showing 36 of ~574560 from 574555 documents
Stratification strength and light climate explain variation in chlorophyll a at the continental scale in a European multilake survey in a heatwave su…
2021
The authors acknowledge COST Action ES 1105 "CYANOCOST Cyanobacterial blooms and toxins in water resources: Occurrence impacts and management" and COST Action Global Change Biology ES 1201 NETLAKE -Networking Lake Observatories in Europe" for contributing to this study through networking and knowledge sharing with European experts in the field. We acknowledge the members of the Global Lake Ecological Observatory Network (GLEON) for their collaborative spirit and enthusiasm that inspired the grassroots effort of the EMLS. E.M. was supported by a grant from the Swiss State Secretariat for Education, Research and Innovation to Bas Ibelings and by supplementary funding from University of Geneva…
Scalable and effective multi-level entangled photon states: a promising tool to boost quantum technologies
2021
Abstract Multi-level (qudit) entangled photon states are a key resource for both fundamental physics and advanced applied science, as they can significantly boost the capabilities of novel technologies such as quantum communications, cryptography, sensing, metrology, and computing. The benefits of using photons for advanced applications draw on their unique properties: photons can propagate over long distances while preserving state coherence, and they possess multiple degrees of freedom (such as time and frequency) that allow scalable access to higher dimensional state encoding, all while maintaining low platform footprint and complexity. In the context of out-of-lab use, photon generation…
Temporal turnover of the soil microbiome composition is guild-specific.
2021
Although spatial and temporal variation are both important components structuring microbial communities, the exact quantification of temporal turnover rates of fungi and bacteria has not been performed to date. In this study, we utilised repeated resampling of bacterial and fungal communities at specific locations across multiple years to describe their patterns and rates of temporal turnover. Our results show that microbial communities undergo temporal change at a rate of 0.010-0.025 per year (in units of Sorensen similarity), and the change in soil is slightly faster in fungi than in bacteria, with bacterial communities changing more rapidly in litter than soil. Importantly, temporal deve…
“Sensing” the destination: Development of the destination sensescape index
2021
Abstract Despite the increasing academic interest in the sensory dimension of the tourist experience, the quantitative empirical research in the field is limited by a lack of measurement instruments for evaluating the sensory stimuli perceived by tourists during a destination visit. The study addresses this gap by developing a composite index to assess the sensory destination panorama, termed as “destination sensescape”. The construct is conceptualised as a formative multidimensional variable with 5 dimensions (visualscape, smellscape, tastescape, soundscape, and hapticscape). The psychometric validity and reliability of the 17 items integrating the formative index were established by a rig…
Early symptomatic benefit indicates long-term prognosis after transcatheter mitral valve edge-to-edge repair in functional and degenerative etiology
2021
Mitral regurgitation (MR) is common in patients with heart failure and constitutes an independent risk factor for adverse prognosis besides NYHA-class. The predictive value of dyspnea reduction after transcatheter mitral valve repair (TMVr) on outcome has not been investigated up to now.We enrolled 627 consecutive patients (47.0% female, 57.4% functional MR; median follow-up 486 days[IQR 157/961]; survival status available in 96.8%; symptoms assessed in n = 556 at baseline / n = 406 at 1 month) treated with isolated percutaneous mitral valve edge-to-edge repair in our center from 06/2010-03/2018 (exclusion of combined forms of TMVr) in a monocentric retrospective analysis. Survival was 97.6…
Cinema Futuro. Cinema interattivo
2021
L'interattività sta diventando una opportunità concreta per la costruzione di nuovi storytelling digitali cinematografici. Vengono qui presi come esempio alcuni titoli recenti ed esaminati nelle loro dinamiche. Interactivity is becoming a concrete opportunity for the construction of new digital cinematic storytelling. Here some recent titles are taken as an example and examined in their dynamics.
