showing 36 of ~574560 from 574555 documents
Drug‐refractory myasthenia gravis: Clinical characteristics, treatments, and outcome
2022
[Objective] To describe the clinical characteristics and outcomes in patients with refractory myasthenia gravis (MG) and to determine the effectiveness and side effects of the drugs used for their treatment.
Quantum Algorithms for Some Strings Problems Based on Quantum String Comparator
2022
We study algorithms for solving three problems on strings. These are sorting of n strings of length k, “the Most Frequent String Search Problem”, and “searching intersection of two sequences of strings”. We construct quantum algorithms that are faster than classical (randomized or deterministic) counterparts for each of these problems. The quantum algorithms are based on the quantum procedure for comparing two strings of length k in O(k) queries. The first problem is sorting n strings of length k. We show that classical complexity of the problem is Θ(nk) for constant size alphabet, but our quantum algorithm has O˜(nk) complexity. The second one is searching the most frequent string among n …
In-Hospital and One-Year Outcomes of Patients after Early and Late Resuscitated Cardiac Arrest Complicating Acute Myocardial Infarction—Data fr…
2022
The prognostic role of early (less than 48 h) resuscitated cardiac arrest (ErCA) complicating acute myocardial infarction (AMI) is still controversial. The present study aimed to analyse the short-term and one-year outcomes of patients after ErCA and late resuscitated cardiac arrest (LrCA) compared to patients without cardiac arrest (CA) complicating AMI. Data from the prospective nationwide Polish Registry of Acute Coronary Syndromes (PL-ACS) were used to assess patients with resuscitated cardiac arrest (rCA) after AMI. Baseline clinical characteristics and the predictors of all-cause death were assessed. The all-cause mortality rate, complications, performed procedures, and re-hospitalisa…
Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic A…
2022
Acknowledgments: The authors are grateful to the NRCT for supporting research facilities (grant no. NRCT5-RRI63004-P05), Chiang Mai University for the Fundamental Fund 2022, and the partially support grant. We would like to thank Lanna Rice Research Center, Chiang Mai University, and Saleekam Trading Co., Ltd., Thailand, for providing the rice bran and husk samples.
Fruiting, Morphology, and Architecture of ‘Arbequina’ and ‘Calatina’ Olive Branches
2022
Two different olive cultivars grown under a high-density hedgerow system were studied to compare their fruiting and branch architecture features and to determine the possibility to use ‘Calatina’ olive trees for intensive plantings, as a local alternative to the international reference ‘Arbequina’. Weights of two-year-old branches, fruits and leaves were recorded to estimate the growth partitioning. Growth and architectural parameters, such as shoot length, vector and diameter, branching angle, branch total length, height, width, area, and branching frequency, were determined by digital image analysis. Digital images of the fruits were also used to estimate fruit maturation by peel color an…
Pandemia, gobernanza y municipalismo, en las coronas metropolitanas a partir de su estudio en Riba-roja de Túria (València)
2022
La crisis del COVID-19 ha impactado en el sistema sanitario de los territorios, pero también en sus ámbitos socioeconómicos, lo que ha requerido una respuesta eficaz por las autoridades. El objetivo de esta investigación es la identificación de las dinámicas generales derivadas de la pandemia en las áreas metropolitanas, a partir de un estudio local realizado en el municipio valenciano de Riba-roja de Túria. Se ha aplicado una metodología que combina el tratamiento de estadísticas y documentación técnica municipal, con información cualitativa obtenida mediante entrevistas con agentes locales. La crisis ha incidido en la totalidad de sectores, con un aumento de las desigualdades y la vulnera…
Recent advances in copper-based solid heterogeneous catalysts for azide-alkyne cycloaddition reactions
2022
The copper(I)-catalyzed azide−alkyne cycloaddition (CuAAC) reaction is considered to be the most representative ligation process within the context of the “click chemistry” concept. This CuAAC reaction, which yields compounds containing a 1,2,3-triazole core, has become relevant in the construction of biologically complex systems, bioconjugation strategies, and supramolecular and material sciences. Although many CuAAC reactions are performed under homogenous conditions, heterogenous copper-based catalytic systems are gaining exponential interest, relying on the easy removal, recovery, and reusability of catalytically copper species. The present review covers the most recently developed copp…
GLP-1 receptor agonists and renal outcomes in patients with diabetes mellitus type 2 and diabetic kidney disease: state of the art
2022
