showing 36 of ~574560 from 574555 documents
SALVATORE GREGORIETTI : IL MESTIERE DEL GRAFICO
2021
Salvatore Gregorietti ha attraversato i tanti anni, ormai più di cinquanta, dedicati al mestiere del grafico, fatti di studio, sperimentazione, ricerca, sempre inarrestabili, conditi da altrettanta leggerezza e irriverenza, oltrepassando i confini anche angusti della scuola grafica svizzera, per trovare una sua strada nel design della comunicazione visiva, ricca di ramificazioni e svolte improvvise, alla scoperta di nuovi strumenti, per generare nuovi linguaggi visivi, che sono sempre la coniugazione e non la giustapposizione in un artefatto di una buona e onesta forma visuale (Gute Form come la definisce Max Bill) in risposta a una precisa funzione da compiere.
La revista Cabás y la SEPHE como órganos de difusión del conocimiento histórico-educativo
2021
El objetivo de este artículo es presentar algunos avances sobre el estudio de las redes de circulación en Historia de la Educación en los espacios de comunicación, representación y construcción social. Concretamente, se analizan tres herramientas: la revista Cabás, la SEPHE y las Jornadas Científicas de la SEPHE. Los focos de interés se centran en aspectos vinculados a las formas y estilos de comunidad científica para articular su vida en común, los espacios creados para la participación y la construcción colectiva del proyecto, las colaboraciones e influencias transnacionales, las líneas de interés científico expresadas en reuniones científicas y publicaciones periódicas, y los canales de …
Chi ha bisogno della mobilità? Per una critica situata del new mobilities paradigm
2021
Nei vent’anni trascorsi dalla pubblicazione di “Sociology Beyond Societies” di John Urry (2000), il testo che ha anticipato e ispirato il successivo mobility turn nelle scienze sociali, si è assistito a un proliferare di discorsi sulla mobilità che hanno travalicato dipartimenti, riviste e discipline portando al centro della scena migrazioni, flussi turistici, viaggi virtuali, trasporti di merci e persone. Obiettivo di questo contributo è di indagare criticamente i processi e le condizioni di produzione del mobility turn e di rileggerne contenuti, attori e metodologie all’interno dell’operazione strategica che l’ha sostenuto. In particolare, muovendo da una delle domande fondative della geo…
DFT/TD-DFT Framework of Mixed-Metal Complexes with Symmetrical and Unsymmetrical Bridging Ligands—Step-By-Step Investigations: Mononuclear, Dinuclear…
2021
Recently, mono- and dinuclear complexes have been in the interest of scientists due to their potential application in optoelectronics. Herein, progressive theoretical investigations starting from mononuclear followed by homo- and heterometallic dinuclear osmium and/or ruthenium complexes with NCN-cyclometalating bridging ligands substituted by one or two kinds of heteroaryl groups (pyrazol-1-yl and 4-(2,2-dimethylpropyloxy)pyrid-2-yl) providing the short/long axial symmetry or asymmetry are presented. Step-by-step information about the particular part that built the mixed-metal complexes is crucial to understanding their behavior and checking the necessity of their eventual studies. Evaluat…
Essential Package of Palliative Care for Women With Cervical Cancer: Responding to the Suffering of a Highly Vulnerable Population
2021
Women with cervical cancer, especially those with advanced disease, appear to experience suffering that is more prevalent, complex, and severe than that caused by other cancers and serious illnesses, and approximately 85% live in low- and middle-income countries where palliative care is rarely accessible. To respond to the highly prevalent and extreme suffering in this vulnerable population, we convened a group of experienced experts in all aspects of care for women with cervical cancer, and from countries of all income levels, to create an essential package of palliative care for cervical cancer (EPPCCC). The EPPCCC consists of a set of interventions, medicines, simple equipment, social s…
Minori di età e formazione dei giovani atleti : storia di una riforma incompiuta
2021
The paper analyses the recent reform of the Italian sport system that includes, for the first time, some new regulations about minors and young athletes. The work underlines that despite the attempt by the legislator, the result is still not satisfying due to the lack of a 'child-centred' perspective.