Measuring well-being in Colombian departments. The role of geography and demography
2021
This paper provides a composite indicator of well-being for the 33 Colombian departments in the year 2016. The indicator is built by adapting the well-known OECD Better Life Index to the regional level, and includes the dimensions of income, health, education, safety, housing, environment, labour market, and civic engagement and governance. As to the methodology, Data Envelopment Analysis and Multi-Criteria Decision-Making techniques are employed, an approach which enables a comparison of well-being across departments and the construction of rankings. The results yield several take-away messages. First, there are substantial disparities in well-being across Colombian departments. Second, de…
On Defining the Participatory Museum: The Case of the Museum of the Second World War in Gdansk
2021
This article seeks to contribute to the current debate on the new definition of the “museum” – a debate which led to turmoil at the 2019 ICOM General Assembly in Kyoto. With reference to the case study of the Museum of the Second World War in Gdansk (MSWW), it analyses the new and very successful genre of the narrative museum, a genre which arguably fulfils the core elements of the definition currently being discussed by ICOM. In this regard, it brings into focus the paramount importance of community involvement in creating and managing narrative museums – an aspect that has been virtually absent in the academic and media debates over the nature of the MSWW and its programme. By pointing ou…
High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms
2021
Dictyophora indusiata or Phallus indusiatus is widely used as not only traditional medicine, functional foods, but also, skin care agents. Biological activities of the fruiting body from D. indusiata were widely reported, while the studies on the application of immature bamboo mushroom extracts were limited especially in the wound healing effect. Wound healing process composed of 4 stages including hemostasis, inflammation, proliferation, and remodelling. This study divided the egg stage of bamboo mushroom into 3 parts: peel and green mixture (PGW), core (CW), and whole mushroom (WW). Then, aqueous extracts were investigated for their nucleotide sequencing, biological compound contents, and…
Potere signorile, consenso, dissenso e controllo del territorio nella Sicilia del Trecento: l’esempio dei Chiaromonte
2021
The essay analyses the reasons why the governments created by Chiaromonte family in the cities of eastern Sicily failed, and investigates the cause of their success in the long lasting urban signorie of western Sicily. To create consensus, they had to ensure the supply of grain for the population, to defend the territory from external attacks, and to maintain public order. In addition to military prowess, they used their speaking skills to influence citizens and showed a magnificent lifestyle by building imposing palaces, celebrating sumptuous weddings and funerals, and commissioning works of art. They created spy networks and used violent methods to repress dissent (imprisonment, torture, …
Scene giudiziarie nelle tragedie e nelle commedie latine del XII e XIII secolo. Il «De Affra et Flavio», il «De Paulino et Polla» di Riccardo da Veno…
2021
La commedia elegiaca e la tragedia latina del XII e XIII secolo mostrano una larga e varia ricchezza di caratteristiche, temi, soggetti e tipologie letterarie: uso del distico elegiaco, "imitatio" ovidiana, preponderanza della tematica amorosa, compresenza di narrazione e dialogo, e così via. Un elemento caratterizzante di alcune di queste commedie e tragedie medievali è rappresentato dalle scene giudiziarie. In questo saggio, dopo una breve introduzione sul genere letterario, viene svolta una puntuale analisi delle scene di giudizio che ricorrono in tre testi latini del XII e XIII secolo, una tragedia (l’anonimo «De Affra et Flavio»), una commedia elegiaca (il «De Paulino et Polla» di Ricc…
Crisi globali, nuove diseguaglianze e co-produzione di spazi: una prospettiva di ricerca
2021
L’articolo propone una riflessione critica sul rischio di negazione sostanziale di diritti di cittadinanza a partire dalle forme di discriminazione nell’uso e fruizione dello spazio pubblico introdotte dalle crisi globali. La co-produzione di nuovi spazi alla micro-scala e alla scala di quartiere (a partire dagli spazi pubblici o semipubblici spesso privatizzati o sottoutilizzati) può divenire l’occasione per la generazione di nuovi luoghi di condivisione e socialità che rispondano alla richiesta di nuovi servizi e definiscano al contempo il profilo di una pratica urbanistica innovativa, fondata sul pieno riconoscimento del diritto alla città e sul patto istituzionicittadini This article pr…
Minori di età e formazione dei giovani atleti : storia di una riforma incompiuta
2021
The paper analyses the recent reform of the Italian sport system that includes, for the first time, some new regulations about minors and young athletes. The work underlines that despite the attempt by the legislator, the result is still not satisfying due to the lack of a 'child-centred' perspective.
