showing 36 of ~574560 from 574555 documents
Association of Vital Pulp Therapy Outcomes with Tooth Type, Arch Location, Treatment Type, and Number of Surfaces Destroyed in Deciduous Teeth: A Ret…
2021
There is a paucity of information concerning vital pulp treatment outcomes in the undergraduate teaching setting. This study aimed to determine which type of deciduous molar, arch location, type of vital pulp therapy, and the number of carious surfaces involved had a better prognosis when carried out by undergraduate dental students. The method used was the review of clinical records of 590 patients with 600 deciduous molars, that visited the outpatient undergraduate dental clinics for vital pulp therapy. Statistical analysis used to determine the associations of tooth type, arch location, treatment type, and the number of carious surfaces involved in successful outcomes was logistic regres…
Debilidades y amenazas en torno al despoblamiento de dos comarcas rurales valencianas: un reto del desarrollo local
2021
Los entornos rurales de interior tienen dificultades en los procesos de desarrollo local por el proceso de despoblación y sus efectos sobre el territorio. A partir de los resultados obtenidos de un estudio realizado en dos comarcas del interior de la provincia de Valencia (España) realizado por la Universidad de Valencia, se determinaron unas líneas de actuación que pusieron de manifiesto la existencia de una vinculación entre la capacidad del territorio rural para generar empleo y la posibilidad para conseguir el asentamiento de la población. Se reflexiona sobre los elementos fundamentales que hacen que este proceso sea tan importante, y se plantean las dificultades y posibilidades que exi…
Per amore e per interesse. Moventi e modelli dell’azione benefica nella riflessione antica
2021
Classical thinkers described sometimes the donor’s move employing some unexpected analogies: Aristotle explains the “benefactor’s love” comparing it to the artist’s love for his artwork, or to the mother’s devotion to her sons. Cicero talks about benivolentia as a permanent and constant affect, very distant from amor adulescentulorum. Seneca, in ben. 1.14, chooses to compare donor’s beneficia amabilia to the behavior of meretrix. The aim of this paper is to recognize the tight bind of love and interest underlying these analogies, and to explain how it could be, after all, a pattern useful for re-thinking the nature of contemporary philanthropy.
Radical innovations: Between established knowledge and future research opportunities
2021
Abstract The fast growing body of radical innovation research is fragmented and difficult to overlook. We provide an overview of the most cited journals, authors, and publications and conduct a bibliographic coupling to structure the literature landscape. We identified the following research clusters: management of radical innovations, organizational learning and knowledge, financial aspects of radical innovation, radical innovation adoption and diffusion, radical industry innovations as challenges for incumbents, and radical innovation in specific industries. Based on an in-depth content analysis of these clusters, we identify the following future research opportunities: A systematic compi…
State Observer with Round-Robin Aperiodic Sampled Measurements with Jitter
2021
International audience; A sampled-data observer is proposed for linear continuous-time systems whose outputs are sequentially sampled via non-uniform sampling intervals repeating a prescribed Round-Robin sequence. With constant sampling intervals (jitter-free case) we provide constructive necessary and sufficient conditions for the design of an asymptotic continuous-discrete observer whose estimation error is input-to-state stable (ISS) from process disturbances and measurement noise. We use a time-varying gain depending on the elapsed time since the last measurement. With non-constant sampling intervals (jitter-tolerant case), our design conditions are only sufficient. A suspension system …
Semiotica e pandemia: un diario
2021
Mediatically, the epidemic is the classic bad news that is good news. Deadly bad news that makes a lot of money. A tasty piece of news that attracts the attention of the blasé public, multiplies the audience and goes on - far more than its subject - by very fast contagion: everyone wants it, everyone is looking for it. For what reason? Quickly said: because it is imprudent to deny its scope, to downplay its nature and value. Who dares to throw water on the fire when, even for a very small percentage, there could be a chain death?
PATRIMONIO CULTURALE E MARGINALITÀ. LA PANDEMIA DELLA SOLITUDINE. QUALE RIGENERAZIONE?
2021
We start from the assumption that culture is what man assimilates, modifies and transforms, to which he contributes with his work, adding to and preserving the historical heritage. The sum of heritage diversities and values gives cultural uniqueness to the coexistence of the communities that make up each territory. Our main task, the task of each one of us who with an educated eye understands the meaning and value of heritage, must be directed towards committing ourselves not only to be actors in the present historical moment in which such testimonies survive, but to be authors of practices of preservation and enhancement. We cannot learn culture just by looking at its symbols, but by livin…
Risk factors of de novo malignancies after liver transplantation: a French national study on 11004 adult patients.
