showing 36 of ~574560 from 574555 documents
GDS score as screening tool to assess the risk of impact of chronic conditions and depression on quality of life in hospitalized elderly patients in …
2021
Aging of population is characterized by multiple chronic conditions in the same individual. Health-related quality of life (HR-QOL) reflects the multidimensional impact of chronic disease on population and it is increasingly analysed as outcomes. The aim of this study was the evaluation of the predictors of quality of life among elderly patients hospitalized in internal medicine ward, investigating the effect of comorbidities on health-related quality of life. Data collected in this cross-sectional study were analysed. Socio-demographic, clinical characteristics, disease distribution and quality of life by the 12-Item Short Form Health Survey (SF-12) were evaluated. Of 240 inpatients, subje…
Riflessioni su pandemia e comunicazione politica: l’interesse online per leader e partiti
2021
Has the pandemic reversed trends already taking place in contemporary politics or has it reinforced ongoing political phenomena? The serious health risk posed by the spread of Covid-19 has in fact legitimised dynamics that more or less silently had long been spreading, including the personalisation of politics, the (alleged) disintermediation of communication, different populist styles, the danger of authoritarian drifts. The challenges to democracy identified by the political literature, as the pandemic spreads, are enriched by new elements. Trust in national institutions, which has been years marked by a negative trend, in countertendency has increased during the peak of the epidemic. new…
Categorising animals and habitats in disaster-related activities
2021
A disaster is typically defined as a situation requiring external assistance, under the (contestable) assumption that the situation must affect people and society to be a disaster. Animals and their habitats are part of society and humans connect with them, so animals and their habitats are part of all disaster-related activities. This straightforward statement has produced divergent theories, policies and practices including challenges to categories, labels and divisions for humans and non-humans. This paper collates many practitioner aspects regarding animals and habitats in disaster-related activities. It assists in understanding and training for situations involving non-humans before, d…
Claudio Panzera, Il diritto all’asilo. Profili costituzionali
2021
El Doctor Claudio Panzera, Profesor Titular de Derecho Constitucional en la Università Mediterranea di Reggio Calabria (Italia), nos ofrece una monografía sólida y de lectura imprescindible para acercarse al régimen jurídico del derecho de asilo en el ordenamiento constitucional italiano. Y ello lo lleva a cabo teniendo presente, como no puede ser de otro modo, un enfoque de constitucionalismo multinivel, dado que inserta las claves constitucionales italianas del derecho de asilo en el contexto de la protección internacional, tanto universal como europea.
Salivary gland proteins alterations in the diabetic milieu
2021
AbstractSalivary glands are considered the chief exocrine glands of the mouth and physiologically contribute to the maintenance of the homeostasis of the oral cavity. They consist of the parotid, submandibular and sublingual glands, which come in pairs and are collectively called the major glands, and the minor glands, which are much smaller and are dispersed throughout the buccal cavity. Salivary glands are distinguished by their size, amount of saliva secretion and their location in the oral cavity. Salivary glands pathophysiology has been a subject of interest in various worldwide metabolic disorders, including diabetes mellitus. Diabetes mellitus (DM), a global health concern, with a pa…
L'esperienza immersiva e le sue ragioni
2021
"L'idea di immersività" che emerge dai volumi: Nel centro del quadro di Bruno Di Marino e "Immagine, arte, virtualità" di Roberto Diodato "The idea of immersiveness" that emerges from the volumes: In the center of the painting by Bruno Di Marino and "Image, art, virtuality" by Roberto Diodato
NNRTI and Liver Damage: Evidence of Their Association and the Mechanisms Involved.