Digital Pathology Enables Automated and Quantitative Assessment of Inflammatory Activity in Patients with Chronic Liver Disease
2021
Traditional histological evaluation for grading liver disease severity is based on subjective and semi-quantitative scores. We examined the relationship between digital pathology analysis and corresponding scoring systems for the assessment of hepatic necroinflammatory activity. A prospective, multicenter study including 156 patients with chronic liver disease (74% nonalcoholic fatty liver disease-NAFLD, 26% chronic hepatitis-CH etiologies) was performed. Inflammation was graded according to the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network system and METAVIR score. Whole-slide digital image analysis based on quantitative (I-score: inflammation ratio) and morphometric (C-sco…
The Differences in the Prevalence of Cardiovascular Disease, Its Risk Factors, and Achievement of Therapeutic Goals among Urban and Rural Primary Car…
2021
A nationwide cross-sectional study, LIPIDOGRAM2015, was carried out in Poland in the years 2015 and 2016. A total of 438 primary care physicians enrolled 13,724 adult patients that sought medical care in primary health care practices. The prevalence of hypertension, diabetes mellitus, dyslipidaemia, and CVD were similar in urban and rural areas (49.5 vs. 49.4%; 13.7 vs. 13.1%; 84.2 vs. 85.2%; 14.4 vs. 14.2%, respectively). The prevalence of obesity (32.3 vs. 37.5%, p p p p = 0.04) and non-HDL-C (147 vs. 148 mg/dL, p = 0.03) were slightly higher in rural populations. Altogether, 14.3% of patients with CVD from urban areas and 11.3% from rural areas reached LDL p = 0.04). There were no import…
Coupled hydro-mechanical analysis of compacted bentonite behaviour during hydration
2021
Abstract This study analyses the response of compacted bentonites upon hydration based on a coupled hydro-mechanical elasto-plastic framework. As an alternative to multi-porosity interpretation, the framework was selected based on the experimental evidence of adsorbed water behaviour in bentonites and the volumetric response at saturated states, apparently independent of its initial state. Based on these premises, a water retention model was formulated using an explicit distinction between adsorbed water and free water, enabling the postulation of the water properties and behaviour depending on its state. In order to effectively account for the transition between unsaturated to saturated st…
Innoeduca : international journal of technology and educational innovation
2021
La integración de las tecnologías en el ámbito educativo es una realidad innegable en la sociedad del siglo XXI, caracterizada por los rápidos cambios que posibilitan la revolución educativa y la innovación. Muestra de ello es el uso de videojuegos en los centros escolares de las etapas de Educación Infantil y Primaria. Estas prácticas gamificadas mediante tecnología no están exentas de críticas o susceptibilidades sobre sus posibilidades educativas. Con el fin de describir los beneficios y posibilidades de la introducción de los videojuegos en las aulas detectados en la literatura científica, se ha realizado un estudio de revisión bibliográfica. Para ello, se utilizaron cuatro bases de dat…
Preclinical characterization of antagomiR-218 as a potential treatment for myotonic dystrophy
2021
Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease caused by expansion of unstable CTG repeats in a non-coding region of the DMPK gene. CUG expansions in mutant DMPK transcripts sequester MBNL1 proteins in ribonuclear foci. Depletion of this protein is a primary contributor to disease symptoms such as muscle weakness and atrophy and myotonia, yet upregulation of endogenous MBNL1 levels may compensate for this sequestration. Having previously demonstrated that antisense oligonucleotides against miR-218 boost MBNL1 expression and rescue phenotypes in disease models, here we provide preclinical characterization of an antagomiR-218 molecule using the HSALR mouse model and patient-d…
