Search results for "Farm"
showing 10 items of 3554 documents
Vitrectomía enzimática por inyección intravítrea de plasmina autóloga como tratamiento inicial del edema macular diabético difuso
2008
espanolObjetivo: Determinar si la inyeccion intravitrea de plasmina es efectiva en el tratamiento del edema macular diabetico difuso (EMDD). Diseno: Estudio piloto prospectivo, comparativo, de intervencion, serie de casos. Pacientes: Dieciocho pacientes con edema macular diabetico bilateral, recibieron como primera actuacion terapeutica una inyeccion intravitrea de plasmina en un ojo, sirviendo el ojo contralateral como control. Tratamiento: Inyeccion intravitrea de 0,2 ml de plasmina autologa bajo anestesia topica. La plasmina fue obtenida por un metodo simplificado. Principales medidas: Engrosamiento macular central (EMC) medido por tomografia de coherencia optica (OCT) y agudeza visual (…
Klīniski nozīmīgo gram negatīvo baktēriju rezistence pret antibakteriālajiem līdzekļiem
2015
Maģistra darba ietvaros ir apkopoti un izanalizēti materiāli no 2013. gada janvāra līdz 2013. gada decembrim. Izolāti tika iegūti no pacientu elpceļiem: bronhu atsūknējumiem, krēpām, pleiras šķidruma un biopsiju paraugiem. Šo izolātu rezistenci pret antibakteriālajiem līdzekļiem tika pārbaudīta ar beta laktāmu, hinolonu un aminoglikozīdu klases pretmikrobu līdzekļiem. Darba mērķis ir klīniski nozīmīgo Gram negatīvo baktēriju identifikācija un jutības pret antibakteriālajiem līdzekļiem noteikšana. Savukārt, lai no hemokultūras ātri identificētu baktēriju sugu, tika lietota molekulārbioloģiskā metode: GenoType BC gramnegative tests. Gram negatīvo mikroorganismu jutības noteikšanai pret antiba…
Vidzemes Lielais Zviedru Kadastrs kā saimniecības vēstures avots
1942
Kadastrs - sistematizēti kādu zemes vai ūdens nogabalu vai citu objektu dati; ar nodokļiem apliekamo zemju saraksts un novērtējums pilsētās un laukos. Zemes kadastru sāka ar zemes uzmērīšanu un vērtēšanu, vienlaikus veicot muižu redukciju, atsavinot lielāko daļu muižas zemju, kuras nodeva Zviedrijas valsts pārziņā. Tas bija labi izstrādāts kadastrs, un to izmantoja no 1691. līdz 1911. gadam, t. i., 220 gadus. Tas pasaulē ir samērā mazpazīstams, un tagadējās Latvijas un Igaunijas teritorijā tam bija tikai lokāla nozīme. Muižu redukcija .17. gs. 2. pusē, pieaugot absolūtisma tendencēm Eiropā, Zviedrijas karalis Kārlis XI (Karl XI) centās nostiprināt varu visā valstī. Viens no pasākumiem bija …
Binge-like alcohol exposure in adolescence: behavioural, neuroendocrine and molecular evidence of abnormal neuroplasticity … and return
2021
Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (NAc). This study explores in rats the long-lasting effects of early intermittent exposure to intoxicating alcohol levels at adolescence, on: (1) the response to natural positive stimuli and inescapable stress
Rilevazione statistica della diffusione dei fenomeni di binge drinking, drunkoressia e gambling tra gli adolescenti palermitani
2017
L’obiettivo dello studio è l’analisi della diffusione dei comportamenti riconducibili ai fenomeni di Binge Drinking, Drunkoressia e Gambling in individui che possiedono un’età compresa tra i 13 e 20 anni: si è deciso di analizzare nello specifico tale fascia d’età poiché la propensione di alcuni soggetti ad assumere condotte pericolose per la propria salute risulta essere particolarmente alta proprio durante la fase adolescenziale. Quest’ultimo è infatti un periodo di intenso sviluppo neuro- cognitivo che conduce a cambiamenti importanti ai fini del comportamento, dell’affettività, della ricerca e della selezione di stimoli più gratificanti: il risultato è un aumento della predisposizione a…
Recent advances in smart biotechnology: Hydrogels and nanocarriers for tailored bioactive molecules depot
2017
Over the past ten years, the global biopharmaceutical market has remarkably grown, with ten over the top twenty worldwide high performance medical treatment sales being biologics. Thus, biotech R&D (research and development) sector is becoming a key leading branch, with expanding revenues. Biotechnology offers considerable advantages compared to traditional therapeutic approaches, such as reducing side effects, specific treatments, higher patient compliance and therefore more effective treatments leading to lower healthcare costs. Within this sector, smart nanotechnology and colloidal self-assembling systems represent pivotal tools able to modulate the delivery of therapeutics. A comprehens…
Immuno-oncological treatment of Non-Small-Cell Lung Cancer (NSCLC) in advanced stage with Nivolumab
2023
Immuno-oncology marked a therapeutic revolution in the treatment of cancer. Thanks to the new strategy that aims to awaken the immune system to fight cancer cells, there has been a change in the clinical course in the treatment of advanced Non-Small Cell Lung Cancer (NSCLC). Our study aimed to evaluate the therapeutic efficacy of nivolumab monotherapy in the treatment of patients with advanced stage IIIB/IV non-small cell lung cancer beyond the second line. The results showed a progression-free survival of 7.35 months and an improvement in the quality of life of patients compared to other treatments. In addition, no type 3 and type 4 adverse reactions were detected in patients treated with …
Meccanismi immunologici e molecolari del danno epatico da farmaci
2015
I polimorfismi genetici e/o i fattori ambientali, ad esempio l’alcol e/o i farmaci concomitanti, contribuiscono alla suscettibilità individuale nel determinare il danno epatico da farmaci. L’HLA si è dimostrato essere uno dei più importanti predittore di suscettibilità individuale anche per quei farmaci per i quali questa non era stata mai sospettata.
N-valproyl-aminoacids as new potential antiepileptic drugs: Synthesis, characterization and in vitro studies on stability
2015
Epilepsy, affecting at least 50 million persons worldwide, is one of the most common neurological disorders. Despite the significant advances in understanding epileptogenic mechanisms and in counteracting their pathological consequences, this clinical condition still has to be faced of treating more effectively the symptoms (epileptic seizures) and of preventing their unfavourable evolution. So far, research has been unsuccessful involved in developing effective antiepileptic drugs (AEDs) capable of preventing the development of the pathogenic process, set in motion by different etiological factors, that leads ultimately to chronic epilepsies .[1, 2] So, a substantial need remains to develo…
The Essential Oil of Thymbra capitata and its Application as A Biocide on Stone and Derived Surfaces
2019
Many chemicals used nowadays for the preservation of cultural heritage pose a risk to both human health and the environment. Thus, it is desirable to find new and eco-friendly biocides that can replace the synthetic ones. In this regard, plant essential oils represent effective alternatives to synthetic substances for the preservation of historical monuments. Thymbra capitata (syn. Thymus capitatus) is a medicinal and aromatic plant growing in the Mediterranean area and endowed with important pharmacological properties related to its essential oil. Among them, the antimicrobial ones make the T. capitata essential oil an ideal candidate for industrial applications