Effects of COVID19 pandemic on the Italian power system and possible countermeasures
2021
Abstract The paper analyses the dramatic effects of the first wave of the COVID-19 pandemic on the Italian power system, considering the impacts on load and generation, market issues and ancillary services provision. During the period between March and May 2020, the Italian scenario was considered as exemplary due to the large reduction of loads and thermal generation caused by the hard lockdown across the Country. Italy has experienced the most severe effects of pandemic in terms of increase of death rates and of pressure on the health system as well as severity of the countermeasures. As a domino effect, the total lockdown of one of the most industrialized countries in the world has creat…
Scalable and effective multi-level entangled photon states: a promising tool to boost quantum technologies
2021
Abstract Multi-level (qudit) entangled photon states are a key resource for both fundamental physics and advanced applied science, as they can significantly boost the capabilities of novel technologies such as quantum communications, cryptography, sensing, metrology, and computing. The benefits of using photons for advanced applications draw on their unique properties: photons can propagate over long distances while preserving state coherence, and they possess multiple degrees of freedom (such as time and frequency) that allow scalable access to higher dimensional state encoding, all while maintaining low platform footprint and complexity. In the context of out-of-lab use, photon generation…
Overdose of Quetiapine—A Case Report with QT Prolongation
2021
Quetiapine is an atypical antipsychotic drug used to treat bipolar disorder, schizophrenia, and major depressive disorder. Although several studies describe the adverse effects of intoxication with Quetiapine, only a few report an extreme overdose without comedications that lead to a life threat. We present a case of a 75-year-old male who tried to attempt suicide by ingesting 28 g of Quetiapine. During the management in the emergency department, both serum and urine samples were collected, allowing a complete pharmacokinetic analysis to be conducted, from the admission to the discharge.
Tracking the evolution of the accretion flow in MAXI J1820+070 during its hard state with the JED-SAD model
2021
X-ray binaries in outburst typically show two canonical X-ray spectral states, i.e. hard and soft states, in which the physical properties of the accretion flow and of the jet are known to change. Recently, the JED-SAD paradigm has been proposed for black hole X-ray binaries, aimed to address the accretion-ejection interplay in these systems. According to this model, the accretion flow is composed by an outer standard Shakura-Sunyaev disk (SAD) and an inner hot Jet Emitting Disk (JED). The JED produces both the hard X-ray emission, effectively playing the role of the hot corona, and the radio jets. In this paper, we use the JED-SAD model to describe the evolution of the accretion flow in th…
Detection of developmental dyslexia with machine learning using eye movement data
2021
Dyslexia is a common neurocognitive learning disorder that can seriously hinder individuals’ aspirations if not detected and treated early. Instead of costly diagnostic assessment made by experts, in the near future dyslexia might be identified with ease by automated analysis of eye movements during reading provided by embedded eye tracking technology. However, the diagnostic machine learning methods need to be optimized first. Previous studies with machine learning have been quite successful in identifying dyslexic readers, however, using contrasting groups with large performance differences between diagnosed and good readers. A practical challenge is to identify also individuals with bord…
FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
2021
Common fragile sites (CFSs) are genomic regions frequently involved in cancer-associated rearrangements. Most CFSs lie within large genes, and their instability involves transcription- and replication-dependent mechanisms. Here, we uncover a role for the mitochondrial stress response pathway in the regulation of CFS stability in human cells. We show that FANCD2, a master regulator of CFS stability, dampens the activation of the mitochondrial stress response and prevents mitochondrial dysfunction. Genetic or pharmacological activation of mitochondrial stress signaling induces CFS gene expression and concomitant relocalization to CFSs of FANCD2. FANCD2 attenuates CFS gene transcription and pr…
Integrating functional traits into correlative species distribution models to investigate the vulnerability of marine human activities to climate cha…
2021
Climate change and particularly warming are significantly impacting marine ecosystems and the services they provided. Temperature, as the main factor driving all biological processes, may influence ectotherms metabolism, thermal tolerance limits and distribution species patterns. The joining action of climate change and local stressors (including the increasing human marine use) may facilitate the spread of non-indigenous and native outbreak forming species, leading to associated economic consequences for marine coastal economies. Marine aquaculture is one among the most economic anthropogenic activities threatened by multiple stressors and in turn, by increasing hard artificial substrates …
Immune biomarkers to predict SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies
2021
AbstractThere is evidence of reduced SARS-CoV-2 vaccine effectiveness in patients with hematological malignancies. We hypothesized that tumor and treatment-related immunosuppression can be depicted in peripheral blood, and that immune profiling prior to vaccination can help predict immunogenicity. We performed a comprehensive immunological characterization of 83 hematological patients before vaccination and measured IgM, IgG, and IgA antibody response to four viral antigens at day +7 after second-dose COVID-19 vaccination using multidimensional and computational flow cytometry. Health care practitioners of similar age were the control group (n = 102). Forty-four out of 59 immune cell types …
Rational solutions to the mKdV equation associated to particular polynomials
2021
International audience; Rational solutions to the modified Korteweg-de Vries (mKdV) equation are given in terms of a quotient of determinants involving certain particular polynomials. This gives a very efficient method to construct solutions. We construct very easily explicit expressions of these rational solutions for the first orders n = 1 until 10.