La Valle dei Templi in epoca medioevale. Caratterizzazione antropologica e paleopatologica delle sepolture antistanti in Tempio della Concordia
2021
Riassunto ― Il lavoro presenta i risultati delle analisi bio-archeologiche effettuate su resti scheletrici umani rinvenuti in quattordici sepolture di epoca medioevale rinvenute nel Parco Archeologico della Valle dei Templi di Agrigento (Sicilia). L’obiettivo è stato l’acquisizione delle informazioni necessarie per la ricostruzione del profilo biologico di ciascun individuo, al fine di determinarne il sesso, la stima dell’età biologica alla morte, la stima della statura e la valutazione delle patologie e degli indicatori di stress occupazionale mediante le correnti metodologie e tecniche diagnostiche di tipo antropologico. Sebbene il cattivo stato di conservazione di alcuni individui non ne…
The Dynamic Relationship between Response Processes and Self-Regulation in Critical Thinking Assessments
2021
Our aim was to explore higher education students’ response and self-regulatory processes plus the relationship between these, as evidenced in two types of performance-based critical thinking tasks included in the Collegiate Learning Assessment (CLA+) International instrument. The data collection consisted of 20 cognitive laboratories. The data were analyzed using a qualitative approach. The tasks were found to trigger different response and self-regulatory processes. Overall, the performance task evoked more holistic processes than the selected-response questions, in which students’ processes were more question-oriented. The results also indicated the entanglement of students’ response and …
COVID-19 and non–COVID-19 pneumonia: a comparison
2021
Abstract Background The COVID-19 pandemic has caused the relocation of huge financial resources to departments dedicated to infected patients, at the expense of those suffering from other pathologies. Aim To compare clinical features and outcomes in COVID-19 pneumonia and non-COVID-19 pneumonia patients. Patients and methods 53 patients (35 males, mean age 61.5 years) with COVID-19 pneumonia and 50 patients (32 males, mean age 72.7 years) with non-COVID-19 pneumonia, consecutively admitted between March and May 2020 were included. Clinical, laboratory and radiological data at admission were analyzed. Duration of hospitalization and mortality rates were evaluated. Results Among the non-COVID…
Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography: A multicenter study.
2021
Objective: The aim of this study was to report the rate of additional anomalies detected exclusively at prenatal magnetic resonance imaging (MRI) in fetuses with isolated severe ventriculomegaly undergoing neurosonography. Method: Multicenter, retrospective, cohort study involving 20 referral fetal medicine centers in Italy, United Kingdom, Spain and Denmark. Inclusion criteria were fetuses affected by isolated severe ventriculomegaly (≥15 mm), defined as ventriculomegaly with normal karyotype and no other additional central nervous system (CNS) and extra-CNS anomalies on ultrasound. In all cases, a multiplanar assessment of fetal brain as suggested by ISUOG guidelines on fetal neurosonogra…
Les eaux captées par le chemin de fer : prises d’eaux et conflits environnementaux autour du tunnel de Blaisy au milieu du XIXe siècle
2021
International audience
Predictors of complicated grief in mourners of sudden cardiac death.