2021
International audience; Background: After liver transplantation (LT),de novo malignancies are one of the leading causes of late mortality. The aim of the present retrospective study was to identify the risk factors of de novo malignancies in a large cohort of LT recipients in France, using Fine and Gray competing risks regression analysis.Methods: The study population consisted in 11004 adults transplanted between 2000 and 2013, who had no history of pre-transplant malignancy, except primary liver tumor. A Cox model adapted to the identification of prognostic factors (competitive risks) was used.Results: From the entire cohort, one (or more)de novo malignancy was reported in 1480 L T recipi…
Transcatheter Heart Valve Implantation in Bicuspid Patients with Self-Expanding Device
2021
Bicuspid aortic valve (BAV) patients are conventionally not treated by transcathether aortic valve implantation (TAVI) because of anatomic constraint with unfavorable outcome. Patient-specific numerical simulation of TAVI in BAV may predict important clinical insights to assess the conformability of the transcathether heart valves (THV) implanted on the aortic root of members of this challenging patient population. We aimed to develop a computational approach and virtually simulate TAVI in a group of n.6 stenotic BAV patients using the self-expanding Evolut Pro THV. Specifically, the structural mechanics were evaluated by a finite-element model to estimate the deformed THV configuration in …
Cognitive and emotional variables predicting treatment outcome of cognitive behavior therapies for patients with medically unexplained symptoms: A me…
2021
Cognitive behavior therapy (CBT) is the best-evaluated psychological approach to treat patients with medically unexplained symptoms (MUS). We still need a better understanding of what characterizes patients with MUS who benefit more or less from CBT. This systematic review aimed to identify patients' cognitive-emotional characteristics predicting the outcome of CBT for MUS.A systematic literature search (PubMed, PsycINFO, Web of Science) revealed 37 eligible studies, 23 of these provided data for meta-analyses. Mean correlation coefficients between predictor variables and the outcomes (symptom intensity, physical or social-emotional functioning) were calculated using a random-effects model.…
Seeing reality through Einstein's eyes: a teaching proposal for special relativity
2021
The teaching of Special Relativity is still a critical issue not only for students but also for teachers. In this paper, we describe the trial of a learning unit on the Special Relativity topic based on Minkowski's approach through spacetime diagrams, following the results in pedagogical researches in this field. The main innovation of our project consists of a mechanical instrument: it allows to physically and mechanically represent Lorentz’s transformations by hands, exploring the effects of a change of the reference frame. Teachers and students can deal “by eye” with unusual phenomena as the loss of simultaneity, time dilation, length contraction, relativistic addition of velocities and …
A multi-proxy long-term ecological investigation into the development of a late Holocene calcareous spring-fed fen ecosystem (Raganu Mire) and boreal…
2021
Abstract The calcareous substrate of spring-fed fens makes them unique islands of biodiversity, hosting endangered, vulnerable, and protected vascular plants. Hence, spring-fed fens ecosystems require special conservation attention because many of them are destroyed (e.g. drained, forested) and it is extremely difficult or even impossible to restore the unique hydrogeological and geochemical conditions enabling their function. The long-term perspective of paleoecological studies allows indication of former wetland ecosystem states and provides understanding of their development over millennia. To examine the late Holocene dynamics of a calcareous spring-fed fen (Raganu Mire) ecosystem on th…
Perceptions of digital technology in nursing education: A qualitative study.
