showing 36 of ~574560 from 574555 documents
Inammissibile la revisione europea in malam partem: il rimedio è volto a ripristinare le previsioni convenzionali violate
2021
I. La Corte di appello di Catanzaro nega la legittimazione del procuratore generale a proporre la revisione europea e ne ribadisce la natura di rimedio straordinario vocato al favor rei.
Migrazioni forzate e diritti disattesi. Lo sguardo di genere sui bisogni di frontiera
2021
La definizione di “tratta di esseri umani”, adottata dal Protocollo delle Nazioni Unite, descrive gli elementi che identificano un fenomeno rilevato su scala mondiale che occupa i primissimi posti delle classifiche relative ai crimini internazionali per la diffusione e la numerosità di casi. Esso prevede l’induzione forzata a varie forme di sfruttamento e, fra queste, un posto di rilievo occupa quello relativo allo sfruttamento a scopo prostitutivo. Malgrado accordi europei e leggi nazionali convergano sul piano giuridico, allo stato attuale, la condizione di “vittima di tratta” fatica ad essere riconosciuta come tale da un sistema di protezione e accoglienza che in Europa evidenzia procedu…
Le fonti del diritto privato
2021
A reconstruction of the system of sources of private law through the examination of the relationships between internal sources and supranational sources
A multi-proxy long-term ecological investigation into the development of a late Holocene calcareous spring-fed fen ecosystem (Raganu Mire) and boreal…
2021
Abstract The calcareous substrate of spring-fed fens makes them unique islands of biodiversity, hosting endangered, vulnerable, and protected vascular plants. Hence, spring-fed fens ecosystems require special conservation attention because many of them are destroyed (e.g. drained, forested) and it is extremely difficult or even impossible to restore the unique hydrogeological and geochemical conditions enabling their function. The long-term perspective of paleoecological studies allows indication of former wetland ecosystem states and provides understanding of their development over millennia. To examine the late Holocene dynamics of a calcareous spring-fed fen (Raganu Mire) ecosystem on th…
Air Quality during New Year’s Eve: A Biomonitoring Study with Moss
2021
Mosses are one of the best bioindicators in the assessment of atmospheric aerosol pollution by heavy metals. Studies using mosses allow both short- and long-term air quality monitoring. The increasing contamination of the environment (including air) is causing a search for new, cheap and effective methods of monitoring its condition. Once such method is the use of mosses in active biomonitoring. The aim of the study was to assess the atmospheric aerosol pollution with selected heavy metals (Ni, Cu, Zn, Cd, Hg and Pb) from the smoke of fireworks used during New Year’s Eve in the years 2019/2020 and 2020/2021. In studies a biomonitoring moss-bag method with moss Pleurozium schreberi (Willd. e…
Global, regional, and national burden of mortality associated with non-optimal ambient temperatures from 2000 to 2019: a three-stage modelling study
2021
Background: Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient temperatures. Methods: In this modelling study, we collected time-series data on mortality and ambient temperatures from 750 locations in 43 countries and five meta-predictors at a grid size of 0·5° × 0·5° across the globe. A three-stage analysis strategy was used. First, the temperature–mortality association was fitted for each location by use of a time-series regression. Second, a multivariate meta-regression model was built between location-specific estimates and meta-predictors. Finally, the gri…
Which method? Right of levy, the réserve héréditaire and protection of heirs against discrimination
2021
International audience
Practicing Ballot Secrecy: Postal Voting and the Witness Requirement at the 2019 Finnish Elections
2021
Electoral rights belong to the core of citizenship in democratic nation-states. Voting, then, represents an actualization of the relationship between the citizen and the political community. For citizens living outside the country in which they are eligible to vote, voting signifies a rare institutional connection to the country of origin. The aim of this article is to explore the introduction of the postal vote, a new form of voting for external voters at Finnish elections, from the grassroots perspective. The study focuses on how a central policy concern, safeguarding ballot secrecy, was resolved in the policy implementation by the witness requirement, and how the individual voters subseq…
Cofilin and Neurodegeneration: New Functions for an Old but Gold Protein
2021
