Risk Factors and treatment needs of batterer intervention program participants with substance abuse problems

2021

espanolEl objetivo de este estudio fue identificar los principales factores de riesgo y necesidades de tratamiento de los participantes en un programa de intervencion con maltratadores (BIP) con problemas de abuso de alcohol y/o drogas (ADAP), mas alla de sus problemas de abuso de substancias, teniendo en cuenta cuatro conjuntos de variables: sociodemograficas (i.e., edad, nivel educativo, ingresos, empleo y estatus de inmigrante), trastornos de personalidad y ajuste psicologico (i.e., sintomatologia clinica, trastornos de personalidad, ira, impulsividad y autoestima), variables socio-relacionales (i.e., apoyo comunitario, apoyo intimo, eventos vitales estresantes y rechazo social percibido…

Invasive ovarian seromucinous carcinoma developed on an endometrioma. The determining role of transvaginal ultrasound

2021

Endometriosis is a chronic inflammatory disease that has been associated with an increased risk of ovarian cancer, especially epithelial tumors. Transvaginal ultrasound is a first-line diagnostic method for the assessment of endometriosis, and of endometriomas, the ovarian cystic form of endometriosis. Endometriomas usually have typical ultrasound features that allow them to be easily diagnosed. When atypical images are observed, such as solid areas with vascular flow, their malignancy should be ruled out, especially in peri-menopausal women. Early diagnosis of these tumors is essential because immediate surgical treatment is crucial for prognosis. Malignant neoplasms associated with endome…

Oncogenic BRAF protein as a molecular target of HDAC inhibitors in melanoma cells

2021

Do categorical representations modulate early automatic visual processing? A visual mismatch-negativity study.

2021

Perceptual categorization is an important cognitive function. In the auditory domain, categorization already occurs within the first 200 ms of information processing, as indexed by the mismatch negativity. Here, we assessed the characteristics of the visual mismatch negativity (vMMN) elicited during the categorization of previously unknown visual stimuli. To examine this, we used five-dot patterns with characteristics that allow for the formation of categories through rotation and reflection but not through other physical properties. To assess whether or not between-category and within-category vMMN differ in amplitude, the data was analyzed with the Bayesian approach. We observed that both…

Longitudinal evidence for an emotion-action lag on desire: The role of emotional understanding

2021

Abstract Many previous studies have found that children understand much earlier what a character who has a false belief will do than what a character will feel. This gap between the understanding of action and emotion is known as the belief-emotion lag and to this day there is no convincing explanation as to why it happens. There are also no studies that have explored whether this same gap occurs in the understanding of desire. This longitudinal study had a twofold objective: to explore the existence of a lag between the prediction of action and emotion based on desire, and to search for the role that specific emotions could have in children’s answers. To this end, we administered the Test …

Dimorare con le voci degli antichi. La biblioteca nel Malpiglio secondo di Torquato Tasso

2021

In the dialogue Il Malpiglio secondo overo del fuggir la moltitudine, Tasso stages the dialogue between Forestiero Napolitano and Giovanlorenzo Malpiglio, son of Vincenzo Malpiglio, a gentleman of the court of Ferrara. The dialogue focuses on the function of the oratories, poets and of philosophers. The library of the young Malpiglio, located at the highest point of the house, in the most central place of the city, in fact it is not only the emblematic space of the identity recognition of the courteous gentleman and of his erudite education; it becomes the space of an uninterrupted dialogue with the voices of the authors, with which the reader entertains himself, appreciating order and vagu…

IGF-1 Haploinsufficiency Causes Age-Related Chronic Cochlear Inflammation and Increases Noise-Induced Hearing Loss

2021

This article belongs to the Collection Insulin-Like Growth Factors in Development, Cancers and Aging.

Long-Term Outcome with New Generation Prostheses in Patients Undergoing Transcatheter Aortic Valve Replacement

2021

The aim of this study was to compare patients with transcatheter aortic valve replacement (TAVR) receiving new generation prostheses SAPIEN 3 (S3, Edwards Lifesc.) and Evolut R (ER, Medtronic Inc.) in terms of periprocedural and long-term outcome. Our retrospective, single-center analysis included 359 consecutive patients with severe aortic stenosis who underwent TAVR with S3 or ER from 2014–2016 (mean age 82 ± 7 years, 47% male, mean EuroSCORE II 8.0 ± 8%, mean follow-up 3.8 years). Device Success was equal (S3 93.0% vs. ER 92.4%, p = 0.812). We report a 30-day mortality of 2.8% in the S3 group, and 2.1% in the ER group (p = 0.674). There was no difference in stroke, conversion to open sur…

