Search results for "BASAL"
showing 10 items of 920 documents
Polypeptide Markers Differentiating Juvenile and Adult Tissues in Chestnut
1993
Differences were observed between the polypeptide contents of in vitro shoot cultures derived from upper branches (adult material) and basal shoots (juvenile material) of the same chestnut tree. Cultures derived from mature crown growth yielded two polypeptide bands that were not afforded by cultures derived from juvenile basal shoots. Since all cultures were derived from the same tree the polypeptide differences appear to reflect the ontogenetic age of the starting material.
Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation
2007
Abstract During murine development, the formation of tight junctions and acquisition of polarity are associated with allocation of the blastomeres on the outer surface of the embryo to the trophoblast lineage, whereas the absence of polarization directs cells to the inner cell mass. Here, we report the results of ultrastructural analyses that suggest a similar link between polarization and cell fate in human embryos. In contrast, the five human embryonic stem cell (hESC) lines displayed apical-basal, epithelial-type polarity with electron-dense tight junctions, apical microvilli, and asymmetric distribution of organelles. Consistent with these findings, molecules that are components of tigh…
The pia mater at the site of the entry of blood vessels into the central nervous system
1982
The entry of blood vessels into the central nervous system (CNS) has been studied at the surface of the brain stem and the spinal cord of two cats and two rabbits. The study was carried out by scanning electron microscopy (SEM). The results obtained by SEM concerning the layers of the pia mater corresponded to those obtained by other authors who used transmission electron microscopy. Between the basal lamina of the superficial glial membrane of the CNS and the cells lining the subarachnoid space, a pial connective tissue space could be clearly recognized. The blood vessles crossing the subarachnoid space were also covered by leptomeningeal lining cells. At the site of entry of these blood v…
Retarded Elimination of a High-Molecular Enzyme-Substrate-Complex after Hydroxyethyl-Starch-Infusion
1978
During a pharmacokinetic study with hydroxyethyl starch we found, that this plasma substitute induces a regular increase of serum amylase. In 54 patients after infusion of 500 ml 6% hydroxyethyl starch (HES) an increase of serum amylase was observed, which in 51 cases exceeded the upper limit of normal (190 U/l). In most cases serum amylase reached values twice as high as the basal value. Renal function influenced duration of increased serum amylase values, but did not influence maximum increases (201 ±15 U/l; mean ± SEM). In patients with advanced renal failure (GFR = 2–10 ml/min) serum amylase was still markedly elevated after 72 hours (298 ± U/l; mean ± SEM). In patients with normal rena…
Ultrastructural Pathology of Anaplastic and Grade II Ependymomas reveals Distinctive Ciliary Structures - Electron Microscopy Redux
2015
Ependymoma tumors likely derive from the ependymal cells lining the CNS ventricular system. In grade II ependymomas, tumor cells resemble typical ependymocytes, while anaplastic ependymomas are poorly differentiated. We studied three grade II and one anaplastic ependymoma, focusing on the ciliary structures. To unambiguously characterize the ultrastructure and number of cilia, we performed electron microscopy serial section analysis of individual cells. Differentiated ependymomas contained large basal bodies and up to three cilia, and lacked centrioles. Anaplastic ependymoma cells showed instead two perpendicularly oriented centrioles and lacked cilia or basal bodies. These findings could c…
Scalp, basal epidural and intravascular far-field recordings after median nerve stimulation: evidence for a separate N18a potential
2000
Far-field somatosensory evoked potentials (SSEPs) after median nerve stimulation were recorded from scalp- (Fz), epidural- (ED) and intravascular electrodes (basilar artery [Bas]) to study the nature of the controversial N18a component of the widespread N18 potential. In healthy volunteers frequently an N18a potential was recorded at Fz. Simultaneous Fz and ED recordings at the pontomesencephalic junction as well as Bas-recordings at the caudal basilar artery showed N18a components identical in latency and shape. With intravascular recordings the shapes differed between the top of the basilar artery and the caudal artery recordings. These findings support the existence of a separate N18a po…
A feature of caudate control of focal hippocampal epilepsy: evidence for an anterograde pathway
1991
Previous experimental evidences showed that the caudate nucleus has a modulatory effect on hippocampal epilepsy. The caudate's regulating action might reach the hippocampus either via the septal region or, retrogradely, via the accumbens nucleus. In order to obtain new data about the pathway involved in caudate hippocampal influence the spreading of abnormal activity towards the nucleus accumbens was studied. Furthermore the effects of caudate stimulation in animals with electrolytic lesions of the nucleus accumbens were analyzed. It was observed that abnormal penicillin-induced activity spreaded from the hippocampus to the nucleus accumbens in about 30 minutes. In animals with and without …
Comparative Analysis of Cell Proliferation Ratio in Oral Lichen Planus, Epithelial Dysplasia and Oral Squamous Cell Carcinoma
2009
Made available in DSpace on 2013-08-12T18:47:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-11-01 Made available in DSpace on 2013-09-30T18:34:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-11-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:04:33Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T14:04:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-11-01 Background: Although oral lichen planus has been classified by the World Health Organization (WHO) as a potentially malignant disorder, such classification is still the target of much controversy. Aim: To evaluate the cell proliferation rate in oral lic…
Old and new basal insulin formulations: understanding pharmacodynamics is still relevant in clinical practice.
2013
Long-acting insulin analogues have been developed to mimic the physiology of basal insulin secretion more closely than human insulin formulations (Neutral Protamine Hagedorn, NPH). However, the clinical evidence in favour of analogues is still controversial. Although their major benefit as compared with NPH is a reduction in the hypoglycaemia risk, some cost/effectiveness analyses have not been favourable to analogues, largely because of their higher price. Nevertheless, these new formulations have conquered the insulin market. Human insulin represents currently no more than 20% of market share. Despite (in fact because of) the widespread use of insulin analogues it remains critical to anal…
Inbreeding depression in the effects of body mass on energy use
2011
Large organisms have higher metabolic rates than small organisms but, if we compare their relative metabolic rates (i.e. per gram of tissue), this relationship is very often reversed. The pervasiveness of this phenomenon, called metabolic scaling, has attracted several theoretical explanations, and also produced lingering debate over whether metabolic scaling is a physically constrained and universally constant phenomenon or a more variable and evolutionarily malleable trait. To bring novel insights to this debate, we manipulated male Gryllodes sigillatus crickets’ coefficients of inbreeding to determine whether metabolic scaling is sensitive to the manipulation of genetic quality. Because …