2021
Due to the improved effectiveness and safety of combined antiretroviral therapy, human immunodeficiency virus (HIV) infection has become a manageable, chronic condition rather than a mortal disease. However, HIV patients are at increased risk of experiencing non-AIDS-defining illnesses, with liver-related injury standing out as one of the leading causes of death among these patients. In addition to more HIV-specific processes, such as antiretroviral drug-related toxicity and direct injury to the liver by the virus itself, its pathogenesis is related to conditions that are also common in the general population, such as alcoholic and non-alcoholic fatty liver disease, viral hepatitis, and age…
Secondary metabolites and eco-friendly techniques for agricultural weed/pest management
2021
In agro-ecosystems, pests (insects, weeds, and other plant’s parasites) compete with crops for edaphic resources, negatively affecting quality and crop yields [1]. Nowadays, synthetic pesticides, easy to apply and accessible to farmers, are the most common and effective methods for pest management [2]. Nevertheless, the negative impact of these chemicals on the environment, human health, and the development of herbicides/pesticides-resistance are shifting the attention to alternative pest control technologies based on natural compounds [3–6]. Therefore, new eco-friendly agronomic techniques and the use of natural or natural-like molecules might represent a valid alternative strategy for pes…
Tra bisogni individuali e fruizione collettiva. Spazi delle biblioteche e pratiche di lettura in una prospettiva diacronica
2021
Over the centuries, libraries have profoundly transformed their spaces, their physical appearance, their organization, but they have always remained faithful to their dual mission: a) to support lifelong learning and individual creativity, and b) to foster community development, that is, the growth of all social groups and age groups. The evolution of libraries has seen a steady acceleration especially since the mid-19th century, when the industrial processes of book production definitely expanded the availability and accessibility of content for a largest audience. The improved socio-economic conditions were best suited to the birth and development of public libraries, acting as democratic…
Autochthonous organic matter promotes DNRA and suppresses N2O production in sediments of the coastal Baltic Sea
2021
Coastal environments are nitrogen (N) removal hot spots, which regulate the amount of land-derived N reaching the open sea. However, mixing between freshwater and seawater creates gradients of inorganic N and bioavailable organic matter, which affect N cycling. In this study, we compare nitrate reduction processes between estuary and offshore archipelago environments in the coastal Baltic Sea. Denitrification rates were similar in both environments, despite lower nitrate and carbon concentrations in the offshore archipelago. However, DNRA (dissimilatory nitrate reduction to ammonium) rates were higher at the offshore archipelago stations, with a higher proportion of autochthonous carbon. Th…
Adjuvant Effect of Titanium Brushes in Peri-Implant Surgical Treatment: A Systematic Review
2021
Background: the prognosis of peri-implant surgery can be affected by poor decontamination of the implant surface, which could be improved with the use of titanium brushes. The objectives of this systematic review were to evaluate the effectiveness of titanium brushes in the decontamination of the implant surface in terms of plaque index, probing depth, bleeding on probing and bone loss/gain; as well as its effectiveness according to the type of peri-implant bone defect. Methods: an electronic search was carried out in the PubMed, Scopus, Cochrane and Embase databases, as well as a manual search. The search strategy included four keywords: “Peri-implantitis”, “Periimplantitis”, “Implant Surf…
Environmental drivers and abrupt changes of phytoplankton community in temperate lake Lielais Svētiņu, Eastern Latvia, over the last Post-Glacial per…
2021
Understanding the long-term dynamics of ecological communities on the centuries-to-millennia scale is important for explaining the emergence of present-day biodiversity patterns and for predicting possible future scenarios. Fossil pigments and ancient DNA present in various sedimentary deposits can be analysed to study long-term changes in ecological communities. We analysed recent compilations of data, including fossil pigments, microfossils, and molecular inventories from the sedimentary archives, to understand the impact of gradual versus abrupt climate changes on the ecosystem status of a regional model lake over the last ~14.5 kyr. Such long and complete paleo-archives are scarce in No…