Depositi di valore e offerte ponderali per gli dei dalle aree sacre indigene della Sicilia
2021
The study analyzes five hoards from some indigenous centers of Sicily, paying particular attention above all to the methods of deposition and the context of discovery in order to advance reflections on their function and destination. Since these are complexes found in the vicinity or within sacred places, it is however possible to further circumscribe the interpretative possibilities. The scrap metal, in fact, as a form of accumulation of wealth, can act as a votive offering, probably cut to precise weight standards, or as a reserve of value of the sanctuary or even have the function of material used by foundries close to sacred places. Only the analysis of the context of discovery and the …
Il filosofo non è il suo doppio: la scivolosa somiglianza tra filosofia e sofistica
2021
Heristics and rhetoric can therefore constitute a dangerous drift of the dialogical method; and despite some apparent similarities between the dialectical and the eristic method, what will always differentiate the philosopher from the erist is a radically different ethical horizon. If the philosopher is genuinely a friend of knowledge, wisdom and justice, and therefore every action of his is aimed at good, it will not be too difficult a task, as instead believes Deleuze, to think that his talks always transform the dispute into new acquisitions for knowledge
The CARe Burn Scale—Adult Form: Translation and linguistic validation into Finnish
2021
Abstract Background Burn injury can dramatically deteriorate health-related quality of life. Effective burn care may minimize the impact of the burn injury and ensure optimal functional outcome. This requires continuous improvement in burn care and assessment of treatment results. The aim of this study was to translate, culturally adapt and linguistically validate the CARe Burn Scale—Adult Form, a burn-specific patient-reported outcome measure, into Finnish. Methods The translation process followed the International Society for Pharmacoeconomics and Outcomes Research guidelines consisting of forward and backward translations, pilot-testing and cognitive debriefing interviews of five burn pa…
Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic
2021
Association of Surgeons in Training Surgical Summit, online, 17 Oct 2020 - 17 Oct 2020 2021 Virtual Annual Meeting / Surgical Research Society, online, 24 Mar 2021 - 25 Mar 2021, National Research Collaborative Meeting, online, 10 Dec 2020 - 10 Dec 2020, Royal Australasian College of Surgeons Annual Academic Surgery Conference, online, 5 Nov 2020 - 5 Nov 2020; The British journal of surgery : BJS 108(12), 1448-1464 (2021). doi:10.1093/bjs/znab336
Post-fotografia etnografica
2021
È evidente come la nostra società tecnologica sia legata senza alcun dubbio alla diffusione delle immagini. Autori come Gottfried Boehm, John Mitchell, Hans Belting hanno indagato la natura dell'immagine ponendo le basi, negli anni Novanta, per l'idea di un pictorial turn, di una cultura totalmente dominata dalle immagini che è diventata adesso una possibilità tecnica reale su scala globale. Un nuovo statuto dell'immagine che si usa raccogliere sotto l'etichetta di iconic turner inserito nel più vasto campo visual culture studies. L'uso del termine cultura accanto a quello di visuale è indicativo dell'ampiezza del campo d'indagine che visual culture studies si prefiggono di ricercare: essi …
Adherence to an Injury Prevention Warm-Up Program in Children’s Soccer : A Secondary Analysis of a Randomized Controlled Trial
2021
This study examined the impact of high adherence to a neuromuscular training (NMT) warm-up on the risk of lower extremity (LE) injuries in children’s soccer. Twenty U11–U14 youth clubs (n = 92 teams, 1409 players) were randomized into intervention (n = 44 teams) and control (n = 48 teams) groups. The intervention group was advised to perform an NMT warm-up 2 to 3 times a week for 20 weeks. Team adherence, injuries, and exposure were registered throughout the follow-up. Primary outcomes were the incidence of soccer-related acute LE injuries and the prevalence of overuse LE injuries. Intervention teams conducted mean 1.7 (SD 1.0) NMT warm-ups weekly through follow-up. The seasonal trend for a…
Early symptomatic benefit indicates long-term prognosis after transcatheter mitral valve edge-to-edge repair in functional and degenerative etiology
2021
