Search results for "CAMEROON"
showing 10 items of 30 documents
Cytotoxicity of 18 Cameroonian medicinal plants against drug sensitive and multi-factorial drug resistant cancer cells
2018
Abstract Ethnopharmacological relevance Cameroonian medicinal plants are traditionally used to treat many ailments, including cancer and related diseases. Cancer is characterized as a condition with complex signs and symptoms. It has been recommended that ethnopharmacological usages such as immune and skin disorders, inflammatory, infectious, parasitic and viral diseases should be taken into account when selecting plants for anticancer screenings, since these reflect disease states bearing relevance to cancer or cancer-like symptoms. Aim of the study The present study aims at investigating 20 methanol extracts from 15 Cameroonian medicinal plants on a panel of human cancer cell lines, inclu…
Genetic Diversity of HIV-1 Non-B Strains in Sicily: Evidence of Intersubtype Recombinants by Sequence Analysis ofgag,pol, andenvGenes
2007
The molecular epidemiology of HIV-1 strains in Sicily (Italy) was phylogenetically investigated by the analysis of HIV-1 gag, pol, and env gene sequences from 11 HIV-1 non-B strains from 408 HIV-1-seropositive patients observed from September 2001 to August 2006. Sequences suggestive of recombination were further investigated by bootscanning analysis of various fragments. Overall, we identified several second-generation recombinant (SGRs) strains, which contained genetic material of CRF02_AG in at least one gene. Notably, three individuals were found to be infected with subsubtype A3, and one of them showed genetic recombination with subsubtype A4. The current study emphasizes the genetic a…
Clinical features and epidemiology of cutaneous leishmaniasis and Leishmania major/HIV co-infection in Cameroon: results of a large cross-sectional s…
2011
Cutaneous leishmaniasis (CL) is endemic in Central Africa, including Cameroon. However, data on its prevalence and co-infection with HIV are scarce. Here we present the results of a large cross-sectional study reporting the prevalence, clinical features and species identification of CL and HIV co-infection in northern Cameroon. A total of 32 466 subjects were clinically screened for CL during a door-to-door survey, followed by parasitological diagnosis in the field laboratory. Amongst the subjects surveyed, 146 (0.4%) were diagnosed with active CL. Seven (4.8%) of these 146 CL patients tested positive for HIV-1 and/or HIV-2. The number of lesions per CL patient ranged from 1 to 20. Three of…
Griffonianone D, an isoflavone with anti-inflammatory activity from the root bark of Millettia griffoniana.
2003
A new isoflavone, griffonianone D (1), and the previously known compounds durmillone and odorantin were isolated from a chloroform extract of the root bark of Millettia griffoniana. The structure of 1 was established as (7E)-(6",7"-dihydroxy-3",7"-dimethyloct-2"-enyl)oxy-4'-methoxyisoflavone on the basis of its spectral data. The chloroform extract of the root bark of M. griffoniana and compound 1 showed anti-inflammatory effects in different experimental models of inflammation.
Pharmacogenomics of Cameroonian traditional herbal medicine for cancer therapy
2011
Abstract Ethnopharmacological relevance A socio-economic burden associated with cancers is reported in Africa. Ethnopharmacological usages such as immune and skin disorders, inflammatory, and others chould be considered when selecting plants used to treat cancer, since these reflect disease states bearing relevance to cancer or a cancer symptoms. Materials and methods Documented compounds of Cameroonian medicinal plants were used as keywords in the National Cancer Institute (NCI) database to establish a library of cytotoxic compounds. Cellular and pharmacogenomic profiling was then performed for the 10 most cytotoxic natural products. By COMPARE and hierarchical cluster analyses, candidate …
Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells
2013
Abstract Ethnopharmacological relevance Beilschmiedia acuta Kosterm, Clausena anisata (Willd) Hook, Fagara tessmannii Engl., Newbouldia laevis Seem., and Polyscias fulva (Hiern) Harms. are medicinal plants used in Cameroonian traditional medicine in the treatment of various types of cancers. The present study aims at investigating 11 methanolic extracts from the above Cameroonian medicinal plants on a panel of human cancer cell lines, including various drug-resistant phenotypes. Possible modes of action were analyzed for two extracts from Beilschmiedia acuta and Polyscia fulva and alpha-hederin, the representative constituent of Polyscia fulva. Materials and methods Cytotoxicity was determi…
Steroidal saponins from the aerial parts of Cordyline fruticosa L. var. strawberries.
2019
A new sulfated steroidal derivative (fruticogenin A: 1-sulfo-australigenin-3-sodium sulphate, 1) and three new steroidal saponins named fruticoside K (3-sulfo-spirostan-25(27)-ene-1β,3β-diol-1-O-[α-L-rhamnopyranosyl-(1 → 4)-β-D-fucopyranoside], 2), fruticoside L (3-sulfo-spirostan-25(27)-ene-1β,3β,6α-triol-1-O-[α-L-rhamnopyranosyl-(1 → 4)-β-D-fucopyranoside], 3) and fruticoside M (spirostan-25(27)-ene-1β,3α-diol-1-O-[α-L-rhamnopyranosyl-(1 → 2)-α-L-rhamnopyranoside], 4) were isolated from the aerial parts of Cordyline fruticosa L. var. strawberries. Their structures were established on the basis of 1D and 2D NMR data, mass spectrometry and chemical methods. Compounds 2 and 4 exhibited weak …
Comparative study of the effectiveness of educational policies of inclusion in France and sub-Saharan Africa: a literature review
2013
Recommended by international bodies (UNESCO, 2006; 2008), inclusive education is based on the principle of equal opportunity. It aims to promote inclusion in the broad sense of the term by addressing specific audiences excluded or marginalized from educational systems. In recent years, regulatory frameworks have been defined for the education of certain categories excluded from educational systems including children with disabilities. Educational policies concerned with taking into account the needs of this group are also implemented. Do these policies promote effective integration of students with disabilities? To what extent can these policies be considered as effective? This paper presen…
Izglītības sistēmu modernizācija efektīvai mācīšanai un vielas apguvei Kamerūnas vispārejā vidējā izglītībā
2022
Vidusskolu modernizācija piedāvā inovatīvus instrumentus mācību un mācīšanās procesu pārstrukturēšanai, sagatavojot skolēnus 21. gadsimta prasmēm. Tomēr nav pietiekamu pētījumu par to, kā izglītības modernizācija iederas dažādās Kamerūnas vidusskolu kultūrās un kā skolotāji un skolu vadītāji vidusskolās ar atšķirīgu pedagoģisko kompetenci un mācību pieredzi spēj darboties dažādās tīkla mācību vidēs. Šajā maģistra darbā aplūkotas skolotāju un administratoru perspektīvas par to, kā modernizēt vidējo izglītību, pamatojoties uz Kamerūnas vidusskolās veikto pētījumu. Pētījums tika veikts, izmantojot jaukto metožu pieeju, sajaucot kvantitatīvos un kvalitatīvos datus, kombinējot atvērtā un slēgtā …
Jusqu'où peut-on comparer les apprentissages scolaires ?
2007
The pertinent review for the early knowledge learning in school and their links with quality matters is a complex issue, expressly in a comparative approach when crossing the variety on the range for economic development. But the increasingly frequent reference for a universal basic knowledge, in a connection with a claim concerning a global convergence, as a necessity in self determination for everyone to apply for a minimum level in literacy, raises the question whereby the comparative description of the factors of effectiveness of the school. In this note, the objective is only centred on the concerns for a comparison in measurement relating to results of a common school test led to pupi…