ABSTRACT Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are highly effective in improving glycaemic control either as monotherapy or in combination with other hypoglycaemic drugs, and have low incidence of side effects, such as hypoglycaemia, nausea and weight gain, thus increasing patients' adherence to therapy. Methods In this review we report the most recent studies demonstrating the beneficial effects of GLP-1RAs on renal outcomes, and also discuss the direct and indirect mechanisms through which they confer kidney protection. Finally, we discuss the metabolic and anti-inflammatory effects of GLP-1RAs in diabetic patients with COVID-19 disease. Results GLP-1RAs have a n…
Association between Self-Reported Childhood Difficulties and Obesity and Health-Related Behaviors in Adulthood—A Cross-Sectional Study among 28…
2022
The aim of the present study was to examine the associations between self-reported childhood difficulties, weight status, and lifestyle behaviors among a representative sample of Norwegian adults. This cross-sectional study included 28,047 adults (>18 years old) living in southern Norway. A self-report questionnaire was used to assess information about the overall quality of the respondents’ childhood retrospectively in addition to current weight status and current lifestyle behaviors. Multivariable logistic regression models adjusted for gender, age, and educational level showed that evaluating childhood as difficult was associated with increased odds of obesity (OR: 1.29; 95% CI;…
Valencia, Rodrigo Osorio, hacia 1589: público, «Autor» y fecha para «El Grao de Valencia», de Lope de Vega
2022
La trayectoria escénica de El Grao de Valencia, de Lope de Vega, nos es desconocida, pero hay buenas razones para suponer que fue el autor de comedias Rodrigo Osorio quien se encargó de llevar la pieza a las tablas ante el público valenciano entre 1588 y 1590, durante el exilio de Lope en Valencia. Para llegar a tales conclusiones -y tras discutir un supuesto estreno en Toledo, que no carece de fundamento- se tendrá en cuenta la posición que ocupa El Grao de Valencia en El peregrino en su patria, la documentación existente en torno a la actividad teatral de Osorio en la ciudad del Turia y la adecuación de su compañía al reparto de la comedia, así como ciertos detalles del texto y el argumen…
Differing kinetics of anti-spike protein IgGs and neutralizing antibodies against SARS-CoV-2 after Comirnaty (BNT162b2) immunization
2022
Abstract Aims Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has had a serious worldwide impact on human health. On December 2020, an immunization campaign with a COVID-19 mRNA vaccine (Comirnaty-BNT162b2 Pfizer-BioNTech) was started in Italy, first targeting healthcare workers (HCWs). This study aims to investigate the antibodies that are response against SARS-CoV-2 vaccine. Methods and Results The kinetics and the persistence of both anti-S1/S2 IgGs and neutralizing antibodies (Nt-Abs) were investigated in 76 HCWs through a 4-month follow-up with multiple testing points starting at the first dose. Temporal analysis of SARS-CoV-2 Abs titre kinetics showed three diff…
The utilization of primary healthcare services among frail older adults – findings from the Helsinki Birth Cohort Study
2022
Abstract Background The impact of frailty on primary healthcare service use, especially general practice office visits and remote contacts, is currently unknown. Further, little is known about the association of frailty with physiotherapy contacts. Methods We examined the utilization of primary healthcare services among 1064 participants from the Helsinki Birth Cohort Study between the years 2013 and 2017. Frailty was assessed based on Fried’s frailty criteria at mean age of 71.0 (2.7 SD) years in clinical examinations between the years 2011 and 2013. General practice office visits and remote contacts, the total number of general practice contacts, physiotherapy contacts, and the total numb…
miRNome Profiling Detects miR-101-3p and miR-142-5p as Putative Blood Biomarkers of Frailty Syndrome
2022
Frailty is an aging-related pathology, defined as a state of increased vulnerability to stressors, leading to a limited capacity to meet homeostatic demands. Extracellular microRNAs (miRNAs) were proposed as potential biomarkers of various disease conditions, including age-related pathologies. The primary objective of this study was to identify blood miRNAs that could serve as potential biomarkers and candidate mechanisms of frailty. Using the Fried index, we enrolled 22 robust and 19 frail subjects. Blood and urine samples were analysed for several biochemical parameters. We observed that sTNF-R was robustly upregulated in the frail group, indicating the presence of an inflammatory state. …
Nomenclature for Hydrogeological Instability Risks
2022
The nomenclature for hydrogeological instability risks includes four main risks, which are distinguished according to the risk causes : 1) hydrogeological risk, that is slowly caused by natural factors (e.g. collapse landslides in a calcareous cliff in uninhabited areas and erosion along a marly-calcareous slope) in environments where human activities are minimal, i.e. woods, forests and mountain pastures; 2) hydraulic-pedological farming risk, that implies the occurrence of landslides in every winter and is caused by incorrect crop selection, not suitable for the soil and climate parameters (e.g. on a hilly slope with a clay vertisol type with a landslide having different fronts, when the …
Weaving words for textile museums: the development of the linked SILKNOW thesaurus.