Mitral regurgitation (MR) is common in patients with heart failure and constitutes an independent risk factor for adverse prognosis besides NYHA-class. The predictive value of dyspnea reduction after transcatheter mitral valve repair (TMVr) on outcome has not been investigated up to now.We enrolled 627 consecutive patients (47.0% female, 57.4% functional MR; median follow-up 486 days[IQR 157/961]; survival status available in 96.8%; symptoms assessed in n = 556 at baseline / n = 406 at 1 month) treated with isolated percutaneous mitral valve edge-to-edge repair in our center from 06/2010-03/2018 (exclusion of combined forms of TMVr) in a monocentric retrospective analysis. Survival was 97.6…
Q-switched mode locking noise-like pulse generation from a thulium-doped all-fiber laser based on nonlinear polarization rotation
2021
Abstract Q-switched mode locking (QML) noise-like pulse (NLP) emission from an all-fiber thulium-doped laser based on the nonlinear polarization rotation effect is reported. The QML emission is obtained in a cavity with net anomalous dispersion in a pump power interval in between the CW laser threshold and the threshold of the NLP regime. Highest-energy QML pulses were observed with a repetition rate of 812 kHz with a pump power of 520 mW at the optical wavelength of 1881.09 nm. A maximum overall energy of 460 nJ at an average output power of 6.4 mW was reached, which corresponds to a burst of mode-locked noise-like sub-pulses with 8.7 ns of pulse duration within a QML envelope of 11 µs. Th…
Runs of homozygosity in the Italian goat breeds: impact of management practices in low-input systems
2021
Abstract Background Climate and farming systems, several of which are considered as low-input agricultural systems, vary between goat populations from Northern and Southern Italy and have led to different management practices. These processes have impacted genome shaping in terms of inbreeding and regions under selection and resulted in differences between the northern and southern populations. Both inbreeding and signatures of selection can be pinpointed by the analysis of runs of homozygosity (ROH), which provides useful information to assist the management of this species in different rural areas. Results We analyzed the ROH distribution and inbreeding (FROH) in 902 goats from the Italia…
Geografia sociale e partecipazione. L’esperienza di #esserefiera
2021
Social geography cannot be confined to a theoretical dimension, however necessary: it is expected to play an active role, to encourage encounters with social actors and stakeholders, to take on a dimension of public engagement. Even in Italy this dimension is increasingly important, as universities are placing a growing value on their so-called third mission. Social geography must then address the fundamental issue of participation and its techniques. In doing so, those who graduate in geography will also be able to claim an essential role in the management of decision-making processes and participatory planning. This paper explores some methods and approaches that younger geographers can u…
Vittorio Gregotti, il Sud e la scoperta della dimensione antropogeografica dell'architettura
2021
In una conferenza tenuta il 23 marzo 2010 a Cosenza, Vittorio Gregotti ha affermato che non si può comprendere l’Italia se non la si guarda da Sud. Nonostante la sua parabola critica sia stata sempre caratterizzata da una forte assertività, l’affermazione sopra citata si colloca oltre la semplice parafrasi retorica della celebre frase di Goethe: essa rappresenta l’esplicito riconoscimento del debito acquisito nei confronti di alcune esperienze progettuali, realizzate dal progettista novarese a partire dalla fine degli anni sessanta in Calabria e in Sicilia. Esperienze che hanno permesso a Gregotti di chiarire e precisare la propria visione critica dell’architettura. Il contributo che qui si…
Duques, princesas y arzobispos: la fecha de redacción de Virtud, pobreza y mujer, de Lope de Vega
2021
En este artículo se aportan las razones oportunas para considerar que la comedia 'Virtud, pobreza y mujer', de Lope de Vega, se escribió a comienzos de 1616, frente a la opinión mayoritaria de la crítica, que hasta ahora se había inclinado por fecharla en un periodo comprendido entre 1612 y 1615. Los indicios a este respecto se encuentran en el segundo acto de la obra: se trata de una serie de referencias a circunstancias concretas, fechables todas ellas en 1616, ligadas a personajes del momento, tales como el arzobispo Pedro González de Mendoza y Silva (1571-1639), la princesa - y futura reina - Isabel de Borbón (1602-1644) y, finalmente, Jorge de Cárdenas y Manrique (ca. 1592-1644), cuart…
