Search results for "APR"
showing 10 items of 2648 documents
Aprites ekonomika sabiedriskajā ēdināšanā kā pelnītspēju veicinošais faktors.
2022
Lai nodrošinātu sabiedriskās ēdināšanas uzņēmumu ilgtspējīgu izaugsmi, resursu izmantošanai jākļūst gudrākai un ilgtspējīgākai. Ir skaidrs, ka agrākais ekonomikas izaugsmes lineārais modelis vairs neder mūsdienu globalizētās pasaules sabiedrības vajadzībām. Nav iespējams izveidot nākotni, ņemot par pamatu modeli „paņemt, uztaisīt, izmest”. Daudzi dabas resursi ir ierobežoti, un ir jāatrod veids, kā tos izmantot no vides un ekonomikas viedokļa ilgtspējīgi. Izmantot esošos resursus labākajā iespējamajā veidā ir arī uzņēmumu ekonomiskajās interesēs. Maģistra darba mērķis ir izpētīt aprites ekonomikas lomu sabiedriskās ēdināšanas uzņēmumos, sabiedrības informētības līmeni, paradumus un viedokli…
The Fatty Liver Assessment in Germany (FLAG) cohort study identifies large heterogeneity in NAFLD care
2020
Background & Aims NAFLD is a growing health concern. The aim of the Fatty Liver Assessment in Germany (FLAG) study was to assess disease burden and provide data on the standard of care from secondary care. Methods The FLAG study is an observational real-world study in patients with NAFLD enrolled at 13 centres across Germany. Severity of disease was assessed by non-invasive surrogate scores and data recorded at baseline and 12 months. Results In this study, 507 patients (mean age 53 years; 47% women) were enrolled. According to fibrosis-4 index, 64%, 26%, and 10% of the patients had no significant fibrosis, indeterminate stage, and advanced fibrosis, respectively. Patients with advanced fib…
Malnutrīcijas riska noteikšana pacientiem pēc insulta internajā aprūpē
2017
Bakalaura darba tēma - Malnutrīcijas riska noteikšana pacientiem pēc insulta internajā aprūpē. Tēmas aktualitāti nosaka tas, ka pietiekams uzturs ir nepieciešams, lai vecinātu pacienta atveseļošanos pēc insulta. Malnutrīcija apgrūtina šādu pacientu ārstēšanu, samazinot pacientu imunitātes spēju pretoties infekcijām, palēninot brūču dzīšanu un palielinot komplikāciju risku, kas, savukārt, pagarina pacientu stacionēšanas laiku un palielina šo pacientu letalitāti. Pētījuma mērķis: Analizēt malnutrīciju un noteikt malnutrīcijas risku pacientiem pēc insulta. Pētniecības uzdevumi ir veikt literatūras analīzi par malnutrīciju un insulta pacientu aprūpes īpatnībām, kas saistītas ar uztura uzņemšanu…
Mechanism of nanocapsules formation by the emulsion-diffusion process.
2007
International audience; A detailed investigation into the mechanisms of nanocapsule formation by means of the two stages “emulsion–diffusion” process is reported. Such widely used process is still poorly understood. An emulsion of oil, polymer and ethyl acetate is fabricated as a first step; dilution with pure water allows ethyl acetate to diffuse out from the droplets, leaving a suspension of nanocapsules at the end. It has been shown that the size of nanocapsules was related to the chemical composition of the organic phase and the size of primary emulsion through a simple geometrical relationship. As a consequence, most of the properties of the nanocapsules were decided at the emulsificat…
Production of polymeric micro- and nanostructures with tunable properties as pharmaceutical delivery systems
2020
Abstract The production of novel graft copolymers based on poly-e-caprolactone (PCL) and polyaspartamide are useful to realize structures for potential biomedical applications. Here, the synthesis of pegylated PCL/polyhydroxyethyl aspartamide (PHEA) graft copolymers (PHEA-g-SUCC-PCL-g-PEG) with tunable composition, was achieved by followpling a synthetic strategy that involved first the grafting of preformed PCL on PHEA backbone, then polyethylen glycol (PEG), by using 1,1′-carbonyldiimidazole (CDI) to speed up the condensation reaction. Graft copolymers with a Derivatization Degree (DD) in PCL ranging between 1.1 and 4.4 mol% were obtained, and processable with different technologies for t…
Drug delivery devices based on mesoporous silicate.
2004
A mesoporous material based on aluminosilicate mixture was studied to investigate its ability to include drugs and then release them. Nonsteroidal anti-inflammatory agents such as diflunisal, naproxen, ibuprofen and its sodium salt have been used in this study. The preparation of the mesoporous material and its characterization by X-ray, N2 absorption-desorption isotherm, and thermogravimetry analysis have been described. Drug loading was performed by a soaking procedure. Drug-loaded matrices were characterized for entrapped drug amount, water absorption ability, and thermogravimetric behavior. Drug release studies also were performed at pH 1.1 and 6.8 mimicking gastrointestinal fluids. Exp…
Oxidative decarboxylation of naproxen.
1992
The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8(2-)] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pi-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen.
Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout.
2011
An urgent need exists to assess the exposure of fish to pharmaceuticals. The aim of the present study was to assess the uptake and metabolism of waterborne pharmaceuticals in rainbow trout (Oncorhynchus mykiss). A further objective was to determine the possibility of monitoring exposure to low levels of pharmaceuticals by bile assays. Rainbow trout were exposed for 10 d under flow-through conditions to mixtures of five pharmaceuticals (diclofenac, naproxen, ibuprofen, bisoprolol, and carbamazepine) at high and low concentrations. The low concentration was used to mimic the conditions prevailing in the vicinity of the discharge points of wastewater treatment plants. The uptake and the biocon…
Preparation and recrystallization behavior of spray-dried co-amorphous naproxen–indomethacin
2016
To improve the dissolution properties and the physical stability of amorphous active pharmaceutical ingredients, small molecule stabilizing agents may be added to prepare co-amorphous systems. The objective of the study was to investigate if spray-drying allows the preparation of co-amorphous drug-drug systems such as naproxen-indomethacin and to examine the influence of the process conditions on the resulting initial sample crystallinity and the recrystallization behavior of the drug(s). For this purpose, the process parameters inlet temperature and pump feed rate were varied according to a 2(2) factorial design and the obtained samples were analyzed with X-ray powder diffractometry and Fo…
Análisis de la interacciones parásito-hospedador en el modelo Echinostoma caproni-roedor, con énfasis en los factores que determinan el curso de la i…
2015
En la presente Tesis Doctoral se analizan diferentes parámetros implicados en las relaciones parásito-hospedador en helmintiasis intestinales mediante la utilización del modelo experimental Echinostoma caproni-roedor. Con esta finalidad se estudian diversos aspectos inmunológicos, además de las alteraciones intestinales inducidas por la infección en dos sistemas parásito-hospedador: E. caproni-ratón y E. caproni-rata. Los resultados obtenidos ponen de manifiesto que el IFN-γ y el óxido nítrico son mediadores fundamentales en el desarrollo de infecciones crónicas en ratón, induciendo disfunción mitocondrial en las células del epitelio intestinal e hiperplasia tisular. No obstante, se sugiere…