Opportunities and Challenges of Liquid Biopsy in Thyroid Cancer

2021

Thyroid cancer is the most common malignancy of the endocrine system, encompassing different entities with distinct histological features and clinical behavior. The diagnostic definition, therapeutic approach, and follow-up of thyroid cancers display some controversial aspects that represent unmet medical needs. Liquid biopsy is a non-invasive approach that detects and analyzes biological samples released from the tumor into the bloodstream. With the use of different technologies, tumor cells, free nucleic acids, and extracellular vesicles can be retrieved in the serum of cancer patients and valuable molecular information can be obtained. Recently, a growing body of evidence is accumulating…

Castration-Induced Downregulation of SPARC in Stromal Cells Drives Neuroendocrine Differentiation of Prostate Cancer.

2021

Abstract Fatal neuroendocrine differentiation (NED) of castration-resistant prostate cancer is a recurrent mechanism of resistance to androgen deprivation therapies (ADT) and antiandrogen receptor pathway inhibitors (ARPI) in patients. The design of effective therapies for neuroendocrine prostate cancer (NEPC) is complicated by limited knowledge of the molecular mechanisms governing NED. The paucity of acquired genomic alterations and the deregulation of epigenetic and transcription factors suggest a potential contribution from the microenvironment. In this context, whether ADT/ARPI induces stromal cells to release NED-promoting molecules and the underlying molecular networks are unestablis…

Challenges and Opportunities of English Grammar Acquisition by Distance at the Tertiary Level

2021

Distance learning introduced in almost all educational establishments in spring 2020 has raised interest among researchers how to deal with it in a more productive way. Thus, the goal of the research was to find out undergraduates’ views on distance learning of English grammar and the use of online revision materials in developing students’ independent study skills at a tertiary institution in Latvia. the research tool was a questionnaire consisting of open-ended and closed questions. Twenty-three students answered the survey questions. the research results indicate that studying by distance is preferred because it allows the students to choose the study time and place, to develop their tim…

Toll-like receptors in neuroinflammation, neurodegeneration, and alcohol-induced brain damage

2021

Toll-like receptors (TLRs) or pattern recognition receptors respond to pathogen-associated molecular patterns (PAMPs) or internal damage-associated molecular patterns (DAMPs). TLRs are integral membrane proteins with both extracellular leucine-rich and cytoplasmic domains that initiate downstream signaling through kinases by activating transcription factors like AP-1 and NF-κB, which lead to the release of various inflammatory cytokines and immune modulators. In the central nervous system, different TLRs are expressed mainly in microglia and astroglial cells, although some TLRs are also expressed in oligodendroglia and neurons. Activation of TLRs triggers signaling cascades by the host as a…

Prevalence of traumatic injuries in deciduous dentition and associated risk factors in a Spanish children population

2021

Background: The frequency of traumatic dental injuries (TDI) in primary dentition and those agents that favor them present a great variability. Therefore, the objective of this study was to determine the prevalence of TDI in a population of Spanish preschoolers in temporary dentition and identify the factors associated with these injuries. Materials and Methods: an epidemiological observational prevalence study was carried out. A total of 343 children aged between 3 and 5 years were selected. A questionnaire was completed in relation to socioeconomic factors, cultural level, dietary habits and oral parafunction. Through an intraoral examination, information was collected on the occlusal cha…

Smoking and Neuropsychiatric Disease-Associations and Underlying Mechanisms.

2021

Despite extensive efforts to combat cigarette smoking/tobacco use, it still remains a leading cause of global morbidity and mortality, killing more than eight million people each year. While tobacco smoking is a major risk factor for non-communicable diseases related to the four main groups—cardiovascular disease, cancer, chronic lung disease, and diabetes—its impact on neuropsychiatric risk is rather elusive. The aim of this review article is to emphasize the importance of smoking as a potential risk factor for neuropsychiatric disease and to identify central pathophysiological mechanisms that may contribute to this relationship. There is strong evidence from epidemiological and experiment…

Recombinant GII.P16 genotype challenges RT-PCR-based typing in region A of norovirus genome