Predictors of nurses' attitudes and knowledge towards pain management in Italy. A cross-sectional study in the hospital settings.
2021
Abstract Introduction Pain is multidimensional, and as such it is the chief reason patients require urgent health care services. If inadequately assessed and untreated, pain may negatively impact on the quality of life of the patient. Pain management is an essential part of Nursing. The aim to this study is to examine the level of knowledge and attitudes with regard to pain among Italian nurses who work in clinical settings. Methods The Ferrell and McCaffery's Knowledge and Attitudes Survey Regarding Pain was distributed to 266 nurses employed in one specialized hospital in Rome, Italy. The staff in the survey work in three different settings: the intensive care unit, the sub-intensive care…
Lifelong soya consumption in males does not increase lifespan but increases health span under a metabolic stress such as type 2 diabetes mellitus.
2021
Soya consumption can decrease oxidative stress in animal models. Moreover, phytoestrogens such as genistein, present in soya, can mimic some of the beneficial effects of estrogens and are devoid of significant side effects, such as cancer. In this study, we have performed a controlled lifelong study with male OF1 mice that consumed either a soya-free diet or a soya-rich diet. We show that, although we found an increase in the expression and activity of antioxidant enzymes in soya-consuming mice, it did not increase lifespan. We reasoned that the soya diet could not increase lifespan in a very healthy population, but perhaps it could extend health span in stressed animals such as type 2 diab…
Cuerpos estereotipados, cuerpos enterrados, cuerpos representados, cuerpos cambiantes. Una aproximación panorámica desde la arqueología feminista
2021
En este trabajo abordamos distintas vías de aproximación a las identidades corporales femeninas y a su agencia, desde una perspectiva transversal, tomando como referencia algunos casos de estudio procedentes de contextos seleccionados de la prehistoria y protohistoria de la península ibérica, así como del Mediterráneo Antiguo. Tres ejes principales ordenarán este acercamiento: en primer lugar, una reflexión sobre los estereotipos de las imágenes de la prehistoria, que han generado modelos comprensivos sobre el pasado que están profundamente distorsionados; en segundo lugar, el estudio de las identidades corporales, a través del análisis de los cuerpos depositados y representados en distinto…
Identification of Partner Proteins of the Algae Klebsormidium nitens NO Synthases: Toward a Better Understanding of NO Signaling in Eukaryotic Photos…
2021
In animals, NO is synthesized from L-arginine by three isoforms of nitric oxide synthase (NOS) enzyme. NO production and effects have also been reported in plants but the identification of its sources, especially the enzymatic ones, remains one of the critical issues in the field. NOS-like activities have been reported, although there are no homologs of mammalian NOS in the land plant genomes sequenced so far. However, several NOS homologs have been found in algal genomes and transcriptomes. A first study has characterized a functional NOS in the chlorophyte Ostreococcus tauri and the presence of NOS homologs was later confirmed in a dozen algae. These results raise the questions of the sig…
Alterations of panoramic radiomorphometric indices in children and adolescents with beta-thalassemia major: A fractal analysis study
2021
Background Beta-thalassemia major is an inherited disorder that can cause bone deformity and loss of bone mineral density. The objective of this study is to evaluate the cortical and trabecular mandibular bone morphology of children and adolescents who have beta-thalassemia major (ß-TM) using a fractal dimension (FD) analysis and different panoramic radiomorphometric indices with digital panoramic radiographic images (DPRIs). Material and Methods The study included 80 patients (with 40 patients each of ß-TM and control). The mandibular cortical width (MCW), panoramic mandibular index (PMI), mandibular cortical index (MCI), and simple visual estimation (SVE) were evaluated, and an FD analysi…
Role of prenatal magnetic resonance imaging in fetuses with isolated severe ventriculomegaly at neurosonography: A multicenter study.
