showing 36 of ~574560 from 574555 documents
Ecological characteristics of pre-imaginal stages of blackflies (diptera: simuliidae) in Southern England
2021
Data on pre-imaginal stages of blackflies obtained in southern England during the summer and early autumn of 2020 were supplemented by additional surveys and analysed in relation to environmental factors. Fourteen taxa from 29 locations were recorded. Of these, seven are of medical and/or veterinary importance: Simulium (Wilhelmia) equinum (Linnaeus, 1758), S. (Boophthora) erythrocephalum (De Geer, 1776), S. (Simulium) intermedium Roubaud, 1906 sensu lato (s.l., a complex of species), S. (W.) lineatum (Meigen, 1804), S. (S.) morsitans Edwards, 1915, S. (S.) noelleri Friederichs, 1920 and S. (S.) ornatum (Meigen, 1818) s.l. Analyses of a variety of environmental factors recorded at the insec…
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models
2021
Local immunotherapy ideally stimulates immune responses against tumors while avoiding toxicities associated with systemic administration. Current strategies for tumor-targeted, gene-based delivery, however, are limited by adverse effects such as off-targeting or antivector immunity. We investigated the intratumoral administration of saline-formulated messenger (m)RNA encoding four cytokines that were identified as mediators of tumor regression across different tumor models: interleukin-12 (IL-12) single chain, interferon-α (IFN-α), granulocyte-macrophage colony-stimulating factor, and IL-15 sushi. Effective antitumor activity of these cytokines relied on multiple immune cell populations and…
Exploring Potential Benefits of Accumulated Multicomponent-Training in Non-Active Older Adults: From Physical Fitness to Mental Health
2021
The present study aimed to analyze the impact of a multicomponent training (MCT) program in a group of non-active older adults, comparing two different dose distributions. Twenty-four individuals, assigned to two groups, completed 15 weeks of MCT (2 days/week). The continuous group (CMCT
History of Mathematics: A Global Cultural Approach
2021
Identification of a genetic signature enriching for response to ibrutinib in relapsed/refractory follicular lymphoma in the DAWN phase 2 trial.
2021
Abstract Background The single‐arm DAWN trial (NCT01779791) of ibrutinib monotherapy in patients with relapsed/refractory follicular lymphoma (FL) showed an overall response rate (ORR) of 20.9% and a median response duration of 19.4 months. This biomarker analysis of the DAWN dataset sought to determine genetic classifiers for prediction of response to ibrutinib treatment. Methods Whole exome sequencing was performed on baseline tumor samples. Potential germline variants were excluded; a custom set of 1216 cancer‐related genes was examined. Responder‐ versus nonresponder‐associated variants were identified using Fisher's exact test. Classifiers with increasing numbers of genes were created …
Correlation between Baroreflex Sensitivity and Cerebral Autoregulation Index in Healthy Subjects
2021
Despite the acknowledged interaction between baroreflex and cerebral autoregulation (CA), their functional relationship remains controversial. The study investigates this relationship in a healthy population undergoing an orthostatic challenge. Thirteen healthy subjects (age: 27pm 8 yrs; 5 males) underwent electrocardiogram, arterial pressure (AP) and cerebral blood flow velocity (CBFV) recordings at supine resting (REST) and during 60° head-up tilt (TILT). CA was assessed via the autoregulation index (ARI) from spontaneous variations of mean AP and mean CBFV. The cardiac control and baroreflex were evaluated via frequency domain and transfer function analyses applied to systolic AP and hea…
Eltrombopag treatment for severe immune thrombocytopenia during pregnancy: a case report
2021
Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia (platelet count <100 × 109/l) in the absence of other causes or disorders associated. The incidence of ITP in pregnancy is one to two cases per 1000 gestations. ITP could be diagnosed before or during pregnancy; sometimes a relapse of a previously diagnosed ITP can occur. Intravenous immune globulins (IVIg) and corticosteroids are the standard frontline therapy because of their well known safety profile either for the mother or for the neonate. Treatments for refractory patients are limited by potential fetal risk. We report the case of a patient with ITP along pregnancy, refractory…
Comparison of two sensory methods to obtain reliable dose-intensity curves for sweet taste compounds
2021
International audience
Tailoring large magnetoresistance in Dirac semimetal SrIrO3 films
2021
Perovskite SrIrO3 is a special Dirac material with fascinating effects due to its strong electron correlation and spin–orbit coupling. In this work, a large magnetoresistance (MR) was observed not only in epitaxial SrIrO3 films but also in a SrIrO3/PbZr0.2Ti0.8O3 epitaxial heterostructure with a magnetic field applied perpendicular to the external electric field. The magnetoresistance of SrIrO3 (10 nm) and SrIrO3/PbZr0.2Ti0.8O3 (10 nm/30 nm) reach values as large as 40% and 110% at 9 T and 5 K, respectively. We believe that the unusual magnetoresistance is from the Dirac/Weyl state. Especially, the SrIrO3/PbZr0.2Ti0.8O3 bilayer shows negative magnetoresistance with strong oscillations close…