2021

Abstract Objectives In latest years GII.4[P16] and GII.2[P16] noroviruses have become predominant in some temporal/geographical settings. In parallel with the emergence of the GII.P16 polymerase type, norovirus surveillance activity in Italy experienced increasing difficulties in generating sequence data on the RNA polymerase genomic region A, using the widely adopted JV12A/JV13B primer set. Two sets of modified primers (Deg1 and Deg2) were tested in order to improve amplification and typing of the polymerase gene. Methods Amplification and typing performance of region A primers was assessed in RT-PCR on 452 GII norovirus positive samples obtained from 2194 stool samples collected in 2016–2…

Breaking the barriers of animosity: innovation in business models as a positioning strategy

2021

Consumer animosity is often studied in the large economies of the world, in order to explain the negative feelings generated by an individual towards another country and its products, due to various political, economic and social conflicts. This study presents three specific developments in this field. First, to demonstrate how companies in the retail sector have been able to develop innovations in their business models through their shops and virtual channels, which generate a positive positioning in the mind of the consumer, capable of minimizing animosity towards them. In this way it is shown that a consumer can have strong feelings of patriotism, animosity and ethnocentrism, and yet a p…

Learning Design for Future Higher Education – Insights From the Time of COVID-19

2021

The COVID-19 pandemic brought many challenges in higher education. All teaching and learning activities were moved online. Universities had to provide adapted solutions to facilitate learning and maintain students’ engagement. Online education implies creating new learning environments with the help of digital technologies. Beyond the process of acquisition of knowledge, teachers needed to facilitate cooperative learning, build positive relations, and reduce negative emotions. We provide some expert insights based on empirical observations on teaching and assessment practices connected with psychology models applied in education. The aim of the paper is to formulate specific learning design…

Factores de riesgo de enfermedad residual en la re-RTU en una gran cohorte de pacientes con enfermedad T1G3

2021

Resumen Introduccion y objetivos Los objetivos de la reseccion transuretral (RTU) del tumor vesical son la reseccion completa de las lesiones y la realizacion de un diagnostico correcto con el objetivo de estadificar adecuadamente al paciente. Es bien sabido que la presencia de musculo detrusor en el especimen es un requisito previo para minimizar el riesgo de infraestadificacion. La persistencia de enfermedad tras la reseccion de los tumores vesicales no es infrecuente, y es la razon por la que las guias europeas recomiendan una re-reseccion transuretral (re-RTU) para todos los tumores T1. Recientemente se ha publicado que, en los casos con inclusion de musculo en el especimen, la re-RTU n…

The role of hemostatic devices in neurosurgery. A systematic review.

2021

Hemostasis represents a fundamental step in every surgical procedure. During neurosurgical procedures, proper and robust hemostasis into confined spaces can significantly reduce the odds of perioperative complications. Over the decades, multiple methods have been applied, and several medical devices have been developed to promote and guarantee proper hemostasis. This study presents a systematic review of the most used intraoperative hemostatic methods and devices in neurosurgery. Insightful research was performed on the PubMed database according to the PRISMA guidelines. This comprehensive review of scientific literature represents a synoptic panel where the most used intraoperative hemosta…

Zirconium and hafnium fractionation and distribution of Rare Earth Elements in neutral–alkaline waters: Case study of Lake Van hydrothermal system, T…

2021

International audience; We investigated the distribution of Zr, Hf, and rare earth elements (REE) as the sum of lanthanides plus Y in the hydrothermal system in the Lake Van area of south-eastern Turkey. This system is characterised by water with variable pH in alkaline conditions resulting from hydrothermal CO2 upraise and neoformation of calcite minerals in near equilibrium with the interacting waters. Zr, Hf, and REE determinations were carried out for aqueous phases and suspended solids in lake water and surrounding thermal springs. We found that dissolved Hf is partitioned relative to Zr during calcite formation and that such fractionation is a function of the Ca2+ activity in warm wat…

Supercritical water gasification of waste oils as a source of syngas

2021

A huge amount of waste oil is produced worldwide. Also substantial amount of virgin oils is available that are interesting candidates for upgrading into syngas. Supercritical water gasification (SCWG) can be considered as an aqueous phase reforming process to produce syngas from oils. In this work, a variety of waste and virgin oils were gasified in a continuous down-flow autoclave reactor at supercritical conditions. Experiments were carried out at 430 °C and 660 °C, 25 MPa, with a residence time in the range 103-170 s, in order to investigate gasification and carbon efficiency, hydrogen yield and composition of the produced gas. All the analysed feedstocks were suspended in water at vario…

Stem cell-secreted factor therapy regenerates the ovarian niche and rescues follicles.