2022
Abstract The cultural heritage domain in general and silk textiles, in particular, are characterized by large, rich and heterogeneous data sets. Silk heritage vocabulary comes from multiple sources that have been mixed up across time and space. This has led to the use of different terminology in specialized organizations in order to describe their artefacts. This makes data interoperability between independent catalogues very difficult. To address these issues, SILKNOW created a multilingual thesaurus related to silk textiles. It was carried out by experts in textile terminology and art historians and computationally implemented by experts in text mining, multi-/cross-linguality and semanti…
Baccalaureate nursing students’ experiences of how the COVID-19 pandemic influenced learning – a mixed method study
2022
Abstract Background The COVID-19 pandemic mandated the reconstruction of educational programs globally. For nursing students in need of practical learning and training as a part of their curriculum, the pandemic also caused restrictions and alterations in practical placements and limited access to simulation training at campuses. The aim of this study is therefore, to describe and explore how the COVID- 19 pandemic influenced baccalaureate nursing students’ experiences of learning and their social life as a student. Method We used a mixed method study design including quantitative data from one of the universities (University of Agder) from a national Norwegian survey of baccalaureate nursi…
Categories, Quantum Computing, and Swarm Robotics: A Case Study
2022
The swarms of robots are examples of artificial collective intelligence, with simple individual autonomous behavior and emerging swarm effect to accomplish even complex tasks. Modeling approaches for robotic swarm development is one of the main challenges in this field of research. Here, we present a robot-instantiated theoretical framework and a quantitative worked-out example. Aiming to build up a general model, we first sketch a diagrammatic classification of swarms relating ideal swarms to existing implementations, inspired by category theory. Then, we propose a matrix representation to relate local and global behaviors in a swarm, with diagonal sub-matrices describing individual featur…
Guillain-Barré Syndrome
2022
Background: Guillain–Barré syndrome is a rare disorder in which our body’s immune system attacks nerves determining weakness and tingling of extremities as first symptoms. It can also be associated to respiratory failure and require mechanical ventilation during hospitalization (up to 30% of patients). Nowadays patient’s hyper-reactive immune responses benefits from immunotherapies such as intravenous immunoglobulin (IVIg), therapeutic plasma exchange (TPE) and new biological drugs. Case Report: We report our experience with the case of a 64-year-old woman who presented a symmetric progressive flaccid paralysis after a week of mild cold symptoms. The respiratory and neurological symptoms wo…
TIGER: TIme-Gated Electric field Reconstruction
2022
We present a novel self-referenced method for the complete temporal characterization (phase and amplitude) of ultrashort optical laser pulses. The technique, called TIme-Gated Electric field Reconstruction (TIGER), measures a second-order nonlinear signal (namely, second harmonic generation or two-photon absorption) produced by four time-delayed replicas of the input pulse. The delays are spatially encoded in the beam profile using a four-faced pyramid-like optical element. The presented technique enables single shot measurement and does not require any spectral measurements, in contrast with well-known self-referenced characterization methods. Depending on the chosen geometry, the recorded…
MIF rs755622 and IL6 rs1800795 Are Implied in Genetic Susceptibility to End-Stage Renal Disease (ESRD)
2022
Chronic kidney disease (CKD) is characterized by an increased risk of kidney failure and end-stage renal disease (ESRD). Aging and comorbidities as cardiovascular diseases, metabolic disorders, infectious diseases, or tumors, might increase the risk of dialysis. In addition, genetic susceptibility factors might modulate kidney damage evolution. We have analyzed, in a group of ESRD patients and matched controls, a set of SNPs of genes (Klotho rs577912, rs564481, rs9536314; FGF23 rs7955866; IGF1 rs35767; TNFA rs1800629; IL6 rs1800795; MIF rs755622, rs1007888) chosen in relation to their possible involvement with renal disease and concomitant pathologies. Analysis of the raw data did indicate …
Assessment of intravitreal anti-VEGF drugs and dexamethasone for retinal diseases in real world setting: A multi-centre prospective study from Southe…
2022
Describe drug utilisation and clinical outcomes of intravitreal anti-VEGF drug and dexamethasone use in the real-world setting in Southern Italy using data from multi-centre study of retinal disease. Clinical data of retinal disease patients treated with anti-VEGF drugs and dexamethasone implant in 6 out-patient ophthalmology centres from Southern Italy were collected by means of an electronic case report form. Patients receiving at least one intravitreal injection/implant of the study drugs were followed for up to two years and described in terms of demographics and clinical characteristics. Drug utilisation patterns were described. A sign-rank test was used to compare clinical data on vi…
