Search results for "Digest"
showing 10 items of 3038 documents
Bioaccessibility of glucoraphanin from broccoli using anin vitrogastrointestinal digestion model
2014
This study investigated the effect of cooking methods on the degradation of glucoraphanin (GR) in broccoli and the bioaccessibility of this compound through simulated gastrointestinal digestion. Broccoli was cooked using three different techniques: boiling, steaming and microwave cooking. Then, GR was extracted and quantified by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). In addition, the cooked samples were added to a system that simulates the digestion characteristics of the mouth, stomach and duodenum. Samples were drawn before and after the digestion, and GR bioaccessibility was calculated. GR losses were higher when broccoli was boiled (47.03%), followed by …
Intestinal Microbiota and Celiac Disease: Cause, Consequence or Co-Evolution?
2015
It is widely recognized that the intestinal microbiota plays a role in the initiation and perpetuation of intestinal inflammation in numerous chronic conditions. Most studies report intestinal dysbiosis in celiac disease (CD) patients, untreated and treated with a gluten-free diet (GFD), compared to healthy controls. CD patients with gastrointestinal symptoms are also known to have a different microbiota compared to patients with dermatitis herpetiformis and controls, suggesting that the microbiota is involved in disease manifestation. Furthermore, a dysbiotic microbiota seems to be associated with persistent gastrointestinal symptoms in treated CD patients, suggesting its pathogenic implic…
DRUG DELIVERY FROM MUCOADHESIVE DISKS BASED ON A PHOTO-CROSS-LINKABLE POLYASPARTAMIDE DERIVATIVE
2005
Disks for local delivery of amoxicillin to the buccal or gastric cavity were prepared using as starting polymer a polyaspartamide derivative. In particular, α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) was derivatized with glycidyl methacrylate (GMA) in order to synthesize PHG, a photo-cross-linkable and biodegradable polymer that gives rise to the formation of a chemical hydrogel (PHG-UV) by UV irradiation. This hydrogel was shaped as disks whose mucoadhesive properties have been confirmed by swelling measurements in phosphate buffer/citric acid solution at pH 7.0 in the presence of various concentrations of mucin. Swelling ability of PHG-UV disks was also evaluated in simulated saliva…
Food Processing and Foodborne Illness
2015
Food processing means manipulation of raw materials from plants or animals into food. Since agriculture and animal husbandry were established postharvest procedures were necessary to preserve for a longer time the increasing food supplies coming from the fields and domesticated animals. Food is one of the best culture medium for a lot of microorganisms and preventing food spoilage caused by enzymes and microorganisms is crucial. Deterioration of food is caused mainly by three natural processes: 1. Oxidation – vegetables after harvesting or meat after animal slaughtering get in contact with the oxygen in the air that makes them rancid and unpleasant. 2. Enzyme action – all food contains natu…
Taenia Species, Uterine Branches and Capsule Endoscopy
2018
Hamada et al. show, in their article, several proglottids of an adult stage of a Taenia species in the small bowel of a woman by capsule endoscopy (1). One of the images clearly shows a gravid proglottid that allows the view of the characteristic Taenia uterus morphology, with a central axis and a n
Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins.
2001
Methylation at the O(6)-position of guanine (O(6)-MeG) by alkylating agents is efficiently removed by O(6)-methylguanine-DNA methyltransferase (MGMT), preventing from cytotoxic, mutagenic, clastogenic and carcinogenic effects of O(6)-MeG-inducing agents. If O(6)-MeG is not removed from DNA prior to replication, thymine will be incorporated instead of cytosine opposite the O(6)-MeG lesion. This mismatch is recognized and processed by mismatch repair (MMR) proteins which are known to be involved in triggering the cytotoxic and genotoxic response of cells upon methylation. In this work we addressed three open questions. (1) Is MGMT able to repair O(6)-MeG mispaired with thymine (O(6)-MeG/T)? (…
Histokompatibilitäts-(HLA) Antigene bei Patienten mit HBsAg-positiver und -negativer chronisch aktiver Hepatitis und gesunden Trägern von HBsAg und A…
1976
Eine Analyse der Literatur und eigene Befunde uber die Haufigkeit von 23 HLA-Antigenen bei Patienten mit Hepatitis-Oberflachen-Antigen (HBsAg)-positiver und -negativer chronisch aktiver Hepatitis (CAH) und gesunden Tragern von HBsAg und Antikorpern gegen HBsAg (Anti-HBs) erlauben die folgenden Schlusfolgerungen: 1. Bei Patienten mit CAH und HBsAg-Persistenz findet sich eine normale Haufigkeit von HLA-B8 (und -A1). 2. Auch bei Patienten mit HBsAg-negativen Formen einer CAH ohne Autoimmunphanomene (AutoAk) ist die HLA-B8-Haufigkeit normal. 3. Nur Patienten mit HBsAg-negativer CAH mit AutoAk haben eine statistisch signifikant grosere Haufigkeit von HLA-B8 (und -A1) (p < 0,01 nach Korrektion fu…
Transanal coloanal anastomosis for Hirschsprung's disease: comparison between endorectal and perirectal pull-through procedures.
2006
Le but de cette etude est de comparer les resultats de 2 techniques chirurgicales d'abaissement transanal par voie perineale pour maladie de Hirschsprung de forme recto-sigmoidienne. Materiel et Methode: Vingt-et-un patients porteurs de maladie de Hirschsprung de forme recto-sigmoidienne ont ete consecutivement operes entre novembre 1999 et avril 2003 dans les services de Chirurgie Pediatrique de Dijon et Strasbourg. Les 21 enfants ont ete operes par voie perineale transanale: Douze d'entre eux ont eu une dissection peri-rectale (TPR) et 9 une endorectale type Soave (TER). Les 2 groupes de patients ont ete compares pour la longueur du segment aganglionnaire, l'âge et le poids au moment de l…
Hauttestungen mit Nahrungsmittelallergenen
2008
Hauttestungen haben einen zentralen Stellenwert in der Abklarung von Sensibilisierungen bei Nahrungsmittelallergien. Insbesondere der Pricktest stellt eine Routinemethode dar. Allerdings komplizieren instabile Allergene und das Fehlen standardisierter Extrakte das diagnostische Vorgehen bei Verdacht auf eine Nahrungsmittelallergie. Deswegen ist man nach wie vor auf einen Prick-zu-Prick-Test mit nativen Lebensmitteln angewiesen. Indikationen und Kontraindikationen fur eine Hauttestung mit Nahrungsmittelallergenen unterscheiden sich nicht wesentlich von anderen Allergien. Vorsicht ist bei Zustand nach schwerer anaphylaktischer Reaktion und bei bekannter hoher allergener Potenz der Nahrungsmit…
Blefaritis asociada al tratamiento con Cetuximab en adenocarcinoma colorrectal avanzado
2008
espanolCaso clinico: Mujer de 52 anos diagnosticada de adenocarcinoma colorrectal, remitida a nuestro servicio por presentar tras iniciar tratamiento con Cetuximab reaccion adversa palpebral. Discusion: El Cetuximab es un anticuerpo monoclonal cuya diana es el receptor del factor de crecimiento epidermico. Ha sido incorporado recientemente al tratamiento de tumores, principalmente el cancer colorrectal metastatico y los tumores del area otorrinolaringologica. Su tolerancia es en principio mejor que la de los agentes quimioterapicos clasicos. Sin embargo, no esta exento de efectos secundarios. La toxicidad palpebral asociada a Cetuximab ha sido recientemente descrita, por lo que la patogenia…