2021

Background Ovarian senescence is a normal age-associated phenomenon, but increasingly younger women are affected by diminished ovarian reserves or premature ovarian insufficiency. There is an urgent need for developing therapies to improve ovarian function in these patients. In this context, previous studies suggest that stem cell–secreted factors could have regenerative properties in the ovaries. Objective This study aimed to test the ability of various human plasma sources, enriched in stem cell–secreted factors, and the mechanisms behind their regenerative properties, to repair ovarian damage and to promote follicular development. Study Design In the first phase, the effects of human pla…

Los efectos a largo plazo de las competencias emocionales y la autoestima sobre los síntomas internalizantes de los adolescentes

2021

Internalizing symptoms such as depressive mood, somatic complaints and anxiety among adolescents are a major and global concern for parents, educators and professionals. Empirical research suggests that high level of self-esteem during adolescents is associated with psychological adjustment and emotional well-being. This study examines self-esteem as a potential mediator in the interplay between emotional competencies and internalizing symptoms during adolescence. Self-report data from 855 Spanish adolescents (Mage = 13.6, SD = 1.09, 52% girls) were collected in two waves, using a longitudinal design. The mediation model was estimated using structural equation modelling (SEM). Results show …

Ventilation and air-conditioning systems in dental clinics and COVID-19: How much do we know?

2021

Background: This study evaluated the association between knowledge and management of ventilation and air-conditioning systems (VAC) to avoid the spread of the SARS-CoV-2 virus in health facilities by dentists and demographic variables. Material and Methods: A cross-sectional digital media survey was administered to dentists as part of global research. The core questionnaire was used including four additional questions on VAC (Q1: knowledge, Q2: work settings, Q3: temperature, and Q4: maintenance). A descriptive analysis was conducted for sociodemographic and VAC variables, and bivariate analysis was carried out using different tests. Results: 5370 dentists answered the survey (median age of…

Global, regional, and national burden of mortality associated with non-optimal ambient temperatures from 2000 to 2019: a three-stage modelling study

2021

Background: Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures. Methods: In this modelling study, we collected time-series data on mortality and ambient temperatures from 750 locations in 43 countries and five meta-predictors at a grid size of 0·5° × 0·5° across the globe. A three-stage analysis strategy was used. First, the temperature–mortality association was fitted for each location by use of a time-series regression. Second, a multivariate meta-regression model was built between location-specific estimates and meta-predictors. Finally, the gri…

Corporate Networks and business influence in Panama, Costa Rica, and El Salvador.

2021

Objective/Context: This paper explores the relationship between corporate networks and business influence to figure out the conditions of state capture. Methodology: We analyze corporate networks through interlocking directorates in three Central American countries - Panama, Costa Rica, and El Salvador - using network analysis, and we pinpoint the relationship between the structure of the corporate network and two corporate political actions: contributions to presidential campaigns and revolving doors. Conclusions: Results show corporate networks were fragmented in the three Central American countries, except for a well-connected business cluster in Panama. The organization of business elit…

Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions

2021

Simple Summary Glioblastoma multiforme is a futile disease usually leading to the patient’s death within one year post-diagnosis; therefore, novel treatment options are desperately needed. In this regard, activation of the inert immune system has moved into focus in recent years. Malignant brain tumors, as well as autoimmune diseases, elicit aberrant immune responses. In this way, glioma escapes the host’s immune system and, thus, activation of the immune response in order to reduce tumor tolerance can serve as an alternative treatment option. Immune checkpoint modulators in combination with traditional therapies have gained attention in both glioma and autoimmune diseases. In this review, …

ANALYSIS OF THE SEXUAL VARIABILITY IN THE SHELL OF THE SPANISH UPPER CRETACEOUS TURTLE DORTOKA VASCONICA (PAN-PLEURODIRA, DORTOKIDAE)

2021

The present study characterizes the morphological variability related to the sexual dimorphism in the shells of the Spanish Upper Cretaceous turtle  Dortoka vasconica . This study is based on the material from its type locality: Lano, Burgos. Two morphotypes were identified there based on the posterior plastral area as well as two for the anterior plastral lobe. However, a correlation with the previously indicated morphotypes could not be established due to the disarticulation of the specimens and the limited information available on the sexual dimorphism of Pleurodira. The morphological variability previously identified for  Dortoka vasconica  is analysed here through a quantitative approa…

A photoswitchable helical peptide with light-controllable interface/transmembrane topology in lipidic membranes

