mixed-component metal-organic frameworks (MOFs) –including multivariate MOFs (MTV-MOFs), multicomponent MOFs, mixed-metals MOFs and mixed-ligands and metals MOFs– is becoming a very active research field. This is mainly based on the unique possibilities these materials offer to incorporate multiple functionalities and in how this heterogenity and complexity is translated in unexpected properties, which are not just the sum of each component. This review critically encompasses the progress made in this field, covering the synthetic approaches, and specially focusing on the current reported applications –such as gas storage and separation, catalysis, luminescence, conductivit…
Torilis pseudonodosa Bianca (Apiaceae) – new species for the flora of Ukraine
2022
We report the first record of Torilis pseudonodosa Bianca (Apiaceae) from Ukraine. It was found on 28th of May 2021 in the “Potiivska” section of the Black Sea Biosphere Reserve near the village of Zaliznyi Port (Southern Ukraine). Torilis pseudonodosa previously was known from various countries in the Mediterranean Basin and Western Asia, but not from Ukraine nor elsewhere in Eastern Europe. We discovered a hitherto unknown population of Torilis pseudonodosa during the 15th EDGG Field Workshop, an international expedition of the Eurasian Dry Grassland Group (EDGG) taking place in Southern Ukraine, from 23 May to 2 June 2021. We present the taxon, its morphology and general distribution, de…
Endoscopic findings in periapical surgery. A cross-sectional study of 206 roots
2022
A study is made of the findings of high-magnification rigid endoscopy at the root end surface following apicoectomy of teeth subjected to periapical surgery. A cross-sectional study was made of patients subjected to periapical surgery at the Unit of Oral Surgery and Implantology (University of Valencia, Valencia, Spain) between 2011 and 2019. Following apicoectomy, the root end surfaces were inspected, with the evaluation of untreated canals, isthmuses, craze lines, crack lines, opaque dentin and gaps. Likewise, an analysis was made of the association between patient age and the tooth type and restoration and the presence of craze lines, cracks, opaque dentin and gaps. The final sample cons…
An open-source GA framework for optimizing the seismic upgrading design of RC frames through BRBs
2022
Abstract Optimizing seismic upgrading interventions in reinforced concrete (RC) structures is a difficult task, due to the inner non-linearity of the analyses usually performed. Additionally, it is well known that the displacement demand to the structure depends from the mass and stiffness of the system, and consequently its definition cannot be made a-priori. This paper presents the application of a soft-computing method -i.e. Genetic Algorithm (GA)- for the shaping optimization of code-compliant seismic upgrading interventions on plane RC frames through Buckling-Restrained Braces (BRB). The metaheuristic procedure allows to minimize the cost while ensuring the required safety level, witho…
Soil and organic carbon redistribution in a recently burned Mediterranean hillslope affected by water erosion processes
2022
Forest fires cause many changes in the physical, chemical and biological soil properties such as aggregation and soil organic carbon contents (SOC) as well as on soil hydrology and erosion processes. Most studies on post-fire soil erosion in Mediterranean environments have been plot-based and research at hillslope or broader scale is scarce. Understanding SOC nature, distribution and modifications, as produced by forest fires and erosion, has become crucial to model and define the role of soil erosion as source or sink of C, and to sustainably manage ecosystem services related to the soil resource. This research provides data about the loss and redistribution of soil and SOC in a Mediterran…
CT angiography for the assessment of EVAR complications : a pictorial review
2022
Aortic aneurysm; Blood vessel prosthesis implantation; Endovascular procedures Aneurisma aórtico; Implantación de prótesis de vasos sanguíneos; Procedimientos endovasculares Aneurisma aòrtic; Implantació de pròtesis de vasos sanguinis; Procediments endovasculars Endovascular aneurysm repair (EVAR) is a minimally invasive treatment proposed as an alternative to open repair in patients with abdominal aortic aneurysms. EVAR consists in a stent-graft placement within the aorta in order to exclude the aneurysm from arterial circulation and reduce the risk of rupture. Knowledge of the various types of devices is mandatory because some stents/grafts are more frequently associated with complication…
Effects of organic matter complexation on partitioning of transition metals into calcite: Cave-analogue crystal growth experiments
2022
We highlight the potential for first row transition metals to carry paleohydrological signals in speleothems, and argue that these metals constitute valuable proxies for climate reconstructions. Metal availability to speleothems is hypothesised to be restricted by organic complexation, which strongly limits the free ion activity of transition metals (Co2+, Ni2+ and Cu2+) in dripwater, thereby creating a kinetic overprint on metal concentrations and isotope ratios in speleothem calcite. This study presents the results of the first cave-analogue experiments of transition metal partitioning into calcite in the absence and presence of organic ligands. The Geological Microclimate (GeoMic) system…
Kinesiological Treatment of Early Spine Osteoarthritis in a Motorcyclist
2022
This case report speculates that the prolonged vibrations from enduro off-road sports are deleterious to the spine. The results of this case report may also aid sports physicians in better understanding this complex and relatively unknown phenomenon. No published data are present in the current literature that demonstrate the correlation between early spine osteoarthritis from enduro motorcycle overuse and the long-term management effects of a non-invasive kinesiological approach to reduce pain and inflammation and improve spine mobility and muscle strength.
