Auswirkungen der COVID-19-Pandemie auf die logopädische Therapie von Kindern mit einer Sprachentwicklungsstörung

2021

ZusammenfassungHintergrund Im Dezember 2019 begann sich die COVID-19-Pandemie weltweit auszubreiten und sorgte für massive Einschränkungen im täglichen Leben. Viele Bildungseinrichtungen und logopädische Praxen wurden vorübergehend geschlossen (sog. Lockdown). Kinder mit einer Sprachentwicklungsstörung waren gezwungen, ihre Therapie zu pausieren. Ziel dieser Studie war es zu beschreiben, ob und wie die logopädische Therapie während des Lockdowns durchgeführt wurde und welche psychische Belastung für die betroffenen Eltern damit verbunden war.Material und Methoden Eltern von Kindern mit einer Sprachentwicklungsstörung wurden über die Therapie ihres Kindes während des Lockdowns und über ihre …

What Can Linguistics Do to Technology Design?

2021

Intelligent technologies have already revolutionized the economy, and they will continue to do so via autonomous, AI-based systems and artefacts. Artefacts can handle much more intellectually complicated tasks than was possible before. However, the technological transformation will set new demands for technology design and designers. Designing electromechanical technologies has been based on natural science, but intelligent technologies will extensively use knowledge of human research and information processing to create new artefacts. Intelligent information processing has so far been possible only for biological systems and especially for human minds. Therefore, their functions and behavi…

Evaluation of the IKKβ Binding of Indicaxanthin by Induced-Fit Docking, Binding Pose Metadynamics, and Molecular Dynamics

2021

Background: Indicaxanthin, a betaxanthin belonging to the betalain class of compounds, has been recently demonstrated to exert significant antiproliferative effects inducing apoptosis of human melanoma cells through the inhibition of NF-κB as the predominant pathway. Specifically, Indicaxanthin inhibited IκBα degradation in A375 cells. In resting cells, NF-κB is arrested in the cytoplasm by binding to its inhibitor protein IκBα. Upon stimulation, IκBα is phosphorylated by the IKK complex, and degraded by the proteasome, liberating free NF-κB into the nucleus to initiate target gene transcription. Inhibition of the IKK complex leads to the arrest of the NF-κB pathway.Methods: To acquire deta…

From the Strait of Gibraltar to northern Europe: Pleistocene refugia and biogeographic history of heather (Calluna vulgaris, Ericaceae)

2021

Abstract Calluna vulgaris (Ericaceae) is the most widespread and prevalent woody species of the European dry heathland, from the African side of the Strait of Gibraltar to northern Europe. However, previous biogeographic analyses of this species have ignored the western Mediterranean region, despite its preponderant role as a major glacial refugium for European biota. Here, we explore the existence of further Pleistocene glacial refugia for C. vulgaris in the Iberian Peninsula and the Strait of Gibraltar area and provide new insights into the post-glacial colonization of Europe by this emblematic heathland species. We carried out phylogeographical analyses of C. vulgaris samples from 44 loc…

Virtual Clinical and Precision Medicine Tumor Boards-Cloud-Based Platform-Mediated Implementation of Multidisciplinary Reviews Among Oncology Centers…

2021

Background Multidisciplinary tumor boards play a pivotal role in the patient-centered clinical management and in the decision-making process to provide best evidence-based, diagnostic, and therapeutic care to patients with cancer. Among the barriers to achieve an efficient multidisciplinary tumor board, lack of time and geographical distance play a major role. Therefore, the elaboration of an efficient virtual multidisciplinary tumor board (VMTB) is a key point to successfully obtain an oncology team and implement a network among health professionals and institutions. This need is stronger than ever during the COVID-19 pandemic. Objective This paper presents a research protocol for an obse…

Study of High-Temperature Behaviour of ZnO by Ab Initio Molecular Dynamics Simulations and X-ray Absorption Spectroscopy

2021

Wurtzite-type zinc oxide (w-ZnO) is a widely used material with a pronounced structural anisotropy along the c axis, which affects its lattice dynamics and represents a difficulty for its accurate description using classical models of interatomic interactions. In this study, ab initio molecular dynamics (AIMD) was employed to simulate a bulk w-ZnO phase in the NpT ensemble in the high-temperature range from 300 K to 1200 K. The results of the simulations were validated by comparison with the experimental Zn K-edge extended X-ray absorption fine structure (EXAFS) spectra and known diffraction data. AIMD NpT simulations reproduced well the thermal expansion of the lattice, and the pronounced …