Triply Factorised Groups and the Structure of Skew Left Braces
2021
The algebraic structure of skew left brace has proved to be useful as a source of set-theoretic solutions of the Yang–Baxter equation. We study in this paper the connections between left and right $$\pi $$ -nilpotency and the structure of finite skew left braces. We also study factorisations of skew left braces and their impact on the skew left brace structure. As a consequence of our study, we define a Fitting-like ideal of a left brace. Our approach depends strongly on a description of a skew left brace in terms of a triply factorised group obtained from the action of the multiplicative group of the skew left brace on its additive group.
Scattering and gluon emission in a color field : a light-front Hamiltonian approach
2021
We develop a numerical method to nonperturbatively study scattering and gluon emission of a quark from a colored target using a light-front Hamiltonian approach. The target is described as a classical color field, as in the color glass condensate effective theory. The Fock space of the scattering system is restricted to the |q⟩+|qg⟩ sectors, but the time evolution of this truncated system is solved exactly. This method allows us to study the interplay between coherence and multiple scattering in gluon emission. It could be applied both to studying subeikonal effects in high-energy scattering and to understanding jet quenching in a hot plasma.
Predicting physical activity change in cancer survivors: an application of the Health Action Process Approach
2021
Low Frequency of Human Papillomavirus in Strictly Site-Coded Oral Squamous Cell Carcinomas, Using the Latest NHI/SEER-ICD Systems: A Pilot Observatio…
2021
Simple Summary The incidence of oropharyngeal squamous cell carcinomas (OPSCCs) has increased in the last decades, and this seems to be correlated to the infectious epidemiological trend of human papillomavirus (HPV). The prevalence of HPV-positive OPSCCs is approximately 70%, with involvement mainly of the tonsillar area. On the role of HPV in oral squamous cell carcinoma (OSCC), very few studies have investigated the prevalence of HPV in strictly site-codified OSCC, excluding the base of the tongue as distinct oropharyngeal entity. As a result, an inappropriate estimation of HPV infection in OSCC has been observed. We investigated HPV status, using a combination of detection methods, in a…
An assessment of regulation, education practices and socio-economic perceptions of non-native aquatic species in the Balkans
2021
Alongside climate change, the introduction of non- native species (NNS) is widely recognized as one of the main threats to aquatic biodiversity and human wellbeing. Non-native species and biodiversity are generally low priority issues on the political agendas of many countries, particularly in European countries outside the European Union (EU). The objectives and tasks of this study were to address the policy regulation, education level, education practices, and socioeconomic perceptions of NNS in the Balkans. A questionnaire based survey was conducted in Albania, Bosnia and Herzegovina, Montenegro, North Macedonia and Turkey (Balkan EU candidate and potential candidate members), in Croatia…
false
2021
In humans and mammals, effort-based decision-making for monetary or food rewards paradigms contributes to the study of adaptive goal-directed behaviours acquired through reinforcement learning. Chronic distress modelled by repeated exposure to glucocorticoids in rodents induces suboptimal decision-making under uncertainty by impinging on instrumental acquisition and prompting negative valence behaviours. In order to further disentangle the motivational tenets of adaptive decision-making, this study addressed the consequences of enduring distress on relevant effort and reward-processing dimensions. Experimentally, appetitive and consummatory components of motivation were evaluated in adult C…
Architettura e second digital turn, l’evoluzione degli strumenti informatici e il progetto
2021
La condizione digitale che ha gradualmente ibridato le nostre esistenze, trasformando atomi in bit, si è oggi cementificata sulla nostra società, arricchendone la postmodernità e determinando una nuova liquidità acuitasi con l’avvento di internet. Un momento storico segnato da una nuova maturità del digitale, evidente nel nostro diverso rapporto con i dati, e nella diffusione di metodi di machine learning avanzato, che promettono una nuova capacità di comprensione della complessità contemporanea e nel frattempo contribuiscono alla propagazione dell’apparato tecnico sul mondo. Questi cambiamenti, tanto profondi da toccare la nostra cultura, stanno modificando il nostro modo di interpretare e…
Comparison of two techniques (in vivo and ex-vivo) for evaluating the elastic properties of the ascending aorta: Prospective cohort study.