Cofilin is an actin-binding protein that plays a major role in the regulation of actin dynamics, an essential cellular process. This protein has emerged as a crucial molecule for functions of the nervous system including motility and guidance of the neuronal growth cone, dendritic spine organization, axonal branching, and synaptic signalling. Recently, other important functions in cell biology such as apoptosis or the control of mitochondrial function have been attributed to cofilin. Moreover, novel mechanisms of cofilin function regulation have also been described. The activity of cofilin is controlled by complex regulatory mechanisms, with phosphorylation being the most important, since t…
Modeling particle acceleration and non-thermal emission in supernova remnants
2021
According to the most popular model for the origin of cosmic rays (CRs), supernova remnants (SNRs) are the site where CRs are accelerated. Observations across the electromagnetic spectrum support this picture through the detection of non-thermal emission that is compatible with being synchrotron or inverse Compton radiation from high energy electrons, or pion decay due to proton-proton interactions. These observations of growing quantity and quality promise to unveil many aspects of CRs acceleration and require more and more accurate tools for their interpretation. Here, we show how multi-dimensional MHD models of SNRs, including the effects on shock dynamics due to back-reaction of acceler…
Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions
2021
Simple Summary Glioblastoma multiforme is a futile disease usually leading to the patient’s death within one year post-diagnosis; therefore, novel treatment options are desperately needed. In this regard, activation of the inert immune system has moved into focus in recent years. Malignant brain tumors, as well as autoimmune diseases, elicit aberrant immune responses. In this way, glioma escapes the host’s immune system and, thus, activation of the immune response in order to reduce tumor tolerance can serve as an alternative treatment option. Immune checkpoint modulators in combination with traditional therapies have gained attention in both glioma and autoimmune diseases. In this review, …
Sex differences in the management of patients with acute coronary syndrome: A population-based ecological cross-sectional study in Spain
2021
Abstract Introduction and objectives Despite evidence of a reduction in the incidence and mortality of acute coronary syndrome (ACS), some studies have highlighted differences in outcomes between men and women. We aimed to explore sex differences in the management and treatment of patients with ACS in Spain. Methods This ecological cross-sectional study combined ACS data from 10 Spanish registries (54 centres). Meta-regression analysis was performed using aggregated data of baseline characteristics, interventional procedures, treatments, and events that occurred during hospitalization and one-year follow-up. Results Aggregated data from 34 605 patients (75.1% men) was included. ST-segment e…
Generalized Dehn twists in low-dimensional topology
2021
The generalized Dehn twist along a closed curve in an oriented surface is an algebraic construction which involves intersections of loops in the surface. It is defined as an automorphism of the Malcev completion of the fundamental group of the surface. As the name suggests, for the case where the curve has no self-intersection, it is induced from the usual Dehn twist along the curve. In this expository article, after explaining their definition, we review several results about generalized Dehn twists such as their realizability as diffeomorphisms of the surface, their diagrammatic description in terms of decorated trees and the Hopf-algebraic framework underlying their construction. Going t…
Source strength determination in iridium-192 and cobalt-60 brachytherapy : A European survey on the level of agreement between clinical measurements …
2021
Background and purpose: Brachytherapy treatment outcomes depend on the accuracy of the delivered dose distribution, which is proportional to the reference air-kerma rate (RAKR). Current societal recommendations require the medical physicist to compare the measured RAKR values to the manufacturer source calibration certificate. The purpose of this work was to report agreement observed in current clinical practice in the European Union. Materials and methods: A European survey was performed for high- and pulsed-dose-rate (HDR and PDR) highenergy sources (Ir-192 and Co-60), to quantify observed RAKR differences. Medical physicists at eighteen hospitals from eight European countries were contac…
Effectiveness and safety of a new helmet CPAP configuration allowing tidal volume monitoring in patients with COVID-19.