Genotype influence on shelf life behaviour of minimal processed loquat (Eriobotrya japonica (Thunb.) Lindl.) fruit: the role of sugar, acid organics …
2022
AbstractBackgroundLoquat cultivars cultivated in Southern Italy are very appreciated by consumers for their sensorial characteristics, such as persistent aroma and taste. Apposite maturity indexes for peeling and processing loquat fruit were investigated to increase diffusion of minimally processed loquat. The genotype’s effect on the minimally processed loquat fruit shelf life and quality harvested at commercial maturity (80% yellow color) was investigated on peeled fruit stored at 5 °C for 10 days. The role of sugars, organic acids and phenols composition was observed through in depth qualitative analysis. In addition, several qualitative analyses were carried out to determine the quality…
Enhanced Electrochemical Properties of Na0.67MnO2 Cathode for Na-Ion Batteries Prepared with Novel Tetrabutylammonium Alginate Binder
2022
This research was funded by the State Education Development Agency, the Republic of Latvia, grant number 1.1.1.2/VIAA/1/16/166, "Advanced Materials for Sodium-Ion Batteries". Institute of Solid-State Physics, University of Latvia as the Centre of Excellence has received funding from the European Union's Horizon 2020 Framework Program H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2.
Post-mortem enamel surface texture alteration during taphonomic processes—do experimental approaches reflect natural phenomena?
2022
Experimental approaches are often used to better understand the mechanisms behindand consequences of post-mortem alteration on proxies for diet reconstruction.Dental microwear texture analysis (DMTA) is such a dietary proxy, using dental wearfeatures in extant and extinct taxa to reconstruct feeding behaviour and mechanicalfood properties. In fossil specimens especially, DMTA can be biased by post-mortemalteration caused by mechanical or chemical alteration of the enamel surface. Herewe performed three different dental surface alteration experiments to assess the effectof common taphonomic processes by simplifying them: (1) tumbling in sedimentsuspension to simulate fluvial transport, (2) s…
Digital Health Platform for Emotional and Self-Management Support of Caregivers of Children Receiving Growth Hormone Treatment
2022
In recent years there has been growing research on the combination of evidence-based behavioral change techniques with mobile-based recommender systems. In this paper, we have focused on understanding the psychological burdens experienced by caregivers of children undergoing growth hormone treatment (GHt) and the perceived barriers to and drivers of the adoption of a digital health solution. This is a mixed-methods formative research study looking into technical acceptance aspects of using digital health for the emotional support of parents of children undergoing GHt. After one month using the ADHERA CARING platform (Adhera Health, Inc., Palo Alto, CA), individual semi-structured interviews…
Human Digital Twins in Acquiring Information About Human Mental Processes for Cognitive Mimetics
2022
Modern information technology makes it possible to redesign the ways people work. In the future, machines can carry out intelligence-requiring tasks, which previously were done by people. It is thus good to develop methodologies for designing intelligent systems. An example of such methods is cognitive mimetics, i.e. imitating human information processing. Today, machines cannot by themselves navigate in archipelagos. However, the fact that people can take care of ship steering and navigation means that there is an information process, which makes it possible to navigate ships. This information process takes place inside the minds of navigating people. If we are able to explicate the inform…
BIOMECHANICS AND NEUROSCIENCE IN SPORTS: FOCUS ON THE EFFECTS OF PRISMATIC ADAPTATION ON POSTURE AND SPORTS SKILLS ACCURACY
2022
Machine learning-assisted identification of factors contributing to the technical variability between bulk and single-cell RNA-seq experiments
2022