2021 European Thyroid Association Guidelines for the Management of Iodine-Based Contrast Media-Induced Thyroid Dysfunction
2021
Given the fact that a large number of radiological examinations using iodine-based contrast media (ICM) are performed in everyday practice, clinicians should be aware of potential ICM-induced thyroid dysfunction (TD). ICM can induce hyperthyroidism (Hyper) or hypothyroidism (Hypo) due to supraphysiological concentrations of iodine in the contrast solution. The prevalence of ICM-induced TD varies from 1 to 15%. ICM-induced Hyper is predominantly found in regions with iodine deficiency and in patients with underlying nodular goiter or latent Graves’ disease. Patients at risk for ICM-induced Hypo include those with autoimmune thyroiditis, living in areas with sufficient iodine supply. Most cas…
REFLECTIVE AND GENERATIVE LEARNING IN FUTURE SUPPORT TEACHERS’ LABORATORIES TRAINING
2021
Learning is a generative and reflective activity. Generative learning involves actively making sense of to-be-learned information by mentally reorganizing and integrating it with one’s prior knowledge, thereby enabling learners to apply what they have learned to new situations. Generative learning theory has its roots in Bartlett (1932) view of learning as an act of construction, in which people invest effort after meaning by integrating new experiences with their existing knowledge structures or schemas. Wittrock (1974, 1989) pioneered efforts to apply these early insights toward a theory of meaningful learning relevant to education. Wittrock generative model of learning is based on the pr…
Mottes castrales et maisons fortes. Prospection aérienne et typologies formelles
2021
National audience
Oral antiseptics against coronavirus: in-vitro and clinical evidence
2021
Background Angiotensin converting enzyme II (ACE2) is the cellular receptor for SARS-CoV-2, so ACE2-expressing cells can act as target cells and are susceptible to infection. ACE2 receptors are highly expressed in the oral cavity so this may be a potential high-risk route for SARS-CoV-2 infection. Furthermore, the virus can be detected in saliva, even before COVID-19 symptoms appear, with the consequent high risk of virus transmission in asymptomatic/pre-symptomatic patients. Reducing oral viral load could lead to a lower risk of transmission via salivary droplets or aerosols and therefore contribute to the control of the pandemic. Aim To evaluate the available evidence testing the in vitro…
Transcriptional Changes after Enniatins A, A1, B and B1 Ingestion in Rat Stomach, Liver, Kidney and Lower Intestine
2021
Enniatins (ENs) are depsipeptide mycotoxins produced by Fusarium fungi. They are known for their capacity to modulate cell membrane permeability and disruption of ionic gradients, affecting cell homeostasis and initiating oxidative stress mechanisms. The effect of the acute toxicity of ENs A, A1, B and B1 at two different concentrations after 8 h of exposure was analysed in Wistar rats by a transcriptional approach. The following key mitochondrial and nuclear codified genes related to the electron transport chain were considered for gene expression analysis in stomach, liver, kidney and lower intestine by quantitative Real-Time PCR: mitochondrially encoded NADH dehydrogenase 1 (MT-ND1), mit…
Do Saharan Dust Days Carry a Risk of Hospitalization From Respiratory Diseases for Citizens of the Canary Islands (Spain)?
2021
Background: Saharan dust meets the Canary Islands at the beginning of its westward path across the North Atlantic, exceeding the European daily levels for PM10; for this reason, their two provincial capital cities, constitute optimal sites where to evaluate the health effects of this natural event. Objectives: To assess the short-term association between Saharan Dust Days (SDDs) and respiratory morbidity in the two capital cities. Methods: We carried out a time-series analysis with daily emergency hospital admissions due to all respiratory system diseases, chronic obstructive pulmonary disease (COPD) and asthma between 2001 and 2005, assessing the independent effect of SDDs, defined accordi…
Qu’est-ce que la mobilité sociale ?