2021
Objective: The aim of this study was to report the rate of additional anomalies detected exclusively at prenatal magnetic resonance imaging (MRI) in fetuses with isolated severe ventriculomegaly undergoing neurosonography. Method: Multicenter, retrospective, cohort study involving 20 referral fetal medicine centers in Italy, United Kingdom, Spain and Denmark. Inclusion criteria were fetuses affected by isolated severe ventriculomegaly (≥15 mm), defined as ventriculomegaly with normal karyotype and no other additional central nervous system (CNS) and extra-CNS anomalies on ultrasound. In all cases, a multiplanar assessment of fetal brain as suggested by ISUOG guidelines on fetal neurosonogra…
The Differences in the Prevalence of Cardiovascular Disease, Its Risk Factors, and Achievement of Therapeutic Goals among Urban and Rural Primary Car…
2021
A nationwide cross-sectional study, LIPIDOGRAM2015, was carried out in Poland in the years 2015 and 2016. A total of 438 primary care physicians enrolled 13,724 adult patients that sought medical care in primary health care practices. The prevalence of hypertension, diabetes mellitus, dyslipidaemia, and CVD were similar in urban and rural areas (49.5 vs. 49.4%; 13.7 vs. 13.1%; 84.2 vs. 85.2%; 14.4 vs. 14.2%, respectively). The prevalence of obesity (32.3 vs. 37.5%, p p p p = 0.04) and non-HDL-C (147 vs. 148 mg/dL, p = 0.03) were slightly higher in rural populations. Altogether, 14.3% of patients with CVD from urban areas and 11.3% from rural areas reached LDL p = 0.04). There were no import…
Potere signorile, consenso, dissenso e controllo del territorio nella Sicilia del Trecento: l’esempio dei Chiaromonte
2021
The essay analyses the reasons why the governments created by Chiaromonte family in the cities of eastern Sicily failed, and investigates the cause of their success in the long lasting urban signorie of western Sicily. To create consensus, they had to ensure the supply of grain for the population, to defend the territory from external attacks, and to maintain public order. In addition to military prowess, they used their speaking skills to influence citizens and showed a magnificent lifestyle by building imposing palaces, celebrating sumptuous weddings and funerals, and commissioning works of art. They created spy networks and used violent methods to repress dissent (imprisonment, torture, …
Multiphysics Optimization for First Wall Design Enhancement in Water-Cooled Breeding Blankets
2021
Abstract The commercial feasibility of the first fusion power plant generation adopting D-T plasma is strongly dependent upon the self-sustainability in terms of tritium fuelling. Within such a kind of reactor, the component selected to house the tritium breeding reactions is the breeding blanket, which is further assigned to heat power removal and radiation shielding functions. As a consequence of both its role and position, the breeding blanket is heavily exposed to both surface and volumetric heat loads and, hence, its design requires a typical multiphysics approach, from the neutronics to the thermo-mechanics. During last years, a great deal of effort has been put in the optimization of…