Challenges in the evolution toward process‐based interventions

2021

Interspecific attraction between ground-nesting songbirds and ants: the role of nest-site selection

2021

Abstract Background Interspecific interactions within ecological networks can influence animal fitness and behaviour, including nest-site selection of birds and ants. Previous studies revealed that nesting birds and ants may benefit from cohabitation, with interspecific attraction through their nest-site choice, but mutual interactions have not yet been tested. We explored a previously undescribed ecological link between ground-nesting birds and ants raising their own broods (larvae and pupae) within the birds’ nests in a temperate primeval forest of lowland Europe. We tested whether the occurrence of ant broods within bird nests resulted from a mutual or one-sided interspecific attraction …

Mobile (Self-)Socialization: The Role of Mobile Media and Communication in Autonomy and Relationship Development in Adolescence

2021

Two of the most important developmental tasks in adolescence are developing autonomy and establishing relationships (i.e., friendships and romantic relationships). Self-socialization processes are ...

false

2021

The aim of this study was to investigate whether recovery from eccentric squat exercise varies depending on age and to assess whether the use of a mixed-method recovery (MMR) consisting of cold water immersion and compression tights benefits recovery. Sixteen healthy and resistance-trained young (age, 22.1±2.1years; N=8) and master male athletes (age, 52.4±3.5years; N=8), who had a similar half squat 1-repetition maximum relative to body weight, completed two identical squat exercise training sessions, separated by a 2-week washout period. Training sessions were followed by either MMR or passive recovery (PR). Internal training loads [heart rate and blood lactate concentration (BLa)] were r…

Sponsored consumer-generated advertising in the digital era: what prompts individuals to generate video ads, and what creative strategies do they ado…

2021

This study investigates individuals’ motivations to create sponsored video ads in response to corporate online advertising competitions, and the creative strategies they employ when so doing. The findings from two studies that combined qualitative (42 semi-structured interviews and netnography) and quantitative (content analysis of 1,102 ads) research methods showed that individuals are motivated to produce sponsored video advertising by six factors: learning, enjoyment, self-expression, remuneration, recognition and influencing others. In turn, these motivations can be categorised as intrinsic, extrinsic, rational and affective, leading to a typology of four advertising creators. It was fo…

Macula structural and vascular differences in glaucoma eyes with and without high axial myopia

2021

AbstractAimsTo assess the thickness of various retinal layers, and the superficial vessel density (sVD) in the macula of glaucomatous eyes and their associations with axial length (AL) and visual field mean deviation (VFMD) to identify parameters useful for glaucoma management in myopic eyes.Methods248 glaucoma patients (401 eyes) participating in the Diagnostic Innovations in Glaucoma Study observational cohort representing 3 axial myopia groups (non-myopia: n=146 eyes; mild myopia: n=208 eyes; high myopia (AL>26 mm): n=47 eyes) who completed macular OCT and OCT-Angiography imaging were included. The cross-sectional associations of AL and VFMD with the thickness of the ganglion cell inn…

Role of Solvent Compatibility in the Phase Behavior of Binary Solutions of Weakly Associating Multivalent Polymers

2021

AbstractCondensate formation of biopolymer solutions, prominently those of various intrinsically disordered proteins (IDPs), is determined by “sticky” interactions between associating residues, multivalently present along the polymer backbone. Using a ternary mean field “stickers-and-spacers” model, we demonstrate that if sticker association is of the order of a few times the thermal energy, a delicate balance between specific binding and non-specific polymer-solvent interactions gives rise to a particularly rich ternary phase behavior under physiological circumstances. For a generic system represented by a solution comprising multi-associative scaffold and client polymers, the difference i…

Correlation Analysis of Node and Edge Centrality Measures in Artificial Complex Networks

2021

The role of an actor in a social network is identified through a set of measures called centrality. Degree centrality, betweenness centrality, closeness centrality, and clustering coefficient are the most frequently used metrics to compute the node centrality. Their computational complexity in some cases makes unfeasible, when not practically impossible, their computations. For this reason, we focused on two alternative measures, WERW-Kpath and Game of Thieves, which are at the same time highly descriptive and computationally affordable. Our experiments show that a strong correlation exists between WERW-Kpath and Game of Thieves and the classical centrality measures. This may suggest the po…