2021
Abstract Background High generated tidal volumes (Vt) have been correlated with higher risk of self-induced lung injury and worse clinical outcome. This study aimed to evaluate the effectiveness and safety of a new helmet continuous positive airway pressure delivered (h-CPAP) configuration allowing Vt monitoring in patients affected by COVID-19. Methods This prospective observational study was performed in the respiratory intermediate care unit of University Hospital in Turin, Italy, between March 24th, and June 15th, 2020. Included patients were treated with CPAP via a single-limb intentional leak configuration by a turbine-driven ventilator, provided with a dedicated patch. Effectiveness …
A branch-and-price framework for decomposing graphs into relaxed cliques
2021
We study the family of problems of partitioning and covering a graph into/with a minimum number of relaxed cliques. Relaxed cliques are subsets of vertices of a graph for which a clique-defining property—for example, the degree of the vertices, the distance between the vertices, the density of the edges, or the connectivity between the vertices—is relaxed. These graph partitioning and covering problems have important applications in many areas such as social network analysis, biology, and disease-spread prevention. We propose a unified framework based on branch-and-price techniques to compute optimal decompositions. For this purpose, new, effective pricing algorithms are developed, and new…
Lymphocytes as a Biomarker of Frailty Syndrome: A Scoping Review
2021
Frailty is a geriatric syndrome characterized by a decrease in physiological reserve and reduced resistance to stress, as a result of an accumulation of multiple deficits in physiological systems. Frailty increases the vulnerability to adverse events and is associated with the aging process. Several studies show an association between frailty syndrome and altered blood lymphocyte levels, which is therefore potentially useful for monitoring interventions to improve or delay frailty. The main objective of this review is to provide an analysis of the current evidence related to changes in lymphocyte counts and their associations with frailty syndrome. To that end, the literature published in t…
A Convolutional Neural Network based Cascade Reconstruction for the IceCube Neutrino Observatory
2021
Continued improvements on existing reconstruction methods are vital to the success of high-energy physics experiments, such as the IceCube Neutrino Observatory. In IceCube, further challenges arise as the detector is situated at the geographic South Pole where computational resources are limited. However, to perform real-time analyses and to issue alerts to telescopes around the world, powerful and fast reconstruction methods are desired. Deep neural networks can be extremely powerful, and their usage is computationally inexpensive once the networks are trained. These characteristics make a deep learning-based approach an excellent candidate for the application in IceCube. A reconstruction …
FLEXIBLE ELECTRODE BASED ON GOLD NANOPARTICLES AND REDUCED GRAPHENE OXIDE FOR URIC ACID DETECTION USING LINEAR SWEEP VOLTAMMETRY
2021
In this work, an electrochemical sensor for uric acid determination is shown with a preliminary study for its validation in real samples (milk and urine). Uric acid can be electrochemically oxidized in aqueous solutions and thus it is possible to obtain electrochemical sensors for this chemical by means of this electrooxidation reaction. Indium tin oxide coated on flexible polyethylene terephthalate substrate, modified with reduced graphene oxide and gold nanoparticles by co-electrodeposition, was used. Electrodeposition was performed at -0.8V vs SCE for 200 s. All samples were characterized by electron scan microscopy and electron diffraction spectroscopy. A careful investigation on the ef…
Integrazione tra ricerca e didattica per qualificare i contesti di apprendimento-insegnamento
2021
Il panel ha registrato la presentazione di sedici studi o ricerche che hanno affrontato direttamente o indirettamente alcuni aspetti significativi della intelligenza, della comprensione e della partecipazione nei contesti di apprendimento-insegnamento (Lucisano & De Luca, 2015). Uno dei contesti ricorrenti nelle indagini è quello universitario, che è esaminato con riferimento particolare: alla introduzione nella didattica di dispositivi (pod- cast - Tore, Tino e Fedeli, Università di Padova); alla sperimenta- zione di modelli innovativi (IMPROVe Model - Miranda, Uni- versità di Salerno, Di Palma, Università di Napoli “Parthenope”) e predisposizione di interventi che possono qualifi…
The cumulative effect of multiple dimensions of lifestyle on risky drinking during the Covid-19 pandemic
2021
Lifestyle impacts morbidity and mortality worldwide. Herein, we evaluated the association of a multidimensional lifestyle measure and its domains (diet/nutrition, substance use, physical activity, social, stress management, sleep, environmental exposure) with risky drinking. Also, we analyzed the cumulative effect of unhealthy domains in the likelihood of presenting risky drinking. To reach these objectives, data from a web survey conducted in Brazil and Spain was analyzed. The main outcome was risky drinking assessed by the AUDIT-C. Lifestyle was measured using the Short Multidimensional Inventory Lifestyle Evaluation (SMILE). Fixed logistic models were used to evaluate associations betwee…
Self-reported sickness absence and presenteeism as predictors of future disability pension: Cohort study with 11-year register follow-up
2021
Many healthcare workers in eldercare are pushed out of the labor market before the official retirement age due to poor health. Identification of early warnings signs is important to avoid complete loss of work ability. The aim of this study was to investigate to what degree sickness absence and presenteeism increase future risk for disability pension among eldercare workers. A total of 8952 Danish female eldercare workers responded to a survey about work environment and health. They were followed for 11 years in the Danish Register for Evaluation of Marginalization, with time-to-event analyses estimating the hazard ratios (HRs) for disability pension from sickness absence and presenteeism a…
Assessment of Human Exposure to Deoxynivalenol, Ochratoxin A, Zearalenone and Their Metabolites Biomarker in Urine Samples Using LC-ESI-qTOF.