2021
International audience
Constructing Antidictionaries of Long Texts in Output-Sensitive Space
2021
AbstractA wordxthat is absent from a wordyis calledminimalif all its proper factors occur iny. Given a collection ofkwordsy1, … ,ykover an alphabetΣ, we are asked to compute the set$\mathrm {M}^{\ell }_{\{y_1,\ldots ,y_k\}}$M{y1,…,yk}ℓof minimal absent words of length at mostℓof the collection {y1, … ,yk}. The set$\mathrm {M}^{\ell }_{\{y_1,\ldots ,y_k\}}$M{y1,…,yk}ℓcontains all the wordsxsuch thatxis absent from all the words of the collection while there existi,j, such that the maximal proper suffix ofxis a factor ofyiand the maximal proper prefix ofxis a factor ofyj. In data compression, this corresponds to computing the antidictionary ofkdocuments. In bioinformatics, it corresponds to c…
Efficient on-the-fly Web bot detection
2021
Abstract A large fraction of traffic on present-day Web servers is generated by bots — intelligent agents able to traverse the Web and execute various advanced tasks. Since bots’ activity may raise concerns about server security and performance, many studies have investigated traffic features discriminating bots from human visitors and developed methods for automated traffic classification. Very few previous works, however, aim at identifying bots on-the-fly, trying to classify active sessions as early as possible. This paper proposes a novel method for binary classification of streams of Web server requests in order to label each active session as “bot” or “human”. A machine learning appro…
Over-ordering and food waste: The use of food delivery apps during a pandemic
2021
There is a paucity of research on the role of food delivery apps (FDAs) in food waste generation. This gap needs to be addressed since FDAs represent a fast-growing segment of the hospitality sector, which is already considered to be a key food waste generator globally. Even more critically, FDAs have become a prominent source of ordering food during the COVID-19 pandemic. In addition, the growing usage of FDAs warrants an improved understanding of the complexities of consumer behavior toward them, particularly during a health crisis. The present study addresses this need by examining the antecedents of FDA users’ food ordering behavior during the pandemic that can lead to food waste. The s…
Modeling the outdoor cooling impact of highly radiative “super cool” materials applied on roofs
2021
Abstract Highly reflective “cool materials” are commonly used to reduce temperatures in the urban environment. Recently developed “super cool” materials feature an even higher albedo and emissivity (both above 0.95) than traditional cool materials. To examine the impacts of super cool roofing materials on outdoor air temperature compared to traditional cool roofs and green roofs, we conduct a sensitivity study with the microclimate model ENVI-met. Simulated surface temperature of super cool roofs remained around 6 K below ambient air temperature during high solar irradiation, which is consistent with observations. Super cool roofs – with an averaged street-level air temperature cooling of a…
D-dimer testing after anticoagulant discontinuation to predict recurrent venous thromboembolism
2021
O-102 Polymeric scaffold loaded with CD133+ BMDSCs for endometrial regeneration in Asherman’s syndrome
2021
Abstract Study question Can CD133+ bone marrow-derived stem cells (BMDSCs) loaded in polyethylene glycol diacrylate (PEGda) and gelatin divide and decidualize? Summary answer Biocompatible porous PEGda and gelatin scaffold provides a three-dimensional environment for CD133+ cells to attach, divide, and decidualize in vitro. What is known already Intrauterine adhesions (IUA) develop due to acquired damages in the endometrium resulting in partial to complete endometrial dysfunction in the Asherman syndrome. Previous works from our group have demonstrated the engraftment of CD133+ BMDSCs and its paracrine effect on endometrial proliferation, improved endometrial thickness and clinical outcome …
Measurement of the absolute branching fraction of inclusive semielectronic $D_s^+$ decays
2021
We measure the inclusive semielectronic decay branching fraction of the $D_s^+$ meson. A double-tag technique is applied to $e^+e^-$ annihilation data collected by the BESIII experiment at the BEPCII collider, operating in the center-of-mass energy range $4.178 - 4.230$ GeV. We select positrons from $D_s^+\rightarrow Xe^{+}\nu_e$ with momenta greater than 200 MeV/$c$, and determine the laboratory momentum spectrum, accounting for the effects of detector efficiency and resolution. The total positron yield and semielectronic branching fraction are determined by extrapolating this spectrum below the momentum cutoff. We measure the $D_s^+$ semielectronic branching fraction to be $\mathcal{B}\le…
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Qu’est-ce que la culture ?
2021
International audience
Developing doctoral students' / researchers’ understanding of the journal peer-review process
2021
Abstract A growing body of knowledge has confirmed that the journal peer-review process is an integral part of the scientific publication process and provides demonstrable benefits to journal editors and authors. This study aims to develop doctoral students' understanding of the journal peer-review process and highlight the most common errors and pitfalls reviewers identify in novice authors’ manuscripts, which could lead to rejection. A qualitative content analysis research method was used to analyse the primary data as experience collected from senior researchers, editors and associate editors. Among the major contributions of this study is an interactive diagram that provides an overview…
Emotional intelligence, resilience and personality traits neuroticism and extraversion: predictive capacity in perceived academic efficacy.