2021
Droplet digital PCR as a tool for investigating dynamics of cryptic symbionts
2021
Abstract Interactions among symbiotic organisms and their hosts are major drivers of ecological and evolutionary processes. Monitoring the infection patterns among natural populations and identifying factors affecting these interactions are critical for understanding symbiont–host relationships. However, many of these interactions remain understudied since the knowledge about the symbiont species is lacking, which hinders the development of appropriate tools. In this study, we developed a digital droplet PCR (ddPCR) assay based on apicomplexan COX1 gene to detect an undescribed agamococcidian symbiont. We show that the method gives precise and reproducible results and enables detecting cryp…
The integration of informal business law in the OHADA framework. Methodological reflections
2021
OHADA represents today a successful example of legal integration that offers a modern and reliable legal environment regarding business law in those countries that have joined it. However, such a modern integrated system of business law appears to be unsuited to the informal business sector that still represents a vital segment of the economy in most of the African countries. The paper discusses the attempts that have been made to integrate the informal business sector in the OHADA framework, trying to understand the reasons why they have been substantially unsuccessful and suggests a possible way forward to make such integration possible.
Is It Possible to Produce Certified Hazelnut Plant Material in Sicily? Identification and Recovery of Nebrodi Genetic Resources, in vitro Establishme…
2021
Eight Sicilian cultivars of hazelnut (Corylus avellanaL.), namely-Curcia, Nociara Collica, Panottara Collica, Panottara Galati Grande, Parrinara, Panottara Baratta Piccola, Enzo, and Rossa Galvagno, registered into the Italian Cultivar Register of fruit tree species in 2017 were selected from Nebrodi area and establishedin vitro. The aim of the work was to carry out the sanitation of the cultivars and get virus-free plants from the most important viral pathogen threat, theapple mosaic virus. Virus-free plant material is essential for the production of certified plants from Sicilian hazelnut cultivars, complying the CE (cat. CAC) quality and the technical standards established in 2017 for vo…
Iron-based metal-organic framework: Synthesis, structure and current technologies for water reclamation with deep insight into framework integrity.
2021
Water is a supreme requirement for the existence of life, the contamination from the point and non-point sources are creating a great threat to the water ecosystem. Advance tools and techniques are required to restore the water quality and metal-organic framework (MOFs) with a tunable porous structure, striking physical and chemical properties are an excellent candidate for it. Fe-based MOFs, which developed rapidly in recent years, are foreseen as most promising to overcome the disadvantages of traditional water depolluting practices. Fe-MOFs with low toxicity and preferable stability possess excellent performance potential for almost all water remedying techniques in contrast to other MOF…
Sull'essenza di Beatrice. Caratteri pedagogici della Divina Commedia
2021
Fra i capitoli da Romano Guardini dedicati alle guide che figurano al fianco di Dante nella Divina Commedia, un posto di tutto rilievo è occupato dalle pagine su Beatrice. Alla donna, personificazione della grazia che interviene a sostegno dell’uomo, l’autore riconosce la missione di affiancare Dante nel regno del Paradiso e di lì mediare il suo incontro con Dio. Indagando in profondità l’essenza di Beatrice, Guardini vi scorge il più nobile compito di un amore terreno che non termina alle soglie dell’eternità, poiché partecipando dell’essenza di Dio conferisce all’esistenza il suo più pieno significato.