Molecular Features Behind Formation of α or β Co-Crystalline and Nanoporous-Crystalline Phases of PPO
2022
Guest molecular features determining the formation of α and β phases of poly(2-6-dimethyl-1,4-phenylene) oxide (PPO) are explored by collecting literature data and adding many new film preparations, both by solution casting and by guest sorption in amorphous films. Independently of the considered preparation method, the α-form is favored by the hydrophobic and bulky guest molecules, while the hydrophilic and small guest molecules favor the β-form. Furthermore, molecular modeling studies indicate that the β-form inducer guests establish stronger dispersive interactions with the PPO units than the α-form inducer guests. Thus, the achievement of co-crystalline (and derived nanoporous crystalli…
Disparities in the prevalence of clinical features between systemic juvenile idiopathic arthritis and adult-onset Still's disease
2022
Abstract Objective To compare clinical features and treatments of patients with systemic JIA (sIJA) and adult-onset Still’s disease (AOSD). Methods The clinical charts of consecutive patients with sJIA by International League of Association of Rheumatology criteria or AOSD by Yamaguchi criteria were reviewed. Patients were seen at a large paediatric rheumatology referral centre or at 10 adult rheumatology academic centres. Data collected included clinical manifestations, inflammation biomarkers, systemic score, macrophage activation syndrome (MAS), parenchymal lung disease, disease course, disability, death and medications administered. Results A total of 166 patients (median age at diagnos…
Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample…
2022
This work was supported by funding from the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). (...) CA was supported by the Spanish Ministry of Science and Innovation; Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024), co-financed by ERDF Funds from the European Commission, ‘A way of making Europe’, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), Fundación Familia Alonso and Fundación Alicia Koplowitz. MB was supported by the Ministry of Economy and Competitivity (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III – ERDF Funds from the European Commission, ‘A way of making Europ…
Prevalence and Sociodemographic Predictors of Mental Health in a Representative Sample of Young Adults from Germany, Israel, Poland, and Slovenia: A …
2022
The aim of this cross-national longitudinal study was to evaluate the prevalence and sociodemographic predictors of mental health indicators (coronavirus-related post-traumatic stress disorder (PTSD), perceived stress, anxiety, depression, and suicidal/self-harm ideation) during the coronavirus disease-2019 (COVID-19) pandemic in a three-month period among representative samples of young adults from Germany, Israel, Poland, and Slovenia. The participants were 1724 young adults between 20 and 40 years of age (M = 30.74, SD = 5.74). The first measurement (T1) was in February 2021 and the second (T2) was in May–June 2021. The samples were representative of young adults in each country: Germany…
Massively bleeding trauma patient: intervene but not too late
2022
Co-branding research: where we are and where we could go from here
2022
Purpose The motivations behind co-branding alliances, the differences in performance between the paired brands and the emergence of “spillover effects” have been pillars of the marketing research agenda for almost three decades. We observe an extensive number of studies on co-branding alliances, combined with multiple theoretical perspectives and empirical approaches informing extant literature. The purpose of this paper is to summarize of the state of the art of this research. Design/methodology/approach The authors offer a systematic literature review of 190 papers on co-branding alliances. The authors portray a picture of the theories informing co-branding research and build a conceptua…
An individual-based dataset of carbon and nitrogen isotopic data of Callinectes sapidus in invaded Mediterranean waters
2022
The characterisation of functional traits of non-indigenous and invasive species is crucial to assess their impact within invaded habitats. Successful biological invasions are often facilitated by the generalist diet of the invaders which can modify their trophic position and adapt to new ecosystems determining changes in their structure and functioning. Invasive crustaceans are an illustrative example of such mechanisms since their trophic habits can determine important ecological impacts on aquatic food webs. The Atlantic blue crab Callinectes sapidus is currently established and considered invasive in the Mediterranean Sea where it has been recorded for the first time between 1947 and 19…
Tadpole Responses to Environments With Limited Visibility: What We (Don’t) Know and Perspectives for a Sharper Future
2022