2021
Abstract Aim The aim of this study was to explore how digital technologies can facilitate interactive learning in a 15-credit theory module on basic nursing. Background Digital platforms are in widespread use in nursing education; however, the rapid technological advancement provides new opportunities to support teaching and learning. This indicates the need to explore how educational digital technologies can be used as an integral part of learning activities to promote quality and relevance in nursing education. This study was carried out at the Department of Nursing Science at a university in Norway. The university has been using a digital platform for many years and has recently adopted …
Análisis una propuesta didáctica para trabajar la poesía en un aula de Primaria: leer a Leopoldo de Luis
2021
Muchas son las propuestas para llevar la lectura de un poema a un aula, aunque los resultados, a pesar de las buenas voluntades, no siempre son muy satisfactorios, quizá porque sea parte de una idea algo equivocada de lo que es un texto poético y de lo que este requiere. En este trabajo se pretende revisar todo ello, valorando, además, la idoneidad de un poema del poeta Leopoldo de Luis, sobre un partido de fútbol. Frente a esta propuesta se ha llevado a cabo toda una revisión seria de los resultados obtenidos en su aplicación, tanto en un aula de Primaria como en unos grupos de estudiantes universitarios. Los resultados son esclarecedores y también inquietantes en algunos sentidos, pues ev…
Population as the body of society
2021
International audience
CD4+ T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria
2021
The progression through different steps of T-cell development, activation, and effector function is tightly bound to specific cellular metabolic processes. Previous studies established that T-effector cells have a metabolic bias toward aerobic glycolysis, whereas naive and regulatory T cells mainly rely on oxidative phosphorylation. More recently, the field of immunometabolism has drifted away from the notion that mitochondrial metabolism holds little importance in T-cell activation and function. Of note, T cells possess metabolic promiscuity, which allows them to adapt their nutritional requirements according to the tissue environment. Altogether, the integration of these metabolic pathway…
Vulnerability, Human Rights and Climate Change
2021
The article aims at establishing the specificity of the human rights approach to environmental issues such as the climate change, in order to test its advantages and limits. While responsibilities in the side of climate change is controversial, the approach from human rights and in particular from their vulnerability is easier to focus and define and it involves also the problem of inequalities produced by the degradation of environment. In addition, the human rights approach is dynamic (open to specification and to proceses of implementation) and it is compatible with an intergenerational perspective.
Evaluation of the ERA5 reanalysis-based Universal Thermal Climate Index on mortality data in Europe
2021
Air temperature has been the most commonly used exposure metric in assessing relationships between thermal stress and mortality. Lack of the high-quality meteorological station data necessary to adequately characterize the thermal environment has been one of the main limitations for the use of more complex thermal indices. Global climate reanalyses may provide an ideal platform to overcome this limitation and define complex heat and cold stress conditions anywhere in the world. In this study, we explored the potential of the Universal Thermal Climate Index (UTCI) based on ERA5 – the latest global climate reanalysis from the European Centre for Medium-Range Weather Forecasts (ECMWF) – as a h…
Novel Three-Phase Multilevel Inverter With Reduced Components for Low- and High-Voltage Applications
2021
In this article, a novel multilevel topology for three-phase applications, having three-level and hybrid N -level modular configurations, enabling low-, medium-, and high-voltage operations, is presented. The proposed topology has several attractive features, namely reduced component count, being capacitor-, inductor-, and diode-free, lowering cost, control-complexity, and size, and can operate in a wide range of voltages and powers. Selected simulation and experimental results are presented to verify the performance of the proposed topology. Further, the overall efficiency of the topology and loss distribution in switches are studied. Finally, the key features of the proposed topology in t…
Positive Psychological Capital as a Predictor of Satisfaction With the Fly-In Fly-Out Model
2021
The flexibility of the markets and international agreements lure a growing number of companies to expand their business beyond frontiers in search for new markets and a bigger business network. Workers, initially called expatriates, become keystones to implant and promote the so desired expansion into the international markets. From the concept of flexpatriate present in the literature in general, we adapted the concept of FLY-in FLY-out (FIFO) to comprehend the organizational flexpatriates. In the midst of the Positive Psychology theories, Luthans et al. underline that workers are the psychological capital of the companies. Therefore, the development of the Positive Psychological Capital b…
Enriching Didactic Similarity Measures of Concept Maps by a Deep Learning Based Approach
2021
Concept maps are significant tools able to support several tasks in the educational area such as curriculum design, knowledge organization and modeling, students' assessment and many others. They are also successfully used in learning activities in which students have to represent domain knowledge according to teacher's assignment. In this context, the development of Learning Analytics approaches would benefit of methods that automatically compare concept maps. Detecting concept maps similarities is relevant to identify how the same concepts are used in different knowledge representations. Algorithms for comparing graphs have been extensively studied in the literature, but they do not appea…