2021
Introduction Aneurysms of the ascending aorta (AA) correspond to a dilatation of the ascending aorta that progressively evolves over several years. The main complication of aneurysms of the ascending aorta is type A aortic dissection, which is associated with very high rates of morbidity and mortality. Prophylactic ascending aorta replacement guidelines are currently based on maximal AA diameter. However, this criterion is imperfect. Stretching tests on the aorta carried out ex-vivo make it possible to determine the elastic properties of healthy and aneurysmal aortic fragments (tension test, resistance before rupture). For several years now, cardiac magnetic resonance imaging (MRI) has pro…
El Antropoceno. Riesgos y oportunidades para las nuevas generaciones
2021
Nuestro propósito en este trabajo es presentar la estrategia que venimos utilizando desde hace más de dos décadas para contribuir a implicar a diversos sectores de la ciudadanía —y, muy especialmente, a estudiantes y docentes en formación- en la comprensión de la actual situación de emergencia planetaria, caracterizada por un conjunto de graves problemas socioambientales de origen antrópico, que han conducido a denominar Antropoceno la presente etapa de la evolución del planeta. Analizaremos las causas y consecuencias de estos problemas estrechamente vinculados y que se potencian mutuamente, provocando la transgresión de diversos límites planetarios. Y nos centraremos en las posibles medida…
Physical Activity and Exercise: Text Mining Analysis
2021
It is currently difficult to have a global state of the art vision of certain scientific topics. In the field of physical activity (PA) and exercise, this is due to information overload. The present study aims to provide a solution by analysing a large mass of scientific articles using text mining (TM). The purpose was to analyse what is being investigated in the PA health field on young people from primary, secondary and higher education. Titles and abstracts published in the Web of Science (WOS) database were analysed using TM on 24 November 2020, and after removing duplicates, 85,368 remained. The results show 9960 (unique) words and the most frequently used bi-grams and tri-grams. A co-…
L’ABITARE MINIMO NECESSARIO TRA TEMPORANEITÀ E PERMANENZA, il progetto degli alloggi per i lavoratori stagionali di Campobello di Mazara (TP)
2021
Chronic Distress in Male Mice Impairs Motivation Compromising Both Effort and Reward Processing With Altered Anterior Insular Cortex and Basolateral …
2021
AbstractIn humans and mammals, effort-based decision-making for monetary or food rewards paradigms contribute to the study of adaptive goal-directed behaviours acquired through reinforcement learning. Chronic distress modelled by repeated exposure to glucocorticoids in rodents induces suboptimal decision-making under uncertainty by impinging on instrumental acquisition and prompting negative valence behaviours. In order to further disentangle the motivational tenets of adaptive decision-making, this study addressed the consequences of enduring distress on relevant effort and reward processing dimensions. Experimentally, appetitive and consummatory components of motivation were evaluated in …
Forest accessibility, Madonie mountains (northern Sicily, Italy): implementing a GIS decision support system
2021
Valorisation and sustainable exploitation of woody biomass from cultivation interventions might be an important opportunity to track alternative development trails for rural communities in natural protected areas. The governance of Mediterranean protected areas is characterized by overlapping, sometimes conflicting institutions, stakeholders and regulations, causing negative impacts on decision-making processes. We present an open source GIS-based decision support system tool for mapping forest accessibility and optimizing woody biomass extraction. Two models were implemented to support forest managers during the decision-making process in designing and managing wood-energy supply chains. T…
Expression of selected molecular factors in two types of endometrial cancer
2021
BACKGROUND Endometrial cancers (EC) are a heterogeneous group of malignant neoplasms differing in etiology, clinical-pathological features and prognosis. OBJECTIVES To determine the differences between the expression of selected molecular factors and find connections between them in order to isolate possible biomarkers influencing treatment options. MATERIAL AND METHODS The investigated data involved archival histological preparations obtained from uterine EC samples taken from 137 patients, treated surgically between 2007 and 2014. The immunohistochemical Dako EnVisionTM Flex+ method was applied. RESULTS The expression of ERβ, MLH1 and BRCA1 was lower in ECI than in ECII patients. The ERα …