2021
Human are exposed to a wide range of mycotoxins through dietary food intake, including processed food. Even most of the mycotoxin exposure assessment studies are based on analysis of foodstuffs, and evaluation of dietary intake through food consumption patterns and human biomonitoring methods are rising as a reliable alternative to approach the individual exposures, overcoming the limitations of the indirect dietary assessment. In this study, human urine samples were analyzed, seeking the presence of deoxynivalenol (DON), ochratoxin A (OTA), zearalenone (ZEA), and their metabolites. For this purpose, 40 urine samples from female and male adult residents in the city of Valencia (Spain) were …
EPILOGO. RIGENERAZIONE STRATEGICA SOSTENIBILE: RIVOLUZIONE VERDE E PROGETTAZIONE SALUTOGENICA
2021
Questa silloge è un’occasione di confronto culturale e scientifico tra studiosi ed esperti volta ad innescare nuove riflessioni sulle strategie per il riequilibrio ambientale nell’ambito della riqualificazione edilizia e della rigenerazione urbana. Le tematiche di ricerca presenti in antologia, si riassumono nei seguenti focus di indagine: - rigenerazione urbana - riconversione di immobili dismessi e/o contrassegnati da manomissioni illecite (metodologie e sistemi innovativi per l’intervento sul costruito, gestione e costruzione del consenso, governance ambientale, pianificazione strategica, knowledge management di rete, capacity building); - progettazione partecipata - evoluzione dei conce…
Evaluation of the coupled high-resolution atmospheric chemistry model system MECO(n) using in situ and MAX-DOAS NO2 measurements
2021
We present high spatial resolution (up to 2.2×2.2 km2) simulations focussed over south-west Germany using the online coupled regional atmospheric chemistry model system MECO(n) (MESSy-fied ECHAM and COSMO models nested n times). Numerical simulation of nitrogen dioxide (NO2) surface volume mixing ratios (VMRs) are compared to in situ measurements from a network with 193 locations including background, traffic-adjacent and industrial stations to investigate the model's performance in simulating the spatial and temporal variability of short-lived chemical species. We show that the use of a high-resolution and up-to-date emission inventory is crucial for reproducing the spatial variability and…
De súplica a pseudo-debate: Helena 894 ss.
2021
En Helena la pareja Helena y Menelao deben suplicar a Teónoe que no informe a su hermano Teoclímeno de la presencia de Menelao en Egipto, pero Menelao se niega a hacerlo y adopta una actitud diferente. Este rito de súplica truncado se transforma en un supuesto debate, que tampoco lo es.