Competitive arsenate and phosphate adsorption on α-FeOOH, LaOOH, and nano-TiO2: Two-dimensional correlation spectroscopy study
2021
Abstract Competitive adsorption of arsenate (AsO43−) and phosphate (PO43−) on α-FeOOH, LaOOH, and nano-TiO2 was studied using batch adsorption experiments and in-situ flow cell ATR-FTIR coupled with two-dimensional correlation spectroscopy (2D-COS) for the first time. With a higher temporal resolution, our results found a highly dynamic adsorption sequence for AsO43− and PO43−. When AsO43− and PO43− were simultaneously exposed to the adsorbents at the same concentrations, AsO43− was preferentially adsorbed by α-FeOOH and TiO2, but PO43− adsorption was dominant on LaOOH. The results implied that the PO43− adsorbed on LaOOH had to be remobilized to allow for AsO43− adsorption, but that PO43− …
First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (C…
2021
First-line chemotherapy for advanced or metastatic human epidermal growth factor receptor 2 (HER2)-negative gastric or gastro-oesophageal junction adenocarcinoma has a median overall survival (OS) of less than 1 year. We aimed to evaluate first-line programmed cell death (PD)-1 inhibitor-based therapies in gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma. We report the first results for nivolumab plus chemotherapy versus chemotherapy alone.In this multicentre, randomised, open-label, phase 3 trial (CheckMate 649), we enrolled adults (≥18 years) with previously untreated, unresectable, non-HER2-positive gastric, gastro-oesophageal junction, or oesophageal adenocarcinoma, …
Autochthonous organic matter promotes DNRA and suppresses N2O production in sediments of the coastal Baltic Sea
2021
Coastal environments are nitrogen (N) removal hot spots, which regulate the amount of land-derived N reaching the open sea. However, mixing between freshwater and seawater creates gradients of inorganic N and bioavailable organic matter, which affect N cycling. In this study, we compare nitrate reduction processes between estuary and offshore archipelago environments in the coastal Baltic Sea. Denitrification rates were similar in both environments, despite lower nitrate and carbon concentrations in the offshore archipelago. However, DNRA (dissimilatory nitrate reduction to ammonium) rates were higher at the offshore archipelago stations, with a higher proportion of autochthonous carbon. Th…
Exomorphism of jacobsite precipitates in bixbyite single crystals from the Thomas Range in Utah
2021
Abstract Naturally occurring single crystals of bixbyite, (Fe,Mn)2O3, from the Thomas Mountain Range in Utah, U.S.A., were studied via (scanning) transmission electron microscopy (S)TEM. With up to 5 cm edge length, these mineral specimens are the largest bixbyite crystals found worldwide. Their hexahedral shapes are often modified by {211} facets at the corners and small {211} truncations along their cube edges. Characteristic lamellar defects, running parallel to the {100} planes, can be observed via TEM imaging. The defects are, according to EDS analyses, attributed to the tetragonal manganese silicate braunite, Mn7[SiO12]. In the present study, electron nano-diffraction and atomic resol…
Diversity, Complexity and Ordinality: Mental Health Services Outside the Institutions—Service Users’ and Professionals’ Experience-Based Practices an…
2021
In conjunction with the dismantling of psychiatric hospitals, social workers have been commissioned to help service users in their daily living in their homes and in the community. The consequences of these changes for experience-based knowledge and practices in their contexts remain relatively unknown. In this study, eighteen service users and the social workers they described as helpful for them were interviewed. The interviews were recorded, transcribed, and analyzed using Thematic Analysis. The following themes emerged: “Here, there and everywhere”, “Doing, being, becoming”, “Talking” and “Order, planning and improvisation” concerning the contradictions service users and professionals m…
Ureteral Stones: Shockwave Lithotripsy or Ureteroscopy, Which is Best?
2021
Background Renal stone disease is common and can cause emergency presentation with acute pain due to ureteric colic. International guidelines have stated the need for a multicentre randomised controlled trial (RCT) to determine whether a non-invasive outpatient (shockwave lithotripsy [SWL]) or surgical (ureteroscopy [URS]) intervention should be the first-line treatment for those needing active intervention. This has implications for shaping clinical pathways. Objective To report a pragmatic multicentre non-inferiority RCT comparing SWL with URS. Design, setting, and participants This trial tested for non-inferiority of up to two sessions of SWL compared with URS as initial treatment for ur…
LC-MS/MS characterisation and determination of dansyl chloride derivatised glyphosate, aminomethylphosphonic acid (AMPA), and glufosinate in foods of…
2021
Abstract Glyphosate and other polar and acidic pesticides have been particularly studied due to the concerns over widespread and intensive use. The chemical properties of these compounds necessitate use of customised methods, such as derivatisation or ion exchange chromatography. These approaches present a compatibility problem with ESI-MS due to presence of salts and non-volatile compounds. For that reason, a simple procedure has been developed for the extraction, pre-column derivatisation with dansyl chloride (5-(dimethylamino)naphthalene-1-sulfonyl chloride), and mass spectrometric detection of glyphosate, AMPA, and glufosinate after the separation on a C18 stationary phase. The dansyl d…
Réactions des patients face au déremboursement des médicaments
2021
Le personnel officinal est regulierement confronte a des patients qui s’insurgent contre le deremboursement de leurs medicaments. Ces reactions, parfois virulentes, relevent de differents mecanismes psychiques qui doivent etre connus afin de savoir reagir au cas par cas.