Die reinste Form und der höchste Gehalt: teoria e prassi nel teatro di Friedrich Hebbel
2021
Self-Optimising Breather Ultrafast Fibre Laser
2021
We demonstrate the self-optimisation of the breather regime in an ultrafast fibre laser through an evolutionary algorithm. Depending on the specified merit function, single breathers with controllable breathing ratio and period, and breather molecular complexes with a controllable number of constituents can be obtained.
EntityBot: Supporting Everyday Digital Tasks with Entity Recommendations
2021
Everyday digital tasks can highly benefit from systems that recommend the right information to use at the right time. However, existing solutions typically support only specific applications and tasks. In this demo, we showcase EntityBot, a system that captures context across application boundaries and recommends information entities related to the current task. The user’s digital activity is continuously monitored by capturing all content on the computer screen using optical character recognition. This includes all applications and services being used and specific to individuals’ computer usages such as instant messaging, emailing, web browsing, and word processing. A linear model is then …
Rate-Splitting Random Access Mechanism for Massive Machine Type Communications in 5G Cellular Internet-of-Things
2021
The cellular Internet-of-Things has resulted in the deployment of millions of machine-type communication (MTC) devices. These massive number of devices must communicate with a single gNodeB (gNB) via the random access channel (RACH) mechanism. However, existing RACH mechanisms are inefficient when dealing with such large number of devices. To address this issue, we propose the rate-splitting random access (RSRA) mechanism, which uses rate splitting and decoding in rate-splitting multiple access (RSMA) to improve RACH success rates. The proposed mechanism divides the message into common and private messages and enhances the decoding performance. We demonstrate, using extensive simulations, t…
Light-Driven Extremely Nonlinear Bulk Photogalvanic Currents
2021
We predict the generation of bulk photocurrents in materials driven by bichromatic fields that arc circularly polarized and corotating. The nonlinear photocurrents have a fully controllable directionality and amplitude without requiring carrier-envelope-phase stabilization or few-cycle pulses, and can be generated with photon energies much smaller than the band gap (reducing heating in the photoconversion process). We demonstrate with ab initio calculations that the photocurrent generation mechanism is universal and arises in gaped materials (Si, diamond, MgO, hBN), in semimetals (graphene), and in two- and three-dimensional systems. Photocurrents are shown to rely on sub-laser-cycle asymme…
Trust, mistrust and distrust as blind spots of Social Licence to Operate: illustration via three forerunner countries in nuclear waste management
2021
The notion of social licence to operate (SLO) has become a widely applied concept for companies in mining and resource extraction industries to manage their social and community relations, in the face of local criticism and opposition. SLO literature and practice have highlighted earning the trust of the local community as a key requirement for an SLO. This article addresses three weaknesses in how the current SLO literature addresses trust. The arguments are illustrated via examples from nuclear waste management in Finland, France and Sweden–three forerunners in implementing high-level nuclear waste repository projects. Nuclear waste management constitutes a relevant case for analysis, as …
Topology of multiplex heterogeneous networks of Hodgkin-Huxley-type of models with bistability leading to stabilization stable equilibrium
2021
The dynamics of a multiplex heterogeneous networks of oscillators is studied. Two types of very similar models based on the Hodgkin-Huxley formalism are used as the basic elements of the network: the first one demonstrates bursting oscillations; the second one manifests bistability between bursting oscillations and stable equilibrium. Multiplex networks were developed and investigated, assuming more active communication between models with bistability. Different topologies of the networks are studied. It is shown that in this case it is enough to have one element with bistability in the subnetworks in order to stabilize the equilibrium state in the entire network.