2021
Abstract Background Recent studies have shown the importance of promoting emotional intelligence and resilience, as well as knowing the personality (extraversion versus emotional instability or neuroticism) in both nursing students and nursing professionals, for better academic adherence, due to stressful situations derived from high academic and attendance requirements for healthcare practices in clinical settings. However, there is little research that analyzes the importance of the perceived academic effectiveness of university students and its relationship with the psychological variables of resilience, emotional intelligence and personality. Objective To analyse the relationships betwe…
Detection of Indoor Air Pollutants Using Reactive Sputtering/GLAD of Tin Oxide Thin Films
2021
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Musculoskeletal manifestations of childhood cancer and differential diagnosis with juvenile idiopathic arthritis (ONCOREUM): a multicentre, cross-sec…
2021
Summary Background Presenting symptoms of childhood cancers might mimic those of rheumatic diseases. However, the evidence available to guide differential diagnosis remains scarce. Preventing wrong or delayed diagnosis is therefore important to avoid incorrect administration of glucocorticoid or immunosuppressive therapy and worsening of prognosis. As such, we aimed to assess the prevalence and characteristics of presenting musculoskeletal manifestations in patients at cancer onset and to identify the factors that differentiate childhood malignancies with arthropathy from juvenile idiopathic arthritis. Methods We did a multicentre, cross-sectional study at 25 paediatric haemato-oncology cen…
Influence of gas environment on the dynamics of wetting transition of laser-textured stainless steel meshes
2021
We analyze the role of surrounding gas and aging in ambient air in the wettability behavior of laser-processed stainless steel meshes. Laser texturing of meshes was carried out in the presence of different gases (N2, O2, CO2, Ar, and SF6) in ambient atmospheric air and under different vacuum conditions. The influence of each gas on the evolution of the wettability properties after aging in ambient air is analyzed. The effects of low-pressure and vacuum aging allowed transforming the initial superhydrophilic characteristics of the laser-structured meshes to an almost superhydrophobic state.
Myotonic dystrophy type 1 drug development: A pipeline toward the market
2021
Highlights • Myotonic dystrophy, a neuromuscular disease, affects at least around half a million people worldwide. • Close to two dozen preclinical and clinical drug development programs active. • Drugs encompass new chemical entities, repurposing, oligonucleotide, and gene therapy. • Tideglusib, mexiletine, and metformin are close to reaching marketing authorization.
Design and implementation of the AMIGA embedded system for data acquisition
2021
The successful installation, commissioning, and operation of the Pierre Auger Observatory would not have been possible without the strong commitment and effort from the technical and admin-istrative staff in Malargtie. We are very grateful to the following agencies and organizations for financial support: Comision Nacional de Energla Atomica, Agencia Nacional de Promocion Cientffica y Tec-nologica (ANPCyT) , Consejo Nacional de Investigaciones Cientfficas y Tecnicas (CONICET) , Gobierno de la Provincia de Mendoza, Municipalidad de Malargtie, NDM Holdings and Valle Las Leilas, in gratitude for their continuing cooperation over land access, Argentina; the Australian Research Council; Conselho…
Generalized finite difference schemes with higher order Whitney forms
2021
Finite difference kind of schemes are popular in approximating wave propagation problems in finite dimensional spaces. While Yee’s original paper on the finite difference method is already from the sixties, mathematically there still remains questions which are not yet satisfactorily covered. In this paper, we address two issues of this kind. Firstly, in the literature Yee’s scheme is constructed separately for each particular type of wave problem. Here, we explicitly generalize the Yee scheme to a class of wave problems that covers at large physics field theories. For this we introduce Yee’s scheme for all problems of a class characterised on a Minkowski manifold by (i) a pair of first ord…