2021

Summary The spontaneous insertion of helical transmembrane (TM) polypeptides into lipid bilayers is driven by three sequential equilibria: solution-to-membrane interface (MI) partition, unstructured-to-helical folding, and MI-to-TM helix insertion. A bottleneck for understanding these three steps is the lack of experimental approaches to perturb membrane-bound hydrophobic polypeptides out of equilibrium rapidly and reversibly. Here, we report on a 24-residues-long hydrophobic α-helical polypeptide, covalently coupled to an azobenzene photoswitch (KCALP-azo), which displays a light-controllable TM/MI equilibrium in hydrated lipid bilayers. FTIR spectroscopy reveals that trans KCALP-azo folds…

Motivating Low-Achievers—Relative Performance Feedback in Primary Schools

2021

Abstract Relative performance feedback (RPF) has often been shown to improve effort and performance in the workplace and educational settings. Yet, many studies also document substantial negative effects of RPF, in particular for low-achievers. We study a novel type of RPF designed to overcome these negative effects of RPF on low-achievers by scoring individual performance improvements. With a sample of 400 children, we conduct a class-wise randomized-controlled trial using an e-learning software in regular teaching lessons in primary schools. We demonstrate that this type of RPF significantly increases motivation, effort, and performance in math for low-achieving children, without hurting …

Photobiomodulation and myofascial temporomandibular disorder: Systematic review and meta-analysis followed by cost-effectiveness analysis

2021

Background Photobiomodulation (PBM) is a non-invasive and non-pharmacological treatment, which, has shown beneficial results in the treatment of temporomandibular disorders (TMD) related pain. This systematic review and meta-analysis study aimed to evaluate the efficacy of photobiomodulation in the treatment of myofascial pain associated with (TMD by analyzing randomized clinical trials published from 2007 to February 2019. The secondary objective of the study was to perform a cost-effectiveness analysis of TMD treatment with photobiomodulation in patients with myofascial pain. Material and methods International databases were used: Pubmed, Medline and Web of Science; the initial search rai…

The Cultural and landscapes heritages: mobility, fruitioin and accessibility by all

2021

This study analyzes some international and national experiences already realized, or at an advanced stage of planning, which point to a new way of understanding the accessibility of places by users with specific needs, allowing the visitability so far denied. In particular we will deal with Agrigento.

Odontogenic Myxoma: Follow-Up of 13 cases after conservative surgical treatment and review of the literature

2021

Background We aim to report a serie of odontogenic myxoma over a 40-year period. Material and Methods We conducted a retrospective and sectional review of OM cases. The clinical, radiographic and treatment data were collected from clinical records included cases whose medical records contained clinical, radiographic, histopathological, follow-up data of at least six months. Results There was a mild preference for the male with a mean age of 22.8 years. Seventy-seven percent of the lesions occurred in the posterior region of the mandible, presenting a multilocular radiolucent aspect (54%) with one presenting symptomatology. Conservative treatment was performed in all patients initially and r…

Emergenza Covid-19 e sviluppo della competenza metacognitiva dei docenti universitari neoassunti

2021

La spinta all’innovazione verso ambienti di apprendimento caratterizzati da un uso intensivo della tecnologia, determinata dalla crisi pandemica, costituisce una questione strategica per lo sviluppo dell’alta formazione. In questa direzione, la formazione e professionalizzazione del docente universitario sul versante pedagogico-didattico-valutativo rappresenta un’azione rilevante con potenziale impatto sul sistema universitario nel suo complesso che va oltre il periodo di emergenza COVID- 19. Il presente contributo si propone di indagare alcuni fattori utili alla programmazione di iniziative di faculty development specificatamente dedicate ai docenti neoassunti, finalizzate al miglioramento…

Tempio e sinagoga. La relazione spazio-tempo nella religione ebraica

2021

the complex definition of a sacred place starting from the biblical text and from founding texts such as the Mishnah and the Talmud; sacred time in the exegetical tradition of traditional Judaism.

When Does Alzheimer′s Disease Really Start? The Role of Biomarkers

2021

While Alzheimer’s disease (AD) classical diagnostic criteria rely on clinical data from a stablished symptomatic disease, newer criteria aim to identify the disease in its earlier stages. For that, they incorporated the use of AD’s specific biomarkers to reach a diagnosis, including the identification of Aβ and tau depositions, glucose hypometabolism, and cerebral atrophy. These biomarkers created a new concept of the disease, in which AD’s main pathological processes have already taken place decades before we can clinically diagnose the first symptoms. Therefore, AD is now considered a dynamic disease with a gradual progression, and dementia is its final stage. With …