Search results for "Donor"

showing 10 items of 436 documents

Allogeneic Stem Cell Transplant Versus Tandem High-Dose Melphalan for Front-Line Treatment of Deletion 13q14 Myeloma – An Interim Analysis of the Ger…

2009

Abstract Abstract 51 Background Allogeneic stem cell transplantation (allo SCT), a treatment modality based on transfer of immunocompetent donor lymphocytes offers curative potential to subjects with a variety of hematological cancers. In multiple myeloma (MM), high-dose melphalan followed by autologous stem cell transplantation (auto SCT) is adopted as a standard of care. However, it remains palliative since virtually all patients (pts) relapse and renders allo SCT an option of interest. Deletion of chromosome 13q14 (13q-) in MM has been shown to negatively impact prognosis. Therefore, improvement of therapy for 13q- pts is highly desirable. Patients and methods A prospective two-arm multi…

MelphalanOncologymedicine.medical_specialtybusiness.industryImmunologyCell BiologyHematologymedicine.diseaseInterim analysisDonor LymphocytesBiochemistrySurgeryFludarabineTransplantationsurgical procedures operativeAutologous stem-cell transplantationMedian follow-uphemic and lymphatic diseasesInternal medicinemedicinebusinessMultiple myelomamedicine.drugBlood
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Selective Stepwise Suzuki Cross-Coupling Reaction for the Modelling of Photosynthetic Donor−Acceptor Systems

2009

A Suzuki reaction performed as a selective stepwise substitution of two boryl groups on a diarylporphyrin precursor is reported for straightforward construction of a porphyrin trimer, modeling photosynthetic donor-acceptor systems.

[CHIM.ORGA]Chemical Sciences/Organic chemistry010405 organic chemistryOrganic ChemistryTrimer010402 general chemistryPhotosynthesisPhotochemistry01 natural sciencesBiochemistryPorphyrinCoupling reaction0104 chemical scienceschemistry.chemical_compounddonor-acceptor systemchemistrySuzuki reaction[ CHIM.ORGA ] Chemical Sciences/Organic chemistryface to faceSuzuki couplingPhysical and Theoretical ChemistryDonor acceptorporphyrinComputingMilieux_MISCELLANEOUSOrganic Letters
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Tackling Performance Challenges in Organic Photovoltaics: An Overview about Compatibilizers

2020

Organic Photovoltaics (OPVs) based on Bulk Heterojunction (BHJ) blends are a mature technology. Having started their intensive development two decades ago, their low cost, processability and flexibility rapidly funneled the interest of the scientific community, searching for new solutions to expand solar photovoltaics market and promote sustainable development. However, their robust implementation is hampered by some issues, concerning the choice of the donor/acceptor materials, the device thermal/photo-stability, and, last but not least, their morphology. Indeed, the morphological profile of BHJs has a strong impact over charge generation, collection, and recombination processes; control o…

additiveOrganic solar cellComputer sciencePharmaceutical ScienceMature technologymixing interfaceReviewcompatibilizersdonor/acceptor interfaceAnalytical Chemistrylcsh:QD241-441lcsh:Organic chemistryPhotovoltaicsDrug DiscoverySolar Energycompatibilizermorphology modulatorPhysical and Theoretical ChemistrySustainable developmentFlexibility (engineering)morphology modulatorsbusiness.industryOrganic Chemistrybulk heterojunctionEngineering physicsCharge generationModels ChemicalChemistry (miscellaneous)mixing interfacesMolecular Medicineadditivesorganic photovoltaicsbusiness
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Zvaguļu (Rhinanthus) izmantošana zālāju ekoloģiskajā atjaunošanā auglīgās augsnēs: sēklu kvalitātes un konkurences nozīme

2022

Ir zināms, ka mūsdienās viena no globālām problēmām ir klimata pārmaiņas, kura skar arī dažādas ekosistēmas un to stāvokli. Zālāju ekosistēmas ir diezgan jūtīgas pret apkārtējās vides izmaiņām, līdz ar to Latvijā ir novērojama dabisko zālāju sarukšanas tendence. Tādēļ, dabiskos zālājus ir nepieciešams saglābāt, apsaimniekot un atjaunot Latvijas mērogā. Ekoloģiskās atjaunošanas metodes mēdz būt visai dažādas, taču viena no jaunākajām, līdz šim Latvijā neaprobētām metodēm, ir zvaguļu pusparazītaugu ieviešanas metode, kura paredzēta zālājā esošo sugu konkurences samazināšanai, un maģistra darba mērķis ir noskaidrot sēklu kvalitātes un veģetācijas konkurences nozīmi zvaguļu izmantošanā zālāju e…

Vides zinātnedzīvotspējaveģetācijas konkurencedonorzālājsdīgtspējazālāju atjaunošanas metodes
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Effect of transition metals and homogeneous hydrogen producers in the hydrothermal liquefaction of sewage sludge

2022

Hydrothermal liquefaction (HTL) of sewage sludge (SS) was performed in the presence of metallic Zn, Fe and Ni to investigate their effect on the performances of the process in terms of product yields and quality. Experiments were performed in subcritical water at 350 ◦C for 10 min using each metal individually and in the presence of homogenous hydrogen producers like formic acid (FA) and KOH. Interesting results were obtained with Zn that when used alone or in the presence of KOH, increased the cumulative biocrude (BC) yields and resulted in energy recoveries (ER) higher than 100% with respect to initial energy content of the biomass, thus indicating that HTL of SS is globally endothermic. …