Boosting Long-Term Stability of Pure Formamidinium Perovskite Solar Cells by Ambient Air Additive Assisted Fabrication
2021
Due to the high industrial interest for perovskite-based photovoltaic devices, there is an urgent need to fabricate them under ambient atmosphere, not limited to low relative humidity (RH) conditions. The formamidinium lead iodide (FAPI) perovskite α-black phase is not stable at room temperature and is challenging to stabilize in an ambient environment. In this work, we show that pure FAPI perovskite solar cells (PSCs) have a dramatic increase of device long-term stability when prepared under ambient air compared to FAPI PSCs made under nitrogen, both fabricated with N-methylpyrrolidone (NMP). The T80 parameter, the time in which the efficiency drops to 80% of the initial value, increases f…
Green Extraction Strategies for Sea Urchin Waste Valorization
2021
Commonly known as “purple sea urchin,” Paracentrotus lividus occurs in the Mediterranean Sea and the eastern Atlantic Ocean. This species is a highly appreciated food resource and Italy is the main consumer among the European countries. Gonads are the edible part of the animal but they represent only a small fraction (10–30%) of the entire sea urchin mass, therefore, the majority ends up as waste. Recently, an innovative methodology was successfully developed to obtain high-value collagen from sea urchin by-products to be used for tissue engineering. However, tissues used for the collagen extraction are still a small portion of the sea urchin waste (&lt;20%) and the remaining part, main…
Boson stars in Palatini f(R) gravity
2021
Monitoring Water and Energy Cycles at Climate Scale in the Third Pole Environment (CLIMATE-TPE)
2021
A better understanding of the water and energy cycles at climate scale in the Third Pole Environment is essential for assessing and understanding the causes of changes in the cryosphere and hydrosphere in relation to changes of plateau atmosphere in the Asian monsoon system and for predicting the possible changes in water resources in South and East Asia. This paper reports the following results: (1) A platform of in situ observation stations is briefly described for quantifying the interactions in hydrosphere-pedosphere-atmosphere-cryosphere-biosphere over the Tibetan Plateau. (2) A multiyear in situ L-Band microwave radiometry of land surface processes is used to develop a new microwave r…
Electrocatalytic Behavior of Tetrathiafulvalene (TTF) and Extended Tetrathiafulvalene (exTTF) [FeFe] Hydrogenase Mimics
2021
TTF- and exTTF-containing [(μ-S2)Fe2(CO)6] complexes have been prepared by the photochemical reaction of TTF or exTTF and [(μ-S2)Fe2(CO)6]. These complexes are able to interact with PAHs. In the absence of air and in acid media an electrocatalytic dihydrogen evolution reaction (HER) occurs, similarly to analogous [(μ-S2)Fe2(CO)6] complexes. However, in the presence of air, the TTF and exTTF organic moieties strongly influence the electrochemistry of these systems. The reported data may be valuable in the design of [FeFe] hydrogenase mimics able to combine the HER properties of the [FeFe] cores with the unique TTF properties
Mélange de Gaussiennes Photométriques pour l'Asservissement Visuel Virtuel Direct d'une Caméra Omnidirectionnelle
2021
International audience; Cet article traite du suivi de pose direct basé modèle 3D. Nous considérons la transformation d’images omnidirectionnelles en Mélange de Gaussiennes Photométriquesn (MGP) comme primitives directes. Les contributions sont d’adapter l’optimisation de pose aux caméras omnidirectionnelles et de repenser les règles d’initialisation et d’optimisation du paramètre d’extension du MGP. Plusieurs évaluations montrent que cette approche augmente la taille du domaine de convergence. L’application à des images acquises avec un robot mobile placé dans un environnement urbain, représenté par un grand nuage de points 3D coloré, montre une robustesse significative aux grands mouvemen…