[Atrial fibrillation in patients with COVID-19. Usefulness of the CHA
2021
Resumen Introduccion y objetivos La enfermedad por coronavirus de 2019 (COVID-19) esta causada por el segundo coronavirus del sindrome respiratorio agudo y grave. La fibrilacion auricular (FA) es comun en situaciones agudas, en las que conlleva mas complicaciones y mortalidad. Metodos Analisis del Registro internacional HOPE (NCT04334291); el objetivo es evaluar la informacion pronostica de FA en pacientes con COVID-19. Se realizo un analisis multivariable y un emparejamiento por puntuacion de propension para evaluar la relacion entre FA y mortalidad. Ademas, se evaluo en estos pacientes el impacto en la mortalidad y los eventos embolicos de la puntuacion CHA2DS2-VASc. Resultados Entre los …
“Pédaler en toute sécurité”: The Cycling Behavior Questionnaire (CBQ) in Belgium – A validation study
2021
Abstract Introduction: During the last few years, the use of behavioral questionnaires for assessing risky behaviors of road users different from motor-vehicle drivers has grown considerably in applied research for road safety. In this regard, recent tools such as the Cycling Behavior Questionnaire (CBQ) are gaining ground, being adapted and tested in further languages, thus getting useful to address the case of countries whose language is different to the English and Spanish. Therefore, and in order to extend the use of the CBQ, this study aimed (i) to develop the validation of the CBQ to the French and Dutch languages, in order to cover the population of Belgian cyclists and (potentially)…
Investigating the Relationship Between Community-aware and Classical Centrality Measures
2021
International audience
Anatomie du syndicalisme
2021
Railway workers' movements, demonstrations against the reform of the Labour Code, strikes against the new pension system... Collective action by employees regularly polarises social news in France. However, it is not limited to these media phenomena and the disruption of daily life that they cause. It primarily concerns everyday life at work, the participation of employees in the management of companies and administrations and, more broadly, in that of the social protection system. Trade unions have a key role to play in this collective action. This book analyses the evolution of these organisations as vectors of collective action: their successes and failures, their relations with employee…
false
2021
BackgroundMultiple synergistic combination approaches with cancer drugs are developed to overcome primary resistance to immunotherapy; however, the mechanistic rationale to combine chemoradiotherapy (CRT) with immune checkpoint inhibitors remains elusive.MethodsThis study described the immunological landscape of tumor microenvironment (TME) exposed to CRT. Tumor samples from patients with rectal cancer (n=43) treated with neoadjuvant CRT or radiotherapy were analyzed by nanostring and immunohistochemistry. Studies in mice were performed using three syngeneic tumors (TC1, CT26 and MC38). Tumor-bearing mice were treated either with platinum-based CRT, radiotherapy or chemotherapy. Anti-CTLA-4…
Uomini e alberi. Tre indagini storico-religiose. Nota introduttiva
2021
In this introductory note I present three essays on the relationship between trees and rituals in ancient Mediterranean civilisations and in Vedic India.
Virtual reality and 3D printing improve preoperative visualization of 3D liver reconstructions-results from a preclinical comparison of presentation …
2021
BACKGROUND: Preoperative three-dimensional (3D) reconstructions for liver surgery planning have been shown to be effective in reduction of blood loss and operation time. However, the role of the ‘presentation modality’ is not well investigated. We present the first study to compare 3D PDFs, 3D printed models (PR) and virtual reality (VR) 3D models with regard to anatomical orientation and personal preferences in a high volume liver surgery center. METHODS: Thirty participants, 10 medical students, 10 residents, 5 fellows and 5 hepatopancreatobiliary (HPB) experts, assigned the tumor-bearing segments of 20 different patient’s individual liver reconstructions. Liver models were presented in a…
Advantages of Hyaluronic Acid and Its Combination with Other Bioactive Ingredients in Cosmeceuticals
2021
This study proposes a review on hyaluronic acid (HA) known as hyaluronan or hyaluronate and its derivates and their application in cosmetic formulations. HA is a glycosaminoglycan constituted from two disaccharides (N-acetylglucosamine and D-glucuronic acid), isolated initially from the vitreous humour of the eye, and subsequently discovered in different tissues or fluids (especially in the articular cartilage and the synovial fluid). It is ubiquitous in vertebrates, including humans, and it is involved in diverse biological processes, such as cell differentiation, embryological development, inflammation, wound healing, etc. HA has many qualities that recommend it over other substances used…
Benchmarking plant diversity of Palaearctic grasslands and other open habitats
2021
© 2021 The Authors.
Online interventions to prevent mental health problems implemented in school settings: the perspectives from key stakeholders in Austria and Spain
2021
Abstract Background Schools are key settings for delivering mental illness prevention in adolescents. Data on stakeholders’ attitudes and factors relevant for the implementation of Internet-based prevention programmes are scarce. Methods Stakeholders in the school setting from Austria and Spain were consulted. Potential facilitators (e.g. teachers and school psychologists) completed an online questionnaire (N=50), policy makers (e.g. representatives of the ministry of education and health professional associations) participated in semi-structured interviews (N=9) and pupils (N=29, 14–19 years) participated in focus groups. Thematic analysis was used to identify experiences with, attitudes a…