Comparison of condylar position in normal occlusion, Class II Division 1, Class II Division 2 and Class III malocclusions using CBCT imaging

2021

Background The aim of this study was to establish the condylar position in a group of patients with normal occlusion, compared to Class II Div 1, Class II Div 2 and Class III malocclusions using CBCT imaging. Material and Methods Retrospective case-control study carried out by analyzing CBCT images of 80 patients. The sample was divided into 4 different groups with 20 patients each (40 TMJ). All patients were positioned using the Frankfurt plane, parallel to the floor and in maximum intercuspation. The control group included asymptomatic patients with normal occlusion (Less than 2mm of tooth size-arch length discrepancy, positive or negative, 0-2mm overjet, 2-4mm overbite, less than 15o rot…

false

2021

(1) Background: The purpose of this study was to evaluate the day-to-day variability and year-to-year reproducibility of an accelerometer-based algorithm for sit-to-stand (STS) transitions in a free-living environment among community-dwelling older adults. (2) Methods: Free-living thigh-worn accelerometry was recorded for three to seven days in 86 (women n = 55) community-dwelling older adults, on two occasions separated by one year, to evaluate the long-term consistency of free-living behavior. (3) Results: Year-to-year intraclass correlation coefficients (ICC) for the number of STS transitions were 0.79 (95% confidence interval, 0.70–0.86, p < 0.001), for mean angular velocity—0.81 (95…

Marine Pyrrole Alkaloids

2021

Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal intriguing structures. They are not only widespread in terrestrial habitats but can also frequently be found as natural products in the marine environment. This review highlights the important class of marine pyrrole alkaloids, well-known for their diverse biological activities. A broad overview of the marine pyrrole alkaloids with a focus on their isolation, biological activities, chemical synthesis, and derivatization covering the decade from 2010 to 2020 is provided. With relevant structural subclasses categorized, this review shall provide a clear and timely synopsis of this area.

A Full-Scale Agent-Based Model to Hypothetically Explore the Impact of Lockdown, Social Distancing, and Vaccination During the COVID-19 Pandemic in L…

2021

Background The COVID-19 outbreak, an event of global concern, has provided scientists the opportunity to use mathematical modeling to run simulations and test theories about the pandemic. Objective The aim of this study was to propose a full-scale individual-based model of the COVID-19 outbreak in Lombardy, Italy, to test various scenarios pertaining to the pandemic and achieve novel performance metrics. Methods The model was designed to simulate all 10 million inhabitants of Lombardy person by person via a simple agent-based approach using a commercial computer. In order to obtain performance data, a collision detection model was developed to enable cluster nodes in small cells that can b…

T-model field equations: the general solution

2021

We analyze the field equations for the perfect fluid solutions admitting a group G$_3$ of isometries acting on orbits S$_2$ whose curvature has a gradient that is tangent to the fluid flow (T-models). We propose several methods to integrate the field equations and we present the general solution without the need to calculate any integral.

Emerging contributions of formyl peptide receptors to neurodegenerative diseases.

2021

Abstract Inflammation is a central element of many neurodegenerative diseases. Formyl peptide receptors (FPRs) can trigger several receptor-dependent signal transduction pathways that play a key role in neuroinflammation and neurodegeneration. They are chemotactic receptors that help to regulate pro- and anti-inflammatory responses in most mammals. FPRs are primarily expressed in the immune and nervous systems where they interact with a complex pattern of pathogen-derived and host-endogenous molecules. Mounting evidence points towards a contribution of FPRs – via neuropathological ligands such as Amyloid beta, and neuroprotective ligands such as Humanin, Lipoxin A4, and Annexin A1 – to mult…

Modelling Photoionisations in Tautomeric DNA Nucleobase Derivatives 7H-Adenine and 7H-Guanine: Ultrafast Decay and Photostability