TechnologyFuel TechnologyHydrothermal liquefaction Biocrude Metals Hydrogen donor Sewage sludge Waste biomassGeneral Chemical EngineeringEnergy Engineering and Power TechnologySettore ING-IND/27 - Chimica Industriale E Tecnologicaddc:600
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Science to Practice: Should Biopsy Be Performed in Potential Liver Donors When Unenhanced CT Shows an Unacceptable Degree of Steatosis for Transplant…

2006

Park et al (1) have demonstrated that unenhanced CT can accurately depict moderate to severe (ie, ≥30%) macrovesicular steatosis, thereby allowing avoidance of biopsy in potential living liver donors who have an unacceptable degree of steatosis for transplantation. Biopsy will still be needed in donors with macrovesicular steatosis of less than 30% at unenhanced CT to rule out occult chronic liver disease and more severe steatosis that is undetected at CT. © RSNA, 2006.

Moderate to severemedicine.medical_specialtymedicine.diagnostic_testbusiness.industryBiopsyChronic liver diseasemedicine.diseaseMacrovesicular steatosisOccultLiver TransplantationFatty LiverTransplantationLiverBiopsyLiver donorsLiving DonorsmedicineHumansRadiology Nuclear Medicine and imagingRadiologySteatosisTomography X-Ray ComputedbusinessRadiology
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313: A cDNA-based assay for donor-chimerism analysis of epidermal langerhans cells

2007

Transplantationsurgical procedures operativeimmune system diseasesbusiness.industryComplementary DNADonor chimerismMedicineHematologybusinessMolecular biologyBiology of Blood and Marrow Transplantation
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Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Settore BIO/18 - Geneticainstead chromosomes of controls were almost uniformly decorated by brilliant grains. Studies on methylation of PTHrP gene promoter 2 performed on five CpG island internal sites using the Methylation-Sensitive Restriction Endonuclease Multiplex (MSREM)-PCR showed that one of the sites nearest the trascription starting point is heavy methylated in a significantly high number of RA patients. Thus RA seems to be characterized by genomewide hypomethylation associated with local hypermethylation like the most part of tumors. This result raises the possibility that susceptibility to lymphomas is related to abnormal DNA methylation levels and suggests the opportunity to evaluate the DNA methylation status in RA patientin fact the demethylating therapies together with diet and life style can act towards an increase of tumor risk. Future studies using a larger number of subjects could confirm these findings.Rheumatoid Arthritis (RA) is a chronic multisystem inflammatory disease characterized by high recurrence of lymphomas as well as hypercalcemia due to PTHrP overexpression. Because of DNA methylation plays a critical role in development of neoplasias we determined in RA patients the global DNA methylation status and local methylation pattern of the CpG island of one of the three promoters of PTHrP gene utilizing molecular and cytogenetic techniques. Investigations performed on DNA from peripheral blood of patients and donors amplified by Methylation-Sensitive Arbitrarily Primed (MeS-AP)-PCR indicated that RA is strongly associated with global DNA hypomethylation. Similarly chromosomal DNA methylation pattern analysis by indirect immunofluorescence technique with anti 5-methylcitosine antibody showed all peripheral lymphocyte metaphases from RA patients with chromosomes weakly fluorescent without discrete grain
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Large Quadratic Hyperpolarizabilities with Donor–Acceptor Polyenes Exhibiting Optimum Bond Length Alternation: Correlation Between Structure and Hype…

1997

Donor-acceptor polyenes of various lengths, and that combine aro- matic electron-donating moieties with powerful heterocyclic electron-withdraw- ing terminal groups, have been synthe- sized and characterized as efficient non- linear optical (NLO) chromophores. Their linear and nonlinear optical proper- ties have been investigated, and variations in these properties have been related to ground-state polarization (dipole p) and structure. In particular, unprecedented quadratic hyperpolarizabilities (p) have been achieved (up to p(0) =I500 x 10-30esu) by reduction of the bond- length alternation (BLA) in the polyenic chain. In each series of homologous com-

ChemistryOrganic ChemistryBond length alternationAlternation (geometry)Nonlinear opticsHyperpolarizabilityGeneral ChemistryChromophoreCatalysisDipoleCrystallographyQuadratic equationComputational chemistryDonor acceptorChemistry - A European Journal
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Impact of hydroxy and octyloxy substituents of phenothiazine based dyes on the photovoltaic performance

2013

Two novel organic dyes containing hydroxy and octyloxy substituents onto a phenothiazine skeleton were synthesized and their effects on the photovoltaic performance were studied. Hydroxy acts as an ancillary anchoring unit along with the carboxylic group, while the phenothiazine modified moiety acts as an electron donor. The photophysical and electrochemical studies revealed that maximum absorbance of the dye with the hydroxy group in the solution was blue shifted and its band gap increased, indicating that donor acceptor strength was reduced as compared to the octyloxy substituted dye. Furthermore, electron lifetime of the organic dye with the hydroxy moiety was shorter due to smaller resi…

Absorbancechemistry.chemical_compoundDye-sensitized solar cellchemistryBand gapProcess Chemistry and TechnologyGeneral Chemical EngineeringPhenothiazineEnergy conversion efficiencyMoietyElectron donorPhotochemistryElectrochemistryDyes and Pigments
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