P-138 Margetuximab combined with anti-PD-1 (retifanlimab) or anti-PD-1/LAG-3 (tebotelimab) +/- chemotherapy in first-line therapy of advanced/metasta…
2021
Oral antiseptics against coronavirus: in-vitro and clinical evidence
2021
Background Angiotensin converting enzyme II (ACE2) is the cellular receptor for SARS-CoV-2, so ACE2-expressing cells can act as target cells and are susceptible to infection. ACE2 receptors are highly expressed in the oral cavity so this may be a potential high-risk route for SARS-CoV-2 infection. Furthermore, the virus can be detected in saliva, even before COVID-19 symptoms appear, with the consequent high risk of virus transmission in asymptomatic/pre-symptomatic patients. Reducing oral viral load could lead to a lower risk of transmission via salivary droplets or aerosols and therefore contribute to the control of the pandemic. Aim To evaluate the available evidence testing the in vitro…
Constructing Antidictionaries in Output-Sensitive Space
2021
A word $x$ that is absent from a word $y$ is called minimal if all its proper factors occur in $y$. Given a collection of $k$ words $y_1,y_2,\ldots,y_k$ over an alphabet $\Sigma$, we are asked to compute the set $\mathrm{M}^{\ell}_{y_{1}\#\ldots\#y_{k}}$ of minimal absent words of length at most $\ell$ of word $y=y_1\#y_2\#\ldots\#y_k$, $\#\notin\Sigma$. In data compression, this corresponds to computing the antidictionary of $k$ documents. In bioinformatics, it corresponds to computing words that are absent from a genome of $k$ chromosomes. This computation generally requires $\Omega(n)$ space for $n=|y|$ using any of the plenty available $\mathcal{O}(n)$-time algorithms. This is because a…
The Application of the Essential Oils of Thymus vulgaris L. and Crithmum maritimum L. as Biocidal on Two Tholu Bommalu Indian Leather Puppets
2021
The chemical profile of the Thymus vulgaris (Lamiaceae) essential oil (EO) was investigated in order to evaluate its biological properties against microorganisms affecting two Tholu Bommalu, typical Indian leather puppets stored at the International Puppets Museum “Antonio Pasqualino” of Palermo, Italy. A GC–MS analysis, using both polar and apolar columns, was used to determine the chemical composition of the essential oil. The aim of this study was to evaluate the antimicrobial effectiveness of the Thymus vulgaris and Crithmum maritimum essential oils in vapor phase to disinfect heritage leather puppets. Pieces of leather artifacts that were affected by different bacterial colonies were e…
P–178 Mural granulosa cells of the human follicles indirectly show death molecular signals not depending on different ovarian stimulation protocols
2021
Abstract Study question Could the expression of the anti-apoptotic molecules AKT, p-Akt and ERK1/2 in Mural Granulosa Cells (MGC) be considered as marker of oocyte quality? Summary answer MGCs activate cell death pathways in analyzed follicles and it is not influenced by different stimulation protocols and it is not correlated to oocyte competence. What is known already It has been previously demonstrated that apoptosis rate of mural granulosa or cumulus cells (CC) were correlated with follicular oocyte number, age, embryo numbers in IVF/ICSI and also clinical pregnancy. Moreover, our previous data demonstrated that in selected patients, who received recombinant LH associated with recombina…
L'esperienza immersiva e le sue ragioni
2021
"L'idea di immersività" che emerge dai volumi: Nel centro del quadro di Bruno Di Marino e "Immagine, arte, virtualità" di Roberto Diodato "The idea of immersiveness" that emerges from the volumes: In the center of the painting by Bruno Di Marino and "Image, art, virtuality" by Roberto Diodato
COVID-19 and the impact on the cranio-oro-facial trauma care in Italy:An epidemiological retrospective cohort study
2021
The coronavirus disease 2019 (COVID-19) has deeply modified the organization of hospitals, health care centers, and the patient’s behavior. The aim of this epidemiological retrospective cohort study is to evaluate if and how the COVID-19 pandemic has determined a modification in cranio-oro-facial traumatology service. Methods: The dataset included hospital emergency room access of a six-month pre-pandemic period and six months into pandemic outbreak. The variables collected were: patient age, gender, type of emergency access with relative color code, Glasgow Coma Scale Score, type of discharge. Results: 537 vs. 237 (pre-pandemic vs. pandemic) patients accessed the hospital emergency room an…