2021

The study of radiation effects in DNA is a multidisciplinary endeavour, connecting the physical, chemical and biological sciences. Despite being mostly filtered by the ozone layer, sunlight radiation is still expected to (photo)ionise DNA in sizeable yields, triggering an electron removal process and the formation of potentially reactive cationic species. In this manuscript, photoionisation decay channels of important DNA tautomeric derivatives, 7H-adenine and 7H-guanine, are characterised with accurate CASSCF/XMS-CASPT2 theoretical methods. These simulation techniques place the onset of ionisation for 7H-adenine and 7H-guanine on average at 8.98 and 8.43 eV, in line with recorded experimen…

First measurement of coherent ρ0 photoproduction in ultra-peripheral Xe–Xe collisions at √sNN = 5.44 TeV

2021

The first measurement of the coherent photoproduction of ρ0 vector mesons in ultra-peripheral Xe–Xe collisions at sNN=5.44 TeV is presented. This result, together with previous HERA γp data and γ–Pb measurements from ALICE, describes the atomic number (A) dependence of this process, which is particularly sensitive to nuclear shadowing effects and to the approach to the black-disc limit of QCD at a semi-hard scale. The cross section of the Xe+Xe→ρ0+Xe+Xe process, measured at midrapidity through the decay channel ρ0→π+π−, is found to be dσ/dy=131.5±5.6(stat.)−16.9+17.5(syst.) mb. The ratio of the continuum to resonant contributions for the production of pion pairs is also measured. In additio…

Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error

2021

Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…

Testing for goodness rather than lack of fit of continuous probability distributions.

2021

The vast majority of testing procedures presented in the literature as goodness-of-fit tests fail to accomplish what the term is promising. Actually, a significant result of such a test indicates that the true distribution underlying the data differs substantially from the assumed model, whereas the true objective is usually to establish that the model fits the data sufficiently well. Meeting that objective requires to carry out a testing procedure for a problem in which the statement that the deviations between model and true distribution are small, plays the role of the alternative hypothesis. Testing procedures of this kind, for which the term tests for equivalence has been coined in sta…

Spontaneous fission instability of the neutron-deficient No and Rf isotopes: The new isotope No249

2021

In the heaviest elements, the instability of atomic nuclei against spontaneous fission leads to ever shorter nuclear half-lives. Upon falling below a timescale of ${10}^{\ensuremath{-}14}$ s, the border of existence of isotopes is crossed because this is the timescale on which the formation of atomic shells occurs. Analysis of the experimental data on the spontaneous fission half-lives of Rf isotopes in relation with their expected single-particle orbitals hint at a potentially abrupt decrease in half-lives of unknown neutron-deficient Rf isotopes with neutron numbers $l149$, which suggests that the isotopic border is already almost reached. However, this conjecture, which cannot be explain…

Dispersion of pressure at the inner edge of the neutron star crust

2021

This paper presents a method for estimating the pressure variance at the inner edge of a neutron star crust. The obtained results quantify uncertainty in the estimation of pressure at the core-crust interface, implying that they depend on the selected equation of state and the neutron star’s mass distribution function. The quality of the transition pressure determination depends on the neutron star’s mass, with a significant decrease in accuracy for configurations with masses close to 2M . The method used makes it possible to control the theoretical part of the core-crust pressure dispersion in determining the observational quantities.

Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes : A Longitudinal Study of Master Athletes

2021

The age-related decline in muscle function, particularly muscle power, is associated with increased risk of important clinical outcomes. Physical activity is an important determinant of muscle function, and different types of physical activity e.g. power-based versus endurance-based exercise appear to have differential effects on muscle power. Cross-sectional studies suggest that participation in power-based exercise is associated with greater muscle power across adulthood but this has not been investigated longitudinally. We recruited eighty-nine male and female power and endurance master athletes (sprint and distance runners respectively, baseline age 35–90y). Using jumping mechanography,…

« De l'aventure agro-industrielle à l'aventure culturelle : le cas de Stella Matutina à La Réunion », 109-121

2021

International audience

Acrometastases to the Hand: A Systematic Review

2021

Background and Objectives: The term acrometastases (AM) refers to secondary lesions sited distally to the elbow and knee, representing 0.1% of all bony metastases. By frequency, pulmonary cancer and gastrointestinal and genitourinary tract neoplasms are the most responsible for the reported AM. Improvements in oncologic patient care favor an increase in the incidence of such rare cases. We performed a systematic review of acrometastases to the hand to provide further insight into the management of these fragile patients. We also present a peculiar case of simultaneous acrometastasis to the ring finger and pathological vertebral fracture. Material and Methods: A literature search according t…

