Search results for "Ash"

Phase Ib Trial Trial of Rg7116, a Glycoengineered Monoclonal Antibody Targeting Her3, in Combination with Cetuximab or Erlotinib in Patients with Adv…

2014

ABSTRACT Aim: To evaluate the safety profile of RG7116 in combination with cetuximab or erlotinib. Methods: Patients (pts) with advanced or metastatic carcinomas with centrally confirmed HER3 protein expression were included. RG7116 plus cetuximab (400 mg/m2 followed by 250 mg/m2 qw IV) and RG7116 plus erlotinib (150 mg/day p.o.) combinations were evaluated in a dose escalation study with “3 + 3” design at a starting dose of 400 mg IV of RG7116 in a q2w regimen. Results: Twenty-seven pts were enrolled in 5 cohorts (400 to 2000 mg) in the cetuximab arm. One dose-limiting toxicity (DLT) of grade 3 dehydration was reported in the 800-mg cohort. Twenty-seven pts were enrolled in 4 cohorts (400 …

Cash-for-childcare. The consequences for caring mothers

2012

Diversity and Evolution of the Phenazine Biosynthesis Pathway

2010

ABSTRACT Phenazines are versatile secondary metabolites of bacterial origin that function in biological control of plant pathogens and contribute to the ecological fitness and pathogenicity of the producing strains. In this study, we employed a collection of 94 strains having various geographic, environmental, and clinical origins to study the distribution and evolution of phenazine genes in members of the genera Pseudomonas , Burkholderia , Pectobacterium , Brevibacterium , and Streptomyces . Our results confirmed the diversity of phenazine producers and revealed that most of them appear to be soil-dwelling and/or plant-associated species. Genome analyses and comparisons of phylogenies inf…

Liver-related and extrahepatic events in patients with non-alcoholic fatty liver disease: a retrospective competing risks analysis.

2022

Background & Aim: Non-alcoholic fatty liver disease (NAFLD), and especially fibrotic non-alcoholic steatohepatitis, is associated with high risks of liver-related events (LRE) and extrahepatic events (EHE). We evaluated the competitive risk occurrence of LRE and EHE in a large cohort of biopsy-proven NAFLD stratified according to baseline severity of fibrosis. Methods: Two thousand one hundred thirty-five patients with biopsy-proven NAFLD were enrolled. Observed cumulative incidence functions (CIFs) were used to evaluate the risk of LRE and EHE; cause-specific Cox model and predicted CIFs were fitted to identify predictors of LRE and EHE. A replication cohort of NAFLD patients with live…

Adult-onset Still's disease: an Italian multicentre retrospective observational study of manifestations and treatments in 245 patients

2016

Adult-onset Still’s disease (AOSD) is a systemic inflammatory condition of unknown aetiology characterized by typical episodes of spiking fever, evanescent rash, arthralgia, leukocytosis and hyperferritinemia. Given the lack of data in Italian series, we promote a multicentric data collection to characterize the clinical phenotype of Italian patients with AOSD. Data from 245 subjects diagnosed with AOSD were collected by 15 centres between March and May 2013. The diagnosis was made following Yamaguchi’s criteria. Data regarding clinical manifestations, laboratory features, disease course and treatments were reported and compared with those presented in other published series of different et…

Consensus in inventory games

2008

This paper studies design, convergence, stability and optimality of a distributed consensus protocol for n-player repeated non cooperative games under incomplete information. Information available to each player concerning the other players' strategies evolves in time. At each stage (time period), the players select myopically their best binary strategy on the basis of a payoff, defined on a single stage, monotonically decreasing with the number of active players. The game is specialized to an inventory application, where fixed costs are shared among all retailers, interested in reordering or not from a common warehouse. As information evolves in time, the number of active players changes t…

Spatial beam self-cleaning in multimode fibres

2017

Multimode optical fibres are enjoying a renewed attention, boosted by the urgent need to overcome the current capacity crunch of single-mode fibre systems and by recent advances in multimode complex nonlinear optics [1-13]. In this work, we demonstrate that standard multimode fibres can be used as ultrafast all-optical tool for transverse beam manipulation of high power laser pulses. Our experimental data show that the Kerr effect in a graded-index multimode fibre is the driving mechanism for overcoming speckle distortions, leading to a somewhat counter-intuitive effect resulting in a spatially clean output beam robust against fibre bending. Our observations demonstrate that nonlinear beam …

Ground-state fidelity and bipartite entanglement in the Bose-Hubbard model.

2007

We analyze the quantum phase transition in the Bose-Hubbard model borrowing two tools from quantum-information theory, i.e. the ground-state fidelity and entanglement measures. We consider systems at unitary filling comprising up to 50 sites and show for the first time that a finite-size scaling analysis of these quantities provides excellent estimates for the quantum critical point.We conclude that fidelity is particularly suited for revealing a quantum phase transition and pinning down the critical point thereof, while the success of entanglement measures depends on the mechanisms governing the transition.

Metaforas modes emuāros

2017

Lai gan metaforas pētījumi ir piesaistījuši daudzu zinātnieku uzmanību, metaforu lietojums modes emuāros nav daudz pētīts. Emuārs kā žanrs parādījās 2000.gadu sākumā un kopš tā laika ir izveidojušies dažādi emuāra veidi. Empīriskie dati ir ekscerpēti no modes emuāra The Blonde Salad. Pētījums ir izstrādāts, lai atbildētu uz pētījuma jautājumu - kāda metaforu funkcija dominē emuārā The Blonde Salad. Pētījuma mērķis ir noteikt avota domēnus, kas metaforiski raksturo modi izvēlētajā modes emuārā. Teorētiskā pētījuma daļa ir balstīta uz teorijām par metaforām, to funkcijām un iedalījumu tādu zinātnieku kā Lakofs, Džonsons, Gibs, Knovles, Mūns un Kovecses skatījumā. Empīŗiskais pētījums ir veikt…

Periodontal disease associated to systemic genetic disorders

2007

A number of systemic disorders increase patient susceptibility to periodontal disease, which moreover evolves more rapidly and more aggressively. The underlying factors are mainly related to alterations in immune, endocrine and connective tissue status. These alterations are associated with different pathologies and syndromes that generate periodontal disease either as a primary manifestation or by aggravating a pre-existing condition attributable to local factors. This is where the role of bacterial plaque is subject to debate. In the presence of qualitative or quantitative cellular immune alterations, periodontal disease may manifest early on a severe localized or generalized basis - in s…