AbstractBackgroundRecent studies in the area of transcriptomics performed on single-cell and population levels reveal noticeable variability in gene expression measurements provided by different RNA sequencing technologies. Due to increased noise and complexity of single-cell RNA-Seq (scRNA-Seq) data over the bulk experiment, there is a substantial number of variably-expressed genes and so-called dropouts, challenging the subsequent computational analysis and potentially leading to false positive discoveries. In order to investigate factors affecting technical variability between RNA sequencing experiments of different technologies, we performed a systematic assessment of single-cell and bu…
SIRM-SIN-AIOM: appropriateness criteria for evaluation and prevention of renal damage in the patient undergoing contrast medium examinations-consensu…
2022
AbstractThe increasing number of examinations and interventional radiological procedures that require the administration of contrast medium (CM) in patients at risk for advanced age and/or comorbidities highlights the problem of CM-induced renal toxicity. A multidisciplinary group consisting of specialists of different disciplines—radiologists, nephrologists and oncologists, members of the respective Italian Scientific Societies—agreed to draw up this position paper, to assist clinicians increasingly facing the challenges posed by CM-related renal dysfunction in their daily clinical practice.The major risk factor for acute renal failure following CM administration (post-CM AKI) is the preex…
Efficient contour-based annotation by iterative deep learning for organ segmentation from volumetric medical images
2022
Abstract Purpose Training deep neural networks usually require a large number of human-annotated data. For organ segmentation from volumetric medical images, human annotation is tedious and inefficient. To save human labour and to accelerate the training process, the strategy of annotation by iterative deep learning recently becomes popular in the research community. However, due to the lack of domain knowledge or efficient human-interaction tools, the current AID methods still suffer from long training time and high annotation burden. Methods We develop a contour-based annotation by iterative deep learning (AID) algorithm which uses boundary representation instead of voxel labels to incorp…
Nuclear Charge Radii of the Nickel Isotopes $^{58-68,70}$Ni
2022
Collinear laser spectroscopy is performed on the nickel isotopes Ni58-68,70, using a time-resolved photon counting system. From the measured isotope shifts, nuclear charge radii Rc are extracted and compared to theoretical results. Three ab initio approaches all employ, among others, the chiral interaction NNLOsat, which allows an assessment of their accuracy. We find agreement with experiment in differential radii δ⟨rc2⟩ for all employed ab initio methods and interactions, while the absolute radii are consistent with data only for NNLOsat. Within nuclear density functional theory, the Skyrme functional SV-min matches experiment more closely than the Fayans functional Fy(Δr,HFB). Collinear …
The difference of free light chains as a predictor of kidney damage in patients with Multiple Myeloma
2022

 Background: Multiple myeloma (MM) is a malignant neoplasm characterized by the clonal expansion of plasma cells that can release monoclonal immunoglobulins (monoclonal component) or part of theme. Since 2001, the k and λ serum free light chains (sFLC) evaluation and their ratio (rFLC) have made up the laboratory analysis more sensitive and precise in MM patients. The role of rFLC has been widely studied and discussed and now it is validated in the literature. Instead, the value of free light chains difference (dFLC), especially in MM is less known yet. The aim of this study is to evaluate the relationship between the dFLC and the kidney damage parameters in patients with MM, in compa…
Switching Frequency Effects on the Efficiency and Harmonic Distortion in a Three-Phase Five-Level CHBMI Prototype with Multicarrier PWM Schemes: Expe…
2022
The current climatic scenario requires the use of innovative solutions to increase the production of electricity from renewable energy sources. Multilevel Power Inverters are a promising solution to improve the penetration of renewable energy sources into the electrical grid. Moreover, the performance of MPIs is a function of the modulation strategy employed and of its features (modulation index and switching frequency). This paper presents an extended and experimental analysis of three-phase five-level Cascaded H-Bridges Multilevel Inverter performance in terms of efficiency and harmonic content considering several MC PWM modulation strategies. In detail, the CHBMI performance is analyzed …