Blodets lokkende sange. Ida Jacksons Morfar, Hitler og jeg og perpetrator postmemory

2021

Sammendrag Ida Jacksons essay Morfar, Hitler og jeg (2014) indledes med hendes opdagelse af morfarens medskyldighed i nazistiske krigsforbrydelser under 2. verdenskrig. Opdagelsen sætter scenen for Jacksons undersøgelse af morfarens livshistorie under krigen, som har været holdt skjult i familien, og for hendes udforskning af disse begivenheders betydning for hendes eget liv. Morfaren blev traumatiseret af krigen, og Jacksons essay udforsker konsekvenserne af, at morfarens traume er blevet givet videre i flere generationer. Konsekvenserne viser sig i det problematiske i at erindre, men også som en generationel skyld over morfarens handling. Denne skyld er fortsat til stede hos børn og børne…

Cardioprotective effects of phytopigments via multiple signaling pathways.

2021

Abstract Background Cardiovascular diseases (CVDs) are among the deadliest non-communicable diseases, and millions of dollars are spent every year to combat CVDs. Unfortunately, the multifactorial etiology of CVDs complicates the development of efficient therapeutics. Interestingly, phytopigments show significant pleiotropic cardioprotective effects both in vitro and in vivo. Purpose This review gives an overview of the cardioprotective effects of phytopigments based on in vitro and in vivo studies as well as clinical trials. Methods A literature-based survey was performed to collect the available data on cardioprotective activities of phytopigments via electronic search engines such as Pub…

Validación y aplicación de un instrumento para el análisis de estereotipos de género en largometrajes de dibujos animados

2021

The process of design and validation of the content and structure of a tool for the analysis of gender stereotypes applicable to feature films, short films, and television series, both realistic and cartoonish, is presented. The model is called EG_5x4 and consists of five dimensions (corporal, attitudinal, social, affective-sexual, and audiovisual), being novel because of its distribution into four pairs of items per category. The methodological process began with the writing, based on previous instruments on gender stereotypes, of a draft of the items, which were distributed in dimensions and organized in pairs to be able to independently relate each statement to the male and/or female gen…

Constant sign and nodal solutions for parametric anisotropic $(p, 2)$-equations

2021

We consider an anisotropic ▫$(p, 2)$▫-equation, with a parametric and superlinear reaction term.Weshow that for all small values of the parameter the problem has at least five nontrivial smooth solutions, four with constant sign and the fifth nodal (sign-changing). The proofs use tools from critical point theory, truncation and comparison techniques, and critical groups. Spletna objava: 9. 9. 2021. Abstract. Bibliografija: str. 1076.

Inulin-Based Polymeric Micelles Functionalized with Ocular Permeation Enhancers: Improvement of Dexamethasone Permeation/Penetration through Bovine C…

2021

Ophthalmic drug delivery is still a challenge due to the protective barriers of the eye. A common strategy to promote drug absorption is the use of ocular permeation enhancers, while an innovative approach is the use of polymeric micelles. In the present work, the two mentioned approaches were coupled by conjugating ocular permeation enhancers (PEG2000, carnitine, creatine, taurine) to an inulin-based co-polymer (INU-EDA-RA) in order to obtain self-assembling biopolymers with permeation enhancer properties for the hydrophobic drug dexamethasone (DEX). Inulin derivatives were properly synthetized, were found to expose about 2% mol/mol of enhancer molecules in the side chain, and resulted abl…

L’article 18 de la Charte aux Normands : fondement des débats sur la notion de juge naturel des Normands

2021

National audience

Modelling Drivers’ Adaptation to Assistance Systems

2021

Human factors research and engineering of advanced driving assistance systems (ADAS) must consider how drivers adapt to their presence. The major obstruction to this at the moment is poor understanding of the details of the adaptive processes that the human cognition undergoes when faced with such changes. This paper presents a simulation model that predicts how drivers adapt to a steering assistance system. Our approach is based on computational rationality, and demonstrates how task interleaving strategies adapt to the task environment and the driver’s goals and cognitive limitations. A supervisor controls eye movements between the driving and non-driving tasks, making this choice on the …