Search results for "Continuation"
showing 10 items of 276 documents
Dose adjustments and discontinuation in TNF inhibitors treated patients: when and how. A systematic review of literature.
2018
Objectives To review the available evidence concerning the possibility of discontinuing and/or tapering the dosage of TNF inhibitors (TNFi) in RA patients experiencing clinical remission or low disease activity. Methods A systematic review of the literature concerning the low dosage and discontinuation of TNFi in disease-controlled RA patients was performed by evaluation of reports published in indexed international journals (Medline via PubMed, EMBASE), in the time frame from 8 April 2013 to 15 January 2016. Results We analysed the literature evaluating the efficacy and the safety of two different strategies using TNFi, decreasing dosage or discontinuation, in patients experiencing clinica…
Cautionnement. Plan de continuation, Délai consenti par un créancier dans le cadre de l'article 24 de la loi de 1985, Impossibilité pour la caution d…
1992
International audience; (Com. 28 mai 1991, Casas c/ Banque Nationale de Paris)
Adverse events associated with encorafenib plus binimetinib in the COLUMBUS study: incidence, course and management.
2019
Abstract Background Dual inhibition of the mitogen-activated protein kinase pathway with BRAF/MEK inhibitor (BRAFi/MEKi) therapy is a standard treatment for BRAFV600-mutant metastatic melanoma and has historically been associated with grade III pyrexia or photosensitivity depending on the combination used. The objective of this study was to fully describe adverse events from the COLUMBUS study evaluating the most recent BRAF/MEK inhibitor combination encorafenib+binimetinib. Patients and methods Patients with locally advanced, unresectable or metastatic BRAFV600-mutant melanoma were randomised to receive encorafenib 450 mg once daily plus binimetinib 45 mg twice daily, encorafenib 300 mg on…
Unique continuation of the normal operator of the x-ray transform and applications in geophysics
2020
We show that the normal operator of the X-ray transform in $\mathbb{R}^d$, $d\geq 2$, has a unique continuation property in the class of compactly supported distributions. This immediately implies uniqueness for the X-ray tomography problem with partial data and generalizes some earlier results to higher dimensions. Our proof also gives a unique continuation property for certain Riesz potentials in the space of rapidly decreasing distributions. We present applications to local and global seismology. These include linearized travel time tomography with half-local data and global tomography based on shear wave splitting in a weakly anisotropic elastic medium.
A Prospective Open‐Label Observational Study of a Buffered Soluble 70 mg Alendronate Effervescent Tablet on Upper Gastrointestinal Safety and Medicat…
2021
Upper gastrointestinal (GI) side effects are a main reason for discontinuing bisphosphonate treatment, an important therapeutic option for osteoporosis patients. Consequently, the development of novel formulations with improved tolerability is warranted. In this multicenter prospective, observational, postauthorization safety study conducted in Italy and Spain, postmenopausal women (PMW) with osteoporosis (naïve to bisphosphonates) were treated weekly with a buffered soluble alendronate 70 mg effervescent (ALN-EFF) tablet (Binosto®) and followed for 12 ± 3 months. Information was collected on adverse events (AEs), medication errors, persistence, and compliance using the Morisky-Green questi…
Moderately close Neumann inclusions for the Poisson equation
2016
We investigate the behavior of the solution of a mixed problem for the Poisson equation in a domain with two moderately close holes. If ϱ1 and ϱ2 are two positive parameters, we define a perforated domain Ω(ϱ1,ϱ2) by making two small perforations in an open set: the size of the perforations is ϱ1ϱ2, while the distance of the cavities is proportional to ϱ1. Then, if r∗ is small enough, we analyze the behavior of the solution for (ϱ1,ϱ2) close to the degenerate pair (0,r∗). Copyright © 2016 John Wiley & Sons, Ltd.
Recovery of time-dependent coefficients from boundary data for hyperbolic equations
2019
We study uniqueness of the recovery of a time-dependent magnetic vector-valued potential and an electric scalar-valued potential on a Riemannian manifold from the knowledge of the Dirichlet to Neumann map of a hyperbolic equation. The Cauchy data is observed on time-like parts of the space-time boundary and uniqueness is proved up to the natural gauge for the problem. The proof is based on Gaussian beams and inversion of the light ray transform on Lorentzian manifolds under the assumptions that the Lorentzian manifold is a product of a Riemannian manifold with a time interval and that the geodesic ray transform is invertible on the Riemannian manifold.
Correlation at Low Temperature: II. Asymptotics
2004
The present paper is a continuation of ref. 4, where the truncated two-point correlation function for a class of lattice spin systems was proved to have exponential decay at low temperature, under a weak coupling assumption. In this paper we compute the asymptotics of the correlation function as the temperature goes to zero. This paper thus extends ref. 3 in two directions: The Hamiltonian function is allowed to have several local minima other than a unique global minimum, and we do not require translation invariance of the Hamiltonian function. We are in particular able to handle spin systems on a general lattice.
Effectiveness of cyclosporine and mycophenolate mofetil in a child with refractory evans syndrome
2011
Evans Syndrome is a rare autoimmune disease consisting of hemolytic anemia, thrombocytopenia and/or neutropenia. It may be associated with other autoimmune or lymphoproliferative diseases. Its course can be extremely serious and, rarely, even life-threatening
A construction of Frobenius manifolds from stability conditions
2018
A finite quiver $Q$ without loops or 2-cycles defines a 3CY triangulated category $D(Q)$ and a finite heart $A(Q)$. We show that if $Q$ satisfies some (strong) conditions then the space of stability conditions $Stab(A(Q))$ supported on this heart admits a natural family of semisimple Frobenius manifold structures, constructed using the invariants counting semistable objects in $D(Q)$. In the case of $A_n$ evaluating the family at a special point we recover a branch of the Saito Frobenius structure of the $A_n$ singularity $y^2 = x^{n+1}$. We give examples where applying the construction to each mutation of $Q$ and evaluating the families at a special point yields a different branch of the m…