Cuerpos estereotipados, cuerpos enterrados, cuerpos representados, cuerpos cambiantes. Una aproximación panorámica desde la arqueología feminista
2021
En este trabajo abordamos distintas vías de aproximación a las identidades corporales femeninas y a su agencia, desde una perspectiva transversal, tomando como referencia algunos casos de estudio procedentes de contextos seleccionados de la prehistoria y protohistoria de la península ibérica, así como del Mediterráneo Antiguo. Tres ejes principales ordenarán este acercamiento: en primer lugar, una reflexión sobre los estereotipos de las imágenes de la prehistoria, que han generado modelos comprensivos sobre el pasado que están profundamente distorsionados; en segundo lugar, el estudio de las identidades corporales, a través del análisis de los cuerpos depositados y representados en distinto…
Nutritional parameters associated with prognosis in non-critically ill hospitalized covid-19 patients: the nutri-covid19 study
2021
Background & aims: To investigate the association between the parameters used in nutritional screening assessment (body mass index [BMI], unintentional weight loss [WL] and reduced food intake) and clinical outcomes in non-critically ill, hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: This was a prospective multicenter real-life study carried out during the first pandemic wave in 11 Italian Hospitals. In total, 1391 patients were included. The primary end-point was a composite of in-hospital mortality or admission to ICU, whichever came first. The key secondary end-point was in-hospital mortality. Results: Multivariable models were based on 1183 patients with comple…
Tommaso Stanislao Velasti tra filellenismo partenopeo e ideologia “albanista”
2021
L'opera del gesuita greco originario di Scio, Tommaso Stanislao Velasti, costituisce un compendio dell'ideologia filoellenica che a partire dalla seconda metà del XVIII secolo, influenzò i processi irredentistici che nel 1821 portarono la Grecia a proclamare la propria indipendenza dalla Sublime Porta. Nel suo percorso di ricerca, Velasti ebbe la fortuna di incontrare le opere di intellettuali albanesi di Sicilia, presso il cui seminario palermitano ebbe modo di dimorare negli anni cruciali della sua svolta ideologica. Lo studio di alcuni fondamentali documenti emersi dall'archivio del Seminario fondato da p. Giorgio Guzzetta ha evidenziato la filiazione di idee fondamentali dell'ideologia …
Identification of biomarkers in wastewater-based epidemiology: Main approaches and analytical methods
2021
Wastewater-based epidemiology (WBE) has become popular to estimate the use of drugs of abuse and recently to establish the incidence of CoVID 19 in large cities. However, its possibilities have been expanded recently as a technique that allows to establish a fingerprint of the characteristics of a city, such as state of health/disease, healthy/unhealthy living habits, exposure to different types of contaminants, etc. with respect to other cities. This has been thanks to the identification of human biomarkers as well as to the fingerprinting and profiling of the characteristics of the wastewater catchment that determine these circumstances. The purpose of this review is to analyze the differ…
Physical activity intention and attendance behaviour in Finnish youth with cerebral palsy – results from a physical activity intervention: an applica…
2021
Physical activity is associated with better health in individuals with cerebral palsy (CP). Numerous physical activity interventions have been designed to promote physical activity among youth with CP. No previous studies have explored the factors contributing to the intention to participate and predicting attendance behaviour for these interventions. Using theory of planned behaviour (TPB), this study explored the prediction of physical activity intention and attendance behaviour in a physical activity intervention aiming to promote physical activity in a sample of young individuals with CP. Males with CP aged 9–21 years were asked to complete measures of attitude, subjective norms, percei…
The degradation of intracrystalline mollusc shell proteins: a proteomics study of Spondylus gaederopus.
2021
Mollusc shells represent excellent systems for the preservation and retrieval of genuine biomolecules from archaeological or palaeontological samples. As a consequence, the post-mortem breakdown of intracrystalline mollusc shell proteins has been extensively investigated, particularly with regard to its potential use as a "molecular clock" for geochronological applications. But despite seventy years of ancient protein research, the fundamental aspects of diagenesis-induced changes to protein structures and sequences remain elusive. In this study we investigate the degradation of intracrystalline proteins by performing artificial degradation experiments on the shell of the thorny oyster, Spo…
Methodological approaches for the analysis of transmembrane domain interactions: A systematic review
2021
The study of protein-protein interactions (PPI) has proven fundamental for the understanding of the most relevant cell processes. Any protein domain can participate in PPI, including transmembrane (TM) segments that can establish interactions with other TM domains (TMDs). However, the hydrophobic nature of TMDs and the environment they occupy complicates the study of intramembrane PPI, which demands the use of specific approaches and techniques. In this review, we will explore some of the strategies available to study intramembrane PPI in vitro, in vivo, and, in silico, focusing on those techniques that could be carried out in a standard molecular biology laboratory regarding its previous e…