Search results for "Ears"

Osimertinib in first-line treatment of advanced EGFR-mutated non-small-cell lung cancer: a cost–effectiveness analysis

2019

Aim: Osimertinib improves progression-free survival in first-line EGFR mutation–positive non-small-cell lung cancer. Materials & methods: A Markov cohort model including costs, utilities and disutilities, was conducted to estimate quality-adjusted life-year (QALY) and incremental cost–effectiveness ratio when treating with osimertinib versus standard first-line tyrosine kinase inhibitors (TKIs). Results: Osimertinib presented higher QALYs (0.61) compared with standard EGFR–TKIs (0.42). Osimertinib costs were €83,258.99, in comparison with €29,209.45 for the standard EGFR–TKIs. An incremental cost–effectiveness ratio of €273,895.36/QALY was obtained for osimertinib. Conclusion: Osimerti…

Topical glaucoma medications – Clinical implications for the ocular surface

2022

Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound. A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pharmaceutical compounds on the ocular surface, with resultant tear film instability and dry eye disease. Herein, we critically appraise the published literature exploring the effects of preservatives and pharmaceutical compounds on the ocular surface. publishedVersion

Reducing postharvest decay in cactus pears by dip treatment with imazalil or azoxystrobin

2019

Postharvest decay in cactus pear is a minor problem in fruit marketed directly after harvest, while it may represent a major cause of losses when fruit are cold stored or subjected to cold quarantine treatments. Unfortunately, to date, no postharvest fungicide has been registered to control postharvest decay of cactus pears. Thus, the objective of this study was to evaluate the efficacy of two globally known fungicides, imazalil (IMZ) and azoxystrobin (AZO), registered for postharvest treatment of various fresh produce species, to control decay on cactus pears. Second-crop cactus pears ‘Gialla’ fruits were dipped in 500 mg L(‑1) IMZ or AZO and stored at 1 or 8°C and 90-95% RH for 2 or 3 wee…

Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation

2021

Abstract Purpose Obstructive Meibomian gland dysfunction (MGD) is one of the leading causes of evaporative dry eye disease. Meibomian glands at the eyelid secrete lipids that prevent evaporation of the aqueous tear film. The pathogenesis of obstructive MGD is incompletely understood to date. Herein, we aim to investigate the pathogenesis of obstructive MGD using murine and human samples with various forms of ocular surface inflammation. Method The presence of Neutrophil extracellular Traps (NETs) was detected with immunofluorescence analysis of ocular surface discharge and biopsy samples from patients with blepharitis. Tear fluid from patients with MGD and blepharitis were evaluated for the…

SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye.

2005

Protein and peptides in tears play an important role in ocular surface diseases. In previous studies, changes have been demonstrated in the electrophoretic protein profiles of patients with dry eye. The purpose of this work was to determine the usefulness of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) ProteinChip Array (Ciphergen Biosystems, Inc., Fremont, CA) technology for the automated analysis of proteins and peptides in tear fluid.Patients with dry eye (DRY, n = 88) and healthy subjects (CTRL, n = 71) were examined. Their tear proteins were analyzed using SELDI-TOF-MS ProteinChip Arrays with three different chromatographic surfaces (CM10…

Author Response: Clinical Considerations in Proinflammatory Cytokine Profiling of Tears from Patients with Dry Eye by Means of Antibody Microarrays

2011

Empātijas veicināšana pirmsskolā 5-6 gadus veciem bērniem, izmantojot rotaļas un spēles

2020

Kvalifikācijas darbs “Empātijas veicināšanā pirmsskolā 5-6 gadus veciem bērniem, izmantojot rotaļas un spēles” ir izstrādāts, lai izpētītu empātijas veicināšanas iespējas 5-6 gadus veciem bērniem, kuri apmeklē pirmsskolas iestādi X, izmantojot rotaļas un spēles. Mērķis bija izpētīt empātijas veicināšanas iespējas rotaļās un spēlēs 5-6 gadus veciem bērniem. Darba uzdevumi bija: 1. Analizēt teorētisko literatūru par pētījuma problēmu. 2. Veikt empīrisku pētījumu par empātijas attīstīšanas iespējām 5-6 gadus veciem bērniem. Spēja saprast otra cilvēka jūtas un valdīt pār svešām jūtām ir noteicošā attiecību mākslā. Empātija uzlabo cilvēku attiecības, sekmē sadarbību, jo balstās uz līdzcilvēku iz…

5-6 gadus vecu bērnu prasmes orientēties apvidū veidošanās pirmsskolas izglītības iestādē

2019

Maģistra darba tēma ir “ 5-6 gadus vecu bērnu prasmes orientēties apvidū veidošanās pirmsskolas izglītības iestādē”. Darba mērķis ir izpētīt 5-6 gadus vecu bērnu prasmes orientēties apvidū veidošanos. Darbs sastāv no 50 lappusēm, 4 nodaļām, kas ietver sevī 7 attēlus, 12 tabulas, izmantotās literatūras sarakstu ar 41 vienību un 2 pielikumus. Gan Skola 2030, gan VISC (Valsts izglītības un satura centrs) veidotajās pirmsskolas izglītības programmās ir minēts, ka, pirmsskolu beidzot, bērnam ir jāprot orientēties telpā un plaknē. Orientēšanās apvidū netiek atsevišķi izdalīta, kaut gan tā ir tikpat svarīga kā orientēšanās telpā un plaknē. 5 – 6 gadi ir vecums, kad bērnus sāk gatavot skolai, kur o…

Benefit of using an age-adjusted D-dimer cut-off

2015

Introduction: The association between a low-moderate pretest clinical probability and a negative D-dimer (DD) value is able to exclude the possibility of pulmonary embolism (PE). The value of DD seems to increase with age, reducing its specificity. Therefore, we intend to evaluate the usefulness of an age-adjusted cut-off value for age above 50 years, applying the formula suggested by Douma (age*10) set to our laboratory method (age*5) (1) . Patients and Methods: Observational, retrospective study from January to December 2011. DD test were performed to 1515 patients attended in the emergency room of our hospital according to the clinical suspicion made by the doctor who evaluated them. The…

Expertise

2017

Several sets of guidelines have been published recently and more are in the works. The very recent American College of Physicians/American Academy of Family Practitioners guidelines were put together by a set of authors and consultants without any expertise in the topic under discussion, that is, hypertension. Although we are not maintaining that all guidelines should be written exclusively by experts, complete lack of expertise among guideline authors is not acceptable. ispartof: Journal Of Hypertension vol:35 issue:8 pages:1564-1566 ispartof: location:Netherlands status: published