Amphibian larvae typically inhabit relatively shallow freshwater environments, and within these boundaries there is considerable diversity in the structure of the habitats exploited by different species. This diversity in habitat structure is usually taken into account in relation to aspects such as locomotion and feeding, and plays a fundamental role in the classification of tadpoles into ecomorphological guilds. However, its impact in shaping the sensory worlds of different species is rarely addressed, including the optical qualities of each of these types of water bodies and the challenges and limitations that they impose on the repertoire of visual abilities available for a typical vert…
Application of Wastewater-Based Epidemiology for Tracking Human Exposure to Deoxynivalenol and Enniatins
2022
Wastewater-based epidemiology (WBE) is a promising biomonitoring approach with the potential to provide direct information on human intake and exposure to food contaminants and environmental chemicals. The aim of this study was to apply WBE while employing the normalization method for exploring human exposure to selected mycotoxins according to population biomarker 5-hydroxyindoleacetic acid (5-HIAA). This type of normalization technique has been previously used to detect various other compounds. However, to the best of our knowledge, this is the first study tracking human exposure to mycotoxins. A sensitive analytical methodology was developed to achieve reliable quantification of deoxyniv…
Halloysite Nanotubes: Smart Nanomaterials in Catalysis
2022
The use of clay minerals as catalyst is renowned since ancient times. Among the different clays used for catalytic purposes, halloysite nanotubes (HNTs) represent valuable resources for industrial applications. This special tubular clay possesses high stability and biocompatibility, resistance against organic solvents, and most importantly be available in large amounts at a low cost. Therefore, HNTs can be efficiently used as catalysts themselves or supports for metal nanoparticles in several catalytic processes. This review reports a comprehensive overview of the relevant advances in the use of halloysite in catalysis, focusing the attention on the last five years.
Dažas domas, lasot Mario Livio grāmatu «Vai Dievs ir matemātiķis?»
2022
Galvenais grāmatas jautājums ir: Vai matemātika ir atklājums vai izgudrojums?
Gamma Oscillations in the Temporal Pole Reflect the Contribution of Approach and Avoidance Motivational Systems to the Processing of Fear and Anger W…
2022
Prior reports suggest that affective effects in visual word processing cannot be fully explained by a dimensional perspective of emotions based on valence and arousal. In the current study, we focused on the contribution of approach and avoidance motivational systems that are related to different action components to the processing of emotional words. To this aim, we compared frontal alpha asymmetries and brain oscillations elicited by anger words associated with approach (fighting) motivational tendencies, and fear words that may trigger either avoidance (escaping), approach (fighting) or no (freezing) action tendencies. The participants’ task was to make decisions about approaching or dis…
A Data-Driven Approach for Studying the Influence of Carbides on Work Hardening of Steel
2022
This study proposes a new approach to determine phenomenological or physical relations between microstructure features and the mechanical behavior of metals bridging advanced statistics and materials science in a study of the effect of hard precipitates on the hardening of metal alloys. Synthetic microstructures were created using multi-level Voronoi diagrams in order to control microstructure variability and then were used as samples for virtual tensile tests in a full-field crystal plasticity solver. A data-driven model based on Functional Principal Component Analysis (FPCA) was confronted with the classical Voce law for the description of uniaxial tensile curves of synthetic AISI 420 ste…
Common Misunderstandings of Deterrence Theory in Information Systems Research and Future Research Directions
2022
In the 1980s, information systems (IS) borrowed deterrence theory (DT) from the field of criminology to explain information security behaviors (or intention). Today, DT is among the most commonly used theories in IS security research. Our review of IS research applying DT highlights that many fundamental assumptions of DT are unrecognized and therefore unexamined. This may have resulted in misunderstandings and conceptual confusions regarding some of the basic concepts of DT. For example, some IS studies confuse general deterrence with specific deterrence or do not recognize the difference between the two. Moreover, these fundamental assumptions, when directly examined, may provide importan…
Comparison of saturation vapor pressures of α-pinene + O3 oxidation products derived from COSMO-RS computations and thermal desorption experiments
2022
Accurate information on gas-to-particle partitioning is needed to model secondary organic aerosol formation. However, determining reliable saturation vapor pressures of atmospherically relevant multifunctional organic compounds is extremely difficult. We estimated saturation vapor pressures of α-pinene-ozonolysis-derived secondary organic aerosol constituents using Filter Inlet for Gases and AEROsols (FIGAERO)–chemical ionization mass spectrometer (CIMS) experiments and conductor-like screening model for real solvents (COSMO-RS). We found a good agreement between experimental and computational saturation vapor pressures for molecules with molar masses around 190 g mol−1 and higher, most wit…